Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Prospective identification of tumorigenic breast cancer cells
2003 Standout
Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice
2008
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
2004 StandoutScience
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
2017 StandoutScienceNobel
TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
2008 StandoutScience
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
2011 StandoutScience
Targeted cell killing by reconstituted caspases
2007 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
2008 StandoutScience
Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway
2003
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
2016
Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide
2006
First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
2019
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster
2012
Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis
2002
Schizophrenia risk from complex variation of complement component 4
2016 StandoutNature
Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis
2007
The DNA-damage response in human biology and disease
2009 StandoutNature
Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria
2004
Apoptosis in the nervous system
2000 StandoutNature
Genetic studies of amyotrophic lateral sclerosis: Controversies and perspectives
2009
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn‐superoxide dismutase mutant mice
2006
Glutamate uptake
2001 Standout
Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis
2013
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
2010
Microsecond Barrier-Limited Chain Collapse Observed by Time-Resolved FRET and SAXS
2014
Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice
2005
C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD
2016
From charcot to lou gehrig: deciphering selective motor neuron death in als
2001
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
2005
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
ER stress and neurodegenerative diseases
2006
Non–cell autonomous effect of glia on motor neurons in an embryonic stem cell–based ALS model
2007
Amyotrophic lateral sclerosis
2011 Standout
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
2015
Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis
2016
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
2016
Differential expression of inflammation‐ and apoptosis‐related genes in spinal cords of a mutant SOD1 transgenic mouse
model of familial amyotrophic lateral sclerosis
2001
Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
2015
Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis
2010
The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction
2008
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
2008
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
2007 Standout
Decoding ALS: from genes to mechanism
2016 StandoutNature
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
2005 StandoutNature
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
2015 Nature
Mitochondrial fragmentation in neurodegeneration
2008
Mitochondrial Localization of Mutant Superoxide Dismutase 1 Triggers Caspase-dependent Cell Death in a Cellular Model of Familial Amyotrophic Lateral Sclerosis
2002
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
2008
Ageing and apoptosis
2002
Widespread changes in protein synthesis induced by microRNAs
2008 StandoutNature
β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs
2002 StandoutNobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
The Classical Complement Cascade Mediates CNS Synapse Elimination
2007 Standout
Role of DNA mismatch repair in apoptotic responses to therapeutic agents
2004
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Identification of Two Novel Loci for Dominantly Inherited Familial Amyotrophic Lateral Sclerosis
2003 Nobel
A Fresh Look at iPS Cells
2009 StandoutNobel
Protein kinase C: a physiological mediator of enhanced transmitter output
1998
Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading
2002
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes
2003
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
2004
Metabolism, Cell Surface Organization, and Disease
2009
Mitochondrial DNA damage and repair in neurodegenerative disorders
2008
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
2011
Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers
2016
Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration
2015
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
2002
Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
2014
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
2015
Glia cells in amyotrophic lateral sclerosis: New clues to understanding an old disease?
2007
A decade of caspases
2003
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Autophagy in immunity and inflammation
2011 StandoutNature
Exosomes, an Unmasked Culprit in Neurodegenerative Diseases
2017
Lost in translation: Treatment trials in the SOD1 mouse and in human ALS
2007
Inflammasomes in health and disease
2012 StandoutNature
Genetically engineered mouse models of neurodegenerative diseases
2002
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells
2011
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
2006
Amyotrophic lateral sclerosis: A proposed mechanism
2002
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
2002
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model
2000 Science
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
2009
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
In vivo genome editing improves motor function and extends survival in a mouse model of ALS
2017
Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
2021 StandoutNobel
Mitochondrial damage due to SOD1 deficiency in SH‐SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1
2006
Protein-Catalyzed Capture Agents
2019
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
2010
Spatiotemporal Recapitulation of Central Nervous System Development by Murine Embryonic Stem Cell-Derived Neural Stem/Progenitor Cells
2008
The Serpin Proteinase Inhibitor 9 Is an Endogenous Inhibitor of Interleukin 1β–Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells
2000
Excitotoxicity and Amyotrophic Lateral Sclerosis
2005
A biochemist's view of long-term potentiation.
1996
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
2004
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
2014
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Voltage-Induced Misfolding of Zinc-Replete ALS Mutant Superoxide Dismutase-1
2015
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Assessment of disease progression in motor neuron disease
2005
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Oxidative stress in neurodegeneration: cause or consequence?
2004 Standout
Works of Piera Pasinelli being referenced
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
2012
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
2010
Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
2014
Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD
2016
Decreased Intracellular Superoxide Levels Activate Sindbis Virus-induced Apoptosis
1999
Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria
2004
Amyotrophic Lateral Sclerosis-linked Glutamate Transporter Mutant Has Impaired Glutamate Clearance Capacity
2001
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
2010
Long-term potentiation and synaptic protein phosphorylation
1995
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
2014
Temporal Differences in the Phosphorylation State of Pre- and Postsynaptic Protein Kinase C Substrates B-50/GAP-43 and Neurogranin during Long Term Potentiation
1995
A Caspase-3-cleaved Fragment of the Glial Glutamate Transporter EAAT2 Is Sumoylated and Targeted to Promyelocytic Leukemia Nuclear Bodies in Mutant SOD1-linked Amyotrophic Lateral Sclerosis
2007
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
2006
Antibodies to Postsynaptic PKC Substrate Neurogranin Prevent Long‐term Potentiation in Hippocampal CA1 Neurons
1995
Defects in Synapse Structure and Function Precede Motor Neuron Degeneration inDrosophilaModels of FUS-Related ALS
2013
Protein kinase C in synaptic plasticity: Changes in the in situ phosphorylation state of identified pre- and postsynaptic substrates
1997
Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity
2002
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
2014
Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease
2001
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
1998
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
2000
Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter
2004
RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells
2004