Citation Impact
Citing Papers
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
2010 StandoutNobel
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
2008
Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury
2006
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells
2007
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
2002 StandoutScience
PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening
2013
Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules
2008
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Inflammation and metabolic disorders
2006 StandoutNature
Interferons as pathogenic effectors in autoimmunity
2005
Association between presence of HLA-B*5701, HLA-DR7 , and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
2002 Standout
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
2013
PI3K signalling in inflammation
2014
Rheumatoid arthritis
2016 Standout
In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form
2004
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
2007 StandoutNobel
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients
1998
Childhood obesity: public-health crisis, common sense cure
2002 Standout
Guillain-Barré syndrome
2016 Standout
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
2004 Standout
Interleukin-18, more than a Th1 cytokine
2013
Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish
2010
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Tissue distribution, antitumour activity and in vivo apoptosis induction by MEN10755 in nude mice
2001
2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults
2009 Standout
Mitogen activated protein kinase inhibitors: where are we now and where are we going?
2006
Chemotherapy-induced peripheral neurotoxicity (CIPN): An update
2011
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
Urinary interleukin-18 is a marker of human acute tubular necrosis
2004
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
The role of new agents in the treatment of non-small cell lung cancer
2002
Population modelling of the effect of inogatran, at thrombin inhibitor, on ex vivo coagulation time (APTT) in healthy subjects and patients with coronary artery disease
2001
The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines
2006
Anthracycline secondary alcohol metabolite formation in human or rabbit heart: biochemical aspects and pharmacologic implications
2003
The role of innate mediators in inflammatory response
2002
Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
2011
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Uterine fibroids
2001 Standout
Lipid signalling in disease
2008
Impairment of myocardial contractility by anticancer anthracyclines: role of secondary alcohol metabolites and evidence of reduced toxicity by a novel disaccharide analogue
2001
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
2006
Evidence that cytokines play a role in rheumatoid arthritis
2008
Cancer-specific mutations in phosphatidylinositol 3-kinase
2007
The phosphoinositide-3 kinase γ–Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity
2007
Interleukin‐18 and Host Defense against Infection
2003
Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity
2003
IL‐1, IL‐18, and IL‐33 families of cytokines
2008
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Methods in Mammalian Autophagy Research
2010 Standout
EMT: 2016
2016 Standout
Effect of MEN 10755, a new disaccharide analogue of doxorubicin, on sarcoplasmic reticulum Ca2+ handling and contractile function in rat heart
2000
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
2006
Nuclear factor‐κB, induced in human carcinoma cell line A2780 by the new anthracycline men 10755, is devoid of transcriptional activity
2002
Localization of central MHC genes influencing type I diabetes
2001
Intracellular signal pathways: Potential for therapies
2009
Major Depressive Disorder
2008 Standout
Intravenous immunoglobulin in the treatment of autoimmune neuromuscular diseases: Present status and practical therapeutic guidelines
1999
Myocardial Reperfusion Injury
2007 Standout
Interstitial leukocyte migration and immune function
2008
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
2005
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
2016
Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy
2013 Standout
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The ChEMBL database in 2017
2016 Standout
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
2009 StandoutNature
Use of a novel and highly selective oxytocin receptor antagonist to characterize uterine contractions in the rat
2007
Mechanisms and Functions of Inflammasomes
2014 Standout
Therapeutic strategies for rheumatoid arthritis
2003
Insulin resistance and atherosclerosis
2006
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
The PI3K Pathway in Human Disease
2017 Standout
Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis
2008
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
2005 Standout
A clinical trial of the effects of tibolone administered with gonadotropin-releasing hormone analogues for the treatment of uterine leiomyomata
1998
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Preservation of Fertility in Patients with Cancer
2009 Standout
NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells
2012
Cardiotoxicity of cytotoxic drugs
2003
Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4
2013 StandoutNobel
The Inflammatory Preatherosclerotic Remodeling Induced by Intermittent Hypoxia Is Attenuated by RANTES/CCL5 Inhibition
2011
Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
2007
Emerging DNA topoisomerase inhibitors as anticancer drugs
2004
Potential therapeutic targets for neurokinin-1 receptor antagonists
2004
Regulatory T Cells and Human Disease
2020 StandoutNobel
A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
2015
Signalling through Class I PI3Ks in mammalian cells
2006
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
The Origin of Chalcogen-Bonding Interactions
2017 Standout
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket
2008
Cytokine Storm
2020 Standout
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
2006 StandoutNobel
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
2008
Endometriosis
2020 Standout
Anthracycline Metabolism and Toxicity in Human Myocardium: Comparisons between Doxorubicin, Epirubicin, and a Novel Disaccharide Analogue with a Reduced Level of Formation and [4Fe-4S] Reactivity of Its Secondary Alcohol Metabolite
2000
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of β cells
2007 StandoutNobel
The selectivity of protein kinase inhibitors: a further update
2007 Standout
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
2007
PI3Kγ Is a Key Regulator of Inflammatory Responses and Cardiovascular Homeostasis
2007 Science
Polysialic acid governs T-cell development by regulating progenitor access to the thymus
2009 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
REGULATION OF PROTEIN FUNCTION BY GLYCOSAMINOGLYCANS—AS EXEMPLIFIED BY CHEMOKINES
2003
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Fluorescence-Based Blood Coagulation Assay Device for Measuring Activated Partial Thromboplastin Time
2010 StandoutNobel
Fat distribution and hemostatic measures in obese children
1998
Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun–Regulated Macrophage Activation
2014
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Works of R Cirillo being referenced
Sardinia: A Battlefield Approach to Type I Diabetes Epidemiology
1997
N-3-Substituted Pyrimidinones as Potent, Orally Active, AT1 Selective Angiotensin II Receptor Antagonists
1995
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
2001
Effect of MEN 11467, a new tachykinin NK1 receptor antagonist, in acute rectocolitis induced by acetic acid in guinea-pigs
1999
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
2005
Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity
2008
Effect of Tibolone on Glucose and Lipid Metabolism in Postmenopausal Women
1997
Is the imbalance between thrombin and plasmin activity in diabetes related to the behaviour of antiplasmin activity?
1990
Comparison of Doxorubicin- and MEN 10755-Induced Long-Term Progressive Cardiotoxicity in the Rat
2000
Pharmacology of (2 S,4 Z)-N-[(2 S)-2-Hydroxy-2-phenylethyl]-4-(methoxyimino) -1-[(2′-methyl[1,1′-biphenyl]-4-yl)carbonyl]-2-pyrrolidinecarboxamide, a New Potent and Selective Nonpeptide Antagonist of the Oxytocin Receptor
2003
Dissociation of the anti‐ischaemic effects of cloricromene from its anti‐platelet activity
1993 Nobel
Interference with Heparin Binding and Oligomerization Creates a Novel Anti-Inflammatory Strategy Targeting the Chemokine System
2004
Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase
2005
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
2001
Interruption of Inflammatory Pathways with JNK Inhibitors Induces Regression of Human Endometriotic Lesions and Restores Progesterone Receptor Sensitivity in Endometrium and Lesions.
2008
Serological and molecular studies of HLA in insulin-dependent diabetes mellitus in Sardinia.
1991
Experimental Pharmacology of Hirunorm: a Novel Synthetic Peptide Thrombin Inhibitor
1996