Citation Impact
Citing Papers
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
2008
p50 Nuclear Factor-κB Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor Resistance
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Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
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Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice.
1999
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
1998
The DNA-damage response in human biology and disease
2009 StandoutNature
Functional diversity of helper T lymphocytes
1996 StandoutNature
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Activators and target genes of Rel/NF-κB transcription factors
1999 Standout
The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase
1998
Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation
2012
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Cell-cycle checkpoints and cancer
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2003 Standout
Selected comparison of immune and nervous system development
2001
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Defining interactions between DNA-PK and ligase IV/XRCC4
2002
A Physical and Functional Interaction between Yeast Pol4 and Dnl4-Lif1 Links DNA Synthesis and Ligation in Nonhomologous End Joining
2002
Cryo-EM Structure of the DNA-Dependent Protein Kinase Catalytic Subunit at Subnanometer Resolution Reveals α Helices and Insight into DNA Binding
2008
The Mechanism and Regulation of Chromosomal V(D)J Recombination
2002
XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
2006
Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining: Table 1.
2008
Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFκB and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages
1998
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
2001 StandoutNature
Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes
1996
Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4
2007
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Mechanism and regulation of human non-homologous DNA end-joining
2003
DNA repair is limiting for haematopoietic stem cells during ageing
2007 Nature
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining
2008
Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice
1997
Nucleases of the Metallo-β-lactamase Family and Their Role in DNA and RNA Metabolism
2007
Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event
2001
Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination
2002
The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction
2008
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
1998
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
1999
Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-activating Polypeptide Inhibit Interleukin-12 Transcription by Regulating Nuclear Factor κB and Ets Activation
1999
DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining
2000
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production
1998
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly
2006
DNA Ligase III Is Recruited to DNA Strand Breaks by a Zinc Finger Motif Homologous to That of Poly(ADP-ribose) Polymerase
1999
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein
2002
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice
1999
Electron Crystal Structure of the Transcription Factor and DNA Repair Complex, Core TFIIH
2000 StandoutNobel
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
2003
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
2001 StandoutNature
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
2007
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ
2007
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
2006
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
Perceptions of epigenetics
2007 StandoutNature
Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination
2007
Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV
1998 Nature
Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase
2000
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
2004
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
2000
A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination
2008
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation
2001
Chromosome Breaks and Genomic Instability
2000
Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
1998
Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
1999
Crystal structure of an Xrcc4-DNA ligase IV complex.
2001
A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining
2004
Synapsis of DNA ends by DNA-dependent protein kinase
2002
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
2005
Structure of DNA-dependent protein kinase: implications for its regulation by DNA
1999
Phosphorylation and Regulation of DNA Ligase IV Stability by DNA-dependent Protein Kinase
2004
Cancer-related inflammation
2008 StandoutNature
The Mechanism of Human Nonhomologous DNA End Joining
2007
DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway
2000
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Tetramerization and DNA Ligase IV Interaction of the DNA Double-strand Break Repair Protein XRCC4 are Mutually Exclusive
2003
Chapter 2 DNA-PK
2008
IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses
1996
Identification and Characterization of a Novel Ets-2-related Nuclear Complex Implicated in the Activation of the Human Interleukin-12 p40 Gene Promoter
1997
The roles of IFNγ in protection against tumor development and cancer immunoediting
2002
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Fate vs Choice: The Immune System Reloaded
2005
Activation of DNA-dependent Protein Kinase by Single-stranded DNA Ends
2000
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Pathogen Recognition and Innate Immunity
2006 Standout
Efficient Processing of DNA Ends during Yeast Nonhomologous End Joining
1999
Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
1997
Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
1998 StandoutNobel
Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
1998
Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
2009
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
1999 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
1999 Standout
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Quality Control by DNA Repair
1999 StandoutScienceNobel
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Suppression of IL-12 Transcription in Macrophages Following Fcγ Receptor Ligation
2001
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Ku is associated with the telomere in mammals
1999 StandoutNobel
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
2003
Two distinctive pathways for recruitment of naïve and primed IgM+B cells to the gut lamina propria
2005 StandoutNobel
Synergistic Activation of NF-κB by Tumor Necrosis Factor Alpha and Gamma Interferon via Enhanced IκBα Degradation and De Novo IκBβ Degradation
1997
Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins
1997
Rearranging Views on Neurogenesis
1999
Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini
1998
IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice
1999
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
1998
Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit
1999
Telomere fusions caused by mutating the terminal region of telomeric DNA
2000 StandoutNobel
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10
1998
Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification of a Novel Repressor Element (GA-12) That Responds to IL-4 and Prostaglandin E2
2001
The DNA-damage response: new molecular insights and new approaches to cancer therapy
2009
RNA Scanning of a Molecular Machine with a Built-in Ruler
2016 StandoutNobel
DNA end-joining: from yeast to man
1998
Targeted Disruption of the Artemis Murine Counterpart Results in SCID and Defective V(D)J Recombination That Is Partially Corrected with Bone Marrow Transplantation
2005
Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice
2001 Science
Regulation of interleukin-12 production in antigen-presenting cells
2001
DNA cleavage in immunoglobulin somatic hypermutation depends onde novoprotein synthesis but not on uracil DNA glycosylase
2005 StandoutNobel
Use and Abuse of RNAi to Study Mammalian Gene Function
2012 StandoutScienceNobel
DNA end-joining catalyzed by human cell-free extracts
1998
V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation
2002
Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
1999 Science
Toll‐like receptors: molecular mechanisms of the mammalian immune response
2000
Rejoining Kinetics of DNA Single- and Double-Strand Breaks in Normal and DNA Ligase-Deficient Cells after Exposure to Ultraviolet C and Gamma Radiation: An Evaluation of Ligating Activities Involved in Different DNA Repair Processes
1999
DNA Ligases: Structure, Reaction Mechanism, and Function
2006
Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor–Associated Factor (Traf)6
2000
Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-β in ANA-1 cells
1998
An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages
2000
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends
2000
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
1998
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
2007
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
2007
C-Rel Regulates Interleukin 12 P70 Expression in Cd8+ Dendritic Cells by Specifically Inducing p35 Gene Transcription
2001
Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4
1998 StandoutNobel
Works of Peter Kulesza being referenced
Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer
2008
C-fosAssessment as a Marker of Anti–Epidermal Growth Factor Receptor Effect
2006
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
1997 Nature
Requirement for an Interaction of XRCC4 with DNA Ligase IV for Wild-type V(D)J Recombination and DNA Double-strand Break Repairin Vivo
1998
DNA-PKcs Dependence of Artemis Endonucleolytic Activity, Differences between Hairpins and 5′ or 3′ Overhangs
2006
Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site
1995