Standout Papers
Citation Impact
Citing Papers
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
2009 StandoutScience
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib
2009
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
2011 Science
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
2014 Standout
Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase
2009
Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury
2016
Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival
2008
2019
Global Translational Responses to Oxidative Stress Impact upon Multiple Levels of Protein Synthesis
2006
PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response
2013
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease
2007
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
2011 Standout
HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis
2011
The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
2010
The Unfolded Protein Response and Cell Fate Control
2017
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Inflammation and metabolic disorders
2006 StandoutNature
Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β
2012
The UPR ER : Sensor and Coordinator of Organismal Homeostasis
2017
A compendium of kinetic modulatory profiles identifies ferroptosis regulators
2021
A trip to the ER: coping with stress
2003
Ido expression by dendritic cells: tolerance and tryptophan catabolism
2004 Standout
Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans
2005
GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase
2005
Autophagy and the Integrated Stress Response
2010 Standout
The mitochondrial UPR: mechanisms, physiological functions and implications in ageing
2017
Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs
2007
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
ER stress and the unfolded protein response
2004
The genetics of ageing
2010 StandoutNature
Mfn2 modulates the UPR and mitochondrial function via repression of PERK
2013
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
2009
Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis
2006
XBP1, Downstream of Blimp-1, Expands the Secretory Apparatus and Other Organelles, and Increases Protein Synthesis in Plasma Cell Differentiation
2004
Nrf1 Is Targeted to the Endoplasmic Reticulum Membrane by an N-terminal Transmembrane Domain
2006
Cigarette Smoke Induces an Unfolded Protein Response in the Human Lung
2007
Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade
2015
Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals
2009
Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf
2013
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis
2008
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
2006
ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
2005
Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα
2005
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
2015
Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II
2004
Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
2005
Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway
2006
Endoplasmic reticulum stress: cell life and death decisions
2005 Standout
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression
2005
Frataxin knockdown causes loss of cytoplasmic iron–sulfur cluster functions, redox alterations and induction of heme transcripts
2006
Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling
2009
Gene Therapy Strategies to Restore ER Proteostasis in Disease
2018
DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy
2017
Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation
2013
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Herp Is Dually Regulated by Both the Endoplasmic Reticulum Stress-specific Branch of the Unfolded Protein Response and a Branch That Is Shared with Other Cellular Stress Pathways
2004
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
Translation Attenuation through eIF2α Phosphorylation Prevents Oxidative Stress and Maintains the Differentiated State in β Cells
2009
Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1
2007
PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress
2004
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
2019
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Lipid signalling in disease
2008
Quality control in the endoplasmic reticulum protein factory
2003 Nature
The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
2007
Roles of CHOP/GADD153 in endoplasmic reticulum stress
2003 Standout
ATF6α Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress
2007
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
2005
Acute L ‐glutamine deprivation compromises VEGF‐a upregulation in A549/8 human carcinoma cells
2007
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
2006
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia
2011
Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice
2008
Surviving Endoplasmic Reticulum Stress Is Coupled to Altered Chondrocyte Differentiation and Function
2007
Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
2006
Role of Glutamine Depletion in Directing Tissue-specific Nutrient Stress Responses to L-Asparaginase
2006
Cancer immunotherapy comes of age
2011 StandoutNature
BCL-2 family: integrating stress responses at the ER to control cell demise
2017
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival
2017
Endoplasmic reticulum stress and pancreatic β-cell death
2011
HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes
2015
Molecular and Functional Alterations in a Mouse Cardiac Model of Friedreich Ataxia
2013
Origin and physiological roles of inflammation
2008 StandoutNature
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress
2012
Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress
2003
Degradation of Misfolded Proteins Prevents ER-Derived Oxidative Stress and Cell Death
2004
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Transcribed processed pseudogenes in the human genome: an intermediate form of expressed retrosequence lacking protein-coding ability
2005
TBL2 Is a Novel PERK-Binding Protein that Modulates Stress-Signaling and Cell Survival during Endoplasmic Reticulum Stress
2014
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
2013
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
2004 Standout
UPR Pathways Combine to Prevent Hepatic Steatosis Caused by ER Stress-Mediated Suppression of Transcriptional Master Regulators
2008
The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis
2011
N6-methyladenosine-dependent regulation of messenger RNA stability
2013 StandoutNature
Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN‐β induction via X‐box binding protein 1
2008
Double-stranded RNA-dependent Protein Kinase Phosphorylation of the α-Subunit of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis
2006
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose
2013
GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase
2009
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
2011 Standout
Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
2008
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
2010 StandoutNature
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Translational control in stress and apoptosis
2005
Enhanced Integrated Stress Response Promotes Myelinating Oligodendrocyte Survival in Response to Interferon-γ
2008
Nck-1 Antagonizes the Endoplasmic Reticulum Stress-induced Inhibition of Translation
2004
The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores
2005
ER stress and the unfolded protein response in neurodegeneration
2017
Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4
2008
Gcn4p and Novel Upstream Activating Sequences Regulate Targets of the Unfolded Protein Response
2004
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
2009
Vaticanol B, a resveratrol tetramer, regulates endoplasmic reticulum stress and inflammation
2007
Proteostasis control by the unfolded protein response
2015
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Endoplasmic Reticulum Stress Signaling in Disease
2006
GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress
2006
Autophagy in immunity and inflammation
2011 StandoutNature
The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum
2004
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
2004 Nature
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
p65/RelA Modulates BECN1 Transcription and Autophagy
2009
Oxidative Protein Folding and the Quiescin–Sulfhydryl Oxidase Family of Flavoproteins
2010
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
2007
The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control
2006
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
2018
Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress
2006
Intracellular Signaling by the Unfolded Protein Response
2006
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
2008
Activation of Mammalian Unfolded Protein Response Is Compatible with the Quality Control System Operating in the Endoplasmic Reticulum
2004
Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-γ in IL-12/IL-18-stimulated mouse macrophage populations
2004
Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress
2020
Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK
2006
Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum–Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload
2010
Mediators of endoplasmic reticulum stress‐induced apoptosis
2006 Standout
Intrinsic Capacities of Molecular Sensors of the Unfolded Protein Response to Sense Alternate Forms of Endoplasmic Reticulum Stress
2006
Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival
2003
Targeting glutamine transport to suppress melanoma cell growth
2014
Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages
2013
Activation of the Akt-NF-κB Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response
2009
Endoplasmic Reticulum Stress in Immunity
2014
Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury
2006
Oxidative protein folding in eukaryotes
2004
Generating disulfides enzymatically: Reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p
2006
Nitric Oxide and Endoplasmic Reticulum Stress
2006
The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes
2005
Regulation of basal cellular physiology by the homeostatic unfolded protein response
2010
OGFOD1, a Novel Modulator of Eukaryotic Translation Initiation Factor 2α Phosphorylation and the Cellular Response to Stress
2010
Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
2014
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
2013
Endoplasmic reticulum proteostasis impairment in aging
2017
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
2005
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
2005 Standout
Global Gene Expression Profiling Reveals Widespread yet Distinctive Translational Responses to Different Eukaryotic Translation Initiation Factor 2B-Targeting Stress Pathways
2005
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response
2003 Standout
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development
2009
Luman/CREB3 Induces Transcription of the Endoplasmic Reticulum (ER) Stress Response Protein Herp through an ER Stress Response Element
2006
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
2008
Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
2006 StandoutNobel
A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
2005 Science
Inflammatory Mechanisms in Obesity
2011 Standout
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
2013
Stable Ribosome Binding to the Endoplasmic Reticulum Enables Compartment-specific Regulation of mRNA Translation
2005
TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST
2005
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 StandoutScience
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
2012
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
2004
Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-γ
2005
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
2006
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
Endoplasmic Reticulum Stress Is a Determinant of Retrovirus-Induced Spongiform Neurodegeneration
2003
Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response
2004
BBF2H7, a Novel Transmembrane bZIP Transcription Factor, Is a New Type of Endoplasmic Reticulum Stress Transducer
2006
The Unfolded Protein Response Is an Important Regulator of Inflammatory Genes in Endothelial Cells
2006
Pharmacological brake-release of mRNA translation enhances cognitive memory
2013
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
2014 StandoutNobel
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
The Unfolded Protein Response: A Novel Component of the Hypoxic Stress Response in Tumors
2005
ATF6α induces XBP1-independent expansion of the endoplasmic reticulum
2009
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Works of Phoebe D. Lu being referenced
Cytoprotection by pre‐emptive conditional phosphorylation of translation initiation factor 2
2004
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
2003 Standout
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
2005
Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP, promotes survival of stressed cells
2003
Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
2004
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
2004