Standout Papers
Citation Impact
Citing Papers
Crystal Structure of a Lipid G Protein–Coupled Receptor
2012 Science
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Molecular Chaperone Functions in Protein Folding and Proteostasis
2013
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
In vivo aspects of protein folding and quality control
2016 Science
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
TGF-β-Id1 Signaling Opposes Twist1 and Promotes Metastatic Colonization via a Mesenchymal-to-Epithelial Transition
2013
Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine
2018
Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
2016
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Firefly luciferase mutants as sensors of proteome stress
2011
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
2017 Nature
Theoretical Analysis of Molecular Diffusion in Pressure-Driven Laminar Flow in Microfluidic Channels
2001
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles
2013
Pharmacological targeting of endoplasmic reticulum stress in disease
2021
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Hallmarks of aging: An expanding universe
2023 Standout
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
2017 Nature
Activity-based protein profiling for biochemical pathway discovery in cancer
2010
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
2010
Covalent protein modification: the current landscape of residue-specific electrophiles
2014
Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function
2013
Protein Organic Chemistry and Applications for Labeling and Engineering in Live‐Cell Systems
2013
Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases
2015
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
2012
EMT: 2016
2016 Standout
The present and future role of microfluidics in biomedical research
2014 StandoutNature
Design of activated serine–containing catalytic triads with atomic-level accuracy
2014 StandoutNobel
How Chemoproteomics Can Enable Drug Discovery and Development
2012
Programmable Cell Adhesion Encoded by DNA Hybridization
2005 StandoutNobel
The role of senescent cells in ageing
2014 StandoutNature
The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System
2011
The Hallmarks of Aging
2013 Standout
The proteostasis network and its decline in ageing
2019
Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
2015 Standout
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Nano-magnetite (Fe3O4) as a support for recyclable catalysts in the development of sustainable methodologies
2013 Standout
A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
2016
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
2017
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Coping with Protein Quality Control Failure
2017
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Cooperative capture synthesis: yet another playground for copper-free click chemistry
2016 StandoutNobel
Micro Total Analysis Systems. 1. Introduction, Theory, and Technology
2002 Standout
Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase Inhibitors
2018
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
2014
Spermidine in health and disease
2018 StandoutScience
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Rotational dynamics and transition mechanisms of surface-adsorbed proteins
2022 StandoutNobel
Proteome-Wide Reactivity Profiling Identifies Diverse Carbamate Chemotypes Tuned for Serine Hydrolase Inhibition
2013
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
From SARS to MERS : crystallographic studies on coronaviral proteases enable antiviral drug design
2014
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Organische Proteinchemie und ihre Anwendung für Markierungen und Engineering in Lebendzellsystemen
2013
The Biology of Proteostasis in Aging and Disease
2015
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Emerging Targets in Photopharmacology
2016 StandoutNobel
Analog sensitive chemical inhibition of the DEAD ‐box protein DDX 3
2015 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Quantitative Analysis of Molecular Interaction in a Microfluidic Channel: The T-Sensor
1999
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Activity-Based Profiling of Proteases
2014
Microfluidic Device for Electric Field-Driven Single-Cell Capture and Activation
2005
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes
2015
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Chemical Glycoproteomics
2016 StandoutNobel
Works of Peter Hodder being referenced
Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents
2013
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
2011
Miniaturization of Intracellular Calcium Functional Assays to 1536-Well Plate Format Using a Fluorometric Imaging Plate Reader
2004
Potent and Selective Inhibitors of Glutathione S-Transferase Omega 1 That Impair Cancer Drug Resistance
2011
Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors
2013
Small-molecule proteostasis regulators for protein conformational diseases
2011
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries
2009 StandoutNobel
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)
2010
Small Molecule Activators of TRPML3
2010
Microfabricated Flow Chamber for Fluorescence-based Chemistries and Stopped-flow Injection Cytometry
1997
A Substrate-Free Activity-Based Protein Profiling Screen for the Discovery of Selective PREPL Inhibitors
2011
Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes
2012
An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2)
2014
Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding
2013
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
2016
NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-β-Lactamase
2010 StandoutNobel
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
2011
Ligand-Binding Pocket Shape Differences between Sphingosine 1-Phosphate (S1P) Receptors S1P1 and S1P3 Determine Efficiency of Chemical Probe Identification by Ultrahigh-Throughput Screening
2008