Citation Impact
Citing Papers
Crystal Structure of a Lipid G Protein–Coupled Receptor
2012 Science
Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus
2011
HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P 1 to limit vascular inflammation
2015
The outs and the ins of sphingosine-1-phosphate in immunity
2011
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation
2015 Nature
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
Fourth Universal Definition of Myocardial Infarction (2018)
2018 Standout
Industrial natural product chemistry for drug discovery and development
2013
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
2010 Standout
Identification of natural inhibitors of Entamoeba histolytica cysteine synthase from microbial secondary metabolites
2015 StandoutNobel
A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
2010 Standout
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Multistage Nanoparticles for Improved Delivery into Tumor Tissue
2012 StandoutNobel
A guide to immunometabolism for immunologists
2016 Standout
Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond
2013
Sphingolipids and their metabolism in physiology and disease
2017 Standout
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Marine natural products
1990 Standout
Sphingosine-1-phosphate receptors as emerging targets for treatment of pain
2012
Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes
2011
Trends in GPCR drug discovery: new agents, targets and indications
2017 Standout
Effective gene expression prediction from sequence by integrating long-range interactions
2021 StandoutNobel
Opportunities and challenges in phenotypic drug discovery: an industry perspective
2017
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
2015 Standout
Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer
2016 Standout
Identification of a Metabolizing Enzyme in Human Kidney by Proteomic Correlation Profiling
2013
Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection
2011
Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer
2012
The Immunomodulator FTY720 Has a Direct Cytoprotective Effect in Oligodendrocyte Progenitors
2007
Comparison of the lateral tail vein and the retro-orbital venous sinus as routes of intravenous drug delivery in a transgenic mouse model
2007
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
Sphingosine-1-phosphate signaling and its role in disease
2011
Molecular Basis of Sphingosine Kinase 1 Substrate Recognition and Catalysis
2013
Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?
2015
Pharmacological Approaches to the Management of Secondary Progressive Multiple Sclerosis
2017
Structure-based drug screening for G-protein-coupled receptors
2012 StandoutNobel
Sequential regulatory activity prediction across chromosomes with convolutional neural networks
2018
Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction
2013
Drug repurposing: progress, challenges and recommendations
2018 Standout
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
2012
A new era of GPCR structural and chemical biology
2012 StandoutNobel
FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system
2009
Sphingosine-1-phosphate in chronic intestinal inflammation and cancer
2013
A good practice guide to the administration of substances and removal of blood, including routes and volumes
2001 Standout
G protein-coupled receptors as therapeutic targets for multiple sclerosis
2012
Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
2007
N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
2012 StandoutNobel
A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response
2016 StandoutNobel
Sphingolipid metabolites in inflammatory disease
2014 Nature
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
2013 Standout
The immunopathology of sepsis and potential therapeutic targets
2017 Standout
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
2014 Standout
Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ
2014 Standout
Discovery and resupply of pharmacologically active plant-derived natural products: A review
2015 Standout
Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: Results from a 12-week, open-label pilot study in multiple sclerosis patients
2012
The acute respiratory distress syndrome
2012 Standout
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
2014 Standout
Sphingosine 1-phosphate in coagulation and inflammation
2011
Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis
2007
Second generation S1P pathway modulators: Research strategies and clinical developments
2013
S1PR1 is an effective target to block STAT3 signaling in activated B cell–like diffuse large B-cell lymphoma
2012
Revision of the Troponin T Release Mechanism from Damaged Human Myocardium
2014
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Lipid phosphate phosphatase 3 enables efficient thymic egress
2011
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
2020 Standout
Multiple Sclerosis
2018 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Remote Ischemic Preconditioning in Human Coronary Artery Bypass Surgery
2010
Discovery Of Fingolimod, The Sphingosine 1-Phosphate Receptor Modulator And Its Application For The Therapy Of Multiple Sclerosis
2012
Reengineering Antibiotics to Combat Bacterial Resistance: Click Chemistry [1,2,3]‐Triazole Vancomycin Dimers with Potent Activity against MRSA and VRE
2016 StandoutNobel
Drugging Sphingosine Kinases
2014
The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors
2004
Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite
2011
Fourth Universal Definition of Myocardial Infarction (2018)
2018 Standout
Natural product and natural product derived drugs in clinical trials
2014 Standout
Fourth universal definition of myocardial infarction (2018)
2018 Standout
Natural Products as Sources of New Drugs from 1981 to 2014
2016 Standout
Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012)
2014 Standout
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives
2017
The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets
2020 Standout
Jietacins with potent nematocidal activity; efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D
2015 StandoutNobel
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
2012 Standout
The Sphingosine-1-Phosphate Analog FTY720 Reduces Muscle Ceramide Content and Improves Glucose Tolerance in High Fat-Fed Male Mice
2012
Works of Peter Heining being referenced
Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses
2006
Pharmacokinetics and Cell Trafficking Dynamics of 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol Hydrochloride (FTY720) in Cynomolgus Monkeys after Single Oral and Intravenous Doses
2002
Cardiac troponins and creatine kinase content of striated muscle in common laboratory animals
2001
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
2010
Comparison of clinical pathology parameters with two different blood sampling techniques in rats: retrobulbar plexus versus sublingual vein
2000
Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator
2013