Standout Papers
Citation Impact
Citing Papers
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
2001 StandoutScience
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
2004 StandoutNobel
Linkage Map ofEscherichia coliK-12, Edition 10: The Traditional Map
1998
An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines
2014
Mammalian polyamine metabolism and function
2009
Tumor-Associated Macrophages in Breast Cancer
2002
Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions
2011
Development of Matrix Metalloproteinase Inhibitors in Cancer Therapy
2001
Hallmarks of aging: An expanding universe
2023 Standout
Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production
2011
Metabolism and action of amino acid analog anti-cancer agents
1990
Designing the next generation of proton-exchange membrane fuel cells
2021 StandoutNature
Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation
1998
The Hallmarks of Cancer
2000 Standout
Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum
2000
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
2007
Functions of Polyamines in Mammals
2016
Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
2014
Structural Basis of Inward Rectification
2002 StandoutNobel
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis
1996 StandoutNobel
Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent
1989 StandoutNobel
Role of sulfur chirality in the chemical processes of biology
2005
Matrix metalloproteinase inhibitors in rheumatic diseases
2001
Plasmodium falciparum: effects of amantadine, an antiviral, on chloroquine-resistant and -sensitive parasites in vitro and its influence on chloroquine activity
1993
The microenvironment of the tumour–host interface
2001 StandoutNature
Comparison Between the Natural Postnatal Maturation and the Spermine-Induced Maturation of the Rat Intestine
1998
Barrett's esophagus: A model premalignant lesion for adenocarcinoma
1989
Chloroquine‐Resistant Malaria
2001
Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents
2002
Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase
1995
β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression
2007 StandoutNobel
Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance
2000 Standout
The Hallmarks of Aging
2013 Standout
Impact of Intestinal Microbiota on Intestinal Luminal Metabolome
2012
Polyamines and cancer: old molecules, new understanding
2004
Human DNA Damage Checkpoint Protein hRAD9 Is a 3′ to 5′ Exonuclease
2000 StandoutNobel
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
DNA Repair Excision Nuclease Attacks Undamaged DNA
2001 StandoutNobel
Marimastat in Patients With Advanced Pancreatic Cancer
1999
Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck
1990 Standout
Helicobacter pylori Infection and the Risk of Gastric Carcinoma
1991 Standout
Control of Neglected Tropical Diseases
2007 Standout
Biology of cutaneous squamous cell carcinoma
1992
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
1995 Standout
Drug discovery and development for neglected parasitic diseases
2006
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
2006 Standout
Cutaneous Squamous-Cell Carcinoma
2001 Standout
Effects of a Single Dose of Orally-Administered Spermine on the Intestinal Development of Unweaned Rate
1996
Protective Role of Spermidine in Colitis and Colon Carcinogenesis
2021
Ornithine decarboxylase inhibitors increase the cellular content of the enzyme: Implications for translational regulation
1985
Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome.
1984
Degradation of Ornithine Decarboxylase in Reticulocyte Lysate Is ATP-dependent but Ubiquitin-independent
1989 StandoutNobel
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
1991 StandoutNobel
Antitumor properties of (2R,5R)-6-heptyne-2,5-diamine, a new potent enzyme-activated irreversible inhibitor of ornithine decarboxylase, in rodents.
1984
Cell‐free synthesis of ornithine decarboxylase
1984
Ribosomal Crystallography: Peptide Bond Formation, Chaperone Assistance, and Antibiotics Inactivation
2007 StandoutNobel
Role of Polyamines in the Control of Cell Proliferation and Differentiation
1981 Standout
Transcriptional activation of mammalian ornithine decarboxylase during stimulated growth.
1987
Androgen induction of ornithine decarboxylase mRNA in mouse kidney as studied by complementary DNA.
1984
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism
1982
Synergistic antiproliferative activity of leukocyte interferon in combination with alpha-difluoromethylornithine against human cells in culture.
1984
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells.
2006
Activation of H2O2 by Chiral Confined Brønsted Acids: A Highly Enantioselective Catalytic Sulfoxidation
2012 StandoutNobel
Characterization of reactive oxygen species generated by protoporphyrin IX under X-ray irradiation
2009
Ornithine decarboxylase from hepatoma cells and a variant cell line in which the enzyme is more stable.
1982
Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: a review.
1990
Metalle in der Medizin
1999
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet.
1990
Calcium regulation of growth and differentiation of mouse epidermal cells in culture
1980 Standout
The transition state for formation of the peptide bond in the ribosome
2006 StandoutNobel
Aspirin Use and Reduced Risk of Fatal Colon Cancer
1991 Standout
Association of Increased Spontaneous Mutation Rates with High Levels of Transcription in Yeast
1995 Science
Growth of mammalian cells in the absence of the accumulation of spermine
1985
Studies of the specificity and kinetics of rat liver spermidine/spermine N1-acetyltransferase
1983
Role of antizyme in degradation of ornithine decarboxylase in HTC cells
1985
Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney
1985
Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene.
1988
Ornithine decarboxylase may be a multifunctional protein
1983
Comparison of inhibitors of S-adenosylmethionine decarboxylase from different species
1983
Polyamines in microorganisms
1985
Prooxidant States and Tumor Promotion
1985 StandoutScience
Control of ornithine decarboxylase in Chinese hamster ovary cells by polyamines. Translational inhibition of synthesis and acceleration of degradation of the enzyme by putrescine, spermidine, and spermine.
1986
Ornithine decarboxylase modification and polyamine-stimulated enzyme inactivation in HTC cells
1985
Effect of 1,3-diaminopropane on ornithine decarboxylase enzyme protein in thioacetamide-treated rat liver
1983
Isolation and characterization of the mouse ornithine decarboxylase gene.
1988
4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum
1996
(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase
1983
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Induction of spermidine/spermine N1-acetyltransferase in rat tissues by polyamines
1985
A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase.
1983
α‐Allenyl putrescine, an enzyme‐activated irreversible inhibitor of bacterial and mammalian ornithine decarboxylases
1984
Studies of mammalian ornithine decarboxylase using a monoclonal antibody
1984
Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.
1977 Standout
A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole.
1991
The Relationship between Microbiota and Polyamine Concentration in the Human Intestine: A Pilot Study
2007
Studies of the acetyl-CoA-binding site of rat liver spermidine/spermine N1-acetyltransferase
1983
Organization and expression of early genes of simian virus 40
1978 StandoutNobel
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Ornithine decarboxylase in mouse kidney. Purification, characterization, and radioimmunological determination of the enzyme protein.
1983
Spermidine in health and disease
2018 StandoutScience
Polyamine deprivation causes major chromosome aberrations in a polyamine-dependent Chinese hamster ovary cell line
1982
Stabilization of ornithine decarboxylase and N1-spermidine acetyltransferase in rat liver by methylglyoxal bis(guanylhydrazone)
1984
Metal–ligand interactions in drug design
2018
Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.
2001
The mechanism of inward rectification of potassium channels: "long-pore plugging" by cytoplasmic polyamines.
1995
Accumulation of ornithine decarboxylase-antizyme complex in HMOA cells
1985
A human neuroblastoma cell line with an altered ornithine decarboxylase.
1984
Dissociation of tumor promoter-stimulated ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo and in vitro by fluocinolone acetonide, a tumor-promotion inhibitor.
1977
Translational regulation of mammalian ornithine decarboxylase by polyamines.
1985 Nobel
The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with α-difluoromethylornithine
1984
Phase I and Pharmacologic Study of the Specific Matrix Metalloproteinase Inhibitor BAY 12-9566 on a Protracted Oral Daily Dosing Schedule in Patients With Solid Malignancies
2000
Posttranscriptional regulation of ornithine decarboxylase activity
1986
Effect of androgens on turnover of ornithine decarboxylase in mouse kidney. Studies using labeling of the enzyme by reaction with [14C] alpha-difluoromethylornithine.
1982
The regulation and function of ornithine decarboxylase and of the polyamines.
1979
The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins
1991 StandoutNobel
Influence of spermine on intestinal maturation of the glycoprotein glycosylation process in neonatal rats
1999
Polyamines in mammalian ageing: An oncological problem, too? A review
1984
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells
1984
Trypanothione: A Novel Bis(glutathionyl)spermidine Cofactor for Glutathione Reductase in Trypanosomatids
1985 Science
Studies of the induction of spermidine/spermine N1-acetyltransferase using a specific antiserum.
1984
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
1997 StandoutScience
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
Tetrahedron report number 163
1984 Standout
Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice.
1984
alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.
1982
Ornithine Decarboxylase Is Important in Intestinal Mucosal Maturation and Recovery from Injury in Rats
1980 Science
Polyamine biosynthetic enzymes as targets in cancer chemotherapy
1984
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
2010 Standout
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay.
1983
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
1977
Purification and some properties of a protein inhibitor (antizyme) of ornithine decarboxylase from rat liver.
1984
Gene expression during the mammalian cell cycle
1986
A macromolecular inhibitor of the antizyme to ornithine decarboxylase
1982
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Absence of inactivation or phosphorylation of ornithine decarboxylase by nuclear protein kinase NII and of immunological cross-reactivity between RNA polymerase I and ornithine decarboxylase
1984
S‐Adenosylmethionine decarboxylase: A brief review
1984
Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells
1985
Ornithine decarboxylase activity from an extremely thermophilic bacterium, Clostridium thermohydrosulfuricum effect of GTP analogues on enzyme activity
1983
Effects of DNA methylation on topoisomerase I and II cleavage activities.
1994 StandoutNobel
Limited Blood‐Brain Barrier Transport of Polyamines
1985
Organization of the Genomes of Polyoma Virus and SV40
1977
DNA topoisomerase II as a target of antineoplastic drug therapy
1985
Ornithine decarboxylase inactivation in HeLa cells
1976
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Suicide substrates: mechanism-based enzyme inactivators
1982
Effects of (2R, 5R)‐6‐heptyne‐2,5‐diamine, a potent inhibitor of l ‐ornithine decarboxylase, on rat hepatoma cells cultured in vitro
1984
Retinoic acid inhibition of Epstein-Barr virus induction
1979 StandoutNatureNobel
Androgen-regulated ornithine decarboxylase mRNAs of mouse kidney.
1984
Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate.
1985
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents
2003
New region of the simian virus 40 genome required for efficient viral transformation.
1978 StandoutNobel
Spermidine Requirement for Cell Proliferation in Eukaryotic Cells: Structural Specificity and Quantitation
1983 Science
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Recent advances in the biochemistry of polyamines in eukaryotes
1986 Standout
Works of Peter P. McCann being referenced
Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis
1985
Effect of α-methyl ornithine on ornithine decarboxylase activity of rat hepatoma cells in culture
1977
Matrix Metalloproteinase Inhibition as a Novel Anticancer Strategy: A Review with Special Focus on Batimastat and Marimastat
1997
S-adenosylmenthionine decarboxylase as an enzyme target for therapy
1992
Ornithine decarboxylase as an enzyme target for therapy
1992
Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer
1996
Further studies on difluoromethylornithine in African trypanosomes.
1981
Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate
1982
Polyamine metabolism and function
1982 Standout
DL-α-Monofluoromethylputrescine is a potent irreversible inhibitor of Escherichia coli ornithine decarboxylase
1982
In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei
1983
Plasmodium berghei: Inhibitors of ornithine decarboxylase block exoerythrocytic schizogony
1985
Inhibition of bacterial aminopropyltransferases by S‐adenosyl‐1,8‐diamino‐3‐thiooctane and by dicyclohexylamine
1983
Inhibition of Polyamine Metabolism : Biological Significance and Basis for New Therapies
1987
Role of Antibody in the Elimination of Trypanosomes after DL-a-Difluoromethylornithine Chemotherapy
1983
Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice.
1983
DL-.alpha.-(Difluoromethyl)arginine: a potent enzyme-activated irreversible inhibitor of bacterial arginine decarboxylases
1981
Bis(benzyl)polyamine analogs as novel substrates for polyamine oxidase.
1990
Inhibition of Growth of Giardia lamblia by Difluoromethylornithine, a Specific Inhibitor of Polyamine Biosynthesis1
1984
Inhibition of Polyamine Biosynthesis by α-Difluoromethylornithine in African Trypanosomes and Pneumocystis carinii as a Basis of Chemotherapy: Biochemical and Clinical Aspects
1986
Regulation of ornithine decarboxylase by ODC-antizyme in HTC cells
1977
REGULATORY MUTANTS OF THE TRYPTOPHAN OPERON OF SALMONELLA TYPHIMURIUM
1970
Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.
1986
Antagonism by polyamines of the curative effects of α-difluoromethylornithine in Trypanosoma brucei brucei infections
1981
The response of several murine embryonal carcinoma cell lines to stimulation of differentiation by α‐difluoromethylornithine
1985
Inhibition of growth of Mycoplasma dispar by DL-α-Difluoromethyllysine, a selective irreversible inhibitor of lysine decarboxylase, and reversal by cadaverine (1,5-diaminopentane)
1984
Nuclease digestion of the DNA · protein complex from simian virus 40 virions
1975
Reversal of Chloroquine Resistance in Malaria Parasite Plasmodium falciparum by Desipramine
1988 Science
Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation
1983
Divergent effects of ornithine decarboxylase inhibition on murine erythropoietic precursor cell proliferation and differentiation.
1983
The dual action of the non-physiological diamines 1,3 diaminopropane and cadaverine on ornithine decarboxylase of HTC cells
1980
Intestinal changes caused by dl-α-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase
1983
Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.
1983
Characterization of Trypanosoma brucei brucei S-adenosyl-l -methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone)
1986
S‐Adenosylmetliionine and methylation
1996
Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
1981
Biphasic induction of ornithine decarboxylase and putrescine levels in growing HTC cells
1975
Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line.
1983
Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture.
1976
Two distinct mechanisms for ornithine decarboxylase regulation by polyamines in rat hepatoma cells
1979
Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.
1983