Citation Impact
Citing Papers
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
2005
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
2007
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
2010 StandoutScience
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
2007
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
2004
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
2005
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
2017 Standout
Sonic hedgehog signaling in basal cell carcinomas
2004
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
2000
The Gli code: an information nexus regulating cell fate, stemness and cancer
2007
Genome-wide Prediction of Mammalian Enhancers Based on Analysis of Transcription-Factor Binding Affinity
2006
Hedgehog Activates Fused through Phosphorylation to Elicit a Full Spectrum of Pathway Responses
2011
Targeted Expression of GLI1 in the Mammary Gland Disrupts Pregnancy-induced Maturation and Causes Lactation Failure
2007
STRING v9.1: protein-protein interaction networks, with increased coverage and integration
2012 Standout
The role of the Atg1/ULK1 complex in autophagy regulation
2010 Standout
Hedgehog: functions and mechanisms
2008 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Mutations in the NF-κB signaling pathway: implications for human disease
2006
Interactions with Costal2 and Suppressor of fused regulate nuclear translocation and activity of Cubitus interruptus
2000
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
2001
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
2003 StandoutNature
Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb
2000 Standout
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
2011 StandoutNatureNobel
Myf5 is a direct target of long-range Shh signaling and Gli regulation for muscle specification
2002
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling
2012
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
2009
Hedgehog signalling in the mouse requires intraflagellar transport proteins
2003 StandoutNature
Hedgehog–GLI signaling and the growth of the brain
2002
Control of Shh activity and signaling in the neural tube
2000
Shared Principles in NF-κB Signaling
2008 Standout
Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics
2009
Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3
2000
The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord
2003
The Graded Response to Sonic Hedgehog Depends on Cilia Architecture
2007
Multiple Muscle Cell Identities Induced by Distinct Levels and Timing of Hedgehog Activity in the Zebrafish Embryo
2003
The hedgehog signaling network
2003
Communicating with Hedgehogs
2005
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies
2012
Sonic hedgehog in CNS development: one signal, multiple outputs
2002
A Genomic and Functional Inventory of Deubiquitinating Enzymes
2005 Standout
Vertebrate Smoothened functions at the primary cilium
2005 StandoutNature
The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
2016 Standout
Intraflagellar transport, cilia, and mammalian Hedgehog signaling: Analysis in mouse embryonic fibroblasts
2008
Identification of a Tetrameric Hedgehog Signaling Complex
2000
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Mechanically Activated Ion Channels
2015 StandoutNobel
Network organization of the human autophagy system
2010 StandoutNature
A unique chromatin signature uncovers early developmental enhancers in humans
2010 StandoutNature
Genetic Dissection of the Drosophila Cubitus interruptus Signaling Complex
2001
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
2007
Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling
2008
Loss of SUFU Function in Familial Multiple Meningioma
2012
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
2010
Negative Regulation of JNK Signaling by the Tumor Suppressor CYLD
2004
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity
2002 Nature
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
2009 Standout
An Amphioxus Gli Gene Reveals Conservation of Midline Patterning and the Evolution of Hedgehog Signalling Diversity in Chordates
2007
SUMOylation by Pias1 Regulates the Activity of the Hedgehog Dependent Gli Transcription Factors
2010
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling
2006
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
2000 StandoutNature
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
2010
Gli regulation by the opposing activities of Fused and Suppressor of Fused
2000
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification
2003
Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels
2010
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites
2007
The Autophagy-related Protein Kinase Atg1 Interacts with the Ubiquitin-like Protein Atg8 via the Atg8 Family Interacting Motif to Facilitate Autophagosome Formation
2012 StandoutNobel
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo
2004
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
2002
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Prioritizing candidate disease genes by network-based boosting of genome-wide association data
2011
Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport
2000
A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
2007 Standout
IκB kinase complexes: gateways to NF-κB activation and transcription
2006
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2
2007 StandoutNobel
Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function
2005
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Divergence of Hedgehog Signal Transduction Mechanism between Drosophila and Mammals
2006
Hyaluronidase Can Modulate Expression of CD44
2001
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
2009
Cancer-related inflammation
2008 StandoutNature
Genetic Elimination of Suppressor of Fused Reveals an Essential Repressor Function in the Mammalian Hedgehog Signaling Pathway
2006
Identification of Glis1, a Novel Gli-related, Krüppel-like Zinc Finger Protein Containing Transactivation and Repressor Functions
2002
Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities
2004 Standout
The primary cilium: a signalling centre during vertebrate development
2010 Standout
Dorsoventral Patterning of the Telencephalon Is Disrupted in the Mouse Mutant extra-toesJ
2000
Autophagy in immunity and inflammation
2011 StandoutNature
Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity
2008
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
SWI/SNF Chromatin-Remodeling Factors Induce Changes in DNA Methylation to Promote Transcriptional Activation
2005
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Mice Deficient in the Fused Homolog Do Not Exhibit Phenotypes Indicative of Perturbed Hedgehog Signaling during Embryonic Development
2005
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer
2004
Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation
2010
Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities
2000
CBP/p300 in cell growth, transformation, and development
2000
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes
2010
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Nonviral Vectors for Gene Delivery
2008 Standout
Genomewide Expression Profiling in the Zebrafish Embryo Identifies Target Genes Regulated by Hedgehog Signaling During Vertebrate Development
2006
Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism
2004
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
2007
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
2000
Gli Proteins in Development and Disease
2011
Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
2000
Gli proteins encode context-dependent positive and negative functions: implications for development and disease
1999
Small molecule modulation of Smoothened activity
2002 Standout
Cilia and Developmental Signaling
2007
Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction
2008
Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways fromDrosophilato vertebrates
2005
Recent Developments in Peptide-Based Nucleic Acid Delivery
2008
Regulation of the Deubiquitinating Enzyme CYLD by IκB Kinase Gamma-Dependent Phosphorylation
2005
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
2018 Standout
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
2005
Genetic analysis of zebrafishgli1andgli2reveals divergent requirements forgligenes in vertebrate development
2003
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network
2008
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
2010
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma
2007
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
2011
Hedgehog-Gli Signaling Pathway Inhibitors as Anticancer Agents
2009
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
PTCH1 and SMO Gene Alterations in Keratocystic Odontogenic Tumors
2008
The Hedgehog Signaling Pathway in Cancer
2006
Works of Priit Kogerman being referenced
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein
2002
Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1
2002
Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1
1999
Hedgehog signalling: how to get from Smo to Ci and Gli
2006
Dual Function of UNC-51-like Kinase 3 (Ulk3) in the Sonic Hedgehog Signaling Pathway
2010
Evaluation of transportan 10 in PEI mediated plasmid delivery assay
2005
Counter-selection for over-expressed human CD44s in primary tumors versus lung metastases in a mouse fibrosarcoma model
1997
A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues
2006
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway
2009
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site
2004
Characterization of the Physical Interaction of Gli Proteins with SUFU Proteins
2003
The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor κB Activation by Tumor Necrosis Factor
2003
Inhibition of GLI1 gene activation by Patched1
2006
GLI 3 mutations in human disorders mimic Drosophila Cubitus interruptus protein functions and localization
1999
Overexpressed human CD44s promotes lung colonization during micrometastasis of murine fibrosarcoma cells: Facilitated retention in the lung vasculature
1997