Citation Impact
Citing Papers
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Cellular Functions of Human RPA1
2008
Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks
2009
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro
2001
The DNA-damage response in human biology and disease
2009 StandoutNature
Cell mechanics and the cytoskeleton
2010 StandoutNature
Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
2000
A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage
1995 StandoutNobel
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
DNA topoisomerase I is involved in both repression and activation of transcription
1993 Nature
In vivo dynamics of RNA polymerase II transcription
2007
Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene
1992 StandoutNobel
A Two-drug Model for Etoposide Action against Human Topoisomerase IIα
2003
Secondary leukemias induced by topoisomerase-targeted drugs
1998
26 S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes
2001
Molecular mechanisms of drug resistance
2005
Cell death induced by topoisomerase-targeted drugs: more questions than answers
1998
Distinct Effects of Topoisomerase I and RNA Polymerase I Inhibitors Suggest a Dual Mechanism of Nucleolar/Nucleoplasmic Partitioning of Topoisomerase I
2004
Using Yeast to Understand Drugs that Target Topoisomerasesa
1996
Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin
2003
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Cloning of the mouse cDNA encoding DNA topoisomerase I and chromosomal location of the gene
1993
Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages
2005
When Checkpoints Fail
1997 StandoutNobel
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents
1992 StandoutNobel
Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes
2003
Histone H1 inhibits eukaryotic DNA topoisomerase I
1991
The Nuclear Ubiquitin-Proteasome System Degrades MyoD
2001 StandoutNobel
Differential Stabilization of Eukaryotic DNA Topoisomerase I Cleavable Complexes by Camptothecin Derivatives
1995 StandoutNobel
The Involvement of DNA-Damage and -Repair Defects in Neurological Dysfunction
2008
DNA Topoisomerase II as a Target for Cancer Chemotherapy
2002
SUMO-1 Conjugation to Human DNA Topoisomerase II Isozymes
2000
SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity
2005
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Binding characteristics of Ustilago maydis topoisomerase I to DNA containing secondary structures
1998
The Crystal Structure of Human Tyrosyl-DNA Phosphodiesterase, Tdp1
2002
Cellular processing pathways contribute to the activation of etoposide-induced DNA damage responses
2008
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
Antitopoisomerase drug action and resistance
1996
Catalytic inhibitors of topoisomerase II are DNA‐damaging agents: induction of chromosomal damage by merbarone and ICRF‐187
2002
DNA Topoisomerases: Essential Enzymes and Lethal Targets
1994
Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative
1991
A Mutation in Yeast TOP2 Homologous to a Quinolone-resistant Mutation in Bacteria
1995
The molecular basis for cell cycle delays following ionizing radiation: a review
1994
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
2003
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Induction of mammalian DNA topoisomerase I and II mediated DNA cleavage by saintopin, a new antitumor agent from fungus
1991
Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites
1991
DNA topoisomerase I and II in cancer chemotherapy: update and perspectives
1993
Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors
1994 StandoutNobel
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
Induction of cleavage in topoisomerase I c-DNA by topoisomerase I enzymes from calf thymus and wheat germ in the presence and absence of camptothecin
1993 StandoutNobel
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
1994 StandoutNobel
Targeting DNA topoisomerase II in cancer chemotherapy
2009 Standout
Human CtIP promotes DNA end resection
2007 Nature
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
2000 Standout
In vitro mutagenesis and functional expression inEscherichia coliof a cDNA encoding the catalytic domain of human DNA ligase I
1991 StandoutNobel
A Protease Pathway for the Repair of Topoisomerase II-DNA Covalent Complexes
2006
Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
2011
A Yeast Type II Topoisomerase Selected for Resistance to Quinolones
1995
Global quantification of mammalian gene expression control
2011 StandoutNature
Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II
2005
Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA
1991
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin
2002
Repair of Topoisomerase I‐Mediated DNA Damage
2006
Camptothecins: from bench research to hospital wards.
1994
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.
1994
Defective G2 checkpoint function in cells from individuals with familial cancer syndromes.
1995
Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication
1991
The Bacterial Cytoskeleton
2003
Mammalian DNA ligases. Catalytic domain and size of DNA ligase I.
1990 StandoutNobel
DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts
1989 Science
DNA?protein crosslinks: their induction, repair, and biological consequences
2005
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
1993 StandoutNobel
Liposomal encapsulation of topotecan enhances anticancer efficacy in murine and human xenograft models.
2000
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.
1994
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.
1994
Cancer Cell Cycles
1996 StandoutScience
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
1995 StandoutNobel
Structure of the human type I DNA topoisomerase gene
1991
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
2001
Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells
2012
Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function
2000
Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae.
1990 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Three-dimensional superresolution colocalization of intracellular protein superstructures and the cell surface in live Caulobacter crescentus
2011 StandoutNobel
Specific DNA cleavage and binding by vaccinia virus DNA topoisomerase I.
1990
Functional complementation of xeroderma pigmentosum complementation group E by replication protein A in an in vitro system.
1996 StandoutNobel
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Induction of mammalian DNA topoisomerase I-mediated DNA cleavage and DNA winding by bulgarein
1993
Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system.
1993
Roles of nonhomologous end-joining pathways in surviving topoisomerase II–mediated DNA damage
2006
Location of the active site for enzyme-adenylate formation in DNA ligases.
1991 StandoutNobel
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.
1989
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Effects of DNA topoisomerase inhibitors on nonhomologous and homologous recombination in mammalian cells
1996
Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma.
1996
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies
2007
Protein Modification by SUMO
2004 Standout
Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function
2000
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A.
1993
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Targeted Disruption of the Mouse Topoisomerase I Gene by Camptothecin Selection
1996 StandoutNobel
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors
1993
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway
2003
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance.
1993
Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.
1994 StandoutNobel
Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II.
1992
DNA Repair Functions That Control Sensitivity to Topoisomerase-Targeting Drugs
2004
SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage
2000
Works of Peter D’Arpa being referenced
Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I
2002
Cell Cycle-Specific and Transcription-Related Phosphorylation of Mammalian Topoisomerase I
1995
Determinants of Cellular Sensitivity to Topoisomerase-Targeting Antitumor Drugs
1994
The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication
1998
Topoisomerase-targeting antitumor drugs
1989
Sumoylation of Topoisomerase I Is Involved in Its Partitioning between Nucleoli and Nucleoplasm and Its Clearing from Nucleoli in Response to Camptothecin
2002
Ubiquitin-dependent Destruction of Topoisomerase I Is Stimulated by the Antitumor Drug Camptothecin
1997
Mechanism of Action of Camptothecin
1996
cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.
1988
Topoisomerase-targeting antitumor drugs: mechanisms of cytotoxicity and resistance.
1992
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.
1990
Replication-dependent and -independent camptothecin cytotoxicity of seven human colon tumor cell lines.
1998
A model for tumor cell killing by topoisomerase poisons.
1990
The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B.
1992