Citation Impact
Citing Papers
Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer
2015
Identification of a Primary Target of Thalidomide Teratogenicity
2010 StandoutScience
The outs and the ins of sphingosine-1-phosphate in immunity
2011
The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function
2006
Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host
2004
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
2010 Standout
A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis
2017
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells
2006
Role for Neutral Sphingomyelinase-2 in Tumor Necrosis Factor α-Stimulated Expression of Vascular Cell Adhesion Molecule-1 (VCAM) and Intercellular Adhesion Molecule-1 (ICAM) in Lung Epithelial Cells
2006
Sphingosine Kinase 1 in Cancer
2013
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
1999 StandoutNature
THE CELLULAR AND MOLECULAR MECHANISMS OF DIABETIC COMPLICATIONS
1996
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Oxidative Stress and Diabetic Retinopathy
2007
Inflammation and metabolic disorders
2006 StandoutNature
Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins
1998
A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
2013 Standout
Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
2010 Standout
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
2000 StandoutNature
The vascular S1P gradient—Cellular sources and biological significance
2008
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
2010 Standout
Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages
2006
High-density lipoproteins attenuate interleukin-6 production in endothelial cells exposed to pro-inflammatory stimuli
2005
Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.
1997
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?
2002
High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
2001
Sphingosine 1-phosphate signalling in mammalian cells
2000
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Sphingosine 1-Phosphate, a Key Cell Signaling Molecule
2002
Lack of inhibitory effect of HDL on TNFα-induced adhesion molecule expression in human aortic endothelial cells
2002
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
2002
Lymphangiogenesis: Molecular Mechanisms and Future Promise
2010 Standout
High-density lipoproteins as therapeutic targets
2005
Genesis and pathogenesis of lymphatic vessels
2003
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
2004 StandoutNature
Sphingosine‐1‐phosphate: signaling inside and out
2000
The Coordination of Prostaglandin E2 Production by Sphingosine-1-phosphate and Ceramide-1-phosphate
2005
High-density lipoproteins and atherosclerosis
2002
Principles of bioactive lipid signalling: lessons from sphingolipids
2008 Standout
Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
1998 Standout
Ceramide in Apoptosis: A Revisited Role
2002
How hyperglycemia promotes atherosclerosis: molecular mechanisms
2002
Sphingosine 1-phosphate receptors
2001
Effect of high-density lipoproteins on the expression of adhesion molecules in endothelial cells
2002
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
Severe Sepsis and Septic Shock
2013 Standout
The biology of VEGF and its receptors
2003 Standout
Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer
2012
PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane
2002
Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
2003
Cholesterol efflux pathways and other potential mechanisms involved in the athero‐protective effect of high density lipoproteins
2008
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
2002
Lymphangiogenesis in development and human disease
2005 StandoutNature
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis
2013
The Nucleotide-binding Site of Human Sphingosine Kinase 1
2002
Metazoan MicroRNAs
2018 Standout
Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid
2004
Hyperglycemia and the O-GlcNAc Transferase in Rat Aortic Smooth Muscle Cells: Elevated Expression and Altered Patterns of O-GlcNAcylation
2001
Sphingosine kinases: A novel family of lipid kinases
2002
Ceramide: Physiological and pathophysiological aspects
2007
Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?
2015
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Sphingosine Kinases Are Not Required for Inflammatory Responses in Macrophages
2013
Lipid signalling in disease
2008
Disruption of Retinoic Acid Receptor Alpha Reveals the Growth Promoter Face of Retinoic Acid
2007
Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity
2002
Autophagy in Human Health and Disease
2013 Standout
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer
2013
Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells
1999
EMT: 2016
2016 Standout
High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component
2004
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators
2005
Regulation of Autophagy by Sphingosine Kinase 1 and Its Role in Cell Survival during Nutrient Starvation
2006
Autophagy and Aging
2011 Standout
Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases
2006
Inflammation in atherosclerosis
2002 StandoutNature
Diabetes and advanced glycation endproducts
2002
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions
2003
Endothelial Functions of Sphingosine-1-phosphate
2010
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
C-reactive protein comes of age
2005
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
1999
Sphingosine 1-Phosphate and Isoform-specific Activation of Phosphoinositide 3-Kinase β
2001
Basic and Therapeutic Aspects of Angiogenesis
2011 Standout
Accelerated atherogenesis in autoimmune rheumatic diseases
2002
Sphingosine Kinase Type 1 Promotes Estrogen-Dependent Tumorigenesis of Breast Cancer MCF-7 Cells
2002
The Hippo pathway and human cancer
2013
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Defining a role for sphingosine kinase 1 in p53-dependent tumors
2011
Involvement of transcription factors in plasma HDL protection against TNF-α-induced vascular cell adhesion molecule-1 expression
2002
Structural and functional characteristics of S1P receptors
2004
Current understanding of the metabolism and biological actions of HDL
2005
Biologically active sphingolipids in cancer pathogenesis and treatment
2004
Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide Production
2001
Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and Atherosclerosis
2011 Standout
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
Sphingosine-1-phosphate: an enigmatic signalling lipid
2003 Standout
VEGF in Signaling and Disease: Beyond Discovery and Development
2019 Standout
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
2009
Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/WOR diabetic rat
2000
Physiological and pathological actions of sphingosine 1-phosphate
2004
Sirolimus for Kaposi's Sarcoma in Renal-Transplant Recipients
2005 Standout
A review of CETP and its relation to atherosclerosis
2004
Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
2006 Standout
Inflammation in obesity, diabetes, and related disorders
2022 Standout
Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.
1997
HDL and arteriosclerosis: beyond reverse cholesterol transport
2002
Identification and Characterization of RPK118, a Novel Sphingosine Kinase-1-binding Protein
2002
Sphingosine Kinase 1 Promotes Malignant Progression in Colon Cancer and Independently Predicts Survival of Patients With Colon Cancer by Competing Risk Approach in South Asian Population
2014
Time sequence of the inhibition of endothelial adhesion molecule expression by reconstituted high density lipoproteins
2001
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase
2010
RAGE Mediates a Novel Proinflammatory Axis
1999 Standout
Diabetic Retinopathy: Mitochondrial Dysfunction and Retinal Capillary Cell Death
2005
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
2006
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.
2000
Diagnosis and Management of the Metabolic Syndrome
2005 Standout
Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival
1999
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death
2000
Endothelial Protection by High-Density Lipoproteins
2003
The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE 2 production in response to TNF‐α
2003
Abnormalities of Retinal Metabolism in Diabetes and Experimental Galactosemia
2001
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
2002
Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
2000
Broken Barriers: A New Take on Sepsis Pathogenesis
2011
Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E
2000
The Pathobiology of Diabetic Complications
2005 Standout
Protein kinase C activation and the development of diabetic complications.
1998
Tumor Budding: The Name is EMT. Partial EMT.
2016
Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes
2005 Standout
Endothelial Nitric Oxide Synthase Activation by Tumor Necrosis Factor α Through Neutral Sphingomyelinase 2, Sphingosine Kinase 1, and Sphingosine 1 Phosphate Receptors
2005
Oxidative Stress and Diabetic Complications
2010 Standout
Loss of sphingosine kinase‐1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis
2005
EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
2001
HDL counterbalance the proinflammatory effect of oxidized LDL by inhibiting intracellular reactive oxygen species rise, proteasome activation, and subsequent NF‐κB activation in smooth muscle cells
2003
Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region
2003
Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
2014
ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex
2016
Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling
2005
Phospholipid composition of reconstituted high density lipoproteins influences their ability to inhibit endothelial cell adhesion molecule expression
2000
High-Density Lipoproteins and Endothelial Function
2001
Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
2002 StandoutScience
Effect of Reinstitution of Good Glycemic Control on Retinal Oxidative Stress and Nitrative Stress in Diabetic Rats
2003
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate
2005
VEGF Receptor Signal Transduction
2001
Role for sphingosine kinase 1 in colon carcinogenesis
2008
Activation of Receptor for Advanced Glycation End Products
1999
Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications
2010
Expression of neutral sphingomyelinase‐2 (NSMase‐2) in primary rat hepatocytes modulates IL‐β‐induced JNK activation
2004
Reconstituted High-Density Lipoproteins Inhibit the Acute Pro-Oxidant and Proinflammatory Vascular Changes Induced by a Periarterial Collar in Normocholesterolemic Rabbits
2005
Intracellular Role for Sphingosine Kinase 1 in Intestinal Adenoma Cell Proliferation
2006
Atheroprotective Effects of High-Density Lipoproteins
2003
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling
2001
Diabetes and Vascular Disease
2003
G-protein-coupled receptors and cancer
2007
Emerging Pharmacotherapies for Diabetic Macular Edema
2012
Regulation of Endothelial Constitutive Nitric Oxide Synthase Gene Expression in Endothelial Cells and In Vivo
2000
Role of sphingosine kinase‐1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro
2010
Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases
2002
Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways
2008
Antiinflammatory Properties of HDL
2004 Standout
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Treatment of Periodontitis and Endothelial Function
2007 Standout
Works of Pu Xia being referenced
Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ
2015
An oncogenic role of sphingosine kinase
2000
Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells
1999
Sphingosine 1-phosphate, a key mediator of the cytokine network: Juxtacrine signaling
2010
Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects
2005
Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation
2000
High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway
1999
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
1996
Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1
2019
Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling
2002
Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells
2009
Tumour budding is a reproducible index for risk stratification of patients with S tage II colon cancer
2013
Restoring Endocrine Response in Breast Cancer Cells by Inhibition of the Sphingosine Kinase-1 Signaling Pathway
2009
Insulin's effect on protein kinase C and diacylglycerol induced by diabetes and glucose in vascular tissues
1994
Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells
2003
Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1
2006
PPARγ Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol–Protein Kinase C Signaling Pathway
2004
Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway
1998
Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia
1994
Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling
2004
Basal and angiopoietin-1–mediated endothelial permeability is regulated by sphingosine kinase-1
2008
Biochemical and Molecular Mechanisms in the Development of Diabetic Vascular Complications
1996
High-Density Lipoproteins Neutralize C-Reactive Protein Proinflammatory Activity
2004
Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes
2000
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1–dependent activation of PI-3K/Akt and regulation of Bcl-2 family members
2005
Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2.
1995
Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes
2000