Standout Papers
Citation Impact
Citing Papers
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.
1986
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Cell Death Mechanisms and the Immune System
1991
S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination
1991 StandoutNobel
Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes
1995 Standout
Bacterial Meningitis: Pathogenesis, Pathophysiology, and Progress
1992
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
2007
A Central Role of Perforin in Cytolysis?
1991
The history, properties, and biological effects of cachectin
1988 StandoutNobel
Death by TNF: a road to inflammation
2022
Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor.
1989 StandoutNobel
Identification of the residues in human CD4 critical for the binding of HIV
1989 StandoutNobel
Effective screening method of agonistic diabodies based on autocrine growth
2009
Resistance of tumor cells to tumor necrosis factor
1988
Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal
1990 StandoutNobel
Rheumatoid Arthritis
1990
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Tumor necrosis factor expression in human epithelial tumor cell lines.
1988
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
The molecular action of tumor necrosis factor‐α
1991
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α
1987 StandoutNature
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
1989
Adhesion receptors of the immune system
1990 StandoutNature
Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement
2018 StandoutNobel
Characterization of the G Protein-coupled Receptor Kinase GRK4
1996 StandoutNobel
Molecular cloning and expression of a receptor for human tumor necrosis factor
1990
Cell-mediated cytotoxicity
1993 StandoutNobel
Emergence of vancomycin tolerance in Streptococcus pneumoniae
1999 StandoutNatureNobel
Atherosclerosis — An Inflammatory Disease
1999 Standout
Mechanism of human lymphotoxin and tumor necrosis factor induced destruction of cells in vitro: Phospholipase activation and deacylation of specific‐membrane phospholipids
1990
Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes
1988 Nature
Single amino-acid changes in HIV envelope affect viral tropism and receptor binding
1989 StandoutNatureNobel
Orientation‐specific signalling by thrombopoietin receptor dimers
2011
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
1991 Standout
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.
1987
Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES
1996 StandoutNobel
Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor
1988
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor
1990
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
2001 Standout
Local and Systemic Effects of Intradermal Recombinant Interferon-γ in Patients with Lepromatous Leprosy
1986 StandoutNobel
The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution
1989
Sequestration From Immune CD4 + T Cells of Mycobacteria Growing in Human Macrophages
1993 StandoutScienceNobel
Allosteric inhibition of complement function by a staphylococcal immune evasion protein
2010
Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor
1986 Nature
Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice
1986
The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.
1989
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.
1986
Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.
1988
Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology
1989 StandoutNature
Species specificity of human and murine tumor necrosis factor. A comparative study of tumor necrosis factor receptors.
1986
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScienceNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.
1987
DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ
1987
Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation
1986
Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage
1986 Nature
Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.
1987
Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor
1987
Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.
1986
Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family
1989 Science
Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin
1985 StandoutScienceNobel
Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts.
1990
Identification of a Protein with Homology to hsp90 That Binds the Type 1 Tumor Necrosis Factor Receptor
1995
Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon.
1986
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
1994 StandoutNobel
Transient Expression Shows Ligand Gating and Allosteric Potentiation of GABA A Receptor Subunits
1988 Science
Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.
1987
Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism
1988 Science
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.
1990
Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.
1991
TNF induces c-fos via a novel pathway requiring conversion of arachidonic acid to a lipoxygenase metabolite.
1991
Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells.
1986
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
1991
Hematopoietic cytokines
2008
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
1996 StandoutScienceNobel
Seppuku and Autoimmunity
1992 StandoutScienceNobel
Viruses in Human Cancers
1991 StandoutScienceNobel
Real time quantitative PCR.
1996 Standout
Epitope mapping of the human immunodeficiency virus type 1 gp120 with monoclonal antibodies
1988
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.
1986
Possible roles of tumor necrosis factor in the pathology of malaria.
1987
Mitogenic and cytotoxic actions of tumor necrosis factor in BALB/c 3T3 cells
1989
Receptor class desensitization of leukocyte chemoattractant receptors.
1991
Interferon gamma receptor deficient mice are resistant to endotoxic shock.
1994
Tumour necrosis factors α and β inhibit virus replication and synergize with interferons
1986 Nature
Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.
1988
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.
1992
Differential regulation of the JE gene encoding the monocyte chemoattractant protein (MCP-1) in cervical carcinoma cells and derived hybrids
1994 StandoutNobel
Barriers to the free diffusion of proteins and lipids in the plasma membrane
2015
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins.
1989
Isolation and Characterization of Eight Tumor Necrosis Factor-Induced Gene Sequences from Human Fibroblasts
1990
Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor
1989
Secretory products of macrophages.
1987 Standout
A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia
1985 StandoutScienceNobel
Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.
1986
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins
1990 Science
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.
1989
Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells
1987
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.
1994 StandoutNobel
Works of Philip E. Hass being referenced
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
2011
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
1994 Nature
Structure of C3b in complex with CRIg gives insights into regulation of complement activation
2006 Nature
An Agonist Murine Monoclonal Antibody to the Human c-Mpl Receptor Stimulates Megakaryocytopoiesis
1998
Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
1985 Nature
Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions
1989 Science
Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes.
1986
Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro
1985 StandoutScience
Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule
1986