Standout Papers
Citation Impact
Citing Papers
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers
2011 Nobel
The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
2012
The Melanoma-Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
2011
Transcriptome Analysis of Triple-Negative Breast Cancer Reveals an Integrated mRNA-lncRNA Signature with Predictive and Prognostic Value
2016
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
2010 StandoutScience
Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma
2015
Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer
2012
Human long non‐coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors
2011
Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus
2011
Identification of novel long non-coding RNAs in clear cell renal cell carcinoma
2015
Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA
2015
The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer
2015
Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16
2015
Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes
2014
Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis
2016
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription
2013 Nature
Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus
2014
Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer
2011
The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence
2015
LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer
2015
HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
2012
lncRNAdb: a reference database for long noncoding RNAs
2010
A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA
2014
Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia
2014
Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq
2010
Control of somatic tissue differentiation by the long non-coding RNA TINCR
2012 StandoutNature
Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma
2012
LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer
2015
Systematic Transcriptome Wide Analysis of lncRNA-miRNA Interactions
2013
Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification
2014
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer
2015
Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18
2012
Non-coding RNAs as regulators of embryogenesis
2011
Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy
2012
Making sense of Dlx1 antisense RNA
2013
Control of the Embryonic Stem Cell State
2011
Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol
2013
The rise of regulatory RNA
2014
Cellular roles of DNA topoisomerases: a molecular perspective
2002 Standout
Modular regulatory principles of large non-coding RNAs
2012 StandoutNature
Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation
2011
Gene regulation by the act of long non-coding RNA transcription
2013
The role of long non-coding RNAs in genome formatting and expression
2015
Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery
1999
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
2014
Multi-omics approaches to disease
2017
Estradiol-Induced Transcriptional Regulation of Long Non-Coding RNA, HOTAIR
2015
Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution
2011
P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression
2014
The emerging role of lncRNAs in cancer
2015 Standout
Histone methylation: a dynamic mark in health, disease and inheritance
2012 Standout
Structural and Functional Differences in the Long Non-Coding RNA Hotair in Mouse and Human
2011
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs
2011
Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma
2014
Origins of Metastatic Traits
2013
The language of covalent histone modifications
2000 StandoutNature
Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer
2013
Long Noncoding RNAs in Cancer Pathways
2016 Standout
H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma
2016
Long non-coding RNAs: A new frontier in the study of human diseases
2013
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells
2004
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation
2011
The RNA Degradation Pathway Regulates the Function of GAS5 a Non-Coding RNA in Mammalian Cells
2013
ATP-dependent chromatin remodeling shapes the long noncoding RNA landscape
2014
Increased expression of long noncoding RNA TUG1 predicts a poor prognosis of gastric cancer and regulates cell proliferation by epigenetically silencing of p57
2016
The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse
2013
Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides
2015
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
2011
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
Long non-coding RNAs in cancer: implications for personalized therapy
2014
Long intergenic non‐coding RNA TUG1 is overexpressed in urothelial carcinoma of the bladder
2012
MALAT‐1 interacts with hnRNP C in cell cycle regulation
2013
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene
2010
LNCipedia: a database for annotated human lncRNA transcript sequences and structures
2012
Long non-coding RNAs as regulators of the endocrine system
2015
BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration
2012
Long noncoding RNA in genome regulation
2010
Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells
2015
To repress or not to repress: This is the guardian's question
2011
Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs
2013
The landscape of long noncoding RNAs in the human transcriptome
2015 Standout
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk
2010
Long Noncoding RNAs in Cancer: From Function to Translation
2015
Tumor metastasis: moving new biological insights into the clinic
2013
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
2013
Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma
2015
Long non-coding RNAs as novel therapeutic targets in cancer
2016
Roles of long noncoding RNAs in hepatocellular carcinoma
2016
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Noncoding RNAs and pancreatic cancer
2016
Targeting long non-coding RNA to therapeutically upregulate gene expression
2013
A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma
2014
Long non-coding RNAs: new players in cell differentiation and development
2013 Standout
Large non-coding RNAs: missing links in cancer?
2010
Cis-acting noncoding RNAs: friends and foes
2012
Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer
2013
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Molecular Mechanisms of Long Noncoding RNAs
2011 Standout
Long non-coding RNAs and chromatin modifiers
2013
Long noncoding RNAs and prostate carcinogenesis: the missing ‘linc’?
2014
Malat1 is not an essential component of nuclear speckles in mice
2012
The epigenetics of epithelial-mesenchymal plasticity in cancer
2013
Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer
2013
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss
2015
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Promiscuous RNA binding by Polycomb repressive complex 2
2013 Nobel
Intronic RNAs mediate EZH2 regulation of epigenetic targets
2012
Non-coding RNAs in human disease
2011 Standout
Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A
2014
The long noncoding RNA Vax2os1 controls the cell cycle progression of photoreceptor progenitors in the mouse retina
2011
Junk DNA and the long non-coding RNA twist in cancer genetics
2015
Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer
2015
Long non-coding RNA HOTAIR in carcinogenesis and metastasis
2013
Circulating DNA of HOTAIR in serum is a novel biomarker for breast cancer
2015
A misplaced lncRNA causes brachydactyly in humans
2012
Unique features of long non-coding RNA biogenesis and function
2015 Standout
Repression of the Long Noncoding RNA-LET by Histone Deacetylase 3 Contributes to Hypoxia-Mediated Metastasis
2013
The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult
2012
The hallmarks of cancer
2012 Standout
The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling
2015
Long noncoding RNAs and human disease
2011 Standout
RNA templating the epigenome
2011
Physiological roles of long noncoding RNAs: insight from knockout mice
2014
Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation
2011
Knockdown of Long Non-coding RNA HOTAIR Suppresses Tumor Invasion and Reverses Epithelial-mesenchymal Transition in Gastric Cancer
2013
A Direct Link between Sister Chromatid Cohesion and Chromosome Condensation Revealed through the Analysis of MCD1 in S. cerevisiae
1997
Promoter Analysis Reveals Globally Differential Regulation of Human Long Non-Coding RNA and Protein-Coding Genes
2014
Long noncoding RNAs in C. elegans
2012
A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis
2015
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
2013
Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway
2015
LncRNAs in Stem Cells
2016
MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
2015
Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature
2014
Epigenetic modifications and human disease
2010 Standout
Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions
2011
Genetic variants in lncRNA HOTAIR are associated with risk of colorectal cancer
2014
HOTAIR Forms an Intricate and Modular Secondary Structure
2015
SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates?
1999
Essential functions of DNA topoisomerase I in Drosophila melanogaster
2000
A microRNA polycistron as a potential human oncogene
2005 StandoutNature
Cohesin Rec8 is required for reductional chromosome segregation at meiosis
1999 StandoutNatureNobel
Long noncoding RNAs: Novel insights into hepatocelluar carcinoma
2013
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
1998
The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage
2013
Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression
2011
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1
2011
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
Epigenetic modifications in pluripotent and differentiated cells
2010
Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
2013
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Long non-coding RNAs in colorectal cancer: implications for pathogenesis and clinical application
2014
Field-resolved infrared spectroscopy of biological systems
2020 StandoutNatureNobel
Topological domains in mammalian genomes identified by analysis of chromatin interactions
2012 StandoutNature
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
Long noncoding RNAs: Novel insights into gastric cancer
2014
Role of long noncoding RNAs in malignant disease (Review)
2015
Targeting long non-coding RNAs in cancers: Progress and prospects
2013
Long noncoding RNAs are rarely translated in two human cell lines
2012
Long Intergenic Noncoding RNA HOTAIR Is Overexpressed and Regulates PTEN Methylation in Laryngeal Squamous Cell Carcinoma
2012
Gene regulation by antisense transcription
2013
RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex
2005
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
2013 Standout
Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo
2014
The essential role of yeast topoisomerase III in meiosis depends on recombination
1999
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs
2013 Nature
A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression
2010
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
2013
N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
2015 StandoutNature
Principles for the post-GWAS functional characterization of cancer risk loci
2011
LncRNA: A link between RNA and cancer
2014
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data
2013 Standout
Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression
2011
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
The Emergence of lncRNAs in Cancer Biology
2011
Genome Regulation by Long Noncoding RNAs
2012 Standout
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
2016
Saccharomyces cerevisiaeCTF18 and CTF4 Are Required for Sister Chromatid Cohesion
2001
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Long noncoding RNAs regulate adipogenesis
2013
Transposable elements reveal a stem cell-specific class of long noncoding RNAs
2012
Long Noncoding RNA and Cancer: A New Paradigm
2017 Standout
Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics
2016
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
2002
Long noncoding RNA CCAT1 acts as an oncogene and promotes chemoresistance in docetaxel-resistant lung adenocarcinoma cells
2016
THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA
1997
Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
2001
Correlation of MTDH/AEG-1 and HOTAIR Expression with Metastasis and Response to Treatment in Sarcoma Patients
2012
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
1998 StandoutScience
Repressive Transcription
2010 Science
Large Intervening Non-Coding RNA HOTAIR is Associated with Hepatocellular Carcinoma Progression
2011
Long noncoding RNA ANRIL indicates a poor prognosis of gastric cancer and promotes tumor growth by epigenetically silencing of miR-99a/miR-449a
2014
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.
1996
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression
2015
Long non‐coding RNA UCA 1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling
2014
Metabolic reprogramming and cancer progression
2020 StandoutScience
Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway
2016
The lncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer
2014
HOTAIR is a predictive and prognostic biomarker for patients with advanced gastric adenocarcinoma receiving fluorouracil and platinum combination chemotherapy.
2015
Antisense transcription at the TRPM2 locus as a novel prognostic marker and therapeutic target in prostate cancer
2014
Long Non-Coding RNAs: Challenges for Diagnosis and Therapies
2013
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.
1998
Long Intergenic Noncoding RNAs: New Links in Cancer Progression
2011
Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets?
2015
Current Insights into Long Non-Coding RNAs in Renal Cell Carcinoma
2016
An overview of long non-coding RNAs in ovarian cancers
2016
Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers
2012
LncRNA expression profile reveals the potential role of lncRNAs in gastric carcinogenesis
2015
CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model
2013
Epigenetic Regulation by Long Noncoding RNAs
2012 Science
Long non-coding RNAs in colorectal cancer
2015
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
1998 StandoutScience
Defining a Developmental Path to Neural Fate by Global Expression Profiling of Mouse Embryonic Stem Cells and Adult Neural Stem/Progenitor Cells
2005
Long non‐coding RNA Fer‐1‐like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR‐106a‐5p in colon cancer
2015
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
2015
Cell Cycle Checkpoints: Preventing an Identity Crisis
1996 StandoutScience
2016
Works of Pius Brzoska being referenced
Identification of frequent novel genetic alterations in small cell lung carcinoma.
1994
In Situ-Synthesized Novel Microarray Optimized for Mouse Stem Cell and Early Developmental Expression Profiling
2003
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae.
1996
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.
1995
Frequent novel DNA copy number increase in squamous cell head and neck tumors.
1995