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Citing Papers
Predominant Autoantibody Production by Early Human B Cell Precursors
2003 StandoutScience
IgM Heavy Chain Complementarity-Determining Region 3 Diversity Is Constrained by Genetic and Somatic Mechanisms Until Two Months After Birth
1999
Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.
1990
Peptide-binding specificity of the molecular chaperone BiP
1991 StandoutNatureNobel
Positive and negative selection events during B lymphopoiesis
1995
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Mechanism and Regulation of Immunoglobulin Isotype Switching
1993
Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors
2007 StandoutNobel
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways
1989
Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor
1999 StandoutNobel
Ku80 is required for immunoglobulin isotype switching
1998
The Dynamic Nature of the Antibody Repertoire
1988 Nobel
IgA production without μ or δ chain expression in developing B cells
2001
Reshaping human antibodies for therapy
1988 StandoutNatureNobel
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
1993
Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion
1992 Nature
TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line
1998
Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development
2001
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Analysis of the B-cell progenitor compartment at the level of single cells
1994
Immunoglobulin Class Switching: Molecular and Cellular Analysis
1990
The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice
1994
TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo
2000
Novel B cell population producing functional IgG in the absence of membrane IgM expression
2002
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
1991 StandoutNature
FcϵRI-mediated Induction of Nuclear Factor of Activated T-cells
1995
DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally
1990
Organization and Expression of the Pseudo-Light Chain Genes in Human B-cell Ontogeny
1992
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity
2004
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses
1998
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
2002 Standout
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
1992 StandoutNatureNobel
Clonal selection and learning in the antibody system
1996 StandoutNature
Exploring lymphocyte differentiation pathways
2002
A critical role of λ5 protein in B cell development
1992
Intestinal IgA synthesis: regulation of front-line body defences
2003 StandoutNobel
DNA sequences at immunoglobulin switch region recombination sites
1993
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells
1989 StandoutNatureNobel
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Distinctive Developmental Origins and Specificities of Murine CD5+ B Cells
1994
Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2
1995
Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation
1993
Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.
1994 Nobel
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.
1987
Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes.
1990
Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.
1990
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
1984 StandoutNatureNobel
Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter
1998 StandoutScienceNobel
Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t(14;18)-positive lymphoma
1991 StandoutNobel
Epstein-Barr virus-induced precursor B cell lines from patients with congenital agammaglobulinemia.
1983
Stepwise intraclonal maturation of antibody affinity through somatic hypermutation.
1988
Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.
1984 Nobel
A theory of allelic and isotypic exclusion for immunoglobulin genes.
1982
Two types of immunoglobulin-negative Abelson murine leukemia virus-transformed cells: implications for B-lymphocyte differentiation.
1986
Tγ protein is expressed on murine fetal thymocytes as a disulphide-linked heterodimer
1987 StandoutNatureNobel
Molecular Basis of Heavy-Chain Class Switching and Switch Region Deletion in an Abelson Virus-Transformed Cell Line
1984 Nobel
Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.
1991
Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain
1980
Immunoglobulin chain loss in hybridoma lines.
1980 StandoutNobel
Diversity of immunoglobulin expression in leukaemic cells resembling B-lymphocyte precursors
1981 Nature
Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain
1987 NatureNobel
Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.
1994
Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells.
1991 Nobel
The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.
1990
Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements
1984 StandoutNatureNobel
Idiotype‐Directed Interactions during Ontogeny Play a Major Role in the Establishment of the Adult B Cell Repertoire
1986
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification
1983 StandoutNatureNobel
Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes
1981 Nobel
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
1991
Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch.
1989
Deletions in immunoglobulin mu chains.
1982 StandoutNobel
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes
1981 StandoutNatureNobel
Directed Ig class switch recombination in activated murine B cells.
1987
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
1980 StandoutNatureNobel
Expression of lymphocyte surface IgE does not require switch recombination
1982 StandoutNatureNobel
Mutations, Duplication, and Deletion of Recombined Switch Regions Suggest a Role for DNA Replication in the Immunoglobulin Heavy-Chain Switch
1989
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.
1986
Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors
1985
Unusual organization and diversity of T-cell receptor a-chain genes
1985 StandoutNatureNobel
Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.
1987
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning
1981 StandoutNatureNobel
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter
1986 StandoutNatureNobel
Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa.
1993
The anatomy of T-cell activation and tolerance.
1996
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly
1989 StandoutScienceNobel
Alternate Mucosal Immune System: Organized Peyer’s Patches Are Not Required for IgA Responses in the Gastrointestinal Tract
2000
Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.
1981 Nobel
T-Independent Immune Response: New Aspects of B Cell Biology
2000 StandoutScienceNobel
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
1984 StandoutNatureNobel
Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses
1987
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.
1984
Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.
1990
Structure of the neuraminidase gene in human influenza virus A/PR/8/34
1981 StandoutNatureNobel
λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes
1986 Nature
Exon shuffling generates an immunoglobulin heavy chain gene.
1980 StandoutNobel
Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.
1986
Antigen Receptors on B Lymphocytes
1992
The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo
1994 Science
Immunoglobulin Gene Rearrangement in Immature B Cells
1980 StandoutScienceNobel
Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development
1987
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes
1981 StandoutNatureNobel
Expression of genes of the T-cell antigen receptor complex in precursor thymocytes
1985 Nature
Mutation Drift and Repertoire Shift in the Maturation of the Immune Response
1987 Nobel
Expression of cloned imunoglobulin genes introduced into mouse L cells
1983 StandoutNobel
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
1984 StandoutNatureNobel
Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice
2001 StandoutScienceNobel
Development of the Primary Antibody Repertoire
1987 Science
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Immunoglobulin heavy chain binding protein
1983 Nature
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing
1980 StandoutNatureNobel
The immunoglobulin μ chains of membrane-bound and secreted IgM molecules differ in their C-terminal segments
1980
Mouse pre-B cells synthesize and secrete heavy chains but not light chains
1980
Formation of stable transcription complexes as assayed by analysis of individual templates.
1988
Immune Inhibitory Receptors
2000 Science
Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences
1981 StandoutNatureNobel
Works of Peter D. Burrows being referenced
Partial IgA-Deficiency with Increased Th2-Type Cytokines in TGF-β1 Knockout Mice
1999
B cells are generated throughout life in humans.
1996
Evidence that murine pre-B cells synthesise μ heavy chains but no light chains
1979 Nature
Stage-specific transcription of germline lgH Cγ and Cα regions during human B cell differentiation
1991
B-cell development in man
1993
Human B‐Cell Development
1995
The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors
1997
Mu heavy chains can associate with a pseudo-light chain complex (ψL) in human pre-B cell lines
1989
Switch recombination in normal IgA1+ Blymphocytes.
1994
Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family.
1990
Expression of mu and gamma immunoglobulin heavy chains in different cells of a cloned mouse lymphoid line.
1981
Pre-B Cells: Bone Marrow Persistence in Anti-µ-Suppressed Mice, Conversion to B Lymphocytes, and Recovery after Destruction by Cyclophosphamide
1978
Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus.
1989
Ig DH Gene Segment Transcription and Rearrangement Before Surface Expression of the Pan-B–Cell Marker CD19 in Normal Human Bone Marrow
1997
Immunoglobulin Gene Rearrangements in Pre-B Cells
1987
Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.
1993
Isotype switching in human B lymphocyte malignancies occurs by DNA deletion: evidence for nonspecific switch recombination.
1987
Thirteen hybridomas secreting hapten‐specific immunoglobulin E from mice with Iga or Igb heavy chain haplotype
1981
Partial IgA-deficiency with increased Th2-type cytokines in TGF-beta 1 knockout mice.
1999
Immunoglobulin gene rearrangements and deletions in human Epstein-Barr virus-transformed cell lines producing different IgG and IgA subclasses.
1985
Characterization of B lymphocyte lineage progenitor cells from mice with severe combined immune deficiency disease (SCID) made possible by long term culture.
1987
Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.
1984
A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells
1997
Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.
1992
Pre-B cells: bone marrow persistence in anti-mu-suppressed mice, conversion to B lymphocytes, and recovery after destruction by cyclophosphamide.
1978
Lineage and stage specificity of isotype switching in humans.
1988
Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors.
1995
Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.
1985
Immunoglobulin heavy-chain class switching in a pre-B cell line is accompanied by DNA rearrangement
1983 Nature
Critical test of a sister chromatid exchange model for the immunoglobulin heavy-chain class switch
1985 Nature