Qiyan Lin

Drugs from the deep: marine natural products as drug candidates

m6A modification controls the innate immune response to infection by targeting type I interferons

Natural products: A continuing source of novel drug leads

Stereoselective synthesis of syn and anti 1,2-hydroxyalkyl moieties by Cu-catalyzed asymmetric allylic alkylation

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

Indolizidine and quinolizidine alkaloids

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance.

Marine natural products

Transition-metal mediated carbon–sulfur bond activation and transformations

Polyol Synthesis through Hydrocarbon Oxidation: De Novo Synthesis of L‐Galactose

Asymmetric spiroacetalization catalysed by confined Brønsted acids

Natural products to drugs: natural product-derived compounds in clinical trials

Organocatalytic Asymmetric Aza‐Michael Additions

The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib

Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033

The Catalytic Asymmetric Acetalization

Direct Asymmetric α Benzoyloxylation of Cyclic Ketones

Cascade Reactions in Total Synthesis

A concise asymmetric synthesis of (−)-rasfonin

Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo‐Symmetry

Spongipyran synthetic studies. Evolution of a scalable total synthesis of (+)-spongistatin 1

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

The chemistry and biology of the bryostatin antitumour macrolides

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives

Structure Determination and Total Synthesis of (+)‐16‐Hydroxy‐16,22‐dihydroapparicine

Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete[1]1Dedicated to the memory of Professor Sir Derek H. R. Barton (1918–1998), a great chemist and friend.1

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

Asymmetric Multicomponent Reactions (AMCRs): The New Frontier

Monofluorination of Organic Compounds: 10 Years of Innovation

Die katalytische, asymmetrische Mukaiyama‐Michael‐Reaktion von Silylketenacetalen mit α,β‐ungesättigten Methylestern

Multicomponent Linchpin Couplings. Reaction of Dithiane Anions with Terminal Epoxides, Epichlorohydrin, and Vinyl Epoxides:  Efficient, Rapid, and Stereocontrolled Assembly of Advanced Fragments for Complex Molecule Synthesis

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

Natural Product Synthesis Using Multicomponent Reaction Strategies

Structure and Absolute Stereochemistry of the Anticancer Agent EBC-23 from the Australian Rainforest

Asymmetric Synthesis with Silicon‐Based Bulky Amino Organocatalysts

Total Synthesis of (+)-Spongistatin 1. An Effective Second-Generation Construction of an Advanced EF Wittig Salt, Fragment Union, and Final Elaboration

The Catalytic Asymmetric Mukaiyama–Michael Reaction of Silyl Ketene Acetals with α,β‐Unsaturated Methyl Esters

Advances and Applications in Organocatalytic Asymmetric aza‐Michael Addition

Diversity-Oriented Synthesis of 2,4,6-Trisubstituted Piperidines via Type II Anion Relay Chemistry

Update 1 of: Macrolactonizations in the Total Synthesis of Natural Products

Die katalytische asymmetrische Acetalisierung

Nonanomeric Spiroketals in Natural Products:  Structures, Sources, and Synthetic Strategies

Carbon−Carbon Bond Forming Reactions Mediated by Silicon Lewis Acids

Total Synthesis of Spongistatin 1: A Synthetic Strategy Exploiting Its Latent Pseudo‐Symmetry

The first total synthesis and reassignment of the relative stereochemistry of 16-hydroxy-16,22-dihydroapparicine

Applications of water stable metal–organic frameworks

A novel route to monoanomeric spiroketals

An Intramolecular Case of Sharpless Kinetic Resolution: Total Synthesis of Laulimalide We thank the Austrian Research Foundation (FWF grant P13941-CHE) for financial support, Ing. Sabine Schneider for HPLC separations, and Prof. Hermann Kalchhauser and Dr. Hanspeter Kählig for NMR measurements.

Catalytic Enantioselective Addition of Allylic Organometallic Reagents to Aldehydes and Ketones

Natural Products in the “Marketplace”: Interfacing Synthesis and Biology

The role of 1,3-dithianes in natural product synthesis

Total Synthesis of Microtubule-Stabilizing Agent (−)-Laulimalide¹

Diastereoselective Allylation of Carbonyl Compounds and Imines: Application to the Synthesis of Natural Products

Stereocontrolled Synthesis of Spiroketals via Ti(Oi-Pr)₄-Mediated Kinetic Spirocyclization of Glycal Epoxides with Retention of Configuration

Marine natural products

The modified Julia olefination: alkene synthesis via the condensation of metallated heteroarylalkylsulfones with carbonyl compounds

Organocatalytic asymmetric α-benzoyloxylation of α-branched aldehydes and enals: a useful approach to oxygenated quaternary stereocenters

Multicomponent Linchpin Coupling of Silyl Dithianes Employing an N-Ts Aziridine as the Second Electrophile:  Synthesis of (−)-Indolizidine 223AB

Impact of Natural Products on Developing New Anti-Cancer Agents

Spongistatin Synthetic Studies. An Efficient, Second-Generation Construction of an Advanced ABCD Intermediate

A General, Convergent Strategy for the Construction of Indolizidine Alkaloids:  Total Syntheses of (−)-Indolizidine 223AB and Alkaloid (−)-205B

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

Stereocontrolled synthesis of the CD subunit of the marine macrolide altohyrtin A

Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis

An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions

Anion Relay Chemistry Extended. Synthesis of a Gorgonian Sesquiterpene

The Brook rearrangement in tandem bond formation strategies

Advances in the Total Synthesis of Biologically Important Marine Macrolides

Direct Asymmetric α Benzoyloxylation of Cyclic Ketones

Synthesis, characterization, and biomedical assessment of novel bisimidazole–coumarin conjugates

Organocatalysis emerging as a technology

Catalytic Asymmetric Transacetalization

Cu-Catalyzed Azide−Alkyne Cycloaddition

Total Synthesis of (−)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol

Asymmetric organocatalysis: an enabling technology for medicinal chemistry

Asymmetric Enamine Catalysis

Enantio- and Diastereoselective Allylmetalations:  An Easy and Efficient Access to the AB Spiroketal of Spongistatin

When long bis(pyrazolates) meet late transition metals: structure, stability and adsorption of metal–organic frameworks featuring large parallel channels

Organocatalytic Enantioselective Olefin Aminofluorination

The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment

The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2

Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains

The Spongistatins: Architecturally Complex Natural Products-Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, NIH Postdoctoral Fellowships to A.M.B. and W.H.M., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr. George T. Furst, Dr. Patrick J. Carroll, Dr. Rakesh Kohli, and Mr John Dykins of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra.

The Spongistatins: Architecturally Complex Natural Products—Part One: A Formal Synthesis of (+)-Spongistatin 1 by Construction of an Advanced ABCD Fragment

The Spongistatins: Architecturally Complex Natural Products-Part Two: Synthesis of the C(29-51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2 Financial support was provided by the National Institutes of Health (National Cancer Institute) through Grant CA-70329, a NIH Postdoctoral Fellowship to C.S.B., a Japan Society for Promotion of Science Fellowship to N.M., and a Royal Society Fulbright Fellowship to V.A.D. We also thank the Daiichi Pharmaceutical Co., Ltd, and the Tanabe Seiyaku Co., Ltd for financial support. Finally we thank Dr George T. Furst, Dr. Patrick J. Carroll, and Dr. Rakesh Kohli of the University of Pennsylvania Spectroscopic Service Center for assistance in securing and interpreting high-field NMR spectra, X-ray crystal structures, and mass spectra, respectively.

Enantioselective Synthesis of Janus Kinase Inhibitor INCB018424 via an Organocatalytic Aza-Michael Reaction

The Spongistatins: Architecturally Complex Natural Products—Part Two: Synthesis of the C(29–51) Subunit, Fragment Assembly, and Final Elaboration to (+)-Spongistatin 2

Spongistatin synthetic studies. 2. Assembly of the C(18–28) spiroketal

Spongistatin synthetic studies. 1. Construction of a C(29–48) subtarget