Citation Impact
Citing Papers
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
Programmable RNA recognition using a CRISPR-associated Argonaute
2018 StandoutNobel
Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
2013
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
The C9orf72 protein interacts with Rab1a and the ULK 1 complex to regulate initiation of autophagy
2016
C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
2014 Science
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
2014 Science
Sporadic and hereditary amyotrophic lateral sclerosis (ALS)
2014
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
2016
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy
2015
Roles of tau protein in health and disease
2017
Tau protein liquid–liquid phase separation can initiate tau aggregation
2018
LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
2010
The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain
2019 Standout
CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins
2016
Biomolecular condensates: organizers of cellular biochemistry
2017 Standout
“Structural characterization of the minimal segment of TDP-43 competent for aggregation”
2014
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
Synapses and Alzheimer's Disease
2012 StandoutNobel
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Autophagy as a promoter of longevity: insights from model organisms
2018
The Biogenesis, Functions, and Challenges of Circular RNAs
2018 Standout
ALS-Linked Mutations Enlarge TDP-43-Enriched Neuronal RNA Granules in the Dendritic Arbor
2014
A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis
2018 Nobel
Alzheimer Mechanisms and Therapeutic Strategies
2012
Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
2013
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
2013
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
2013
Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
2010
The UPR ER : Sensor and Coordinator of Organismal Homeostasis
2017
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
2007 Standout
Mechanism and medical implications of mammalian autophagy
2018 Standout
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
2011
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity
2015
The role of autophagy in neurodegenerative disease
2013 Standout
Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
2014
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
2012 Standout
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
2010
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43
2016
Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
2013
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
2017 Standout
C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD
2016
Hallmarks of aging: An expanding universe
2023 Standout
The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism
2010
Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia
2011
Amyotrophic lateral sclerosis
2017
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
2009
Remodeling Neurodegeneration: Somatic Cell Reprogramming-Based Models of Adult Neurological Disorders
2013
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
2014 Nature
Amyotrophic lateral sclerosis
2011 Standout
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
2015
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
2014 Standout
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
2016
Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action
2014
Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
2015
Quality Control of Membraneless Organelles
2018
Ageing, neurodegeneration and brain rejuvenation
2016 Nature
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Tau in physiology and pathology
2015 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
2015 Standout
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Decoding ALS: from genes to mechanism
2016 StandoutNature
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
2015 Nature
TDP-43 is a key player in the clinical features associated with Alzheimer’s disease
2014
ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
2016
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
2010
The amyloidogenicity of a C-terminal region of TDP-43 implicated in Amyotrophic Lateral Sclerosis can be affected by anions, acetylation and homodimerization
2018
An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution
2014
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
2015 Standout
RNA-binding proteins with prion-like domains in ALS and FTLD-U
2011
Circular Intronic Long Noncoding RNAs
2013 Standout
Delineation of the Core Aggregation Sequences of TDP‐43 C‐Terminal Fragment
2011
Tau-aggregation inhibitor therapy for Alzheimer's disease
2013
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
2017
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
2009 Standout
Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
2012
Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
2011
Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant
2011
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Non-coding RNAs in human disease
2011 Standout
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
2016
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
2010
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS
2014
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
2013
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
2014
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
2012
The Amyloid State of Proteins in Human Diseases
2012 Standout
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models
2012
The biogenesis, biology and characterization of circular RNAs
2019 Standout
Adaptive responses to alloxan‐induced mild oxidative stress ameliorate certain tauopathy phenotypes
2011
Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansion
2014
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
2012
The PI3K Pathway in Human Disease
2017 Standout
Updated TDP-43 in Alzheimer’s disease staging scheme
2016
Drugging the Cancer Chaperone HSP90
2007
Heat shock in C. elegans induces downstream of gene transcription and accumulation of double-stranded RNA
2019
Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers
2016
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
2009
Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology
2018
The associations between Parkinson’s disease and cancer: the plot thickens
2015
Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration
2015
Large-scale brain networks and psychopathology: a unifying triple network model
2011 Standout
Development and application of Hsp90 inhibitors
2007
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
2015
Exosome secretion is a key pathway for clearance of pathological TDP-43
2016
Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease
2014
Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy
2008
Post-translational modifications of tau protein: Implications for Alzheimer's disease
2011
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Phase to Phase with TDP-43
2017
Natural Products As A Rich Source Of Tau-Targeting Drugs For Alzheimer’s Disease
2012
Protein clearing pathways in ALS.
2011
Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier
2019 StandoutNobel
AMPK‐mediated formation of stress granules is required for dietary restriction‐induced longevity in Caenorhabditis elegans
2020
Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities
2022
Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)
2014
Review: Prion‐like mechanisms of transactive response DNA binding protein of 43 kDa (TDP ‐43) in amyotrophic lateral sclerosis (ALS )
2014
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
2009
Degradation of tau protein by autophagy and proteasomal pathways
2012
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
2015 Standout
Biology and Genetics of Prions Causing Neurodegeneration
2013 Nobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation
2018
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
2010
Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
2013
The construction system of the brain
2009 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
2016
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
2013
CircRNAs in the brain
2016
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function
2015
2015
Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models
2018
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Works of Peter E.A. Ash being referenced
2014
Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS
2013
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
2006
Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
2016
Neurotoxic effects of TDP-43 overexpression in C. elegans
2010
Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS
2013
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
2007
Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72
2013
Mutations in LRRK2 potentiate age-related impairment of autophagic flux
2015
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
2009
Pathological stress granules in Alzheimer’s disease
2014