Standout Papers
- Heterozygous Mutations in TREX1 Cause Familial Chilblain Lupus and Dominant Aicardi-Goutières Syndrome (2007)
- Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis. (1985)
- Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination (1995)
- Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease (2009)
- Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase. (1982)
- 5-Fluorouracil Incorporated into DNA Is Excised by the Smug1 DNA Glycosylase to Reduce Drug Cytotoxicity (2007)
- Functional domains and methyl acceptor sites of the Escherichia coli ada protein. (1988)
- DNA Ligase IV from HeLa Cell Nuclei (1996)
- Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis (2004)
- Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA (1992)
- Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA. (1991)
- Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase. (1982)
- C → T mutagenesis and γ‐radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases (2005)
- Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase (1983)
- Different active sites of mammalian DNA ligases I and II. (1994)
- Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I. (1994)
- Direct Removal of Alkylation Damage from DNA by AlkB and Related DNA Dioxygenases (2006)
- Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases (2004)
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair
2012 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Specific Interaction of DNA Polymerase β and DNA Ligase I in a Multiprotein Base Excision Repair Complex from Bovine Testis
1996
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
1997 Nature
Which DNA polymerases are used for DNA-repair in eukaryotes?
1997
Reconstitution of mammalian excision repair activity with mutant cell-free extracts and XPAC and ERCC1 proteins expressed inEscherichia coli
1993 StandoutNobel
Specific Function of DNA Ligase I in Simian Virus 40 DNA Replication by Human Cell-free Extracts Is Mediated by the Amino-terminal Non-catalytic Domain
1997 StandoutNobel
Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
2008
Human nucleotide excision repairin vitro: repair of pyrimidine dimers, psoralen and cisplatin adducts by HeLa cell-free extract
1989
Preferential Binding of Yeast Rad4·Rad23 Complex to Damaged DNA
1998
Repair synthesis by human cell extracts in DNA damaged bycis- andtrans-diamminedichloroplatinum(II)
1989
High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene
1995 Nature
In Vitro Chemiluminescence Assay to Measure Excision Repair in Cell Extracts
2003
Requirement for the replication protein SSB in human DMA excision repair
1991 Nature
Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision—repair
1994
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
In vitro eukaryotic DNA excision repair assays: An overview
1995
NUCLEOTIDE EXCISION REPAIR
1993 StandoutNobel
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
2008 Nature
Two Pathways for Base Excision Repair in Mammalian Cells
1996
A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair
1997
Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA
1996
The roles of the eukaryotic DNA polymerases in DNA repair synthesis
1997
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus
2007
Stereoselectivity of Human Nucleotide Excision Repair Promoted by Defective Hybridization
1998
Removal of psoralen monoadducts and crosslinks by human cell free extracts
1991 StandoutNobel
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair
1997
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
1997
The guanosine binding site of the Tetrahymena ribozyme
1989 StandoutNatureNobel
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents
1992 StandoutNobel
DNA damage recognition during nucleotide excision repair in mammalian cells
1999
Yeast DNA ligase IV mediates non-homologous DNA end joining
1997 Nature
Intracellular Toll-like Receptors
2010 StandoutNobel
Innate immune recognition of, and regulation by, DNA
2006
Xeroderma pigmentosum and nucleotide excision repair of DNA
1994
Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
2002 StandoutNatureNobel
Biological basis of germline mutation: Comparisons of spontaneous germline mutation rates among drosophila, mouse, and human
1995
Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
2000 StandoutNobel
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
1994 Nature
DNA Ligase III Is Recruited to DNA Strand Breaks by a Zinc Finger Motif Homologous to That of Poly(ADP-ribose) Polymerase
1999
The Crystal Structure of TREX1 Explains the 3′ Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering
2007
The structure of the E. coli recA protein monomer and polymer
1992 StandoutNatureNobel
Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome
2011
Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)
1997
Role of poly(ADP-ribose) formation in DNA repair
1992 StandoutNatureNobel
Effect of the antitumor drug cis-diamminedichloroplatinum(II) and related platinum complexes on eukaryotic DNA replication
1990
Purification of PCNA as a nucleotide excision repair protein
1992 StandoutNobel
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
1995 Nature
Assay for Nucleotide Excision Repair Protein Activity Using Fractionated Cell Extracts and UV-Damaged Plasmid DNA
2003
Repair of pyrimidine dimer ultraviolet light photoproducts by human cell extracts
1989
Substrate overlap and functional competition between human nucleotide excision repair and Escherichia coli photolyase and (A)BC excision nuclease
1990 StandoutNobel
Purification and Characterization of Escherichia coli and Human Nucleotide Excision Repair Enzyme Systems
2006 StandoutNobel
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA
1979 StandoutNatureNobel
Structure of the Dimeric Exonuclease TREX1 in Complex with DNA Displays a Proline-rich Binding Site for WW Domains
2007
Resistance of 3′-Phosphoglycolate DNA Ends to Digestion by Mammalian DNase III
2002
Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV
1998 Nature
The Exonuclease TREX1 Is in the SET Complex and Acts in Concert with NM23-H1 to Degrade DNA during Granzyme A-Mediated Cell Death
2006
Induction of the adaptive response of Escherichia coli to alkylation damage by the environmental mutagen, methyl chloride
1993 StandoutNobel
A newly identified DNA ligase of Saccharomyces cerevisiaeinvolved in RAD52-independent repair of DNA double-strand breaks
1997 StandoutNobel
Complementation of the xeroderma pigmentosum DNA repair synthesis defect withEscherichia coliUvrABC proteins in a cell-free system
1990 StandoutNobel
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
1994 StandoutNatureNobel
Creation and Removal of Embedded Ribonucleotides in Chromosomal DNA during Mammalian Okazaki Fragment Processing
1997
Two Distinct DNA Ligase Activities in Mitotic Extracts of the Yeast Saccharomyces Cerevisiae
1997
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
1995 StandoutNobel
The General Transcription-Repair Factor TFIIH Is Recruited to the Excision Repair Complex by the XPA Protein Independent of the TFIIE Transcription Factor
1995 StandoutNobel
DNA ligase I is required for fetal liver erythropoiesis but is not essential for mammalian cell viability
1996
Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair
1997
Nucleotide Excision Repair DNA Synthesis by DNA Polymerase .epsilon. in the Presence of PCNA, RFC, and RPA
1995
Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair
1998
Nucleases: diversity of structure, function and mechanism
2010
Mammalian DNA nucleotide excision repair reconstituted with purified protein components
1995
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21
1995 StandoutNobel
Characterization of the XRCC1-DNA ligase III complexin vitroand its absence from mutant hamster cells
1995
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together?
2000
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Excision Repair in Mammalian Cells
1995 StandoutNobel
Molecular mechanism of nucleotide excision repair
1999
Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
1998 StandoutNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Site-specific mutagenesis in vivo by single methylated or deaminated purine bases
1986
Molecular cloning and characterization of the alkB gene of Escherichia coli
1985
Isolation and characterization of Escherichia coli K-12 mutants unable to induce the adaptive response to simple alkylating agents
1979
The intracellular signal for induction of resistance to alkylating agents in E. coli
1986 StandoutNobel
Proliferating cell nuclear antigen is required for DNA excision repair
1992
Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I
1994 StandoutNobel
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
An Alternative Splicing Event Which Occurs in Mouse Pachytene Spermatocytes Generates a Form of DNA Ligase III with Distinct Biochemical Properties That May Function in Meiotic Recombination
1997
DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions.
1993 StandoutNobel
Repair by human cell extracts of single (6-4) and cyclobutane thymine-thymine photoproducts in DNA.
1993
Generation of Single-Nucleotide Repair Patches Following Excision of Uracil Residues from DNA
1992 StandoutNobel
Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli damage recognition protein (UvrA) to the major ultraviolet photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T.
1993 StandoutNobel
XRCC1 Protein Interacts with One of Two Distinct Forms of DNA Ligase III
1997 StandoutNobel
The SOS regulatory system of Escherichia coli
1982
Cloning of theE. coliO6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay
1985
Structure and expression of the alkA gene of Escherichia coli involved in adaptive response to alkylating agents.
1984
Alkylation and Oxidative Damages to DNA: Constitutive and Inducible Repair Systems
1986
Quality Control by DNA Repair
1999 StandoutScienceNobel
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells
1980 StandoutNatureNobel
Determination of minimum substrate size for human excinuclease.
1994
Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells
1998
Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli
1985 StandoutNobel
Stereospecific removal of methyl phosphotriesters from DNA by anEscherichia coli ada+extract
1985
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli
1984
Localization of DNA repair synthesis by human cell extracts to a short region at the site of a lesion
1989
The sequence of a 30 kb fragment on the left arm of chromosome XV fromSaccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes
1996
Induction and autoregulation of ada, a positively acting element regulating the response of Escherichia coli K-12 to methylating agents
1985
Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene.
1991
Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.
1996 StandoutNobel
DNA repair by eukaryotic nucleotide excision nuclease. Removal of thymine dimer and psoralen monoadduct by HeLa cell-free extract and of thymine dimer by Xenopus laevis oocytes.
1993
The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae
1988 StandoutScienceNobel
Sequences of theE. coli uvrCgene and protein
1984 StandoutNobel
Bipartite substrate discrimination by human nucleotide excision repair
1997
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
2004 StandoutNobel
Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA
1984 StandoutNatureNobel
Molecular cloning of a gene which regulates the adaptive response to alkylating agents in Escherichia coli
1983
Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells
2013 StandoutNobel
Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA.
1986
Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents
1982 StandoutNatureNobel
Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.
1985
Host-cell reactivation of cis-diamminedichloroplatinum(II)-treated SV40 DNA in normal human, Fanconi anaemia and xeroderma pigmentosum fibroblasts
1984
Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.
1994
The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity
1994
Cloning and characterization of the alkA gene of Escherichia coli that encodes 3-methyladenine DNA glycosylase II.
1984
Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I.
1994 StandoutNobel
Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents.
1984
Regulation of expression of the cloned ada gene in Escherichia coli
1985
Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase
1980 StandoutNobel
Requirement for ERCC-1 and ERCC-3 gene products in DNA excision repair in vitro. Complementation using rodent and human cell extracts.
1992
DNA end-joining catalyzed by human cell-free extracts
1998
Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.
1980 StandoutNobel
Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase
1991
Rejoining Kinetics of DNA Single- and Double-Strand Breaks in Normal and DNA Ligase-Deficient Cells after Exposure to Ultraviolet C and Gamma Radiation: An Evaluation of Ligating Activities Involved in Different DNA Repair Processes
1999
Inducible repair of O-alkylated DNA pyrimidines in Escherichia coli.
1984 StandoutNobel
Induction of resistance to alkylating agents in E. coli: the ada+ gene product serves both as a regulatory protein and as an enzyme for repair of mutagenic damage.
1984 StandoutNobel
Efficiency of the adaptive response of Escherichia coli to alkylating agents
1980 Nature
Translocation of a UV-damaged DNA binding protein into a tight association with chromatin after treatment of mammalian cells with UV light
1997
A chromatin factor in rat liver which destroys O6‐ethylguanine in DNA
1980
Generation of single-nucleotide repair patches following excision of uracil residues from DNA.
1992 StandoutNobel
Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells
2000 StandoutNobel
Mammalian DNA Ligase III: Molecular Cloning, Chromosomal Localization, and Expression in Spermatocytes Undergoing Meiotic Recombination
1995
Molecular Mechanism of Adaptive Response to Alkylating Agents
1986
Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4
1998 StandoutNobel
Cloning of Escherichia coli genes encoding 3-methyladenine DNA glycosylases I and II
1984
NAD(+)-dependent repair of damaged DNA by human cell extracts.
1993 StandoutNobel
Adaptation to alkylation resistance involves the induction of a DNA glycosylase
1982 Nature
An alkB gene homolog is differentially transcribed during the Caulobacter crescentus cell cycle
1997
Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5' and the 6th phosphodiester bond 3' to the photodimer.
1992 StandoutNobel
A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate
1983
Works of Peter Robins being referenced
The Inducible Repair of Alkylated DNA
1981
DNA Ligase IV from HeLa Cell Nuclei
1996 StandoutNobel
Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases
2004 StandoutNobel
Heterozygous Mutations in TREX1 Cause Familial Chilblain Lupus and Dominant Aicardi-Goutières Syndrome
2007 StandoutNobel
Oxygen Free Radical Damage to DNA
2001
Molecular Characterization of a Human DNA Kinase
1999
DNA repair replication by soluble extracts from human lymphoid cell lines
1989
Use of in vivo and in vitro assays for the characterization of mammalian excision repair and isolation of repair proteins
1990
Complementation of the xeroderma pigmentosum DNA repair defect in cell-free extracts
1988
Effect of exogenous DNA fragments on human cell extract-mediated DNA repair synthesis
1991
Quantitation of the adaptive response to alkylating agents
1979 Nature
Repair of O6-methylguanine in adapted Escherichia coli.
1978
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis.
1985 StandoutNobel
Different active sites of mammalian DNA ligases I and II.
1994 StandoutNobel
Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination
1995 StandoutNobel
Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.
1982 StandoutNobel
Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA.
1991 StandoutNobel
Repair of alkylated DNA in Escherichia coli. Physical properties of O6-methylguanine-DNA methyltransferase.
1982 StandoutNobel
Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis
2004 StandoutNobel
Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O6-methyiguanine-DNA methyttransferase
1983 StandoutNobel
Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: Mutants deficient in thiols and mutants constitutive for the adaptive response
1980
Functional domains and methyl acceptor sites of the Escherichia coli ada protein.
1988 StandoutNobel
Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I.
1994 StandoutNobel