Standout Papers
Citation Impact
Citing Papers
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival
2009 Nature
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Mechanisms of Antileukemic Activity of the Novel Bcl-2 Homology Domain-3 Mimetic GX15-070 (Obatoclax)
2008
Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores
2016
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
2008 Standout
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
2020 StandoutNobel
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis
2019
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly
2019
Mito-priming as a method to engineer Bcl-2 addiction
2016
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size
2013
Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis
2018
Hallmarks of Cancer: The Next Generation
2011 Standout
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
2018
Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine
2017
Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis
2009
To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions
2008
Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic
2012
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
2017
BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
2010
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
2008
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
2010
The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation
2016
BID-induced structural changes in BAK promote apoptosis
2013
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
2015
The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIMEL
2009
Cancer drug resistance: an evolving paradigm
2013 Standout
BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines
2018
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
How Can Folded Biopolymers and Synthetic Foldamers Recognize Each Other?
2009
Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis
2018
Inhibition of α-helix-mediated protein–protein interactions using designed molecules
2013
A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection
2017
BCL-2 family proteins: changing partners in the dance towards death
2017
Comparing the effects of different cell death programs in tumor progression and immunotherapy
2018
The molecular machinery of regulated cell death
2019 Standout
Synthetic foldamers
2011
BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association
2019
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis
2016
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
2011
BAX activation is initiated at a novel interaction site
2008 Nature
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response
2013
Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim
2009
Constraining Cyclic Peptides To Mimic Protein Structure Motifs
2014
Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes
2010
Targeting apoptosis in cancer therapy
2020 Standout
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1
2010
Mitochondrial dynamics and apoptosis
2008
Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices
2016
An interconnected hierarchical model of cell death regulation by the BCL-2 family
2015
Reprogramming eukaryotic translation with ligand-responsive synthetic RNA switches
2016
Cell Death
2009
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
2011
MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
2014
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Protein binding specificity versus promiscuity
2010
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
2007
Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
2011
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
2017
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
2019
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax
2007
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
A fate worse than death: apoptosis as an oncogenic process
2016
Necroptosis in development, inflammation and disease
2016
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
2015
Pore-forming toxins: ancient, but never really out of fashion
2015
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway
2016
Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization
2008
Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
2011
Small-molecule allosteric inhibitors of BAX
2019
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
2014
Mitochondria as multifaceted regulators of cell death
2019 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice
2012
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
The Hallmarks of Aging
2013 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species
2015
Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
2008
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
2016
Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion
2009
Peptidic foldamers: ramping up diversity
2011
Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance
2016
Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
2021 Nature
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
The BCL-2 Family Reunion
2010
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
2011
Towards novel paradigms for cancer therapy
2010
VDAC2 is required for truncated BID‐induced mitochondrial apoptosis by recruiting BAK to the mitochondria
2009
From DARPins to LoopDARPins: Novel LoopDARPin Design Allows the Selection of Low Picomolar Binders in a Single Round of Ribosome Display
2013
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
Clues from cell metabolism
2010 StandoutNatureNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
JAK2 activation by growth hormone and other cytokines
2015
Foldamers with Heterogeneous Backbones
2008
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity
2010
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer
2016 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
2015
Understanding Cell Penetration of Cyclic Peptides
2019
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak
2016
Folding of Oligoviologens Induced by Radical–Radical Interactions
2014 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
Macrocyclic Control in Helix Mimetics
2019
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Direct activation of full-length proapoptotic BAK
2013
RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice
2016
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
2021 StandoutNobel
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Peptide stapling techniques based on different macrocyclisation chemistries
2014
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
2017
Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
2013
Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis
2014
Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling
2012
A new kind of cell suicide: mechanisms and functions of programmed necrosis
2014
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
2019
Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes
2014
Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis
2015
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
Differential Effects of β3‐ versus β2‐Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3‐Derived α/β‐Peptides
2018
Differential retrotranslocation of mitochondrial Bax and Bak
2014
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
2012
Structural Chemistry of Peptides Containing Backbone Expanded Amino Acid Residues: Conformational Features of β, γ, and Hybrid Peptides
2010
CASTp 3.0: computed atlas of surface topography of proteins
2018 Standout
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Peter E. Czabotar being referenced
Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia
2018
Crystal Structure of the Entire Ectodomain of gp130
2010
Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
2015
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations
2019
The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation
2017
Ensemble Properties of Bax Determine Its Function
2018
Bax activation by Bim?
2009
Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices
2009
Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
2015
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
2008
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design
2017
BCL-2 family antagonists for cancer therapy
2008
Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers
2014
Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis
2011
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
2008
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
2013
Physiological restraint of Bak by Bcl-x L is essential for cell survival
2016
High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐xL
2009
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
2009
Cytosolic Bax
2012
Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK
2018
Structural insights into the degradation of Mcl-1 induced by BH3 domains
2007
Molecular biology of Bax and Bak activation and action
2010
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
2007 Science
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
2013
Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity
2012
High‐Resolution Structural Characterization of a Helical α/β‐Peptide Foldamer Bound to the Anti‐Apoptotic Protein Bcl‐xL
2009
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
2018
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
2014
De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-XL: Synthesis, Structural and Biochemical Characterization
2014
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane
2014
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
2008