Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Removing T-cell epitopes with computational protein design
2014 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Use of Positron Emission Tomography for Response Assessment of Lymphoma: Consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma
2007
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
2009 Standout
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
2015
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Effective expansion of alloantigen-specific Foxp3 + CD25 + CD4 + regulatory T cells by dendritic cells during the mixed leukocyte reaction
2006 StandoutNobel
CD43 Regulates Th2 Differentiation and Inflammation
2008
Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses
1999
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
2007 Nature
Early detection of relapse by whole-body positron emission tomography in the follow-up of patients with Hodgkin’s disease
2002
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
The role of B7 co‐stimulation in activation and differentiation ofCD4+and CD8+T cells
1998
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Contribution of PET imaging to the initial staging and prognosis of patients with Hodgkin's disease
2004
Activation requirements for the induction of CD4+CD25+ T cell suppressor function
2004
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
2010
TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation
2011
Signal transduction events leading to T-cell lymphokine gene expression
1993
Substantial impact of FDG PET imaging on the therapy decision in patients with early-stage Hodgkin's lymphoma
2004
18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response
2009
Activation of naive, memory and effector T cells
1994
Active DNA demethylation: many roads lead to Rome
2010
Prognostic value of positron emission tomography in the evaluation of post‐treatment residual mass in patients with Hodgkin's disease and non‐Hodgkin's lymphoma
2001
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin
1995
Clinical Implications of Novel Mutations in Epigenetic Modifiers in AML
2011
Potential pitfalls of 18F-FDG PET in a large series of patients treated for malignant lymphoma: prevalence and scan interpretation
2005
PRC2 mediated H3K27 methylations in cellular identity and cancer
2015
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
2018
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Surveillance imaging during remission identifies a group of patients with more favorable aggressive NHL at time of relapse: a retrospective analysis of a uniformly-treated patient population
2006
Infections in patients with cancer undergoing chemotherapy: aetiology, prevention, and treatment
2003
FDG-PET/CT predicts outcome in patients with aggressive non-Hodgkin’s lymphoma and Hodgkin’s disease
2006
T Cell–Mediated Elimination of B7.2 Transgenic B Cells
1997 StandoutNobel
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation
2012
Early positron emission tomography (PET) restaging: a predictive final response in Hodgkin's disease patients
2006
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
2011
Naive and memory B cells in T-cell-dependent and T-independent responses
2001
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Fluorine-18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin’s disease and non-Hodgkin’s lymphoma
2002
CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca2+‐independent costimulatory activity
1994
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
1993 StandoutNatureNobel
Regulatory T cells in transplantation tolerance
2003 StandoutNobel
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
2010 Nature
Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK
1996
The Role of the CD28 Receptor During T Cell Responses to Antigen
1993
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
2015
Effects ofTET2mutations on DNA methylation in chronic myelomonocytic leukemia
2012
A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q
2006 StandoutNobel
FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma
2005
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
The B-cell surface protein CD72/Lyb-2 is the ligand for CDS
1991 Nature
The B7 and CD28 receptor families
1994
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
New perspectives of C1328-137-mediated T cell costimulation
1995
In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
1999 StandoutNobel
FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma
2005
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase
1994
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+T cell responses
1999 StandoutNobel
The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
1994
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
2011
Impaired TGF-β Responses in Peripheral T Cells of Gαi2−/− Mice
2005 StandoutNobel
The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens
2002
CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
1998 StandoutNobel
Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
2012 StandoutNobel
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
Revised Response Criteria for Malignant Lymphoma
2007 Standout
Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.
1994
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
Blockade of T Cell Activation Using a Surface-Linked Single-Chain Antibody to CTLA-4 (CD152)
2000
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.
1993
Impaired Antibody Response to Group B Streptococcal Type III Capsular Polysaccharide in C3- and Complement Receptor 2-Deficient Mice
2003
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
1994
Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo
2006
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
Positron-Emission Tomography and Assessment of Cancer Therapy
2006
Response Assessment of Aggressive Non-Hodgkin’s Lymphoma by Integrated International Workshop Criteria and Fluorine-18–Fluorodeoxyglucose Positron Emission Tomography
2005
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in aggressive lymphoma: an early prognostic tool for predicting patient outcome
2005
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1
1992
itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.
1992
PET predicts prognosis after 1 cycle of chemotherapy in aggressive lymphoma and Hodgkin's disease.
2002
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
2011
CTLA-4 ligation blocks CD28-dependent T cell activation.
1996
Importance of IL-10 for CTLA-4-Mediated Inhibition of Tumor-Eradicating Immunity
2004
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
2011
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+T cells
2000 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
Single dose of anti–CTLA-4 enhances CD8 + T-cell memory formation, function, and maintenance
2010 StandoutNobel
Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity
1993
Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation
1997 StandoutNobel
Utility of FDG-PET scanning in lymphoma by WHO classification
2003
Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.
1992
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
2016 Standout
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
1993 Science
Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.
1994
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 Standout
Signaling through CD43 regulates CD4 T-cell trafficking
2007
Works of Peter Vandenberghe being referenced
Ligation of the CD5 or CD28 molecules on resting human T cells induces expression of the early activation antigen CD69 by a calcium- and tyrosine kinase-dependent mechanism.
1993
FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations
2005
Immobilized anti‐CD5 together with prolonged activation of protein kinase C induce interleukin 2‐dependent T cell growth: evidence for signal transduction through CD5
1991
Early restaging positron emission tomography with 18F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin’s lymphoma
2002
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia
2001
[18F]FDG PET monitoring of tumour response to chemotherapy: does [18F]FDG uptake correlate with the viable tumour cell fraction?
2003
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
2010
Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells
1993
The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
2011
PHF6 mutations in adult acute myeloid leukemia
2010
Can positron emission tomography with [18F]‐fluorodeoxyglucose after first‐line treatment distinguish Hodgkin's disease patients who need additional therapy from others in whom additional therapy would mean avoidable toxicity?
2001
Acquired mutations in TET2 are common in myelodysplastic syndromes
2009
A new disease categorization of low-grade myelodysplastic syndromes based on the expression of cytopenia and dysplasia in one versus more than one lineage improves on the WHO classification
2007
Crosslinking of the CD5 antigen on human T cells induces functional IL2 receptors
1990
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.
1992
B7 Interactions with CD28 and CTLA-4 Control Tolerance or Induction of Mucosal Inflammation in Chronic Experimental Colitis
2001
Autopsy-Controlled Prospective Evaluation of Serial Screening for Circulating Galactomannan by a Sandwich Enzyme-Linked Immunosorbent Assay for Hematological Patients at Risk for Invasive Aspergillosis
1999
Human CTLA-4 is expressed in situ on T lymphocytes in germinal centers, in cutaneous graft-versus-host disease, and in Hodgkin's disease.
1998
Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.
1995
Prognostic Value of Positron Emission Tomography (PET) With Fluorine-18 Fluorodeoxyglucose ([18F]FDG) After First-Line Chemotherapy in Non-Hodgkin’s Lymphoma: Is [18F]FDG-PET a Valid Alternative to Conventional Diagnostic Methods?
2001
Marginal-Zone B Cells in the Human Lymph Node and Spleen Show Somatic Hypermutations and Display Clonal Expansion
1999
Simultaneous ligation of CD5 and CD28 on resting T lymphocytes induces T cell activation in the absence of T cell receptor/CD3 occupancy.
1993
Prognostic value of pretransplantation positron emission tomography using fluorine 18-fluorodeoxyglucose in patients with aggressive lymphoma treated with high-dose chemotherapy and stem cell transplantation
2003