Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
Protein stability promotes evolvability
2006 StandoutNobel
The role of gene dosage and genetic transpositions in carcinogenesis
1981 Nature
Elevated levels of wild-type p53 induced by radiolabeling of cells leads to apoptosis or sustained growth arrest
1995
Heteromultimeric channels formed by rat brain potassium-channel proteins
1990 StandoutNatureNobel
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
When Checkpoints Fail
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability 1 1Edited by J. Karn
1998
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations
2000
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
ECM signalling: orchestrating cell behaviour and misbehaviour
1998
Biochemical properties and biological effects of p53
1995
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
The ‘wildtype’ conformation of p53: epitope mapping using hybrid proteins
2001 StandoutNobel
A DNA Damage–Induced p53 Serine 392 Kinase Complex Contains CK2, hSpt16, and SSRP1
2001
70K heat shock related proteins stimulate protein translocation into microsomes
1988 StandoutNatureNobel
A teratologic suppressor role for p53 in benzo(a)pyrene–treated transgenic p53-deficient mice
1995
A role for casein kinase 2α in the Drosophila circadian clock
2002 StandoutNatureNobel
Activation of the cryptic DNA binding function of mutant forms of p53
1993
The tumore suppressor p53
1993
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.
1993
Rous sarcoma virus activates embryonic globin genes in chicken fibroblasts.
1975
Evidence for ‘splicing’ of SV40 16S mRNA
1978 Nature
Nucleotide sequence analysis of two simian virus 40 mutants with deletions in the region coding for the carboxyl terminus of the T antigen
1979 StandoutNobel
A role for clathrin light chains in the recognition of clathrin cages by ‘uncoating ATPase’
1984 StandoutNatureNobel
Episomal DNA of a BK virus variant in a human insulinoma
1983
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
1984 StandoutNatureNobel
Simian Virus 40 and Polyoma Virus Gene Expression Explored by the Microinjection Technique
1979
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
1994
Localization of the adenovirus E1Aa protein, a positive-acting transcriptional factor, in infected cells infected cells.
1983
Nucleotide sequence of the 26S mRNA of Sindbis virus and deduced sequence of the encoded virus structural proteins.
1981 StandoutNobel
Sequences of mouse immunoglobulin light chain genes before and after somatic changes
1978 StandoutNobel
Complete nucleotide sequence of SV40 DNA
1978 Nature
Expression of a chicken chromosomal ovalbumin gene injected into frog oocyte nuclei
1980 StandoutNatureNobel
The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins
1981
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA
1983 StandoutNobel
Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.
1994
Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src
1983 StandoutNobel
An enzyme that removes clathrin coats: purification of an uncoating ATPase.
1984 StandoutNobel
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1994
DNAs of simian virus 40 and polyoma direct the synthesis of viral tumor antigens and capsid proteins in Xenopus oocytes.
1978
Nucleotide sequence deletions within the coding region for small-t antigen of simian virus 40
1979 StandoutNobel
The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related
1983 StandoutNatureNobel
Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
1994
p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner
1995
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Regulation of human ribosomal RNA transcription.
1983
The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes
1981 StandoutNobel
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
1993
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins
1987 StandoutNatureNobel
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane
2002
Fission yeast Schizosaccharomyces pombe correctly excises a mammalian RNA transcript intervening sequence
1985 StandoutNatureNobel
p53 functions as a cell cycle control protein in osteosarcomas.
1990
Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of tetrahymena
1984 StandoutNobel
Monoclonal antibodies against simian virus 40 nuclear large T tumour antigen: epitope mapping, papova virus cross-reaction and cell surface staining.
1984
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.
1994
Deletion mutants of simian virus 40 defective in biosynthesis of late viral mRNA.
1979
Uncoating ATPase is a member of the 70 kilodalton family of stress proteins
1986 StandoutNobel
Expression of a Bacterial Gene in Mammalian Cells
1980 StandoutScienceNobel
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses
1978 StandoutNobel
DNA Repair in Drosophila
2000
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome
1979 StandoutNatureNobel
Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.
1994
Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly
1989 StandoutScienceNobel
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing
1979
Viruses in Human Cancers
1991 StandoutScienceNobel
Bcl-2 blocks p53-dependent apoptosis.
1994
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
1984 Nature
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.
1983 StandoutNobel
The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.
1996
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein
1995
Base substitutions, length differences and DNA strand asymmetries in the human Gγ and Aγ fetal globin gene region
1981 StandoutNobel
Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression
1995
Monoclonal antibodies specific for simian virus 40 tumor antigens
1981
In vitro mutagenesis of a putative DNA binding domain of SV40 large-T
1984
Enzymatic recycling of clathrin from coated vesicles
1986 StandoutNobel
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Accumulation of wild-type p53 protein upon gamma-irradiation induces a G2 arrest-dependent immunoglobulin kappa light chain gene expression.
1995
Mapping the spliced and unspliced late lytic SV40 RNAs
1978
Heterogeneity and 5′-terminal structures of the late RNAs of simian virus 40
1978
HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions
1984 StandoutNobel
Association between transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector
1983 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Cell-type-specific contacts to immunoglobulin enhancers in nuclei
1985 StandoutNatureNobel
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Cytokines Inhibit p53-Mediated Apoptosis but Not p53-Mediated G1 Arrest
1995
Stimulation of simian virus 40 late gene expression by simian virus 40 tumor antigen.
1984
The IGF axis and programmed cell death
1999
Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53.
1994
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
1985 StandoutNatureNobel
Works of Pierre May being referenced
Further characterisation of the p53 responsive element – identification of new candidate genes for trans-activation by p53
1997
The phosphoprotein p53 is down-regulated post-transcriptionally during embryogenesis in vertebrates
1988
Structural Aspects of the p53 Protein in Relation to Gene Evolution: A Second Look
1996
Twenty years of p53 research: structural and functional aspects of the p53 protein
1999
p53-Mediated Cell Death: Relationship to Cell Cycle Control
1993
Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes
1997
New Genetic Information Expressed in SV40-transformed Cells: Characterization of the 55K Proteins and Evidence for Unusual SV40 mRNAs
1980
Evolutionary conservation of the biochemical properties of p53: specific interaction of Xenopus laevis p53 with simian virus 40 large T antigen and mammalian heat shock proteins 70
1989
Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line.
1988
Purification et proprietes d'un inhibiteur de la desoxyribonuclease pancreatique, extrait du serum de rat
1967
A Simplifying Concept in Tumor Virology: Virus-specific "Pleiotropic Effectors"
1974
Study of the Functional Activities Concomitantly Retained by the 115,000 M r Super T Antigen, an Evolutionary Variant of Simian Virus 40 Large T Antigen Expressed in Transformed Rat Cells
1983
p53-mediated cell death: relationship to cell cycle control.
1993
Stimulation of cellular RNA synthesis in mouse-kidney cell cultures infected with SV40 virus
1976
Ability of nonpermissive mouse cells to express a simian virus 40 late function(s)
1981
Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B‐cell lymphoma
1987
Characterization of two SV40 early mRNAs and evidence for a nuclear “prespliced” RNA species
1978
Mapping the transcription site of the SV40-specific late 16 S mRNA
1975
Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum
1979