Standout Papers
Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Neutralizing antibody response during acute and chronic hepatitis C virus infection
2004 StandoutNobel
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
2021 StandoutNobel
Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3
2010
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Cell Contact–dependent Regulation of Epithelial–Myofibroblast Transition via the Rho-Rho Kinase-Phospho-Myosin Pathway
2007
Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus
2013
Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus
2014 StandoutNobel
Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C
2010
IFN-λ4: The Paradoxical New Member of the Interferon Lambda Family
2014
Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway
2016
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
2014 Standout
Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling
2016
The DNA-damage response in human biology and disease
2009 StandoutNature
Validation of TaqMan® SNP genotyping specificity for rs12979860 of IL-28B: Modeling primer specificity in vitro
2014
Benefits and limitations of genome-wide association studies
2019
Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C
2010
Comprehensive analysis for viral elements and interleukin-28B polymorphisms in response to pegylated interferon plus ribavirin therapy in hepatitis C virus 1B infection
2012
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Analysis of the Complete Open Reading Frame of Genotype 2b Hepatitis C Virus in Association with the Response to Peginterferon and Ribavirin Therapy
2011
Murine models of hepatitis C: What can we look forward to?
2014
Hepatitis C virus resistance to protease inhibitors
2011
Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs)
2009
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
2009 StandoutNature
Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines
2013 StandoutNobel
Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons
2019
Analysis of long-term persistence of resistance mutations within the hepatitis C virus NS3 protease after treatment with telaprevir or boceprevir
2011
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry
2012 StandoutNobel
Impact of IL28B gene polymorphisms on interferon- 3 plasma levels during pegylated interferon- /ribavirin therapy for chronic hepatitis C in patients coinfected with HIV
2012
Treatment triumphs
2014 StandoutNatureNobel
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Type III Interferons, IL-28 and IL-29, Are Increased in Chronic HCV Infection and Induce Myeloid Dendritic Cell-Mediated FoxP3+ Regulatory T Cells
2012
Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain
2010
Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes
2014
Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient
2007
Regulation of hepatic innate immunity by hepatitis C virus
2013
Analysis of the complete open reading frame of hepatitis C virus in genotype 2a infection reveals critical sites influencing the response to peginterferon and ribavirin therapy
2011
c-Myc-regulated microRNAs modulate E2F1 expression
2005 StandoutNature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection
2012
Serum response factor: toggling between disparate programs of gene expression
2003
Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B -unfavorable genotype patients: Impaired viral kinetics and therapeutic response
2012
Type I interferons in infectious disease
2015 Standout
IL28B Genetic Variation Is Associated with Spontaneous Clearance of Hepatitis C Virus, Treatment Response, Serum IL-28B Levels in Chinese Population
2012
New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectives
2012
New advances in the molecular biology of hepatitis C virus infection: towards the identification of new treatment targets
2012
The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C
2011
Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1
2010
Paricalcitol Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy
2006
Hepatitis C virus and microRNAs: miRed in a host of possibilities
2014
Identifying Recent Adaptations in Large-Scale Genomic Data
2013
Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1
2012
The Course of Posttransplant Hepatitis C Infection
2012
Sequence heterogeneity of NS5A and core proteins of hepatitis C virus and virological responses to pegylated-interferon/ribavirin combination therapy
2011
Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: A longitudinal analysis
2013
IFN-λ3 Inhibits HIV Infection of Macrophages through the JAK-STAT Pathway
2012
Linking actin dynamics and gene transcription to drive cellular motile functions
2010
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Interferon Lambda Alleles Predict Innate Antiviral Immune Responses and Hepatitis C Virus Permissiveness
2014 StandoutNobel
Immune Responses to HCV and Other Hepatitis Viruses
2014
Importance of IL28B gene polymorphisms in hepatitis C virus genotype 2 and 3 infected patients
2010
Recent advances into the understanding of mesenchymal stem cell trafficking
2007
Genomic targets of the human c-Myc protein
2003
Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection
2010
Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy
2010
Therapeutic targeting of a stem cell niche
2007
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells
2013
Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state
2011
Genetic Variation of the IL-28B Promoter Affecting Gene Expression
2011
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Interferon lambdas: the next cytokine storm
2011
Update on hepatitis C virus resistance to direct-acting antiviral agents
2014
Live or let die: the cell's response to p53
2002 Standout
Hepatitis C virus: How genetic variability affects pathobiology of disease
2011
Interferon-stimulated genes and their role in controlling hepatitis C virus
2013
Genes and hepatitis C: susceptibility, fibrosis progression and response to treatment
2011
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
2011
IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza
2014 StandoutNobel
Structure and function of interleukin-22 and other members of the interleukin-10 family
2010
A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression
2017 Nobel
A Single Nucleotide Polymorphism Associated with Hepatitis C Virus Infections Located in the Distal Region of the IL28B Promoter Influences NF-κB-Mediated Gene Transcription
2013
Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
2020 StandoutNobel
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Convergent Evolution of Escape from Hepaciviral Antagonism in Primates
2012
Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses
2013
Host genetic basis for hepatitis C virus clearance: a role for blood collection centers
2010
Hepatitis C pharmacogenetics: State of the art in 2010
2010
IL28B Genotype Is Associated With Differential Expression of Intrahepatic Interferon-Stimulated Genes in Patients With Chronic Hepatitis C
2010
Hepatitis C Virus Pathogen Associated Molecular Pattern (PAMP) Triggers Production of Lambda-Interferons by Human Plasmacytoid Dendritic Cells
2013
Changes in sequences of core region, interferon sensitivity‐determining region and interferon and ribavirin resistance‐determining region of hepatitis C virus genotype 1 during interferon‐alpha and ribavirin therapy, and efficacy of retreatment
2012
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
The Human Condition—A Molecular Approach
2014 StandoutNobel
Innate Immune Responses to Hepatitis C Virus
2013 StandoutNobel
Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C
2013
IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production
2012
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection
2012
Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
2004 Standout
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection
2014
Review article: specifically targeted anti‐viral therapy for hepatitis C – a new era in therapy
2010
Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
2011
δEF1 Mediates TGF-β Signaling in Vascular Smooth Muscle Cell Differentiation
2006
A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection
2013
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
2003 StandoutNobel
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
2014 StandoutNobel
IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction
2013
Effect of the IL28B Rs12979860 C/T polymorphism on the incidence and features of active cytomegalovirus infection in allogeneic stem cell transplant patients
2013
The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections
2014 StandoutNobel
Increased Risk of Severe Hepatitis C Virus Recurrence After Liver Transplantation in Patients With a T Allele of IL28B rs12979860
2012
IL-29 and IFNα differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNγ receptor expression
2010
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies
2014
2013
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
2012
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
Modeling hepatitis C virus infection using human induced pluripotent stem cells
2012 StandoutNobel
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
Transcriptional control of human p53-regulated genes
2008 Standout
IFNL3 mediates interaction between innate immune cells: Implications for hepatitis C virus pathogenesis
2013
Antisense Gets a Grip on miR-122 in Chimpanzees
2010 StandoutNobel
Response of Hepatitis C Virus to Long-Term Passage in the Presence of Alpha Interferon: Multiple Mutations and a Common Phenotype
2013 StandoutNobel
Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC
2010
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
2002 StandoutNobel
Neural Cell Adhesion Molecule Contributes to Hemopoiesis‐Supporting Capacity of Stromal Cell Lines
2005
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
2005 Standout
Conserved C-Terminal Threonine of Hepatitis C Virus NS3 Regulates Autoproteolysis and Prevents Product Inhibition
2003
Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model
2017 StandoutNobel
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
2007
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
2005 StandoutNobel
IFN‐λ‐mediated IL‐12 production in macrophages induces IFN‐γ production in human NK cells
2014
Combinatorial Control of Smooth Muscle–Specific Gene Expression
2003
Viral Quasispecies Evolution
2012
Polysialic acid governs T-cell development by regulating progenitor access to the thymus
2009 StandoutNobel
IFN-λ Exerts Opposing Effects on T Cell Responses Depending on the Chronicity of the Virus Infection
2014
Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
2011 Standout
Works of Ping Qiu being referenced
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
2010 Nature
Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches
2001
Analysis of HCV resistance mutations during combination therapy with protease inhibitor boceprevir and PEG-IFN α-2b using TaqMan mismatch amplification mutation assay
2008
Antiproteinuric effect of oral paricalcitol in chronic kidney disease
2005
Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical studies
2013
Identification of HCV protease inhibitor resistance mutations by selection pressure-based method
2009
Gene Expression Profiles and Transcription Factors Involved in Parathyroid Hormone Signaling in Osteoblasts Revealed by Microarray and Bioinformatics
2003
Association of a polymorphism in the indoleamine- 2,3-dioxygenase gene and interferon-α-induced depression in patients with chronic hepatitis C
2011
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
2009 StandoutNature
Interaction of Smad3 and SRF-associated complex mediates TGF-β1 signals to regulate SM22 transcription during myofibroblast differentiation
2003
Histone Acetylation and Recruitment of Serum Responsive Factor and CREB-Binding Protein Onto SM22 Promoter During SM22 Gene Expression
2002
Myocardin Enhances Smad3-Mediated Transforming Growth Factor-β 1 Signaling in a CArG Box-Independent Manner
2005
Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors
2006
433 FREQUENCIES OF RESISTANCE-ASSOCIATED AMINO ACID VARIANTS DETECTED BY 454-SEQUENCING DURING COMBINATION TREATMENT WITH BOCEPREVIR PLUS PEGINTRON (PEGINTERFERON ALFA-2B)/RIBAVIRIN IN HCV (GT1)-INFECTED PATIENTS
2011
Hepatitis C virus whole genome position weight matrix and robust primer design
2002
Establishment of an adherent cell feeder layer from human umbilical cord blood for support of long-term hematopoietic progenitor cell growth.
1994