Citation Impact
Citing Papers
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases
2004 StandoutNobel
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
1999 Standout
Reaction of hematin with allylic fatty acid hydroperoxides: identification of products and implications for pathways of hydroperoxide-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene
1988
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
2009 StandoutNobel
Drug-Induced Hepatotoxicity
2003 Standout
Oncogene Activation in Chemical Carcinogenesis
1988
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprt gene in CHO cells
1988
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation
1992
Antioxidants and multistage carcinogenesis in mouse skin
1989
The human ATR-mediated DNA damage checkpoint in a reconstituted system
2009 StandoutNobel
Direct Role for the Replication Protein Treslin (Ticrr) in the ATR Kinase-mediated Checkpoint Response
2013 StandoutNobel
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
Molecular themes in oncogenesis
1991 StandoutNobel
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Two genetic hits (more or less) to cancer
2001
Clonal evolution in cancer
2012 StandoutNature
Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)
2011 StandoutNobel
ExCage
2014 StandoutNobel
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
2002 Standout
Fifty years of benzo(a)pyrene
1983 Nature
p53 Mutations in Human Cancers
1991 StandoutScience
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
2003 StandoutNobel
Protein Oxidation and Aging
1992 StandoutScience
Reaction of arene oxides with nucleosides
1977
Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.
1993
Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz[a]-anthracene
1973
Nonenzymatic Covalent Posttranslational Modification of Proteins In Vivo
1985
Photometric assay of hepatic epoxide hydrolase activity with safrole oxide (SAFO) as substrate
1974
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
1975 Standout
A SIMPLE METHOD FOR DETECTING ENVIRONMENTAL CARCINOGENS AS MUTAGENS*
1976
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Glutathione S-Transferases
1974 Standout
Binding of Nenzo[ a ]pyrene 7,8-Diol-9,10-Epoxides to DNA, RNA, and Protein of Mouse Skin Occurs with High Stereoselectivity
1978 Science
Prooxidant States and Tumor Promotion
1985 StandoutScience
ExBox: A Polycyclic Aromatic Hydrocarbon Scavenger
2012 StandoutNobel
Quantitative relationship between carcinogenecity and mutagenicity of polyaromatic hydrocarbons in Salmonnella typhimurium mutants
1975
Binding of benzo(a)pyrene metabolite(s) to main and satellite calf thymus DNA's in vitro
1973
Benzo[ a ]pyrene Metabolites: Efficient and Rapid Separation by High-Pressure Liquid Chromatography
1974 Science
Microsomal epoxidation of cis-stilbene: Decrease in epoxidase activity related to lipid peroxidation
1974
The Chemical Effects ofNucleic Acid Alkylation and Their Relation to Mutagenesis and Carcinogen esis
1975
Some properties of “K-region” epoxides of polycyclic aromatic hydrocarbons
1973
Carcinogenic Effects of Steroids
1969
Carcinogenicity of derivatives of 7,12-dimethylbenz(a)anthracene.
1971
HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION
1977 StandoutNobel
Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons.
1972
[30] Microsomal lipid peroxidation
1978 Standout
Free Radical Mechanisms in Tissue Injury
1988
K-region epoxides of polycyclic hydrocarbons: Reactions with nucleic acids and polyribonucleotides
1973
DNA determinants important in sequence recognition by Eco RI endonuclease.
1981 StandoutNobel
Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells.
1990 StandoutNobel
Approach to risk assessment for genotoxic carcinogens based on data from the mouse skin initiation-promotion model.
1983
The formation of “K-region” epoxides as hepatic microsomal metabolites of 7-methylbenz[a]anthracene and 7,12-dimethylbenz[a]anthracene and their 7-hydroxymethyl derivatives
1973
An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene
1971
A Novel Mechanism for the NIH-Shift
1972
Hair dyes are mutagenic: identification of a variety of mutagenic ingredients.
1975
The Clonal Evolution of Tumor Cell Populations
1976 StandoutScience
Molecular structure of a left-handed double helical DNA fragment at atomic resolution
1979 StandoutNature
Gas Chromatographic Assay of Epoxide Hydrase Activity with 3-Methylcholanthrene-11,12-Oxide
1973 Science
Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.
1978
Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds
1972
Destruction of Cytochrome P 450 by Secobarbital and Other Barbiturates Containing Allyl Groups
1972 Science
Mutagenicity to Mammalian Cells of Epoxides and Other Derivatives of Polycyclic Hydrocarbons
1971
Oxygen radical-dependent epoxidation of (7S,8S)-dihydroxy-7,8-dihydrobenzo[a]pyrene in mouse skin in vivo. Stimulation by phorbol esters and inhibition by antiinflammatory steroids.
1992
Influence of "feeder cells" and inducers and inhibition of microsomal mixed-function oxidases on hydrocarbon-induced malignant transformation of cells derived from C3H mouse prostate.
1972
Chemical Carcinogens as Frameshift Mutagens: Salmonella DNA Sequence Sensitive to Mutagenesis by Polycyclic Carcinogens
1974
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
2012 StandoutNobel
Role of Quinones in Toxicology
2000 Standout
Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase
1969 Science
Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland.
1975 StandoutNobel
Dietary Carcinogens and Anticarcinogens
1983 StandoutScience
On the biochemical mechanism of tumorigenesis in mouse skin
1977
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.
1976
Tumor initiators and promoters in the induction of Epstein—Barr virus
1979 StandoutNobel
A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC).
1995 StandoutNobel
Epoxy derivatives of aromatic polycyclic hydrocarbons. The synthesis of dibenz[a,c]anthracene 10,11-oxide and its metabolism by rat liver preparations
1972
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Naphthalene: A Respiratory Tract Toxicant and Carcinogen for Mice
1992
Polycyclic hydrocarbon‐produced toxicity, transformation, and chromosomal aberrations as a function of aryl hydrocarbon hydroxylase activity in cell cultures
1972
Evaluation of six short term tests for detecting organic chemical carcinogens and recommendations for their use
1976 StandoutNature
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis
2006 StandoutNobel
Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection
1973 Standout
Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to benzo[a]pyrene and to 7,8- and 9,10-dihydrobenzo[a]pyrene
1972
Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations
1970
The metabolism of dibenzo[a, h]pyrene and dibenzo[a, i]pyrene and related compounds by liver preparations and their enzyme-induced binding to cellular macromolecules
1973
Conversion of naphthalene to trans-naphthalene dihydrodiol: Evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes
1972
Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air.
2002
Arene Oxides: A New Aspect of Drug Metabolism
1974 StandoutScience
Carcinogen-specific induction of genetic instability
2001
Molecular analysis of spontaneous somatic mutants
1977 StandoutNatureNobel
The Preparation of 7-Hydroxymethylbenz[a]anthracene 5,6-Oxide and its Metabolism by Rat-liver Preparations
1972
Studies on glutathione-S-arene oxidase transferase—A sensitive assay and partial purification of the enzyme from sheep liver
1974
The metabolism of benz[a]anthracene and dibenz[a,h]anthracene and their related “K-region” epoxides, cis-dihydrodiols and phenols by hamster embryo cells
1973
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.
1975 Standout
An Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens
1973
Heme-Containing Oxygenases
1996 Standout
DISCUSSION PAPER: THE DETECTION OF MUTAGENIC METABOLITES OF CARCINOGENS IN URINE WITH THE SALMONELLA/MICROSOME TEST
1976
Aryl Hydrocarbon Hydroxylase and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding
1972
Metabolism of oxazaphosphorines
1988
Liver microsomal metabolism of aflatoxin B 1 to a reactive derivative toxic to Salmonella typhimurium TA 1530.
1972
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test
1975 Standout
Detection of Mutagenic Activity in Cigarette Smoke Condensates
1974
[28] Analysis of polycyclic aromatic hydrocarbons and their metabolites by high-pressure liquid chromatography
1978
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
1983 StandoutNature
Acetaminophen-induced hepatotoxicity
1981
Isolation and characterization of an active DNA-binding metabolite of benzo(a)pyrene from hamster liver microsomal incubation systems
1972
Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.
1975
DNA sequence selectivity of guanine–N7 alkylation by nitrogen mustards
1986 StandoutNobel
Cytochrome P450 and biological hydroxylation reactions
2005
Identifying Environmental Chemicals Causing Mutations and Cancer
1979 Science
Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens
1972
Chemical Carcinogenesis
1971
In Vitro Transformation of Rodent Cells by K-Region Derivatives of Polycyclic Hydrocarbons
1971
Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz[a]anthracene 8,9-oxide and 10,11-dihydrobenz[a]anthracene 8,9-oxide and their metabolism by rat liver preparations
1971
Works of P.L. Grover being referenced
Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells
1977
The enzyme-catalysed conversion of anti-benzo[alpyrene-7,8-diol 9,10-oxide into a glutathione conjugate
1980
Epoxides as microsomal metabolites of polycyclic hydrocarbons
1971
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation
1999
K‐region epoxides of polycyclic hydrocarbons: Formation and further metabolism of benz[a] anthracene 5, 6‐oxide by human lung preparations
1973
The formation of an epoxide in the microsomal metabolism of 7,12-dimethylbenz[a]anthracene
1972
A Further Study of Bladder Implantation in the Mouse as a means of Detecting Carcinogenic Activity: Use of Crushed Paraffin Wax or Stearic Acid as the Vehicle
1963
Reactivity of the K-region epoxides of some polycyclic hydrocarbons towards the nucleic acids and proteins of BHK 21 cells
1971
Polycyclic hydrocarbon epoxides: The involvement of 8,9‐dihydro‐8,9‐dihydroxybenz (a) anthracene 10,11‐oxide in reactions with the DNA of benz (a) anthracene‐treated hamster embryo cells
1974
Interactions of the k-region epoxides of phenanthrene and dibenz[a,h]anthracene with nucleic acids and histone
1970
Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens
1972 Science
The carcinogenicity of polycyclic hydrocarbon epoxides in newborn mice
1975
Mutagenicity of benzo[a]pyrene 7,8-dihydrodiol and 7,12-dimethylbenz[a]anthracene 3,4-dihydrodiol in S. typhimurium mediated by microsomes from rat liver and mouse skin
1980
Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene
1976
Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro
1968
Microsomal activation of cyclophosphamide in vivo
1970
Mutagenicity of non-K-region diols and diol-epoxides of benz(a)anthracene and benzo(a)pyrene in S. typhimurium TA 100
1975
Reactions of ‘K’-region epoxides of polycyclic hydrocarbons with nucleic acids and polyribonucleotides
1972
Metabolism and activation of benzo[a]pyrene by mouse and rat skin in short-term organ culture and in vivo
1982
Variations dependent on Age and Diet in the Metabolism of 7,12-Dimethylbenz[a]-anthracene by Rat Liver Homogenates
1967 Nature
Quantitative aspects of the metabolism of 7, 12-dimethylbenz[a]anthracene by liver homogenates from animals of different age, sex and species
1968
Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis
1974
Further Experiments on Implantation of Materials into the Urinary Bladder of Mice
1964
Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
1974 Nature
The involvement of a diol‐epoxide in the metabolic activation of benzo(a)pyrene in human bronchial mucosa and in mouse skin
1976
The initiation of tumours on mouse skin by dihydrodiols derived from 7,12‐dimethylbenz(a)anthracene and 3‐methylcholanthrene
1979
The effect of neighbouring bases on G-specific DNA cleavage mediated by treatment with the anti-diol epoxide of benzo(a)pyrene in vitro
1986
Mutagenicity of Epoxides of Polycyclic Hydrocarbons correlates with Carcinogenicity of Parent Hydrocarbons
1971
Formation of K-region epoxides as microsomal metabolites of pyrene and benzo[a]pyrene
1972