Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Reduced Paneth cell α-defensins in ileal Crohn's disease
2005
β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
2004
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Functional Cross-talk between β-Catenin and NFκB Signaling Pathways in Colonic Crypts of Mice in Response to Progastrin
2009
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation
2005
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Deletion of β-catenin impairs T cell development
2003
Hallmarks of Cancer: The Next Generation
2011 Standout
SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130
2000
Innate Immunity in Pluripotent Human Cells
2013
PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
2001
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
2001
Sonic hedgehog is essential to foregut development
1998
The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities
1998
Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster
1999
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 StandoutNature
Oncogenic kinase signalling
2001 StandoutNature
Negative Regulators of Cytokine Signaling
2001
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Anaplastic lymphoma kinase proteins in growth control and cancer
2004
Immunological aspects of intestinal mucus and mucins
2016
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
2004
The paradigm of IL-6: from basic science to medicine.
2002
SAP – a putative DNA-binding motif involved in chromosomal organization
2000
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis
2001
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
2002
Protein-tyrosine Phosphatase PTPεC Inhibits Jak-STAT Signaling and Differentiation Induced by Interleukin-6 and Leukemia Inhibitory Factor in M1 Leukemia Cells
2000
The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3
2000
The hedgehog signaling network
2003
SHP-2 Is a Dual-specificity Phosphatase Involved in Stat1 Dephosphorylation at Both Tyrosine and Serine Residues in Nuclei
2002
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
Wnt signaling in the intestinal epithelium: from endoderm to cancer
2005
The Intestinal Wnt/TCF Signature
2006
Effective targeted gene ‘knockdown’ in zebrafish
2000 Standout
SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation
2003
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
2008
A Testis-specific Androgen Receptor Coregulator That Belongs to a Novel Family of Nuclear Proteins
1999
A novel factor required for the SUMO1/Smt3 conjugation of yeast septins
2001
Dclk1 distinguishes between tumor and normal stem cells in the intestine
2012
Wnt-1 and Wnt-4 regulate thymic cellularity
2002
The roles of the Drosophila JAK/STAT pathway
2000
Cleft lip and palate: understanding genetic and environmental influences
2011 Standout
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
2004
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Oncostatin M Regulates the Synthesis and Turnover of gp130, Leukemia Inhibitory Factor Receptor α, and Oncostatin M Receptor β by Distinct Mechanisms
2001
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
2000
Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53
2001
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Transcription factor Sp3 is silenced through SUMO modification by PIAS1
2002
The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family
2001
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription
2001
Functional Association of Nmi with Stat5 and Stat1 in IL-2- and IFN γ-Mediated Signaling
1999
Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22
1997
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
1997 Standout
A genetic study of the role of the Wnt/β-catenin signalling in Paneth cell differentiation
2008
Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases
2002
Immunity, Inflammation, and Cancer
2010 Standout
Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
2009
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
The genetics of isolated orofacial clefts: from genotypes to subphenotypes
2009
New players and puzzles in the Hedgehog signaling pathway
1998
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
The intestinal stem cell
2008
WNT Signaling and Lymphocyte Development
2002
Sonic hedgehogParticipates in Craniofacial Morphogenesis and Is Down-regulated by Teratogenic Doses of Retinoic Acid
1997
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
1997 Nature
A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3
2002
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
1996 Standout
Increased K+ Efflux and Apoptosis Induced by the Potassium Channel Modulatory Protein KChAP/PIAS3β in Prostate Cancer Cells
2002
Expression Pattern of Wnt Signaling Components in the Adult Intestine
2005
Polycomb complexes repress developmental regulators in murine embryonic stem cells
2006 StandoutNature
Neurogenesis and the Cell Cycle
2003
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination
2000
Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport
2000
Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice
2009 StandoutNobel
Expression of the Sonic hedgehog (SHH) Gene during Early Human Development and Phenotypic Expression of New Mutations Causing Holoprosencephaly
1999
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
1999 StandoutNature
Chapter 13 Long‐Range Gene Control and Genetic Disease
2008
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
Modulation of STAT signaling by STAT-interacting proteins
2000
Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription
2001
Nuclear and unclear functions of SUMO
2003
Activation of STAT proteins and growth control
2001
Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells
2001
Cellular Physiology of STAT3: Where's the Cytoplasmic Monomer?
1999
Protein Inhibitors of Activated STAT Resemble Scaffold Attachment Factors and Function as Interacting Nuclear Receptor Coregulators
2002
Wnt signalling in stem cells and cancer
2005 StandoutNature
Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
2007
Induction of Apoptosis by Protein Inhibitor of Activated Stat1 through c-Jun NH2-terminal Kinase Activation
2001
Yeast Ull1/Siz1 Is a Novel SUMO1/Smt3 Ligase for Septin Components and Functions as an Adaptor between Conjugating Enzyme and Substrates
2001
Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
1997
From head to toes: the multiple facets of Sox proteins
1999 Standout
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system
1999
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Sumoylation of Mdm2 by Protein Inhibitor of Activated STAT (PIAS) and RanBP2 Enzymes
2002
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
α-Defensins in Enteric Innate Immunity
2009
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Receptor subtype discrimination using extensive shape complementary designed interfaces
2019 StandoutNobel
Spatial partitioning of the regulatory landscape of the X-inactivation centre
2012 StandoutNature
Analysis of the Life Cycle of Stat6
2002
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
2002 Standout
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1997
STATs: transcriptional control and biological impact
2002 Standout
A Novel Mutation of desert hedgehog in a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
Establishment and Maintenance of DNA Methylation Patterns in Mouse Ndn: Implications for Maintenance of Imprinting in Target Genes of the Imprinting Center
2001
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction
2000
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Negative regulation of the JAK/STAT pathway
1999
A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases
2001
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
Characterization of two patched receptors for the vertebrate hedgehog protein family
1998
Modification of GATA-2 Transcriptional Activity in Endothelial Cells by the SUMO E3 Ligase PIASy
2003
Sonic hedgehog regulates the growth and patterning of the cerebellum
1999
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
1998
Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice
1998 Standout
Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins
2001
JAKS AND STATS: Biological Implications
1998 Standout
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
1998
Regulation of retinal ganglion cell production by Sonic hedgehog
2001
Epigenetic Reprogramming in Mammalian Development
2001 StandoutScience
Inhibition of Stat1-mediated gene activation by PIAS1
1998
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
2014
Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
2016 StandoutNobel
Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway
1999
Signalling interactions during facial development
1998
A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
2001
The Inhibitory Effect of IL-1β on IL-6-Induced α2-Macroglobulin Expression Is Due to Activation of NF-κB
2001
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
1998 Standout
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity
2002
Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma
2002
PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases
2002
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
2003
Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
2015
Stat5B Shuttles Between Cytoplasm and Nucleus in a Cytokine-Dependent and -Independent Manner
2002
Cellular Control of Actin Nucleation
2002
Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT
2003
PIAS proteins promote SUMO-1 conjugation to STAT1
2003
A Novel Mutation ofdesert hedgehogin a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
2000 StandoutScience
Hedgehog signals regulate multiple aspects of gastrointestinal development
2000
Protein Modification by SUMO
2004 Standout
SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium
2007
Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxβ
2002
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases
1998
Hepatocyte Nuclear Factor 4α, a Key Factor for Homeostasis, Cell Architecture, and Barrier Function of the Adult Intestinal Epithelium
2009
Inhibition of Interleukin 2 Signaling and Signal Transducer and Activator of Transcription (Stat)5 Activation during T Cell Receptor–Mediated Feedback Inhibition of T Cell Expansion
1999
SOCS-3 Is Tyrosine Phosphorylated in Response to Interleukin-2 and Suppresses STAT5 Phosphorylation and Lymphocyte Proliferation
1999
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Interplay of SOX and POU Factors in Regulation of the Nestin Gene in Neural Primordial Cells
2004
Twenty Pairs of Sox
2002
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
2003 StandoutScience
Signal Transduction and the Control of Gene Expression
2002 Science
A Drosophila PIAS homologue negatively regulates stat92E
2001
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
1997
Works of Philippe Jay being referenced
Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells
2008
The intestinal epithelium tuft cells: specification and function
2012
Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium
2011
SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue
1997
The Human SOX11 Gene: Cloning, Chromosomal Assignment and Tissue Expression
1995
β-Catenin/Tcf-4 Inhibition After Progastrin Targeting Reduces Growth and Drives Differentiation of Intestinal Tumors
2007
Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
2016 Nature
The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region
1997
Diversification Pattern of the HMG and SOX Family Members During Evolution
1999
Phosphorylation of an N-terminal Motif Enhances DNA-binding Activity of the Human SRY Protein
1998
ARP3β, the gene encoding a new human actin‐related protein, is alternatively spliced and predominantly expressed in brain neuronal cells
2000
Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription
2001
Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR
1998
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
1996 Standout
Wnt signalling induces maturation of Paneth cells in intestinal crypts
2005
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium
2007
Maturation of Paneth Cells Induces the Refractory State of Newborn Mice to Shigella Infection
2008
Specific Inhibition of Stat3 Signal Transduction by PIAS3
1997 StandoutScience
Expression of the Carcinoembryonic Antigen Gene Is Inhibited by SOX9 in Human Colon Carcinoma Cells
2005
PC8 [corrected], a new member of the convertase family
1996
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
2004