Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Isolation and characterization of Drosophila cAMP-dependent protein kinase genes.
1988
Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture
1995
Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths
1994
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Glutamate release from microglia via glutamate transporter is enhanced by amyloid-beta peptide
1999
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
1994
The nanometer-scale structure of amyloid-Β visualized by atomic force microscopy
1996
Hydrogen peroxide mediates amyloid β protein toxicity
1994 Standout
Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons
1992
Expression of the Cyclic AMP‐dependent Protein Kinase (PKA) Catalytic Subunit from a Herpes Simplex Virus Vector Extends the Survival of Rat Sympathetic Neurons in the Absence of NGF
1994
The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix
1993
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease
1998
Neurogenesis in neonatal rat brain is regulated by peripheral injection of basic fibroblast growth factor (bFGF)
1996
Vitamin E protects nerve cells from amyloid βprotein toxicity
1992
Cerebellar granule cell neurogenesis is regulated by cell-cell interactions in vitro
1991
Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death
1997
Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain
1995
Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells
1997
Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps
1989
Identification of a penta- and hexapeptide of islet amyloid polypeptide (IAPP) with amyloidogenic and cytotoxic properties
2000
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments
1991 StandoutNobel
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Immortalized young adult neurons from the septal region: generation and characterization
1990
Contributory mechanisms in the causation of neurodegenerative disorders
1993
Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons
1997
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Neuroprotection by memantine against neurodegeneration induced by β-amyloid(1–40)
2002
Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease
2004
Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
2012 Standout
Rapid impact of ?-amyloid on Paxillin in a neural cell line
1997
Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog
1999 Standout
Annexin 5 and apolipoprotein E2 protect against Alzheimer’s amyloid-β-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site
2002
A Molecular Model of Alzheimer Amyloid β-Peptide Fibril Formation
1999
Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF
1993
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Amyloid β peptide induces necrosis rather than apoptosis
1994
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
Inhibitors of free radical formation fail to attenuate direct β‐amyloid25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures
1994
Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen‐activated protein kinase
1994
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein
1999
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
1993
System Xc−and Apolipoprotein E Expressed by Microglia Have Opposite Effects on the Neurotoxicity of Amyloid-β Peptide 1–40
2006
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
1992
Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons
1995
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation
1991
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Notch receptor cleavage depends on but is not directly executed by presenilins
2002 StandoutNobel
Neutralizing Intraspinal Nerve Growth Factor Blocks Autonomic Dysreflexia Caused By Spinal Cord Injury
1999
Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
1999
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
1999
Regulation of Neurotrophin-3 Expression by Epithelial-Mesenchymal Interactions: The Role of Wnt Factors
1999 StandoutScienceNobel
Differential Regulation of Chromogranin B and Synapsin I Gene Promoter Activity by cAMP and cAMP‐Dependent Protein Kinase
1994
Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.
1991
Tissue Engineering
1993 StandoutScience
A system for characterizing cellular and molecular events in programmed neuronal cell death
1993
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Activated N‐ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells
1986
GROWTH CONE GUIDANCE: First Steps Towards a Deeper Understanding
1999
Apoptosis in the Pathogenesis and Treatment of Disease
1995 StandoutScience
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
1998 Standout
Complement activation by beta-amyloid in Alzheimer disease.
1992
Unexpected Ca 2+ -binding properties of synaptotagmin 9
2004 StandoutNobel
Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse
1997
Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase.
1990 StandoutNobel
A nerve growth factor-regulated messenger RNA encodes a new intermediate filament protein.
1988
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons.
1988 StandoutNobel
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling
1997
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.
1994
Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.
1994
Characterization of tissue-specific transcription by the human synapsin I gene promoter.
1991 StandoutNobel
Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.
1998
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Activation of a potassium current by rapid photochemically generated step increases of intracellular calcium in rat sympathetic neurons.
1987 StandoutNobel
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
2002 StandoutNobel
Neural Science
2000 StandoutNobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
The Expression of Two Splice Variants of the Kv3.1 Potassium Channel Gene Is Regulated by Different Signaling Pathways
1998
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells.
1992
Transthyretin sequesters amyloid beta protein and prevents amyloid formation.
1994
Internucleosomal DNA cleavage and neuronal cell survival/death
1993
Depolarization maintains neurites and priming of PC12 cells after nerve growth factor withdrawal
1993
Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.
1993
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
1997 Standout
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction
1997
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
1995 StandoutNobel
The Developmental Biology of Brain Tumors
2001
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels.
1987 StandoutNobel
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
1995
Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions.
1991
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
1993
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
The 3D profile method for identifying fibril-forming segments of proteins
2006 StandoutNobel
Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor
1995 Science
Neurotoxicity induces cleavage of p35 to p25 by calpain
2000 Nature
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Inhibitors of Amyloid Toxicity Based on β-sheet Packing of Aβ40 and Aβ42
2006
Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development
1989
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Cell-cell interactions influence survival and differentiation of purified purkinje cells in vitro
1994
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.
1990 StandoutNobel
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.
1988 StandoutNobel
Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNSIn Vivo
1998
Neurotransmitter Release from Synaptotagmin-Deficient Clonal Variants of PC 12 Cells
1992 Science
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
1994
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
1993
Induction of Apoptosis by the Low-Affinity NGF Receptor
1993 Science
Works of R E Rydel being referenced
Characterization of the effects of autoimmune nerve growth factor deprivation in the developing guinea-pig
1983
In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor
1988
Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examplesa
1993
Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.
1994
PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.
1986
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.
1988
Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
1991
Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells
1987
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
1992