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Citing Papers
The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.
1993
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.
1989
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Evidence that murine pre-B cells synthesise μ heavy chains but no light chains
1979 Nature
Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome
1993 StandoutNatureNobel
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase
1989 Nature
Leukemia and the disruption of normal hematopoiesis
1991
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
IκB-β regulates the persistent response in a biphasic activation of NF-κB
1995
Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium
1988
Molecular cloning and expression of an IL-6 signal transducer, gp130
1990
Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity
1990 Nature
Signal transduction by receptors with tyrosine kinase activity
1990 Standout
Activation of the feline c-fms proto-oncogene: Multiple alterations are required to generate a fully transformed phenotype
1988
IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family
1992
The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
1989 StandoutNature
IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain
1999
Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution after High-Dose Chemotherapy and Autologous Bone Marrow Transplantation
1988
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
1995 StandoutNatureNobel
MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α
1996
Monocyte proliferation in a cytokine-freem serum-free system
1992
The immune response of Drosophila
2003 StandoutNatureNobel
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells
1987
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
1995 Standout
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB
1992 Nature
NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats
1992
Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α
1996
Dif, a dorsal-related gene that mediates an immune response in Drosophila
1993
The inhibitory ankyrin and activator Rel proteins
1992 Nobel
Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity
1996
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
1993 Nature
Autoimmunity and Apoptosis
2001 StandoutNobel
Functional Interactions of Transforming Growth Factor β-activated Kinase 1 with IκB Kinases to Stimulate NF-κB Activation
1999
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Function and Activation of NF-kappaB in the Immune System
1994 Standout
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
Role of I Bα Ubiquitination in Signal-induced Activation of NF- B in Vivo
1996
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
1992 StandoutNobel
A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential
1988
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
The precursor of NF-κB p50 has IκB-like functions
1992
Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.
1993
Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance
1986 StandoutScienceNobel
Immunoglobulin messenger RNAs in murine cell lines that have characteristics of immature B lymphocytes
1979
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
2002
Development of Monocytes, Macrophages, and Dendritic Cells
2010 StandoutScience
Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.
1990
A labile inhibitor blocks immunoglobulin kappa-light-chain-gene transcription in a pre-B leukemic cell line.
1986
Expression of functional human EGF receptor on murine bone marrow cells.
1988
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes
1982 StandoutNatureNobel
Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB
1995
CD28 Mediates a Potent Costimulatory Signal for Rapid Degradation of IκBβ Which Is Associated with Accelerated Activation of Various NF-κB/Rel Heterodimers
1996
Modulation of lymphocyte mitogenesis.
1975 Nobel
Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
2009
Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation
2001
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.
1995
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
1990
Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex
1991 Science
Macrophage Lineage Switching of Murine Early Pre-B Lymphoid Cells Expressing Transduced fms Genes
1990
Chromatin changes accompany immunoglobulin κ gene activation: a potential control region within the gene
1982 Nature
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 StandoutScience
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScienceNobel
Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.
1985
Transduction of Human Colony-Stimulating Factor-1 (CSF-1) Receptor into Interleukin-3-Dependent Mouse Myeloid Cells Induces Both CSF-1-Dependent and Factor-Independent Growth
1989
Macrophages as a source of tumoricidal activity (tumor-necrotizing factor)
1980
Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation
1995
H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. Evaluation of the role of H-2I region and non-H-2 genes in regulating immune response.
1976 StandoutNobel
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism
1986 StandoutNobel
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.
1992
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.
1988
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Rapid activation of post-hepatectomy factor/nuclear factor kappa B in hepatocytes, a primary response in the regenerating liver.
1994
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
1993
Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue
1986 StandoutNobel
A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway
1996
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
1990
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.
1994
Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin
1985 StandoutScienceNobel
Synergistic Activation of NF-κB by Tumor Necrosis Factor Alpha and Gamma Interferon via Enhanced IκBα Degradation and De Novo IκBβ Degradation
1997
I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.
1992
Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.
1985 StandoutNobel
Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation
1995 Science
In vivo control of NF-kappa B activation by I kappa B alpha.
1993
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
1980 StandoutNatureNobel
Long-term culture of B lymphocytes and their precursors from murine bone marrow.
1982
Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia
1983 Nature
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
1997 Standout
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites
1974 Standout
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
1986 NatureNobel
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.
1995
Epidermal-Growth-Factor-Dependent Transformation by a Human EGF Receptor Proto-Oncogene
1987 Science
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
1984 StandoutNatureNobel
Growth Factors and Cancer
1991 StandoutScience
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Oncogenic Activation of p185neu Stimulates Tyrosine Phosphorylation In Vivo
1988
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
1985 StandoutScienceNobel
Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.
1988
Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture.
1991 StandoutNobel
Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse
1994
The Hemopoietic Colony-stimulating Factors
1995
Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.
1994
Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis.
1985
Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture
1977 StandoutNature
Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation.
1989
Recombinant Human Granulocyte Colony-Stimulating Factor: Effects on Normal and Leukemic Myeloid Cells
1986 Science
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.
1989
Signal Transduction by the Platelet-Derived Growth Factor Receptor
1989 Science
NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
1993 Science
Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).
1985
Replacing the complementarity-determining regions in a human antibody with those from a mouse
1986 StandoutNatureNobel
Immunoglobulin Gene Rearrangement in Immature B Cells
1980 StandoutScienceNobel
Genomic sequencing.
1984 Standout
Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.
1992
In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB
1995
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
1997 StandoutScience
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 Standout
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
1993
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
1985 StandoutNatureNobel
Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
1984
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells
1988 Science
Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3
1986
Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.
1994 Nobel
Human colony-stimulating factor 1 (CSF-1) receptor confers CSF-1 responsiveness to interleukin-3-dependent 32DC13 mouse myeloid cells and abrogates differentiation in response to granulocyte CSF
1990
Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation
1994 Nobel
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Human T-Cell Leukemia Virus Type I Tax Activation of NF-ΝB/Rel Involves Phosphorylation and Degradation of IΙBκ and RelA (p65)-Mediated Induction of the italic toc-rel Gene
1994
The unique insert of cellular and viral fms protein tyrosine kinase domains is dispensable for enzymatic and transforming activities.
1989
Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.
1993
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.
1993
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.
1992 StandoutNobel
Selective iodination and polypeptide composition of pinocytic vesicles.
1980 StandoutNobel
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region
1981 Nobel
Nucleotide sequence of bacteriophage φX174 DNA
1977 StandoutNatureNobel
Works of Peter Ralph being referenced
Direct toxic effects of immunopotentiators on monocytic, myelomonocytic, and histiocytic or macrophage tumor cells in culture.
1977
Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity
1991
Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)
1987 Nature
Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)
1985 Science
Retention of Lymphocyte Characteristics by Myelomas and θ+-Lymphomas: Sensitivity to Cortisol and Phytohemagglutinin
1973
Antibody-Dependent Killing of Erythrocyte and Tumor Targets by Macrophage-Related Cell Lines: Enhancement by PPD and LPS
1977
Inhibitory Effects of Lectins and Lymphocyte Mitogens on Murine Lymphomas and Myelomas2
1973
Human Leukemic Models of Myelomonocytic Development: A Review of the HL-60 and U937 Cell Lines
1985
Lipopolysaccharides inhibit lymphosarcoma cells of bone marrow origin
1974 Nature
Independent control of immunoglobulin heavy and light chain expression in a murine pre-B-cell line
1981 Nature
Distinct differentiation-inducing activities of gamma-interferon and cytokine factors acting on the human promyelocytic leukemia cell line HL-60.
1985
Clonal differences in response to T cell replacing factor (TRF) for IgM secretion and TRF receptors in a human B lymphoblast cell line
1983
Retention of lymphocyte characteristics by myelomas and theta + -lymphomas: sensitivity to cortisol and phytohemagglutinin.
1973
Synthesis of Membrane-Bound Colony-Stimulating Factor 1 (CSF-1) and Downmodulation of CSF-1 Receptors in NIH 3T3 Cells Transformed by Cotransfection of The Human CSF-1 and c-fms (CSF-1 Receptor) Genes
1987
Functional Subsets of Murine and Human B Lymphocyte Cell Lines
1979
Differential Expression of M-CSF, G-CSF, and GM-CSF by Human Monocytes
1990
Reticulum Cell Sarcoma: An Effector Cell in Antibody-Dependent Cell-Mediated Immunity
1975
Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia
1976
Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression
1978
Lymphosarcoma cell growth is selectively inhibited by B lymphocyte mitogens: LPS, dextran sulfate and PPD
1974
Polyribosomes of Growing Bacteria
1967 Science