Standout Papers
- Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4 (1998)
- A newly identified DNA ligase of Saccharomyces cerevisiaeinvolved in RAD52-independent repair of DNA double-strand breaks (1997)
- Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination (1995)
- Repair and Processing Events at DNA Ends (2007)
- Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. (1996)
Citation Impact
Citing Papers
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
2011 StandoutScience
hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci
2001
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Mutations within the hMLH1 and hPMS2 Subunits of the Human MutLα Mismatch Repair Factor Affect Its ATPase Activity, but Not Its Ability to Interact with hMutSα
2002
Inference and analysis of cell-cell communication using CellChat
2021 Standout
Human endonuclease V is a ribonuclease specific for inosine-containing RNA
2013
Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.
1995
Mechanisms in Eukaryotic Mismatch Repair
2006 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine
2011
DNA Ligase IV from HeLa Cell Nuclei
1996 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Functions of DNA methylation: islands, start sites, gene bodies and beyond
2012 Standout
DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45
2008
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
1997 Nature
Specific Function of DNA Ligase I in Simian Virus 40 DNA Replication by Human Cell-free Extracts Is Mediated by the Amino-terminal Non-catalytic Domain
1997 StandoutNobel
Cyclical DNA methylation of a transcriptionally active promoter
2008 Nature
Repair and Recombination: How to make ends meet
1995 StandoutNobel
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
1998
Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair
2004
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
TGF-β-Dependent Active Demethylation and Expression of the p15ink4b Tumor Suppressor Are Impaired by the ZNF217/CoREST Complex
2012
Role of MutS ATPase Activity in MutS,L-dependent Block of in Vitro Strand Transfer
1998
The Colorful History of Active DNA Demethylation
2008
Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase
2001
Identification of a Second MutL DNA Mismatch Repair Complex (hPMS1 and hMLH1) in Human Epithelial Cells
2000
Repair Pathways for Processing of 8-Oxoguanine in DNA by Mammalian Cell Extracts
1998
DNA mismatch repair: MutS structures bound to mismatches
2001
Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae
2000
Active DNA demethylation: many roads lead to Rome
2010
Solution structure of the single-strand break repair protein XRCC1 N-terminal domain.
1999
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Telomere states and cell fates
2000 StandoutNatureNobel
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair
1997
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
1997
Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1
2001
DNA mismatch repair and mutation avoidance pathways
2002
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
DNA methylation: roles in mammalian development
2013 Standout
Contribution of Human Mlh1 and Pms2 ATPase Activities to DNA Mismatch Repair
2002
The multifaceted mismatch-repair system
2006
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
2003 Nature
Yeast DNA ligase IV mediates non-homologous DNA end joining
1997 Nature
Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta
2000
DNA demethylation by DNA repair
2009
Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein
1999 StandoutNobel
Cytosine Methylation and DNA Repair
2006
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae
2001 Nature
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
2012
Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
2000 StandoutNobel
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
2012
Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway
1997
Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathology
2020
DNA Ligase III Is Recruited to DNA Strand Breaks by a Zinc Finger Motif Homologous to That of Poly(ADP-ribose) Polymerase
1999
AID Enzymatic Activity Is Inversely Proportional to the Size of Cytosine C5 Orbital Cloud
2012
MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks
1999
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)
1997
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
2011
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
1999
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Reprogramming towards pluripotency requires AID-dependent DNA demethylation
2009 Nature
Structure of the MutL C‐terminal domain: a model of intact MutL and its roles in mismatch repair
2004
Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming
2013
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability
2000
Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
1998
Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics
2013
The Fidelity of DNA Polymerase β during Distributive and Processive DNA Synthesis
1999
Switching and Signaling at the Telomere
2001 StandoutNobel
Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV
1998 Nature
Creation and Removal of Embedded Ribonucleotides in Chromosomal DNA during Mammalian Okazaki Fragment Processing
1997
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
1999 Standout
DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation
2009
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming
2013
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
1995 StandoutNobel
Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors
1999
DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability
1996
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
1998
Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
2003
Base Excision Repair
2004
Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair
1997
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
1999
The crystal structure of DNA mismatch repair protein MutS binding to a G·T mismatch
2000 Nature
Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer
2002
Characterization of the XRCC1-DNA ligase III complexin vitroand its absence from mutant hamster cells
1995
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together?
2000
Post-replicative base excision repair in replication foci
1999
Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
1998 StandoutNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
1999 StandoutNobel
Mammalian DNA Mismatch Repair
1999
Structure of an XRCC1 BRCT domain: a new protein-protein interaction module
1998 StandoutNobel
Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae
1997
Lynch Syndrome Genes
2005
DNA Demethylation by TDG
2012
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
1997 StandoutNobel
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
XRCC1 Protein Interacts with One of Two Distinct Forms of DNA Ligase III
1997 StandoutNobel
DNA REPAIR MECHANISMS FOR THE RECOGNITION AND REMOVAL OF DAMAGED DNA BASES
1999
DNA bending and unbending by MutS govern mismatch recognition and specificity
2003
Quality Control by DNA Repair
1999 StandoutScienceNobel
The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential
2011
Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells
1998
Ku is associated with the telomere in mammals
1999 StandoutNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Different DNA Polymerases Are Involved in the Short- and Long-Patch Base Excision Repair in Mammalian Cells
1998
Human Thymine DNA Glycosylase Binds to Apurinic Sites in DNA but Is Displaced by Human Apurinic Endonuclease 1
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
DNA Mismatch Repair: Molecular Mechanisms and Biological Function
2003
Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts
2002
Specificity of Human Thymine DNA Glycosylase Depends on N-Glycosidic Bond Stability
2006
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene
1994
DNA glycosylases in the base excision repair of DNA
1997
Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch Repair
2005
DNA end-joining: from yeast to man
1998
A Role for Exonuclease I from S. pombe in Mutation Avoidance and Mismatch Correction
1995 Science
Recognition and processing of damaged DNA
1995 StandoutNobel
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
1995 StandoutNobel
DNA end-joining catalyzed by human cell-free extracts
1998
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase
1997 StandoutNobel
Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA
1998
Rejoining Kinetics of DNA Single- and Double-Strand Breaks in Normal and DNA Ligase-Deficient Cells after Exposure to Ultraviolet C and Gamma Radiation: An Evaluation of Ligating Activities Involved in Different DNA Repair Processes
1999
Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway
1997
Human DNA Repair Genes
2001 StandoutScienceNobel
Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
2003
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
A Sense of the End
2000 Science
Partial Reconstitution of Human DNA Mismatch Repair In Vitro: Characterization of the Role of Human Replication Protein A
2002
Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells
2000 StandoutNobel
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
2004 StandoutNobel
Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.
1994
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Works of Primo Schär being referenced
Thymine DNA glycosylase
2001
Biochemical Characterization of Uracil Processing Activities in the Hyperthermophilic Archaeon Pyrobaculum aerophilum
2001
Separating Substrate Recognition from Base Hydrolysis in Human Thymine DNA Glycosylase by Mutational Analysis
2000
Homologous Recombination Rescues Mismatch-Repair-Dependent Cytotoxicity of SN1-Type Methylating Agents in S. cerevisiae
2005
Meiotic mismatch repair quantified on the basis of segregation patterns in Schizosaccharomyces pombe.
1993
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability
2011 Nature
Immunohistochemical Analysis Reveals High Frequency of PMS2 Defects in Colorectal Cancer
2005
Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair
1999
T:G Mismatch-specific Thymine-DNA Glycosylase Potentiates Transcription of Estrogen-regulated Genes through Direct Interaction with Estrogen Receptor α
2003
Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
2016
Tumor Initiation Capacity and Therapy Resistance Are Differential Features of EMT-Related Subpopulations in the NSCLC Cell Line A549
2018
Repair and Processing Events at DNA Ends
2007 StandoutNobel
A newly identified DNA ligase of Saccharomyces cerevisiaeinvolved in RAD52-independent repair of DNA double-strand breaks
1997 StandoutNobel
DNA Repair in Mammalian Cells
2009
Meiotic Recombination: Sealing the Partnership at the Junction
2004
Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1
1999
The mutator gene swi8 effects specific mutations in the mating-type region of Schizosaccharomyces pombe.
1994
The enigmatic thymine DNA glycosylase
2006
Marker effects of G to C transversions on intragenic recombination and mismatch repair in Schizosaccharomyces pombe.
1993
Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover
2002
Recognition of DNA alterations by the mismatch repair system
1999
Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination
1995 StandoutNobel
Recognition of DNA alterations by the mismatch repair system
1999
Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.
1996 StandoutNobel
Mismatch Repair in Schizosacchromyces pombe Requires the mutL Homologous Gene pms1: Molecular Cloning and Functional Analysis
1997
Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4
1998 StandoutNobel