Standout Papers
Citation Impact
Citing Papers
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
NF-κB Activation Represses Tumor Necrosis Factor-α-induced Autophagy
2006
Hallmarks of Cancer: The Next Generation
2011 Standout
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Ambra1 regulates autophagy and development of the nervous system
2007 Nature
Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis
2007
Demonstration by NMR of folding domains in lysozyme
1991 StandoutNatureNobel
Autophagy in innate and adaptive immunity
2005
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Novel Roles for Classical Factors at the Interface between Translation Termination and Initiation
1999
Interaction of Translation Initiation Factor 3 with the 30S Ribosomal Subunit
2001
Identification, cloning and sequence of the Streptococcus faecium infB (translational initiation factor IF2) gene
1988
Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
2007
Autophagy Regulates Programmed Cell Death during the Plant Innate Immune Response
2005
Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
2001
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
2006 Standout
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle
1989 StandoutNatureNobel
In Vitro Study of Two Dominant Inhibitory GTPase Mutants of Escherichia coli Translation Initiation Factor IF2
1999
Autophagy in neurodegenerative disease: friend, foe or turncoat?
2006
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
2005 Standout
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4
2006
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
Autophagy Is Disrupted in a Knock-in Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis
2006
The structure of the translational initiation factor IF1 from E.coli contains an oligomer-binding motif
1997
Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development
2007
Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice
2011
Structure of the recA protein–ADP complex
1992 StandoutNatureNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Heteronuclear NMR studies of E. coli translation initiation factor IF3. evidence that the inter-domain region is disordered in solution 1 1 Edited by K. Nagai
1997
Role of autophagy in cancer
2007 Standout
Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution
1999 StandoutNatureNobel
The roles of initiation factor 2 and guanosine triphosphate in initiation of protein synthesis
2003
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
2007
The GTPase superfamily: conserved structure and molecular mechanism
1991 StandoutNature
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells
2016 StandoutNobel
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
2007
The involvement of RNA in ribosome function
2002 StandoutNatureNobel
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells
2010
Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein
2007
Comparative Biochemistry and Biophysics of Ribosomal Proteins
1991
Initiation of mRNA translation in prokaryotes
1990
Viral interactions with macroautophagy: A double-edged sword
2010
The structure of the E. coli recA protein monomer and polymer
1992 StandoutNatureNobel
Potential therapeutic applications of autophagy
2007
The roles of intracellular protein-degradation pathways in neurodegeneration
2006 Nature
Autophagy: from phenomenology to molecular understanding in less than a decade
2007 Standout
Ribosome formation from subunits studied by stopped-flow and rayleigh light scattering
2004
Discrimination by Escherichia coli initiation factor IF3 against initiation on non-canonical codons relies on complementarity rules
1999
Escherichia coli initiation factor 3 protein binding to 30S ribosomal subunits alters the accessibility of nucleotides within the conserved central region of 16S rRNA
1989
Signalling and autophagy regulation in health, aging and disease
2006
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
2007
Characterization of the domains of E. coli initiation factor IF2 responsible for recognition of the ribosome
1999
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
2007
Structure-function analysis of Escherichia coli translation initiation factor IF3: tyrosine 107 and lysine 110 are required for ribosome binding
1992
The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium
2008
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
1994 Standout
GTP Hydrolysis by IF2 Guides Progression of the Ribosome into Elongation
2009
Lysosomes and autophagy in cell death control
2005
Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet
1998
Regulation of autophagy by the inositol trisphosphate receptor
2007
DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
2006
Autophagy: dual roles in life and death?
2005
Interaction of translation initiation factor IF1 with the E. coli ribosomal A site
2000
Self-eating and self-killing: crosstalk between autophagy and apoptosis
2007 Standout
Autophagy in cell death: an innocent convict?
2005 Standout
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Late events of translation initiation in bacteria: a kinetic analysis
2000
AIF deficiency compromises oxidative phosphorylation
2004
Crystallographic study at 2·5 Å resolution of the interaction of methionyl-tRNA synthetase from Escherichia coli with ATP
1990
Structural basis of anticodon loop recognition by glutaminyl-tRNA synthetase
1991 StandoutNatureNobel
Selective degradation of mitochondria by mitophagy
2007
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
2007
Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis
1987
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
1997 StandoutNatureNobel
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
2001 StandoutNatureNobel
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
The autophagy effector Beclin 1: a novel BH3-only protein
2008
Amino acid sequence of mammalian elongation factor 2 deduced from the cDNA sequence: homology with GTP-binding proteins.
1986
Structural insights on the translation initiation complex: ghosts of a universal initiation complex
2006 StandoutNobel
Construction of heterodimer tyrosyl-tRNA synthetase shows tRNATyr interacts with both subunits.
1986 StandoutNobel
Structural and Functional Aspects of Domain Motions in Proteins
1984 StandoutNobel
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
2000 StandoutScienceNobel
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Molecular cloning and sequence determination of the tuf gene coding for the elongation factor Tu of Thermus thermophilus HB8
1987
Kinetic studies on the interaction of chain initiation factor 3 with 70 S Escherichia coli ribosomes and subunits.
1982
Antibody–antigen flexibility
1987 StandoutNatureNobel
Formylmethionyl-tRNA binding to 30 S ribosomes programmed with homopolynucleotides and the effect of translational initiation factor 3
1986
Insulin‐like growth factor‐1 and TNF‐α regulate autophagy through c‐jun N‐terminal kinase and Akt pathways in human atherosclerotic vascular smooth cells
2006
Valyl-tRNA synthetase gene of Escherichia coli K12. Primary structure and homology within a family of aminoacyl-TRNA synthetases.
1988
Autophagy—A double‐edged sword in oncology
2009
The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
2005
Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment
1993 Science
Studies of Glutamate Dehydrogenase
1973
The Solution Structure of the Escherichia coli Initiator tRNA and Its Interactions with Initiation Factor 2 and the Ribosomal 30 S Subunit
1989
Crystal Structure of an Initiation Factor Bound to the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
Deviations from michaelis-menten behaviour of plant glutamate dehydrogenase with ammonium as variable substrate
1980 Standout
A critical role for the autophagy gene Atg5 in T cell survival and proliferation
2006
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
The primary structure of the α subunit of human elongation factor 1
1986
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding
1982 StandoutNatureNobel
Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA Ile and Mupirocin
1999 StandoutScienceNobel
X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix.
1995 StandoutNobel
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins.
1986
GTP-binding domain: three consensus sequence elements with distinct spacing.
1987
Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
2006
Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles
1983
Characterization of the lep operon of Escherichia coli. Identification of the promoter and the gene upstream of the signal peptidase I gene.
1985
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Cross-linking of initiation factor IF3 toEscherichia coli30S ribosomal subunit by trans-dlamminedichloroplatinum(II): characterization of two cross-linking sites in 16S rRNA; a possible way of functioning for IF3
1986
Fluorescence polarization studies of the interaction of Escherichia coli protein synthesis initiation factor 3 with 30S ribosomal subunits
1981
Molecular cloning and sequence of theBacillus stearothermophilus translational initiation factor IF2 gene
1986
1H and 15N Resonance Assignments and Structure of the N-Terminal Domain of Escherichia coli Initiation Factor 3
1995
Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
2007
Cation-induced regulatory mechanism of GTPase activity dependent on polypeptide initiation factor 2
1979
The effects of initiation factors IF‐1 and IF‐3 on the dissociation of escherichia coli 70 S ribosomes
1979
Mechanism of protein biosynthesis in prokaryotic cells
1984
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
2005
Structural domains in proteins and their role in the dynamics of protein function
1983
Structure-activity relationships of methionyl-tRNA synthetase: graphics modelling and genetic engineering
1987
Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.
1985
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.
1986 StandoutNobel
Mutation at position 791 in Escherichia coli 16S ribosomal RNA affects processes involved in the initiation of protein synthesis.
1989
Function of initiation factor 1 in the binding and release of initiation factor 2 from ribosomal initiation complexes in Escherichia coli.
1977
A model of synthetase/transfer RNA interaction as deduced by protein engineering
1986 StandoutNatureNobel
The binding of fluorescein-labeled protein synthesis initiation factor 2 to Escherichia coli 30 S ribosomal subunits determined by fluorescence polarization.
1982
Biased Gene Conversion and the Evolution of Mammalian Genomic Landscapes
2009
Domains of initiator tRNA and initiation codon crucial for initiator tRNA selection by Escherichia coli IF3.
1990
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
The Complete Genome Sequence of Escherichia coli K-12
1997 StandoutScience
Translation initiation factor IF1 is essential for cell viability in Escherichia coli
1994
GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence.
1985
1H and 15N Resonance Assignments and Structure of the N-Terminal Domain of Escherichia coli Initiation Factor 3
1995
Crystal structure of Escherichia coli methionyl-tRNA synthetase at 2.5 Å resolution
1982
A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells.
1989
Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl–mediated drug resistance
2007
Selection of the initiator tRNA by Escherichia coli initiation factors.
1989
The scanning model for translation: an update.
1989 Standout
Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA Gln and ATP at 2.8 Å Resolution
1989 StandoutScienceNobel
Evidence for Dispensable Sequences Inserted into a Nucleotide Fold
1987 Science
Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death
2006
A large increase in enzyme–substrate affinity by protein engineering
1984 StandoutNatureNobel
Location of translational initiation factor IF3 on the small ribosomal subunit
1999 StandoutNobel
Fitting Neurological Protein Aggregation Kinetic Data via a 2-Step, Minimal/“Ockham's Razor” Model: The Finke−Watzky Mechanism of Nucleation Followed by Autocatalytic Surface Growth
2008
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
1990 StandoutScienceNobel
Hydrogen bonding and biological specificity analysed by protein engineering
1985 StandoutNatureNobel
tRNA dynamics on the ribosome during translation
2004 Nobel
Glutamate dehydrogenase: Chemical modification and ligand binding
1977
Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA
1990 StandoutScienceNobel
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation
1983 StandoutNobel
Binding of tyrosine, adenosine triphosphate and analogues to crystalline tyrosyl transfer RNA synthetase
1978
Analysis of Enzyme Structure and Activity by Protein Engineering
1984 StandoutNobel
Works of Philippe Dessen being referenced
[11] Properties and specificity of methionyl-tRNAfMet formyltransferase from Escherichia coli
1984
Chromosomal Minimal Critical Regions in Therapy-Related Leukemia Appear Different from Those of De Novo Leukemia by High-Resolution aCGH
2011
MASH: an interactive program for multiple alignment and consensus sequence construction for biological sequences
1991
Analysis of sequence variability in the macronuclear DNA of Paramecium tetraurelia: A somatic view of the germline
2008
Organisation of the entire rabbit progesterone receptor mRNA and of the promoter and 5′ flanking region of the gene
1988
Impact of the Ku Complex on HIV-1 Expression and Latency
2013
Direct measurement and kinetic analysis of the association of E. coli ribosomal subunits
1973
Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?
2002
Light-scattering studies showing the effect of initiation factors on the reversible dissociation of Escherichia coli ribosomes
1975
Neutron scattering studies of Escherichia coli tyrosyl-tRNA synthetase and of its interaction with tRNATyr
1982
Methionyl‐Transfer‐RNA Transformylase from Escherichia coli
1980
Antico-operative binding of bacterial and mammalian initiator tRNAMet to methionyl-tRNA synthetase from Escherichia coli
1976
Sequence similarities among the family of aminoacyl-tRNA synthetases
1986
Sequence of the initiation factor IF2 gene: unusual protein features and homologies with elongation factors.
1984
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
2014 Standout
Mechanism of bovine liver glutamate dehydrogenase self-association
1975
Proteolytic cleavage of methionyl transfer ribonucleic acid synthetase from Bacillus stearothermophilus: effects on activity and structure
1980
Inhibition of Macroautophagy Triggers Apoptosis
2005 Standout
Neutron-scattering studies of the binding of initiator tRNAMet to Escherichia coli trypsin-modified methionyl-tRNA synthetase
1982
Glutamate déshydrogénase
1969
Kinetics of the reversible association of ribosomal subunits: Stopped-flow studies of the rate law and of the effect of Mg2+
1975
Sequence of a 1.26-kb DNA fragment containing the structural gene for E.coli initiation factor IF3: presence of an AUU initiator codon.
1982
Antico-operative binding of initiator transfer RNAMet to methionyl-transfer RNA synthetase from Escherichia coli: Neutron scattering studies
1978
E. coli tyrosyl- and methionyl-tRNA synthetases display sequence similarity at the binding site for the 3'-end of tRNA
1986