Citation Impact
Citing Papers
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
2004 StandoutNobel
Nature of the protein universe
2009 StandoutNobel
The Mo-Se active site of nicotinate dehydrogenase
2009
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
2004 StandoutScience
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Catalysis at a dinuclear [CuSMo(O)OH] cluster in a CO dehydrogenase resolved at 1.1-Å resolution
2002 Nobel
Cloning of the cDNAs Coding for Two Novel Molybdo-flavoproteins Showing High Similarity with Aldehyde Oxidase and Xanthine Oxidoreductase
2000
Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase
2008
The First Mammalian Aldehyde Oxidase Crystal Structure
2012
The Molybdenum Cofactor
2013
Synthetic Analogues and Reaction Systems Relevant to the Molybdenum and Tungsten Oxotransferases
2003
Molybdenum and tungsten in biology
2002
Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases
2000
Crystal Structure of the Gephyrin-related Molybdenum Cofactor Biosynthesis Protein MogA from Escherichia coli
2000
Towards the reaction mechanism of pyrogallol–phloroglucinol transhydroxylase of Pelobacter acidigallici
1999
A periplasmic aldehyde oxidoreductase represents the first molybdopterin cytosine dinucleotide cofactor containing molybdo‐flavoenzyme from Escherichia coli
2009
Molybdenum enzymes, their maturation and molybdenum cofactor biosynthesis in Escherichia coli
2012
Natural engineering principles of electron tunnelling in biological oxidation–reduction
1999 StandoutNature
Molecular cloning, characterization and expression analysis of three aldehyde oxidase genes from Pisum sativum L.
2007
Oncogenic kinase signalling
2001 StandoutNature
Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation
2000
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Human Xanthine Oxidase Changes its Substrate Specificity to Aldehyde Oxidase Type upon Mutation of Amino Acid Residues in the Active Site: Roles of Active Site Residues in Binding and Activation of Purine Substrate
2007
Pterin chemistry and its relationship to the molybdenum cofactor
2011
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications
2003
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Comparative genomics and evolution of molybdenum utilization
2011
Mammalian xanthine oxidoreductase – mechanism of transition from xanthine dehydrogenase to xanthine oxidase
2008
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria
2010
Coupled Electron/Proton Transfer in Complex Flavoproteins
2001
Gene Sequence and the 1.8 Å Crystal Structure of the Tungsten-Containing Formate Dehydrogenase from Desulfovibrio gigas
2002 Nobel
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Functional expression of the quinoline 2‐oxidoreductase genes (qorMSL) in Pseudomonas putida KT2440 pUF1 and in P. putida 86‐1 Δqor pUF1 and analysis of the Qor proteins
2003
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
SHP-2 Is a Dual-specificity Phosphatase Involved in Stat1 Dephosphorylation at Both Tyrosine and Serine Residues in Nuclei
2002
Substrate Orientation in Xanthine Oxidase
2007
Xanthine dehydrogenase from the phototrophic purple bacterium Rhodobacter capsulatus is more similar to its eukaryotic counterparts than to prokaryotic molybdenum enzymes
1998
Enzymatic Properties and Effect of Ionic Strength on Periplasmic Nitrate Reductase (NAP) fromDesulfovibrio desulfuricansATCC 27774
1997
Association of Atypical Protein Kinase C Isotypes with the Docker Protein FRS2 in Fibroblast Growth Factor Signaling
1999
Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2
1998
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
2002
Thrombin signalling and protease-activated receptors
2000 StandoutNature
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
2004
The Reductive Half-reaction of Xanthine Oxidase
1999
Active Site Geometry and Substrate Recognition of the Molybdenum Hydroxylase Quinoline 2-Oxidoreductase
2004 Nobel
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Regulation of the Mitogen-activated Protein Kinase Signaling Pathway by SHP2
2002
The Role of Active Site Glutamate Residues in Catalysis of Rhodobacter capsulatus Xanthine Dehydrogenase
2004
Substrate Orientation and Catalytic Specificity in the Action of Xanthine Oxidase
2010
Pseudomonas stutzeri soluble nitrate reductase αβ‐subunit is a soluble enzyme with a similar electronic structure at the active site as the inner membrane‐bound αβγ holoenzyme
2002
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
2004
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Signaling—2000 and Beyond
2000 Standout
Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC
2000
Structure of the molybdopterin-bound Cnx1G domain links molybdenum and copper metabolism
2004 Nature
Crystal Structure of Human Protein-tyrosine Phosphatase SHP-1
2003
The Generation of New Protein Functions by the Combination of Domains
2007
Crystal structure of oxidized trimethylamine N -oxide reductase from Shewanella massilia at 2.5 å resolution 1 1Edited by R. Huber
1998
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells
1999
The Role of Arginine 310 in Catalysis and Substrate Specificity in Xanthine Dehydrogenase from Rhodobacter capsulatus
2007
NarJ Chaperone Binds on Two Distinct Sites of the Aponitrate Reductase of Escherichia coli to Coordinate Molybdenum Cofactor Insertion and Assembly
2005
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Molybdenum enzymes in higher organisms
2010
Redox Centers of 4-Hydroxybenzoyl-CoA Reductase, a Member of the Xanthine Oxidase Family of Molybdenum-containing Enzymes
2001
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
2003
Crystal Structures of the Active and Alloxanthine-Inhibited Forms of Xanthine Dehydrogenase from Rhodobacter capsulatus
2002
Tungsten in biological systems
1996
Structure and stability of the molybdenum cofactor intermediate cyclic pyranopterin monophosphate
2011
Molecular Basis of Sulfite Oxidase Deficiency from the Structure of Sulfite Oxidase
1997
Protein Tyrosine Phosphatases in the Human Genome
2004 Standout
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
2007
A structural comparison of molybdenum cofactor-containing enzymes
1998
Crystal structures of human gephyrin and plant Cnx1 G domains: comparative analysis and functional implications
2001
Resonance Raman Characterization of Biotin Sulfoxide Reductase
2000
The effect of intracellular molybdenum in Hydrogenophaga pseudoflava on the crystallographic structure of the seleno-molybdo-iron-sulfur flavoenzyme carbon monoxide dehydrogenase
2000 Nobel
Molybdenum and tungsten enzymes: the xanthine oxidase family
2006
Properties of Xanthine Dehydrogenase Variants from Rosy Mutant Strains of Drosophila melanogaster and their Relevance to the enzyme's Structure and Mechanism
1996
A Novel Protein-Protein Interaction between a G Protein-coupled Receptor and the Phosphatase SHP-2 Is Involved in Bradykinin-induced Inhibition of Cell Proliferation
2002
Crystal Structure of the Molybdenum Cofactor Biosynthesis Protein MobA from Escherichia coli at Near-Atomic Resolution
2000
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
2001
The Crystal Structure of Plant Sulfite Oxidase Provides Insights into Sulfite Oxidation in Plants and Animals
2003
The Crystal Structure of the Escherichia coliMobA Protein Provides Insight into Molybdopterin Guanine Dinucleotide Biosynthesis
2000
Molecular basis for TPR domain‐mediated regulation of protein phosphatase 5
2004
The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
2003
Structural and Biochemical Identification of a Novel Bacterial Oxidoreductase
2004
Crystal structure of the first dissimilatory nitrate reductase at 1.9 Å solved by MAD methods
1999 Nobel
Crystal Structure of a Soluble Form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-Å Resolution
2001
Interactions between the Molybdenum Cofactor and Iron-Sulfur Clusters of Escherichia coli Dimethylsulfoxide Reductase
1999
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling
2001
Purification and Characterization of the FeII- and α-Ketoglutarate-Dependent Xanthine Hydroxylase from Aspergillus nidulans
2007
Substrate Oxidation in the Active Site of Xanthine Oxidase and Related Enzymes. A Model Density Functional Study
1998 Nobel
Protein–protein interactions define specificity in signal transduction
2000
Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus
2004 StandoutNobel
Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3
2003
Protein tyrosine phosphatases
2002
Spectroscopic studies of molybdenum and tungsten enzymes
2011
Kinetic, Structural, and EPR Studies Reveal That Aldehyde Oxidoreductase from Desulfovibrio gigas Does Not Need a Sulfido Ligand for Catalysis and Give Evidence for a Direct Mo−C Interaction in a Biological System
2009
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
2003 Standout
Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S -selanylcysteine
1999 Nobel
Mechanism of Formamide Hydroxylation Catalyzed by a Molybdenum−Dithiolene Complex: A Model for Xanthine Oxidase Reactivity
1999
Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase: Substrate Orientation and Structure of the Key Reaction Intermediate
2010
Tautomerization of the substrate heterocycle in the course of the reaction of xanthine oxidase
1997
Structure of a Xanthine Oxidase-Related 4-Hydroxybenzoyl-CoA Reductase with an Additional [4Fe-4S] Cluster and an Inverted Electron Flow
2004
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
The Reaction Mechanism of Xanthine Oxidase: Evidence for Two-Electron Chemistry Rather Than Sequential One-Electron Steps
2002
X-ray Absorption Spectroscopy of Dimethyl Sulfoxide Reductase from Rhodobacter sphaeroides
1996
The 1.3 Å Crystal Structure ofRhodobacter sphaeroidesDimethyl Sulfoxide Reductase Reveals Two Distinct Molybdenum Coordination Environments
2000
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
13C and 63,65Cu ENDOR studies of CO Dehydrogenase from Oligotropha carboxidovorans. Experimental Evidence in Support of a Copper–Carbonyl Intermediate
2013
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
2018 StandoutNobel
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
2004 StandoutNobel
Purine Catabolism in Escherichia coli and Function of Xanthine Dehydrogenase in Purine Salvage
2000
Structure of the Molybdenum Site of Dimethyl Sulfoxide Reductase
1999
A Theoretical Study on the Mechanism of the Reductive Half-Reaction of Xanthine Oxidase
2005
The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition
2004
Structural aspects of mononuclear Mo/W-enzymes
2010
Cloning and Molecular Characterization of the Genes for Carbon Monoxide Dehydrogenase and Localization of Molybdopterin, Flavin Adenine Dinucleotide, and Iron-Sulfur Centers in the Enzyme of Hydrogenophaga pseudoflava
1999
Dynamic determination of the functional state in photolyase and the implication for cryptochrome
2013 StandoutNobel
The Role of System-Specific Molecular Chaperones in the Maturation of Molybdoenzymes in Bacteria
2010
QM/MM Studies of Xanthine Oxidase: Variations of Cofactor, Substrate, and Active-Site Glu802
2010
A Novel Type of Monoheme Cytochrome c: Biochemical and Structural Characterization at 1.23 Å Resolution of Rhodothermus marinus Cytochrome c
2008
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
2000
CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca 2+ signaling
2013
35 GHz ENDOR Characterization of the “Very Rapid” Signal of Xanthine Oxidase Reacted with 2-Hydroxy-6-methylpurine (13C8): Evidence against Direct Mo−C8 Interaction
2001
Resonance Raman Characterization of the Molybdenum Center in Sulfite Oxidase: Identification of MoO Stretching Modes
1997
Active transition metal oxo and hydroxo moieties in nature's redox, enzymes and their synthetic models: Structure and reactivity relationships
2010
Electronic Structure Description of thecis-MoOS Unit in Models for Molybdenum Hydroxylases
2007
Freeze−Quench Magnetic Circular Dichroism Spectroscopic Study of the “Very Rapid” Intermediate in Xanthine Oxidase
1999
Copper-Catalyzed Synthesis of Mixed Alkyl Aryl Phosphonates
2014 StandoutNobel
SH2 and PTB Domains in Tyrosine Kinase Signaling
2003
Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology
2003
Molybdenum cofactor biosynthesis in plants and humans
2011
Tungstoenzymes
1996
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
1998 Standout
Structure of a Multipartite Protein-Protein Interaction Domain in Splicing Factor Prp8 and Its Link to Retinitis Pigmentosa
2007
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Site-directed Mutagenesis of Recombinant Sulfite Oxidase
1996
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation
2000
Coordinatively Unsaturated Metal Centers in the Extended Porous Framework of Zn3(BDC)3·6CH3OH (BDC = 1,4-Benzenedicarboxylate)
1998 StandoutNobel
Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin
1998
A Theoretical Study of the Primary Oxo Transfer Reaction of a Dioxo Molybdenum(VI) Compound with Imine Thiolate Chelating Ligands: A Molybdenum Oxotransferase Analogue
2001
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
The oxygen‐tolerant and NAD +‐dependent formate dehydrogenase from Rhodobacter capsulatus is able to catalyze the reduction of CO 2 to formate
2013
Crystal Structure of DMSO Reductase: Redox-Linked Changes in Molybdopterin Coordination
1996 Science
Engineering the proteolytic specificity of activated protein C improves its pharmacological properties
2003
Nature of the Oxomolybdenum−Thiolate π-Bond: Implications for Mo−S Bonding in Sulfite Oxidase and Xanthine Oxidase
2004
Crystal Structure of Formate Dehydrogenase H: Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe 4 S 4 Cluster
1997 Science
The Mononuclear Molybdenum Enzymes
1996 Standout
Protein Control of Redox Potentials of Iron−Sulfur Proteins
1996 StandoutNobel
Iron-Sulfur Clusters: Nature's Modular, Multipurpose Structures
1997 StandoutScience
Structural and Electron Paramagnetic Resonance (EPR) Studies of Mononuclear Molybdenum Enzymes from Sulfate-Reducing Bacteria
2006
X-ray Absorption Spectroscopy of the Molybdenum Site of Escherichia coli Formate Dehydrogenase
1998
The DMSO Reductase Family of Microbial Molybdenum Enzymes; Molecular Properties and Role in the Dissimilatory Reduction of Toxic Elements
2002
Theoretical studies on the reactivity of molybdenum enzymes
2011
The Molybdenum Site of Sulfite Oxidase: A Comparison of Wild-Type and the Cysteine 207 to Serine Mutant Using X-ray Absorption Spectroscopy
1996
HIV Gag mRNA Transfection of Dendritic Cells (DC) Delivers Encoded Antigen to MHC Class I and II Molecules, Causes DC Maturation, and Induces a Potent Human In Vitro Primary Immune Response
2000 StandoutNobel
A Solution-Phase Bifunctional Catalyst for Lithium–Oxygen Batteries
2014 StandoutNobel
Electron Tunneling Pathways and Role of Adenine in Repair of Cyclobutane Pyrimidine Dimer by DNA Photolyase
2012 StandoutNobel
ESEEM Investigations of the High pH and Low pH Forms of Chicken Liver Sulfite Oxidase
1998
The Mononuclear Molybdenum Enzymes
2014 Standout
Oxidation Reaction by Xanthine Oxidase. Theoretical Study of Reaction Mechanism
2007
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
1999
Oxo, Sulfido, and Tellurido Mo-enedithiolate Models for Xanthine Oxidase: Understanding the Basis of Enzyme Reactivity
2002
X-ray Crystal Structure and EPR Spectra of “Arsenite-Inhibited” Desulfovibrio gigas Aldehyde Dehydrogenase: A Member of the Xanthine Oxidase Family
2004
Active Site Structures and Catalytic Mechanism ofRhodobacter sphaeroidesDimethyl Sulfoxide Reductase as Revealed by Resonance Raman Spectroscopy
1997
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
A Combined QM/MM Study on the Reductive Half-Reaction of Xanthine Oxidase: Substrate Orientation and Mechanism
2009
The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling
2003
Molybdenum enzymes in bacteria and their maturation
2011
Periplasmic nitrate reductases and formate dehydrogenases: Biological control of the chemical properties of Mo and W for fine tuning of reactivity, substrate specificity and metabolic role
2012
Bioinorganic chemistry of molybdenum and tungsten enzymes: A structural–functional modeling approach
2010
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Mechanistic Studies on Synthetic Fe−S-Based Clusters and Their Relevance to the Action of Nitrogenases
2005 StandoutNobel
Determining complete electron flow in the cofactor photoreduction of oxidized photolyase
2013 StandoutNobel
Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5
2006 StandoutNobel
Nature of the Catalytically Labile Oxygen at the Active Site of Xanthine Oxidase
2005
Inflammation, sepsis, and coagulation.
1999
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Structure and Reversible Pyran Formation in Molybdenum Pyranopterin Dithiolene Models of the Molybdenum Cofactor
2012
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Frozen Density Functional Free Energy Simulations of Redox Proteins: Computational Studies of the Reduction Potential of Plastocyanin and Rusticyanin
2003 StandoutNobel
Tungsten in biological systems
1996
Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin
2009
Works of Peter Hof being referenced
Thermus thermophilus cytochrome- c 552 : a new highly thermostable cytochrome- c structure obtained by MAD phasing 1 1Edited by K. Nagai
1997 Nobel
Cytochrome-c552fromThermus thermophilus:A Functional and Crystallographic Investigation
1997 Nobel
The effect of temperature and protein synthesis on the renaturation of firefly luciferase in intact H9c2 cells
1999
Altered specificity mutations define residues essential for substrate positioning in xanthine dehydrogenase 1 1Edited by A. R. Fersht
1998 Nobel
Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2 Å resolution: Structural characterization of herbicide-conjugating plant glutathione S-transferases and a novel active site architecture
1996 Nobel
Crystal Structure of the Tyrosine Phosphatase SHP-2
1998
Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas
1995 ScienceNobel
A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes.
1996 Nobel
The 2.8 A crystal structure of Gla-domainless activated protein C.
1996 Nobel
The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities.
1996 Nobel
Prediction of Alternative Structures of the Molybdenum Site in the Xanthine Oxidase-Related Aldehyde Oxido Reductase
1997 Nobel