Citation Impact
Citing Papers
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
2017 Science
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
2009
The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells
2008
Nonhomologous End Joining Is Essential for Cellular Resistance to the Novel Antitumor Agent, β-Lapachone
2007
Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
2013
Chromosome 11q13.3 variant modifies renal cell cancer risk in a Chinese population
2011
Tilt-Pair Analysis of Images from a Range of Different Specimens in Single-Particle Electron Cryomicroscopy
2011 StandoutNobel
Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and Cancer
2005 StandoutNobel
Ferroptosis: molecular mechanisms and health implications
2020 Standout
The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage
2020
Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer
2016 StandoutNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
Function of alternative splicing
2004
An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
2013
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine
2004
The Role of NMDA Receptors in Alzheimer’s Disease
2019
The role of DNA dependent protein kinase in synapsis of DNA ends
2003
Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity
2010 StandoutNobel
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis
2005
DNA-PKcs and ATM co-regulate DNA double-strand break repair
2009
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Rag mutations reveal robust alternative end joining
2007 Nature
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
2007
The role of the non‐homologous end‐joining pathway in lymphocyte development
2004
Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding
2008
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break
2006
The FATC Domains of PIKK Proteins Are Functionally Equivalent and Participate in the Tip60-dependent Activation of DNA-PKcs and ATM
2006
Ageing as a risk factor for neurodegenerative disease
2019 Standout
ATM and related protein kinases: safeguarding genome integrity
2003 Standout
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
2009 Nature
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku
2011
Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo
2006
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining
2008
Regulation of DNA double-strand break repair pathway choice
2007
Antigen receptor genes and the evolution of a recombinase
2004
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
2006
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
DNA Damage, Aging, and Cancer
2009 Standout
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Natural products to drugs: natural product-derived compounds in clinical trials
2008 Standout
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends
2010 Nature
Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
2012 StandoutNobel
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
2011 StandoutNobel
Regulation and Function of the PD-L1 Checkpoint
2018 Standout
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
2010
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Helicobacter Pylori Promote B7-H1 Expression by Suppressing miR-152 and miR-200b in Gastric Cancer Cells
2017
B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
2009 StandoutNobel
Single-particle reconstruction of biological macromolecules in electron microscopy – 30 years
2009 StandoutNobel
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
2004
Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis
2006
DNA repair deficiency in neurodegeneration
2011
Involvement of novel autophosphorylation sites in ATM activation
2006
A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination
2008
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Targeting DNA topoisomerase II in cancer chemotherapy
2009 Standout
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
2006
Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma
2015
The AID Dilemma
2012 StandoutNobel
Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks
2006
Phosphorylation and Regulation of DNA Ligase IV Stability by DNA-dependent Protein Kinase
2004
The Mechanism of Human Nonhomologous DNA End Joining
2007
Chapter 2 DNA-PK
2008
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Genome editing with engineered zinc finger nucleases
2010 Standout
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Comprehensive Review on Alzheimer’s Disease: Causes and Treatment
2020 Standout
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation
2014
ATM Activation and Signaling under Hypoxic Conditions
2008
DNA–PKcs function regulated specifically by protein phosphatase 5
2004
Mechanisms of double-strand break repair in somatic mammalian cells
2009
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
2013 StandoutNobel
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
2002
Copper Active Sites in Biology
2014 Standout
Precision animal breeding
2007
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation
2011
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
2011
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
2012 StandoutNobel
Replication protein A: directing traffic at the intersection of replication and repair
2010
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach
2005
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
An Updated Review of Tyrosinase Inhibitors
2009 Standout
Long-term XPC Silencing Reduces DNA Double-Strand Break Repair
2007
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining
2016
ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress
2006
Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.
2007
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Ionizing Radiation Selectively Reduces Skin Regulatory T Cells and Alters Immune Function
2014 StandoutNobel
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
Mechanism and Regulation of Class Switch Recombination
2008
How Shelterin Protects Mammalian Telomeres
2008 Standout
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
2016 Standout
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Cisplatin Sensitizes Cancer Cells to Ionizing Radiation via Inhibition of Nonhomologous End Joining
2005
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
2007
Agricultural sustainability: concepts, principles and evidence
2007 Standout
Non-homologous end-joining, a sticky affair
2007
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
2014 StandoutNobel
Works of Qi Ding being referenced
trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining
2007
Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N-methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity
2013
miR‐152 controls migration and invasive potential by targeting TGFα in prostate cancer cell lines
2013
Quantitative structure–activity relationship studies of mushroom tyrosinase inhibitors
2008
DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination
2003
Non-homologous End Joining Requires That the DNA-PK Complex Undergo an Autophosphorylation-dependent Rearrangement at DNA Ends
2004
DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia
2002
Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma
2010
Genetic polymorphisms in APE1 are associated with renal cell carcinoma risk in a Chinese population
2011
A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population
2010
The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain
2006
Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair
2003
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)
2005