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Citing Papers
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Ionic events induced by epidermal growth factor. Evidence that hyperpolarization and stimulated cation influx play a role in the stimulation of cell growth.
1991
ERBB receptors and cancer: the complexity of targeted inhibitors
2005 Standout
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
1990
Specificity in Signal Transduction
2004
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
1990
Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg
1992 StandoutNobel
The discovery of receptor tyrosine kinases: targets for cancer therapy
2004
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
PDGF induction of tyrosine phosphorylation of GTPase activating protein
1989 Nature
Epidermal growth factor-related peptides and their receptors in human malignancies
1995 Standout
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
1992 Standout
Phospholipase C Isozymes: Structural and Functional Similarities
2007
Signaling Pathways Leading to Transcription and Translation Cooperatively Regulate the Transient Increase in Expression of c-Fos Protein
2001 StandoutNobel
The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development
1989
Signal transduction by receptors with tyrosine kinase activity
1990 Standout
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Regulators and Effectors of ras Proteins
1991
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
1992 StandoutNatureNobel
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
1991
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila
1991 StandoutNobel
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
1991
Structural and Functional Diversity in the FGf Receptor Multigene Family
1992
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
1995 StandoutNobel
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs
1992 Nature
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
The TRPM7 channel is inactivated by PIP2 hydrolysis
2002
Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis
1993 StandoutNobel
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Oncogenes and signal transduction
1991 Standout
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
1991 StandoutNatureNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
1992 Nature
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
1991
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
Involvement of growth factor receptors in the mammalian UVC response
1994
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
1992
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
1992 NatureNobel
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis
1992 Nature
Human colony stimulating factor-1 receptor activates the C-raf-1 proto-oncogene kinase
1990
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
EGFR endocytosis requires its kinase activity and N-terminal transmembrane dimerization motif
2013
Protein kinases and phosphatases that act on histidine, lysine, or arginine residues in eukaryotic proteins: A possible regulator of the mitogen-activated protein kinase cascade
1995
Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
1989
Mechanisms of Signal Transduction to the Cell Nucleus
1990
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein
1996
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
1993 StandoutNobel
Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.
1990
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
Presence of an SH2 Domain in the Actin-Binding Protein Tensin
1991 Science
Substitution of lysine for arginine at position 42 of human transforming growth factor-alpha eliminates biological activity without changing internal disulfide bonds.
1989
Interaction between the epidermal growth factor receptor and phosphoinositide kinases.
1991
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
1991
Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide
1997 Standout
McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits the Heat-Shock Regulator CtsR
2009 StandoutScienceNobel
CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.
1991
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
1990
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
1991 Nobel
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
1992
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
1992
Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor
1990 Science
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Signal transmission by epidermal growth factor receptor: coincidence of activation and dimerization
1992
Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.
1989
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.
1990
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
1992
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.
1988
Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.
1990
The Actin-Binding Protein Profilin Binds to PIP 2 and Inhibits Its Hydrolysis by Phospholipase C
1990 Science
Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.
1989
Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis
1990 Science
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
1991 StandoutNobel
Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors
1990 Science
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
1990
EGF Receptor and erb B-2 Tyrosine Kinase Domains Confer Cell Specificity for Mitogenic Signaling
1990 Science
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen
1990
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
1993
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.
1995
Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
1991 Nobel
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.
1990
High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.
1990
Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits in 3T3 fibroblasts. Coordinate signaling changes and differential suppression of cell growth and transformation.
1994 StandoutNobel
Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
1990
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.
1990
Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.
1990
gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein
1990 StandoutScienceNobel
von Hippel-Lindau Protein-Mediated Repression of Tumor Necrosis Factor Alpha Translation Revealed through Use of cDNA Arrays
2003
Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.
1993
Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product
1989 Science
Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells.
1990
Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation
1990 Science
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
1990
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Mitogen-activated protein kinase stimulation by a tyrosine kinase-negative epidermal growth factor receptor.
1993
Cell cycle arrest and c-mos
1992 StandoutNatureNobel
A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.
1988
A Cell Culture Model for T Lymphocyte Clonal Anergy
1990 StandoutScience
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
1994
Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor.
1992
Inhibitors of human immunodeficiency virus integrase.
1993 StandoutNobel
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.
1989
Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.
1989
Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex
1990
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.
1990
Signal transduction by allosteric receptor oligomerization
1988
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Src homology region 2 domains direct protein-protein interactions in signal transduction.
1990
Transient up-regulation of P2Y2nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
1997 StandoutNobel
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.
1990
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins
1990 Science
Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.
1991
SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors
1992
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.
1992
Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain
1989
Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.
1990
Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor
1989
Works of R. Lyall being referenced
Teatro, Mauá, SP.
1991
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
1989
A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.
1987
Tyrphostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation
1989
A Mutant Epidermal Growth Factor Receptor with Defective Protein Tyrosine Kinase Is Unable To Stimulate Proto-Oncogene Expression and DNA Synthesis
1987