Citation Impact
Citing Papers
An enumerative algorithm for de novo design of proteins with diverse pocket structures
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Discovery of five conserved β-defensin gene clusters using a computational search strategy
2002
Global analysis of protein folding using massively parallel design, synthesis, and testing
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Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis
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Comprehensive computational design of ordered peptide macrocycles
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Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3
2003
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
2004 StandoutScience
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
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Structures of the CRISPR genome integration complex
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Automated de novo prediction of native-like RNA tertiary structures
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Single-Nucleotide Polymorphisms (SNPs) in Human β-Defensin 1: High-Throughput SNP Assays and Association with Candida Carriage in Type I Diabetics and Nondiabetic Controls
2003
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
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The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Expression of β‐defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells
2002
Identification of Human β-Defensin-2 in Respiratory Tract and Plasma and Its Increase in Bacterial Pneumonia
1998
DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis
2002
Renal Effects of Natriuretic Peptide Receptor Blockade in Cirrhotic Rats With Ascites
1994
Cardiovascular and renal functional effects of an antagonist of the guanylyl cyclase-linked ANF receptor
1994
Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co‐inducibility during iron overload 1
2003
Hereditary Hemochromatosis — A New Look at an Old Disease
2004
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
2004 Standout
Defensins: antimicrobial peptides of innate immunity
2003 Standout
Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation
1998
Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis
1997
Decreased Liver Hepcidin Expression in the Hfe Knockout Mouse
2002
Current chemical tagging strategies for proteome analysis by mass spectrometry
2004
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
Balancing Acts
2004 Standout
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
2002
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver
2001 Standout
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
A Novel Murine β-Defensin Expressed in Tongue, Esophagus, and Trachea
2000
Identification of a novel, multifunctional *-defensin (human *-defensin 3) with specific antimicrobial activity
2001
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Targeting the glycoproteome
2012
Homodimeric θ-Defensins from Rhesus macaqueLeukocytes
2002
Design of biologically active binary protein 2D materials
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Increased concentrations of human beta-defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis
2003
Cloning and Expression of Bovine Neutrophil β-Defensins
1999
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Toward a Human Blood Serum Proteome
2002
The immune response of Drosophila
2003 StandoutNatureNobel
RK-2: A Novel Rabbit Kidney Defensin and Its Implications for Renal Host Defense
1998
The Solution Structure of Human Hepcidin, a Peptide Hormone with Antimicrobial Activity That Is Involved in Iron Uptake and Hereditary Hemochromatosis
2002
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
2001 Standout
Mapping of the Gene Encoding Human β-Defensin-2 (DEFB2) to Chromosome Region 8p22–p23.1
1997
The mouse genome encodes a single homolog of the antimicrobial peptide human β‐defensin 1
1997
Natriuretic Peptides
1998 Standout
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
2002
Peptide therapeutics: current status and future directions
2014 Standout
Luminal and intracellular cGMP inhibit the mTAL reabsorptive capacity through different pathways
1993
The Human β-Defensin-1 and α-Defensins Are Encoded by Adjacent Genes: Two Peptide Families with Differing Disulfide Topology Share a Common Ancestry
1997
Hepcidin, A New Iron Regulatory Peptide
2002
Iron in Infection and Immunity
2013
Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.
1998
Differential Gene Induction of Human β-Defensins (hBD-1, -2, -3, and -4) in Keratinocytes Is Inhibited by Retinoic Acid
2004
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
2002 Standout
Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic
2001
Mammalian defensins in the antimicrobial immune response
2005 Standout
Molecular cloning and tissue expression of porcine β‐defensin‐1
1998
The Human Plasma Proteome
2002 Standout
A 450-kb contig of defensin genes on human chromosome 8p23
1999
Comparing the MicroRNA Spectrum between Serum and Plasma
2012
Primate defensins
2004
CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium
2000
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
2017 Standout
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
2011
Antimicrobial peptides of multicellular organisms
2002 StandoutNature
Global quantification of mammalian gene expression control
2011 StandoutNature
Use of proteomic patterns in serum to identify ovarian cancer
2002 Standout
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
2006
Distribution of new human β-defensin genes clustered on chromosome 20 in functionally different segments of epididymis
2003
Antimicrobial Peptides: An Emerging Concept in Cutaneous Biology
1998
Anemia of Chronic Disease
2005 Standout
The Cathelicidin Family of Antimicrobial Peptide Precursors: A Component of the Oxygen‐Independent Defense Mechanisms of Neutrophilsa
1997
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Augmentation of Innate Host Defense by Expression of a Cathelicidin Antimicrobial Peptide
1999
Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease
2001
Rhesus Monkey ( Macaca mulatta ) Mucosal Antimicrobial Peptides Are Close Homologues of Human Molecules
2001
Dissecting racial bias in an algorithm used to manage the health of populations
2019 StandoutScience
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
2003
Inducible Expression of Human β-Defensin 2 byFusobacterium nucleatumin Oral Epithelial Cells: Multiple Signaling Pathways and Role of Commensal Bacteria in Innate Immunity and the Epithelial Barrier
2000
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice
2001
Computational design of a homotrimeric metalloprotein with a trisbipyridyl core
2016 StandoutNobel
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
Airway epithelia regulate expression of human β‐defensin 2 through toll‐like receptor 2
2003
Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells
2000
β-Defensins in Lung Host Defense
2002
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
β-Defensin 1 Contributes to Pulmonary Innate Immunity in Mice
2002
Modulation of Human β-Defensin-2 Transcription in Pulmonary Epithelial Cells by Lipopolysaccharide-Stimulated Mononuclear Phagocytes Via Proinflammatory Cytokine Production
2003
DNA sequence-dependent deformability deduced from protein–DNA crystal complexes
1998
Analysis of the Plasma Peptidome from Pancreas Cancer Patients Connects a Peptide in Plasma to Overexpression of the Parent Protein in Tumors
2009
Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium
1999
Mouse β-Defensin 1 Is a Salt-Sensitive Antimicrobial Peptide Present in Epithelia of the Lung and Urogenital Tract
1998
Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity
2001
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
2005
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
Mass spectrometry-based proteomics
2003 StandoutNature
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
2004 Standout
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
2002
Production of β-defensins by human airway epithelia
1998
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
2003 Standout
Molecular Cloning and Characterization of Rat Genes Encoding Homologues of Human β-Defensins
1999
Porcine Epithelial β-Defensin 1 Is Expressed in the Dorsal Tongue at Antimicrobial Concentrations
1999
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
Psoriatic scales: a promising source for the isolation of human skin-derived antimicrobial proteins
2005
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
1999 StandoutScience
Hepcidin and iron regulation, 10 years later
2011
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Gallinacin-3, an Inducible Epithelial β-Defensin in the Chicken
2001
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Systemic Iron Homeostasis
2013
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.
1999
Enteric β-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum Infection
1998
Mechanisms for induction of acquired host immunity by neutrophil peptide defensins
1999
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
2002
The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system
1999 StandoutNobel
Differential Scanning Microcalorimetry Indicates That Human Defensin, HNP-2, Interacts Specifically with Biomembrane Mimetic Systems,
1997
Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.
1998
Multiple Roles of Antimicrobial Defensins, Cathelicidins, and Eosinophil-Derived Neurotoxin in Host Defense
2004
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs
1999
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Regulation of Iron Metabolism by Hepcidin
2006
Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease
2002
Chemical Glycoproteomics
2016 StandoutNobel
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
2003 Standout
Functional differences between hepcidin 1 and 2 in transgenic mice
2003
Works of Peter Schulz‐Knappe being referenced
HUPO Plasma Proteome Project specimen collection and handling: Towards the standardization of parameters for plasma proteome samples
2005
Peptidomics technologies for human body fluids
2001
Composition of the peptide fraction in human blood plasma: database of circulating human peptides
1999
Isolation and structural analysis of “Urodilatin”, a new peptide of the cardiodilatin-(ANP)-family, extracted from human urine
1988
hBD‐1: a novel β‐defensin from human plasma
1995
LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity
2000
Peptides in body fluids and tissues as markers of disease
2005
Peptidomic analysis of human blood specimens: Comparison between plasma specimens and serum by differential peptide display
2005
Human hemofiltrate as a source of circulating bioactive peptides: Determination of amino acids, peptides and proteins
1994
Screening for disulfide‐rich peptides in biological sources by carboxyamidomethylation in combination with differential matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry
2001
Prerequisites for Peptidomic Analysis of Blood Samples: I. Evaluation of Blood Specimen Qualities and Determination of Technical Performance Characteristics
2005
Liquid chromatography and electrospray mass spectrometric mapping of peptides from human plasma filtrate
1999
Peptidomics technologies for human body fluids
2001
Posttranslationally Processed Forms of the Human Chemokine HCC-1
2000
Human beta-defensin-1: A urinary peptide present in variant molecular forms and its putative functional implication.
1998
Structure and function in proteins
1996
Endogenous natriuretic peptides: effect on collecting duct function in rat kidney
1990