Citation Impact
Citing Papers
TRP channel activation by reversible covalent modification
2006 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Origins of coevolution between residues distant in protein 3D structures
2017 StandoutNobel
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
2014
Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
2009
Listeria monocytogenes -Infected Human Peripheral Blood Mononuclear Cells Produce IL-1β, Depending on Listeriolysin O and NLRP3
2009
Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice
2011
In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8
2011
NF- B as a Critical Link Between Inflammation and Cancer
2009
Ubiquitination in signaling to and activation of IKK
2012
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Deubiquitinases in the regulation of NF-κB signaling
2010
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
2008
SNIPERs—Hijacking IAP activity to induce protein degradation
2019
A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β
2009
TNFR1‐induced activation of the classical NF‐κB pathway
2011
The RING Domain of TRAF2 Plays an Essential Role in the Inhibition of TNFα-Induced Cell Death but Not in the Activation of NF-κB
2010
Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome
2011
Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System
2009
A role for mitochondria in NLRP3 inflammasome activation
2010 StandoutNature
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
2010
Activation and regulation of the inflammasomes
2013 Standout
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling
2012
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Pattern Recognition Receptors and Inflammation
2010 Standout
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
2010
Effector functions of NLRs in the intestine: innate sensing, cell death, and disease
2012
Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model
2016
Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction
2011
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
2019 StandoutNobel
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Anticancer activities of histone deacetylase inhibitors
2006 Standout
IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
2011
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
The non-canonical NF-κB pathway in immunity and inflammation
2017
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
2013
Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity
2010
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Caspase Functions in Cell Death and Disease
2013 Standout
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
2009 Standout
A cell biological view of Toll-like receptor function: regulation through compartmentalization
2009
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ
2010
The RCSB Protein Data Bank: views of structural biology for basic and applied research and education
2014
Return to homeostasis: downregulation of NF-κB responses
2011
Oncogenic Activation of NF- B
2010
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
2008
Histone deacetylase inhibitors: molecular mechanisms of action
2007
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Cancer immunotherapy comes of age
2011 StandoutNature
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
2011 Nature
The Inflammasomes
2010 Standout
Function of Nod‐like receptors in microbial recognition and host defense
2008
The diverse and complex roles of NF-κB subunits in cancer
2012
Crosstalk in NF-κB signaling pathways
2011 Standout
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells
2009
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
2009
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor
2010
Non-canonical NF-κB signaling pathway
2010
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
2006 Standout
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1)
2007
Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
2012
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
NF-κB, inflammation, immunity and cancer: coming of age
2018 Standout
IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases
2013
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
2011
Inflammasomes in health and disease
2012 StandoutNature
Regulation of the Antimicrobial Response by NLR Proteins
2011
Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation
2009
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
2009 Standout
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Regulation and Function of NF-κB Transcription Factors in the Immune System
2009 Standout
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella
2010
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Inflammasomes and Metabolic Disease
2013
Intracellular sensing of microbes and danger signals by the inflammasomes
2011
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
The Inflammasomes: Guardians of the Body
2009 Standout
TRAF2 phosphorylation promotes NF-κB–dependent gene expression and inhibits oxidative stress-induced cell death
2010
AN INTRODUCTION TO TRP CHANNELS
2005 Standout
The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas
2011
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice
2012
Nascent-Seq analysis of Drosophila cycling gene expression
2013 StandoutNobel
Discovery of a Viral NLR Homolog that Inhibits the Inflammasome
2011 Science
IAP inhibitors enhance co-stimulation to promote tumor immunity
2010
NSAIDs Inhibit Tumorigenesis, but How?
2013
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Ping‐Hui Tseng being referenced
From the Cyclooxygenase-2 Inhibitor Celecoxib to a Novel Class of 3-Phosphoinositide-Dependent Protein Kinase-1 Inhibitors
2004
Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex
2008 Science
Histone Acetylation-independent Effect of Histone Deacetylase Inhibitors on Akt through the Reshuffling of Protein Phosphatase 1 Complexes
2005
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
2009
Expanding TRAF function: TRAF3 as a tri-faced immune regulator
2011
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
2008
Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms
2004
Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin
2008
The Canonical Transient Receptor Potential 6 Channel as a Putative Phosphatidylinositol 3,4,5-Trisphosphate-Sensitive Calcium Entry System
2004
Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance
2005
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide
2008