Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Beta-globin locus activation regions: conservation of organization, structure, and function.
1990
Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
2010
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Role of chromatin structure in the regulation of transcription by RNA polymerase II
1993
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Hypoxic Regulation of Lactate Dehydrogenase A
1995 StandoutNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Activation by locus control regions?
1999
Lethal α–thalassaemia created by gene targeting in mice and its genetic rescue
1995
Crystal structure of the nucleosome core particle at 2.8 Å resolution
1997 StandoutNature
The role of the near upstream sequence in hypoxia-induced expression of the erythropoietin gene
1996
Purification and Characterization of Hypoxia-inducible Factor 1
1995 StandoutNobel
A locus control region adjacent to the human red and green visual pigment genes
1992
Vascular endothelial growth factor
1996
Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene
1997 StandoutNobel
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
2008 Standout
Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells
2007
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Allelic inactivation regulates olfactory receptor gene expression
1994 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
1990 Nature
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site
1995
Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma
2012
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.
1996 StandoutNobel
Description and Targeted Deletion of 5′ Hypersensitive Site 5 and 6 of the Mouse β-Globin Locus Control Region
1998
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Molecular Genetics of Human Blue Cone Monochromacy
1989 Science
Cotransplantation of ex vivo–expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation
2007
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
1998
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions
1993 StandoutNobel
Erythropoietin enhancer stimulates production of a recombinant protein by Chinese hamster ovary (CHO) cells under hypoxic condition
1997
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Embryonal Carcinoma P19 Cells Produce Erythropoietin Constitutively But Express Lactate Dehydrogenase in an Oxygen-Dependent Manner
1998 StandoutNobel
Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis
1994 StandoutNobel
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
1996 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
1996
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
2005
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
1994
Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.
1992
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.
1995
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
1995
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.
1993 StandoutNobel
The Orphan Receptor Hepatic Nuclear Factor 4 Functions as a Transcriptional Activator for Tissue-Specific and Hypoxia-Specific Erythropoietin Gene Expression and Is Antagonized by EAR3/COUP-TF1
1995
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
A mouse model for beta 0-thalassemia.
1995 StandoutNobel
Chromatin remodeling by nucleosome disassembly in vitro
2006 StandoutNobel
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
1996 StandoutNobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.
1994
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Description and Targeted Deletion of 5′ Hypersensitive Site 5 and 6 of the Mouse β-Globin Locus Control Region
1998
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region
1994
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
1990
High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.
1989
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
1994 Standout
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
1999 StandoutNobel
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction
1993
A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.
1990
Works of Peter Curtin being referenced
Hypoxia-induced in vivo sickling of transgenic mouse red cells.
1991
Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients
2005
Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.
1989
A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer.
1993
A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.
1985
Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1–risk myelodysplastic syndromes with karyotypes other than deletion 5q
2007
Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice.
1992