Citation Impact
Citing Papers
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
The Tof1p–Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae
2006
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement
2007 StandoutNobel
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ
2008 StandoutNobel
The Role of Replication-Associated Repair Factors on R-Loops
2017
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Nucleosome Movement by CHRAC and ISWI without Disruption or trans-Displacement of the Histone Octamer
1999
Tuning in to Interference: R-Loops and Cascade Complexes in CRISPR Immunity
2012
Separate SCFCDC4 recognition elements target Cdc6 for proteolysis in S phase and mitosis
2001
Cdc7 Is an Active Kinase in Human Cancer Cells Undergoing Replication Stress
2006
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
2005
Initiation of Eukaryotic DNA Replication
2000
Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery
2015
Packaging the Genome: the Structure of Mitotic Chromosomes
2007
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Induced Pluripotent Stem Cells Meet Genome Editing
2016
Xenopus Drf1, a Regulator of Cdc7, Displays Checkpoint-dependent Accumulation on Chromatin during an S-phase Arrest
2003
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs
2018
Mitotic chromosome structure and condensation
2006
Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development
2003
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Identification of the MMS22L-TONSL Complex that Promotes Homologous Recombination
2010
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
2016
Transcription as a source of genome instability
2012
CRL4s: the CUL4-RING E3 ubiquitin ligases
2009
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Therapeutic genome editing: prospects and challenges
2015
BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
2017
Checking on DNA damage in S phase
2004
Evidence for Sequential Action of cdc7 and cdk2 Protein Kinases during Initiation of DNA Replication in Xenopus Egg Extracts
2000
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells
2012
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability
2010
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Cell cycle restriction of telomere elongation
2000
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
2007 StandoutNobel
Human Cdc7-related Kinase Complex
2000
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
2014 Standout
An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication
2003
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors
2006
Nuclear reprogramming and pluripotency
2006 Nature
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
The AID Dilemma
2012 StandoutNobel
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Visualization of Altered Replication Dynamics after DNA Damage in Human Cells
2004
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets
2017
Progress and prospects in plant genome editing
2017
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
2020 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Mutational analysis of conserved sequence motifs in the budding yeast cdc6 protein 1 1Edited by M. Yaniv
2001
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
2015
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Hierarchy of S-Phase-Promoting Factors: Yeast Dbf4-Cdc7 Kinase Requires Prior S-Phase Cyclin-Dependent Kinase Activation
2000
Stepwise assembly of initiation proteins at budding yeast replication origins in vitro
2000
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?
2000
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Distinct Phosphoisoforms of the Xenopus Mcm4 Protein Regulate the Function of the Mcm Complex
2000
Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
2000
From Nuclear Transfer to Nuclear Reprogramming: The Reversal of Cell Differentiation
2006 StandoutNobel
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Chromatin remodeling by DNA bending, not twisting
2005 StandoutNobel
Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae
2010
Regulation of Chromosome Replication
2000
Surviving the Breakup: The DNA Damage Checkpoint
2006
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase
2013 StandoutNobel
Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases
1998
Cdc7p-Dbf4p becomes famous in the cell cycle
2000
Target specificity of the CRISPR‐Cas9 system
2014
DNA Replication in Eukaryotic Cells
2002 Standout
Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle
2001
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Initiating DNA synthesis: from recruiting to activating the MCM complex
2001
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Where it all starts: eukaryotic origins of DNA replication
2001
Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function
2006
Works of Philippe Pasero being referenced
ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase
2002
Mrc1 and Tof1 Promote Replication Fork Progression and Recovery Independently of Rad53
2005
A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication
1999
New systems for replicating DNA in vitro
1998
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
2013
The Cullin Rtt101p Promotes Replication Fork Progression through Damaged DNA and Natural Pause Sites
2006
Mitotic Remodeling of the Replicon and Chromosome Structure
2005
Common DNA Structural Features Exhibited by Eukaryotic Ribosomal Gene Promoters
1996
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
2009
Exo1 Competes with Repair Synthesis, Converts NER Intermediates to Long ssDNA Gaps, and Promotes Checkpoint Activation
2010
RNAi‐based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells
2010
Rtt101 and Mms1 in budding yeast form a CUL4 DDB1 ‐like ubiquitin ligase that promotes replication through damaged DNA
2008
Think global, act local — how to regulate S phase from individual replication origins
2000
An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing
2002
Short DNA Fragments without Sequence Similarity Are Initiation Sites for Replication in the Chromosome of the YeastYarrowia lipolytica
1999
Cyclin B-Cdk1 Kinase Stimulates ORC- and Cdc6-Independent Steps of Semiconservative Plasmid Replication in Yeast Nuclear Extracts
1999
ORC-dependent and origin-specific initiation of DNA replication at defined foci in isolated yeast nuclei.
1997