Standout Papers
Citation Impact
Citing Papers
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Accelerated telomere shortening in response to life stress
2004 StandoutNobel
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
2008 Standout
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
2018 StandoutNobel
Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.
1994
Hallmarks of Cancer: The Next Generation
2011 Standout
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
Telomerase Activity Reconstituted in Vitro with Purified Human Telomerase Reverse Transcriptase and Human Telomerase RNA Component
2000
An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3
1995
Mysterious liaisons: the relationship between c-Myc and the cell cycle
1999
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
1997 Nature
EGFR Antagonists in Cancer Treatment
2008 Standout
Tumor-targeting peptides from combinatorial libraries
2016
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Telomeres, the nucleolus and aging
1998
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
1999
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
2007 StandoutNobel
A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase
1998
Functional requirement of p23 and Hsp90 in telomerase complexes
1999
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Senescence of human fibroblasts induced by oncogenic Raf
1998 Nobel
Myc activates telomerase
1998
Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers
2015 Nobel
Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process
1999
Telomere states and cell fates
2000 StandoutNatureNobel
Cdc25 cell-cycle phosphatase as a target of c-myc
1996 Nature
Telomeres and telomerase in cancer
2009
Oncoprotein Networks
1997
Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27Kip1 and p21Cip1
1999
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
The nature of telomere fusion and a definition of the critical telomere length in human cells
2007
Functionally interacting telomerase RNAs in the yeast telomerase complex
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
TRF2 Protects Human Telomeres from End-to-End Fusions
1998
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
Telomeres in T and B cells
2002
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
1999 StandoutNobel
TIN2, a new regulator of telomere length in human cells
1999
Telomerase and the maintenance of chromosome ends
1999 Nobel
Functional Reconstitution of Human Telomerase Expressed inSaccharomyces cerevisiae
1999
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Reconstitution of human telomerase activity in vitro
1998
Telomeres Do D-Loop–T-Loop
1999 StandoutNobel
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
1999
Secondary Structure of Vertebrate Telomerase RNA
2000 StandoutNobel
Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates
1998
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
1997
Telomeres and senescence: The history, the experiment, the future
1998 StandoutNobel
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
1998
Molecular cloning and characterization of AtTERT, a telomerase reverse transcriptase homolog in Arabidopsis thaliana
1999
Cell death during crisis is mediated by mitotic telomere deprotection
2015 Nature
Regulation of Telomere Length and Telomerase in T and B Cells
1998
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation
1999
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Expression ofmyc-family,myc-interacting, andmyc-target genes during preimplantation mouse development
1997
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Telomerase and chromosome end maintenance
1998 Nobel
Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties
1998
Reversing Time: Origin of Telomerase
1998 Nobel
Efficient tumour formation by single human melanoma cells
2008 Nature
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
1998
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
1999
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression
2000 StandoutNobel
Severe growth defect in mouse cells lacking the telomerase RNA component
1998
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Ectopic Expression of the Catalytic Subunit of Telomerase Protects against Brain Injury Resulting from Ischemia and NMDA-Induced Neurotoxicity
2004
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1999 StandoutNobel
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
Human telomerase contains evolutionarily conserved catalytic and structural subunits
1997
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Life in the balance: how BH3-only proteins induce apoptosis
2005
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube
1999
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
1997
Molecular cloning of bovine telomerase RNA
1998
Inhibition of telomerase limits the growth of human cancer cells
1999
The telomerase reverse transcriptase: components and regulation
1998
Expression of TERT in early premalignant lesions and a subset of cells in normal tissues
1998
Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.
1996
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
Rescue of defective mitogenic signaling by D-type cyclins.
1995
Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter
1996
Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA
1999
TERT regulates cell survival independent of telomerase enzymatic activity
2002
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1999 StandoutNobel
Activation of cyclin A-dependent protein kinases during apoptosis.
1994
Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene.
1994
Repression of cyclin D1: a novel function of MYC.
1994
Ras Induces Anchorage-Independent Growth by Subverting Multiple Adhesion-Regulated Cell Cycle Events
1996
Regulation of Telomerase by Telomeric Proteins
2004
Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.
1997
Telomerase activity, cell proliferation, and cancer
1998 StandoutNobel
Direct activation of TERT transcription by c-MYC
1999
Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
2001 ScienceNobel
Identification of Kluyveromyces lactis Telomerase: Discontinuous Synthesis along the 30-Nucleotide-Long Templating Domain
1998 StandoutNobel
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1994
Cancer Cell Cycles
1996 StandoutScience
Combined effect of 2-5A-linked antisense against telomerase RNA and conventional therapies on human malignant glioma cells in vitro and in vivo
2007
The rate of telomere sequence loss in human leukocytes varies with age
1998 StandoutNobel
Participation of cyclin A in Myc-induced apoptosis.
1994
Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA
2000 StandoutNobel
Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.
1994
Anchorage-Dependent Transcription of the Cyclin A Gene
1996
Two Inactive Fragments of the Integral RNA Cooperate To Assemble Active Telomerase with the Human Protein Catalytic Subunit (hTERT) In Vitro
1999
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
1998
Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.
1996
The Structure and Function of Telomerase Reverse Transcriptase
2006
Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo
2000
Drosophila telomeres: two transposable elements with important roles in chromosomes
1999
Control of Human Telomere Length by TRF1 and TRF2
2000
c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points
1999
Mobile Elements: Drivers of Genome Evolution
2004 Science
Cdc13 Telomere Capping Decreases Mec1 Association but Does Not Affect Tel1 Association with DNA Ends
2007
Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms.
1993
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Drosophila telomeres: two transposable elements with important roles in chromosomes
2000
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax
1998 Nobel
Expression of mouse telomerase catalytic subunit in embryos and adult tissues
1998
Template Boundary in a Yeast Telomerase Specified by RNA Structure
2000 StandoutScienceNobel
Understanding TERT Promoter Mutations: A Common Path to Immortality
2016
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Dyskeratosis congenita: telomerase, telomeres and anticipation
2005
Identification of Putative c-Myc-Responsive Genes: Characterization of rcl, a Novel Growth-Related Gene†
1997
Identification of Functionally Important Domains in the N-Terminal Region of Telomerase Reverse Transcriptase
2000
Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice
1999
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.
1995
Embryonic Stem Cell Lines Derived from Human Blastocysts
1998 StandoutScience
Human Cyclin E, a Nuclear Protein Essential for the G1-to-S Phase Transition
1995
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 StandoutScience
Works of Philipp Steiner being referenced
Differential Regulation of Noxa in Normal Melanocytes and Melanoma Cells by Proteasome Inhibition: Therapeutic Implications
2005
Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth
2007
Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes
1997
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
1997 Standout
Tumor Growth Inhibition with Cetuximab and Chemotherapy in Non–Small Cell Lung Cancer Xenografts Expressing Wild-type and Mutated Epidermal Growth Factor Receptor
2007
Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.
1995
Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation
1994
Abstract 1723: WTX-124 is an IL-2 pro-drug conditionally activated in tumors and able to induce complete regressions in mouse tumor models
2021
Differential modulation of cyclin gene expression by MYC.
1993