Standout Papers
Citation Impact
Citing Papers
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis
2010 StandoutNobel
Meta-analysis of the impacts of global change factors on soil microbial diversity and functionality
2020 Standout
Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin
2003
The amyloid precursor protein: beyond amyloid.
2006
Discovery of archaeal fusexins homologous to eukaryotic HAP2/GCS1 gamete fusion proteins
2022 StandoutNobel
The technological and economic prospects for CO2 utilization and removal
2019 StandoutNature
Inactivation of presenilins causes pre‐synaptic impairment prior to post‐synaptic dysfunction
2010 StandoutNobel
Expanded diversity of Asgard archaea and their relationships with eukaryotes
2021 Nature
Therapeutic strategies for Alzheimer's disease
2002
Synapses and Alzheimer's Disease
2012 StandoutNobel
The Lipoprotein Receptor LR11 Regulates Amyloid β Production and Amyloid Precursor Protein Traffic in Endosomal Compartments
2006
Atopic Dermatitis
2008 Standout
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport
2004 StandoutNobel
Multiple roles of Notch signaling in cochlear development
2007 StandoutNobel
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles
2004 StandoutNobel
A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity
2010
Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation
2007
Dendritic cells: versatile controllers of the immune system
2007 StandoutNobel
Emerging research fronts in science and technology: patterns of new knowledge development
2009
β‐amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment
2007
The secretases: enzymes with therapeutic potential in Alzheimer disease
2010
Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
2009 StandoutNobel
Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen‐2) demonstrate excessive p53‐dependent apoptosis and neuronal loss
2006
Adult hippocampal neurogenesis and its role in Alzheimer's disease
2011
Presenilin-1 Regulates Intracellular Trafficking and Cell Surface Delivery of β-Amyloid Precursor Protein
2003
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Neurovascular regulation in the normal brain and in Alzheimer's disease
2004 Standout
Notch signalling: a simple pathway becomes complex
2006 Standout
Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria
2004
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Predicting Drug‐Resistant Mutations of HIV Protease
2007 StandoutNobel
Soil and soil environmental quality monitoring in China: A review
2014 Standout
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
Effects of microbial activity on perfluorinated carboxylic acids (PFCAs) generation during aerobic biotransformation of fluorotelomer alcohols in activated sludge
2017
Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons
2008 StandoutNobel
p53 in health and disease
2007 Standout
γ-Secretase Complex Assembly within the Early Secretory Pathway
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Complex N-linked Glycosylated Nicastrin Associates with Active γ-Secretase and Undergoes Tight Cellular Regulation
2002
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos
2006
PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1
2003
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Degradation of nicastrin involves both proteasome and lysosome
2007
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Alzheimer's Disease: cholesterol, membrane rafts, isoprenoids and statins
2007
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
2015 Standout
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
2004
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
Alzheimer's Disease
2004 Standout
γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin
2003
Intracellular amyloid-β in Alzheimer's disease
2007 Standout
APH-1 Interacts with Mature and Immature Forms of Presenilins and Nicastrin and May Play a Role in Maturation of Presenilin·Nicastrin Complexes
2003
Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic Proteases
2002
The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing
2002
The amyloid state and its association with protein misfolding diseases
2014 Standout
Multivariate and geostatistical analyses of the spatial distribution and sources of heavy metals in agricultural soil in Dehui, Northeast China
2013
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
2011 Standout
PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin
2002
The microbial nitrogen-cycling network
2018 Standout
Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration
2006 Standout
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Consequences of microbial diversity in forest nitrogen cycling: diverse ammonifiers and specialized ammonia oxidizers
2019
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
Intramembrane proteolysis by presenilin and presenilin-like proteases
2003
Beyond fossil fuel–driven nitrogen transformations
2018 StandoutScienceNobel
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals
2003
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Fluorescence Lifetime Measurements and Biological Imaging
2010 Standout
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved
2007
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes
2003
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Dendritic cells are specialized accessory cells along with TGF-β for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3− precursors
2007 StandoutNobel
Casting Metal Nanowires Within Discrete Self-Assembled Peptide Nanotubes
2003 StandoutScience
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Unveiling the Activity Origin of a Copper‐based Electrocatalyst for Selective Nitrate Reduction to Ammonia
2020 Standout
Cocatalysts for Selective Photoreduction of CO2into Solar Fuels
2019 Standout
Aquaponic trends and challenges – A review
2019 Standout
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Tolerogenic Dendritic Cells
2003 StandoutNobel
Per- and polyfluoroalkyl substances in the environment
2022 StandoutScience
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
bibliometrix : An R-tool for comprehensive science mapping analysis
2017 Standout
Structure and Mechanism of the Pepsin-Like Family of Aspartic Peptidases
2002
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
2004 StandoutNobel
Works of Ping Han being referenced
Newly discovered Asgard archaea Hermodarchaeota potentially degrade alkanes and aromatics via alkyl/benzyl-succinate synthase and benzoyl-CoA pathway
2021
Complete nitrification by Nitrospira bacteria
2015 StandoutNature
Presenilin 1 Is Required for Maturation and Cell Surface Accumulation of Nicastrin
2002
Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation
2005
Multivariate and geostatistical analyses of the spatial distribution and origin of heavy metals in the agricultural soils in Shunyi, Beijing, China
2012
Kinetic analysis of a complete nitrifier reveals an oligotrophic lifestyle
2017 Nature
Cyanate as an energy source for nitrifiers
2015 Nature
The Transmembrane Domain of the Alzheimer's β-Secretase (BACE1) Determines Its Late Golgi Localization and Access to β-Amyloid Precursor Protein (APP) Substrate
2001
Biotransformation of Two Pharmaceuticals by the Ammonia-Oxidizing ArchaeonNitrososphaera gargensis
2016
Abiotic Conversion of Extracellular NH2OH Contributes to N2O Emission during Ammonia Oxidation
2017