Citation Impact
Citing Papers
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
2011 Standout
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
2010 StandoutNobel
Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression
2009
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
2008
Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury
2006
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
A Dual Phosphoinositide-3-Kinase α/mTOR Inhibitor Cooperates with Blockade of Epidermal Growth Factor Receptor in PTEN -Mutant Glioma
2007
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
2009 Standout
Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells
2007
Resistin Inhibits Essential Functions of Polymorphonuclear Leukocytes
2008
Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury
2015
Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis
2017
PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening
2013
Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules
2008
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Inflammation and metabolic disorders
2006 StandoutNature
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
2013
PI3K signalling in inflammation
2014
A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in Mice
2010
Rheumatoid arthritis
2016 Standout
Signal integration by JNK and p38 MAPK pathways in cancer development
2009 Standout
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Therapeutic targeting of chemokine interactions in atherosclerosis
2010
Update on glucocorticoid action and resistance
2006
Hallmarks of aging: An expanding universe
2023 Standout
Cellular pathophysiology of ischemic acute kidney injury
2011 Standout
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish
2010
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design
2017
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Myocardial ischemia-reperfusion injury: a neglected therapeutic target
2013 Standout
Atherosclerosis: current pathogenesis and therapeutic options
2011 Standout
Mitogen activated protein kinase inhibitors: where are we now and where are we going?
2006
A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection
2017
Chemotherapy-induced peripheral neurotoxicity (CIPN): An update
2011
Mitochondrial membrane permeabilization in neuronal injury
2009
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
ANTI-APOPTOTIC AND ANTI-INFLAMMATORY EFFECTS OF HYDROGEN SULFIDE IN A RAT MODEL OF REGIONAL MYOCARDIAL I/R
2009
The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease
2007
Targeting cancer with small molecule kinase inhibitors
2008 Standout
Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
2011
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Induction of heat shock protein 70 inhibits ischemic renal injury
2011
Development, maintenance and disruption of the blood-brain barrier
2013 Standout
Lipid signalling in disease
2008
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
2006
Inhibitors of c-Jun N-terminal kinases—JuNK no more?
2007
Cancer-specific mutations in phosphatidylinositol 3-kinase
2007
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
The phosphoinositide-3 kinase γ–Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity
2007
Collective cell migration in morphogenesis, regeneration and cancer
2009 Standout
Methods in Mammalian Autophagy Research
2010 Standout
EMT: 2016
2016 Standout
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
2006
Intracellular signal pathways: Potential for therapies
2009
Myocardial Reperfusion Injury
2007 Standout
Interstitial leukocyte migration and immune function
2008
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
2005
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
2016
Effect of Duloxetine on Pain, Function, and Quality of Life Among Patients With Chemotherapy-Induced Painful Peripheral Neuropathy
2013 Standout
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The ChEMBL database in 2017
2016 Standout
Insulin resistance and atherosclerosis
2006
Small-molecule allosteric inhibitors of BAX
2019
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
2008 Standout
Mitochondria as multifaceted regulators of cell death
2019 Standout
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Death Receptors DR6 and TROY Regulate Brain Vascular Development
2012
Cytoplasmic DNA: sources, sensing, and role in aging and disease
2021
Getting to the site of inflammation: the leukocyte adhesion cascade updated
2007 Standout
The PI3K Pathway in Human Disease
2017 Standout
Insulin Resistance and Atherosclerosis
2008
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
Adipose Tissue as an Endocrine Organ
2004 Standout
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
Integrating cell-signalling pathways with NF-κB and IKK function
2006 Standout
MAC inhibitors suppress mitochondrial apoptosis
2009
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
2012 Standout
Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
2007
Regulatory T Cells and Human Disease
2020 StandoutNobel
Apoptosis: A Review of Programmed Cell Death
2007 Standout
Signalling through Class I PI3Ks in mammalian cells
2006
Spermidine Alleviates Severity of Murine Experimental Autoimmune Encephalomyelitis
2011
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Oxidative Stress and Diabetic Complications
2010 Standout
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket
2008
Spermidine Ameliorates Neurodegeneration in a Mouse Model of Normal Tension Glaucoma
2015
Spermidine in health and disease
2018 StandoutScience
The Potential of Mesenchymal Stromal Cells as a Novel Cellular Therapy for Multiple Sclerosis
2012
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
2008
Mechanisms of Diabetic Complications
2013 Standout
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
The selectivity of protein kinase inhibitors: a further update
2007 Standout
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
2007
PI3Kγ Is a Key Regulator of Inflammatory Responses and Cardiovascular Homeostasis
2007 Science
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
2019
Leukocyte phosphoinositide-3 kinase γ is required for chemokine-induced, sustained adhesion under flow in vivo
2006
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
An arrestin-dependent multi-kinase signaling complex mediates MIP-1β/CCL4 signaling and chemotaxis of primary human macrophages
2009
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
CASTp 3.0: computed atlas of surface topography of proteins
2018 Standout
Works of Pierre‐Alain Vitte being referenced
AS601245 (1,3-Benzothiazol-2-yl (2-{[2-(3-pyridinyl) ethyl] amino}-4 pyrimidinyl) Acetonitrile): A c-Jun NH2-Terminal Protein Kinase Inhibitor with Neuroprotective Properties
2004
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
2005
Inhibition of c‐Jun N‐terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats
2004
Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity
2008
Bax Channel Inhibitors Prevent Mitochondrion-mediated Apoptosis and Protect Neurons in a Model of Global Brain Ischemia
2005
Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase
2005
An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo
2008
Regulation of the severity of neuroinflammation and demyelination by TLR‐ASK1‐p38 pathway
2010