Standout Papers
Citation Impact
Citing Papers
Comparison of Two Fluid-Management Strategies in Acute Lung Injury
2006 Standout
Intensive versus Conventional Glucose Control in Critically Ill Patients
2009 Standout
Overexpression of Bcl-2 in Transgenic Mice Decreases Apoptosis and Improves Survival in Sepsis
1999
Potential Mechanisms for a Proinflammatory Vascular Cytokine Response to Coagulation Activation
1998
Selective defects of T lymphocyte function in patients with lethal intraabdominal infection
1999
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
2000 StandoutNature
Sepsis after major visceral surgery is associated with sustained and interferon-γ–resistant defects of monocyte cytokine production
2000
Circulating mitochondrial DAMPs cause inflammatory responses to injury
2010 StandoutNature
Pathogenetic Mechanisms of Septic Shock
1993 Standout
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
2001 Standout
A Simple Multiple System Organ Failure Scoring System Predicts Mortality of Patients Who Have Sepsis Syndrome
1993
The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
1989 Standout
Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: Incidence, morbidities and outcomes in surgical ICU patients
1995
Sympathetic activation triggers systemic interleukin-10 release in immunodepression induced by brain injury
1998
The Acute Respiratory Distress Syndrome
2000 Standout
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
1999 Standout
Effect of the platelet‐activating factor antagonist, TCV‐309, and the cyclo‐oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock
1993 StandoutNobel
Antithrombin III in patients with severe sepsis
1998
Comparison of Blue Dye Visualization and Glucose Oxidase Test Strip Methods for Detecting Pulmonary Aspiration of Enteral Feedings in Intubated Adults
1993
Changes of the hemostatic network in critically ill patients-Is there a difference between sepsis, trauma, and neurosurgery patients?
2000
A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients
1995
Severe Sepsis and Septic Shock
2013 Standout
Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock
2002
Swallowing Dysfunction in Patients Receiving Prolonged Mechanical Ventilation
1996
Thrombin signalling and protease-activated receptors
2000 StandoutNature
The enigma of sepsis
2003
University of California/Davis Interdepartmental Conference on Gram-Negative Septicemia
1991 StandoutNobel
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
2001 StandoutNature
A 3-Level Prognostic Classification in Septic Shock Based on Cortisol Levels and Cortisol Response to Corticotropin
2000
Has the mortality of septic shock changed with time?
1998
Gram-Negative Sepsis
1991
Sepsis and septic shock
2018 Standout
Aerosolized Surfactant in Adults with Sepsis-Induced Acute Respiratory Distress Syndrome
1996
Treating Patients with Severe Sepsis
1999
Aspiration Pneumonitis and Aspiration Pneumonia
2001 Standout
Hydrocortisone Therapy for Patients with Septic Shock
2008 Standout
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
1992 Standout
Fiberoptic Endoscopic Documentation of the High Incidence of Aspiration following Extubation in Critically Ill Trauma Patients
1998
Apoptosis in lymphoid and parenchymal cells during sepsis
1997
Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients
2001
Randomized, Controlled Trials, Observational Studies, and the Hierarchy of Research Designs
2000 Standout
CLINICAL TRIALS FOR SEVERE SEPSIS
1999
The Pathophysiology and Treatment of Sepsis
2003 Standout
Evolving strategies in the treatment of sepsis and systemic inflammatory response syndrome (SIRS)
1998
Adjunctive therapy in sepsis: a critical analysis of the clinical trial programme
1999
A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
1993 Standout
Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin
1991
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
2001 Standout
Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein
1996
Disseminated Intravascular Coagulation
1999 Standout
Early versus Late Parenteral Nutrition in Critically Ill Adults
2011 Standout
Dear SIRS, I'm sorry to say that I don't like you
1997
Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis
2000
An international survey: Public awareness and perception of sepsis*
2008
The inflammatory reflex
2002 StandoutNature
Cytokine signaling-regulation of the immune response in normal and critically ill states
2000
Incidence and Outcomes of Acute Lung Injury
2005 Standout
E5531, a synthetic non‐toxic lipid A derivative blocks the immunobiological activities of lipopolysaccharide
1999
Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
1988
The Epidemiology of Sepsis in the United States from 1979 through 2000
2003 Standout
Monocyte deactivation in septic patients: Restoration by IFN-γ treatment
1997
Staphylococcus aureusInfections
1998 Standout
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
Intensive Insulin Therapy in Critically Ill Patients
2001 Standout
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia
2002 Standout
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
1999
The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
2009 Standout
Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.
1989 StandoutNobel
The immunopathogenesis of sepsis
2002 StandoutNature
The Effects of Ibuprofen on the Physiology and Survival of Patients with Sepsis
1997
Ultrafine Particle Deposition and Clearance in the Healthy and Obstructed Lung
2002
Immunologic and Hemodynamic Effects of “Low-Dose” Hydrocortisone in Septic Shock
2003
Gram-positive Organisms and Sepsis
1994
Molecular Basis of Fc Receptor Function
1994
Toxic Potential of Materials at the Nanolevel
2006 StandoutScience
Prevention of lymphocyte cell death in sepsis improves survival in mice
1999
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group.
1994
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScienceNobel
Glucose modulates hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide in rabbits
1997
Enteral nutrition in intensive care patients: a practical approach
1998
Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. studies with paf-receptor antagonist kadsurenone
1985
The Sepsis Syndrome in a Dutch University Hospital
1993
Toward an Epidemiology and Natural History of SIRS (Systemic Inflammatory Response Syndrome)
1992
Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome
2004 Standout
Cytokine Storm
2020 Standout
Experience with prolonged induced hypothermia in severe head injury
1999
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Structural Heterogeneity and Functional Domains of Murine Immunoglobulin G Fc Receptors
1986 Science
Long-term Survival and Function After Suspected Gram-negative Sepsis
1995
Effects of Genomic Polymorphisms on the Course of Sepsis
2001
A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit
2004 Standout
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
A Randomized Trial of Protocol-Based Care for Early Septic Shock
2014 Standout
Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome
1995
Cost-effectiveness of Monoclonal Antibodies to Gram-negative Endotoxin in the Treatment of Gram-negative Sepsis in ICU Patients
1993
Apoptosis in sepsis: a new target for therapeutic exploration
2001
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
Enteral nutrition in intensive care patients: a practical approach.
1999
The Acute Respiratory Distress Syndrome
1996 Standout
Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans
2001
Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III
2000 StandoutNobel
Heparin Blunts Endotoxin-Induced Coagulation Activation
1999
Tumor Necrosis Factor-Dependent Adhesions as a Major Protective Mechanism Early in Septic Peritonitis in Mice
2001
The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)
1995 Standout
The Pathogenesis of Sepsis
1991
Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers
1997
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
2013
Works of R C Bone being referenced
Modulators of coagulation. A critical appraisal of their role in sepsis
1992
Sir Isaac Newton, sepsis, SIRS, and CARS
1996 Standout
Immunoglobulin G-induced single ionic channels in human alveolar macrophage membranes.
1985
Quantitative deposition of ultrafine stable particles in the human respiratory tract
1985
Gram-negative sepsis: a dilemma of modern medicine
1993
Protection of myocardial function during endotoxin shock by ibuprofen
1984
Ibuprofen in canine endotoxin shock.
1982
Incidence of aspiration in tracheally intubated adults.
1987
Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.
1989