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Citing Papers
A Novel Functional Human Eukaryotic Translation Initiation Factor 4G
1998
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
2009 StandoutScience
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
2001 StandoutScience
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase.
1986
β-Arrestin-mediated Signaling Regulates Protein Synthesis
2008 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e Subunit
2006
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F
1998
eIF4E – from translation to transformation
2004
Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast
2002 StandoutNobel
A new translational regulator with homology to eukaryotic translation initiation factor 4G
1997
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Human protein synthesis initiation factor eIF-4γ is encoded by a single gene (EIF4G) that maps to chromosome 3q27—qter
1995
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
2015 StandoutNobel
Inhibition of 2-oxoglutarate dependent oxygenases
2011
4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family
1998
Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
2007
Internal Initiation of Translation Directed by the 5′-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation
1996
Signaling Pathways Leading to Transcription and Translation Cooperatively Regulate the Transient Increase in Expression of c-Fos Protein
2001 StandoutNobel
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
A Consideration of Alternative Models for the Initiation of Translation in Eukaryotes
1992
Phosphorylation of elF‐4E and initiation of protein synthesis in P19 embryonal carcinoma cells
1995
Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases
1995
Intact Eukaryotic Initiation Factor 4G Is Required for Hepatitis A Virus Internal Initiation of Translation
1997
A Novel Interaction between Adrenergic Receptors and the α-Subunit of Eukaryotic Initiation Factor 2B
1997 StandoutNobel
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Development of a Carbon Dioxide-Capture Assay in Microtiter Plate for Aspartyl-β-hydroxylase
1999
Identification and Characterization of a Novel Cap-binding Protein from Arabidopsis thaliana
1998
Does phosphorylation of the cap‐binding protein eIF4E play a role in translation initiation?
2002
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast
1998 StandoutNobel
A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
2009
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
2002 StandoutNatureNobel
Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes
1997
Multiple Isoforms of Eukaryotic Protein Synthesis Initiation Factor 4E in Caenorhabditis elegans Can Distinguish between Mono- and Trimethylated mRNA Cap Structures
1998
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation
1998 Nature
Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA
1998
Inactivation of eIF2B and Phosphorylation of PHAS-I in Heat-shocked Rat Hepatoma Cells
1997
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
2012 Standout
The plant translational apparatus
1996
Modulation of Translation Initiation in Rat Skeletal Muscle and Liver in Response to Food Intake
1997
Comparative sequence analysis and expression of bovine PrP gene in mouse L-929 cells
1992
Cap recap: The involvement of eIF-4F in regulating gene expression
1992
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate
1997
Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein
1991
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation
1993
Participation of initiation factors in the recruitment of mRNA to ribosomes
1994
Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209
1995
The Case for mRNA 5′ and 3′ End Cross Talk During Translation in a Eukaryotic Cell
2006
Regulation and function of non-AUG-initiated proto-oncogenes
1994
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
1998
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Cleavage and binding of a DNA fragment containing a single 8-oxoguanine by wild type and mutant FPG proteins
1993
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Initiation of Protein Synthesis in Eukaryotic Cells
1996
Growth Control of Translation in Mammalian Cells
1995
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
2010 StandoutNobel
Structures of L -proline trans-hydroxylase reveal the catalytic specificity and provide deeper insight into AKG-dependent hydroxylation
2023
Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery
2013 StandoutNobel
Functional Characterization of the Internal Ribosome Entry Site of eIF4G mRNA
1998
An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation
2006
Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines
1995
Translational Initiation Factor eIF-4E
1996
Translational control in stress and apoptosis
2005
Global Brain Ischemia and Reperfusion: Modifications in Eukaryotic Initiation Factors Associated with Inhibition of Translation Initiation
1996
eIF4E expression in tumors: its possible role in progression of malignancies
1999
Insulin and Phorbol Ester Stimulate Initiation Factor eIF–4E Phosphorylation by Distinct Pathways in Chinese Hamster Ovary Cells Overexpressing the Insulin Receptor
1996
Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine
2000 StandoutNobel
A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate
1996
Regulation of eukaryotic translation initiation factor expression during T-cell activation
1993
Direct Cleavage of eIF4G by Poliovirus 2A Protease Is Inefficientin Vitro
1998
unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA
1999
Gene regulation by steroid hormones
1989 Standout
The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro
2004 StandoutNobel
A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
1999 StandoutNobel
Structure of the 80S Ribosome from Saccharomyces cerevisiae—tRNA-Ribosome and Subunit-Subunit Interactions
2001 StandoutNobel
Collagen Hydroxylases and the Protein Disulfide Isomerase Subunit of Prolyl 4‐Hydroxylases
1998
Eukaryotic Translation Initiation Factor 4G Is Targeted for Proteolytic Cleavage by Caspase 3 during Inhibition of Translation in Apoptotic Cells
1998
Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.
1990
The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins
1995
Rat alpha 1-acid glycoprotein. Gene sequence and regulation by glucocorticoids in transfected L-cells.
1985
Regulation of eukaryotic protein synthesis by initiation factors.
1993
The absence of introns within a human fibroblast interferon gene
1981 StandoutNobel
The 2‐oxoglutarate binding site of prolyl 4‐hydroxylase
1984
Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation factor 4F
1992
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A
1997
TOR controls translation initiation and early G1 progression in yeast.
1996
Two-step binding of eukaryotic ribosomes to brome mosaic virus RNA3
1979 Nature
Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E
1991
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Mechanism and regulation of eukaryotic protein synthesis
1992
Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.
1993
Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing
1981 StandoutNobel
Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo
1999
Expression of a chicken chromosomal ovalbumin gene injected into frog oocyte nuclei
1980 StandoutNatureNobel
Rapamycin and Wortmannin Enhance Replication of a Defective Encephalomyocarditis Virus
1998
Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
2006
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
1995
Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.
1990
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell Death
1997
Ascorbate is consumed stoichiometrically in the uncoupled reactions catalyzed by prolyl 4-hydroxylase and lysyl hydroxylase.
1984
Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs
1994 StandoutNobel
Epidermal growth factor or okadaic acid stimulates phosphorylation of eukaryotic initiation factor 4F.
1991
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
1998
Organisation and sequences at the 5′ end of a cloned complete ovalbumin gene
1979 Nature
Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor.
1991
Modification of eukaryotic initiation factor 4F during infection by influenza virus
1993
Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.
1994
Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase.
1989 Nobel
Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds
1972
Differential Regulation of Translation and eIF4E Phosphorylation During Human Thymocyte Maturation
1998
Eukaryotic Initiation Factor 4GII (eIF4GII), but Not eIF4GI, Cleavage Correlates with Inhibition of Host Cell Protein Synthesis after Human Rhinovirus Infection
1999
Macrophage Inflammatory Protein-1α and Interferon-Inducible Protein 10 Inhibit Synergistically Induced Growth Factor Stimulation of MAP Kinase Activity and Suppress Phosphorylation of Eukaryotic Initiation Factor 4E and 4E Binding Protein 1
1997
Definition of the 5′ and 3′ ends of transcripts of the ovalbumin gene
1980
A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.
1997 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
The nucleotide sequence of an untranslated but conserved domain at the 3′ end of the avian sarcoma virus genome
1980 StandoutNobel
Prions
1998 StandoutNobel
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.
1996
Heterogeneity of the 5′ terminus of hen ovalbumin messenger ribonucleic acid
1981
Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation.
1992
New Ways of Initiating Translation in Eukaryotes?
2001
Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.
1993
Sequence studies of several alphavirus genomic RNAs in the region containing the start of the subgenomic RNA.
1982 StandoutNobel
Constitutive Expression of AID Leads to Tumorigenesis
2003 StandoutNobel
Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.
1994
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.
1996
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
1991 StandoutNobel
Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E.
1992
Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein.
1990 StandoutNobel
Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation Complexes
1996
The structure and evolution of the two nonallelic rat preproinsulin genes
1979 StandoutNobel
Arene Oxides: A New Aspect of Drug Metabolism
1974 StandoutScience
Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation factor 4E in vascular smooth muscle cells.
1994
eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the α, β and δ subunits of eIF2B from mammals and yeast
1996
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase
1996
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function.
1993
Insulin and diabetes cause reciprocal changes in the association of eIF-4E and PHAS-I in rat skeletal muscle
1996
The target of rapamycin (TOR) proteins
2001
Cap-Binding Protein (Eukaryotic Initiation Factor 4E) and 4E-Inactivating Protein BP-1 Independently Regulate Cap-Dependent Translation
1996
Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
2004 StandoutNobel
Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.
1990
Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.
1990
Phosphorylation of eukaryotic translation initiation factor 4E is increased in Src-transformed cell lines.
1991
In vitro synthesis of human protein synthesis initiation factor 4 gamma and its localization on 43 and 48 S initiation complexes.
1994
Apolipoprotein II messenger RNA. Transcriptional and splicing heterogeneity yields six 5'-untranslated leader sequences.
1984
Works of R E Rhoads being referenced
Mechanism of Action and Regulation of Protein Synthesis Initiation Factor 4E: Effects on mRNA Discrimination, Cellular Growth Rate, and Oncogenesis
1993
elF4G and its proteolytic cleavage products: effect on initiation of protein synthesis from capped, uncapped, and IRES-containing mRNAs.
1997
VPg-mediated Aggregation of Potyviral RNA
1991
Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma
1992
Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase.
1968
Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.
1990
Structure of the 5' terminus of hen oviduct lysozyme messenger ribonucleic acid.
1983
Increased rate of phosphorylation-dephosphorylation of the translational initiation factor eIF-4E correlates with the induction of protein and glycoprotein biosynthesis in activated B lymphocytes.
1990
Paradoxical observations on the 5' terminus of ovalbumin messenger ribonucleic acid
1978
In Vitro Synthesis, Phosphorylation, and Localization on 48 S Initiation Complexes of Human Protein Synthesis Initiation Factor 4E
1989