Citation Impact
Citing Papers
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
2011 Standout
Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity
2006
PTH Stimulates Bone Formation in Mice Deficient in Lrp5
2006
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
2005
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse
2011
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy
2012
p300 Modulates ATF4 Stability and Transcriptional Activity Independently of Its Acetyltransferase Domain
2005
Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED
2015 StandoutNobel
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
2020 StandoutNobel
Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
2022 StandoutNobel
Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors
2009
The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
2010
Noncanonical Wnt-4 Signaling Enhances Bone Regeneration of Mesenchymal Stem Cells in Craniofacial Defects through Activation of p38 MAPK
2007
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene
2006
Novel Modulators of the Growth Hormone - Insulin-Like Growth Factor Axis: Pregnancy-Associated Plasma Protein-A2 and Stanniocalcin-2
2018
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation
2009
Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)
2013 Standout
Can we safely target the WNT pathway?
2014
Insulin- like Growth Factor-Binding Protein Action in Bone Tissue: A Key Role for Pregnancy- Associated Plasma Protein-A
2018
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity
2008 StandoutNobel
Role of wnts in prostate cancer bone metastases
2005
Cancer to bone: a fatal attraction
2011 Standout
From acute ER stress to physiological roles of the Unfolded Protein Response
2006
Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats
2006
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis
2012
Runx2: A master organizer of gene transcription in developing and maturing osteoblasts
2005
The Oxidative Stressor Arsenite Activates Vascular Endothelial Growth Factor mRNA Transcription by an ATF4-dependent Mechanism
2005
FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice
2010
Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton
2007
Increased skeletal VEGF enhances β‐catenin activity and results in excessively ossified bones
2009
R‐spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
2008
Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT
2005
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
GSK-3β Controls Osteogenesis through Regulating Runx2 Activity
2007
Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A
2015
FIAT, the factor‐inhibiting ATF4‐mediated transcription, also represses the transcriptional activity of the bZIP factor FRA‐1
2010
The proteolytic activity of pregnancy-associated plasma protein-A is potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development
2016
Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines
2007
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo
2009
Pathogenesis of myeloma bone disease
2008
Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes
2008
Does osteocytic SOST suppression mediate PTH bone anabolism?
2010
ATF4 regulates lipid metabolism and thermogenesis
2010
The Pathogenesis of Rheumatoid Arthritis
2011 Standout
Lef1ΔN Binds β-Catenin and Increases Osteoblast Activity and Trabecular Bone Mass
2011
Osteoporosis: now and the future
2011 Standout
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Osteoarthritis
2015 Standout
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
2015 Standout
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
2015 Standout
Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
2008
Skeletal remodeling in health and disease
2007 Standout
Cooperative Interactions between Activating Transcription Factor 4 and Runx2/Cbfa1 Stimulate Osteoblast-specific Osteocalcin Gene Expression
2005
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis*
2010
The WTX Tumor Suppressor Regulates Mesenchymal Progenitor Cell Fate Specification
2011
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase‐3β in osteoblastic Saos‐2 cells
2007 StandoutNobel
Wnt/β-Catenin Signaling and Disease
2012 Standout
Secreted frizzled related protein 1 is a target to improve fracture healing
2009
A twist for survival and cancer progression
2005
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
2008
Wnt signaling as a therapeutic target for bone diseases
2009
Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies
2010
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
2009
Leptin regulation of bone resorption by the sympathetic nervous system and CART
2005 Nature
Stanniocalcin-2 Inhibits Mammalian Growth by Proteolytic Inhibition of the Insulin-like Growth Factor Axis
2014
Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting β-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription
2007
Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
2011
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
2005
Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
2005
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
Building strong bones: molecular regulation of the osteoblast lineage
2011
R‐spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway
2010
Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation
2010
Emerging Biological Principles of Metastasis
2017 Standout
T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling
2009
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
2006
EMT: 2016
2016 Standout
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
2007
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
2014 StandoutNature
A Wnt canon orchestrating osteoblastogenesis
2006
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
2005
Regulation of bone mass by Wnt signaling
2006
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
2011
Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element
2005
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
The basics of epithelial-mesenchymal transition
2009 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae
2006
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
2008 Standout
Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis
2004
Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation
2007
COPII and the regulation of protein sorting in mammals
2011 StandoutNobel
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells
2005
Molecular Bases of the Regulation of Bone Remodeling by the Canonical Wnt Signaling Pathway
2006
The Transcription Factor Mef2 Links the Drosophila Core Clock to Fas2, Neuronal Morphology, and Circadian Behavior
2013 StandoutNobel
A core transcriptional network for early mesoderm development in Drosophila melanogaster
2007
The control of chondrogenesis
2005
Mitosin/CENP-F as a Negative Regulator of Activating Transcription Factor-4
2005
SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum
2012 StandoutNobel
Dickkopf-1 is a master regulator of joint remodeling
2007
Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2
2010
Update on Wnt signaling in bone cell biology and bone disease
2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
2008
SATB2 Is a Multifunctional Determinant of Craniofacial Patterning and Osteoblast Differentiation
2006
The integrated stress response
2016 Standout
One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology
2017
2014
The role of Dickkopf-1 in bone development, homeostasis, and disease
2008
Wntless functions in mature osteoblasts to regulate bone mass
2012
Patients with sclerosteosis and disease carriers: Human models of the effect of sclerostin on bone turnover
2011
The two faces of serotonin in bone biology
2010
Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis
2013
In Vivo Analysis of Wnt Signaling in Bone
2007
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1
2007
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation
2007
PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling
2010
ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo
2008
Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis
2010
Activating transcription factor 4
2007
Lrp6 Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd
2008 StandoutNobel
Osteoblast-Targeted Expression of Sfrp4 in Mice Results in Low Bone Mass
2007
Dominance of SOX9 function over RUNX2 during skeletogenesis
2006
Osteoclasts and Arthritis
2009
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
2009
Regulation of basal cellular physiology by the homeostatic unfolded protein response
2010
ATF4 promotes bone angiogenesis by increasing vegf expression and release in the bone environment
2013
Regulation of osteoblastogenesis and bone mass by Wnt10b
2005
Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects
2009
Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
2008
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis
2013
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by β-Catenin
2011
Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density
2008
Gone with the Wnts: β-Catenin, T-Cell Factor, Forkhead Box O, and Oxidative Stress in Age-Dependent Diseases of Bone, Lipid, and Glucose Metabolism
2007
Identification of a Stanniocalcin Paralog, Stanniocalcin-2, in Fish and the Paracrine Actions of Stanniocalcin-2 in the Mammalian Ovary
2004
Update in New Anabolic Therapies for Osteoporosis
2010
Regulation and function of the RSK family of protein kinases
2011
Distinct roles for Hedgehog and canonical Wnt signaling in specification,differentiation and maintenance of osteoblast progenitors
2006
N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms
2010
TREM2 and β-Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis
2012
From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis
2010 Standout
The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation
2005
Bone Metastases: Molecular Mechanisms and Novel Therapeutic Interventions
2010
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
2004
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Geometric cues for directing the differentiation of mesenchymal stem cells
2010 Standout
Perspective: Cell–Cell Adhesion and Signaling Through Cadherins: Connecting Bone Cells in Their Microenvironment
2006
Regulation of bone formation and remodeling by G-protein-coupled receptor 48
2009
Multiple Myeloma
2011 Standout
Directed evolution methods for overcoming trade‐offs between protein activity and stability
2019
Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass
2006
Axin2 controls bone remodeling through the β-catenin–BMP signaling pathway in adult mice
2009
Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro
2006
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Dominant Negative N-Cadherin Inhibits Osteoclast Differentiation by Interfering With β-Catenin Regulation of RANKL, Independent of Cell-Cell Adhesion
2005
PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification
2013
Epithelial-Mesenchymal Transition and Cell Cooperativity in Metastasis
2009
Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress
2011
Orally Bioavailable GSK-3α/β Dual Inhibitor Increases Markers of Cellular Differentiation In Vitro and Bone Mass In Vivo
2006
Works of Peter Bialek being referenced
ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology
2004
Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation
2005
A Twist Code Determines the Onset of Osteoblast Differentiation
2004
Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody
2016
A Novel Role for Twist-1 in Pulp Homeostasis
2007
Overexpression of Human Stanniocalcin Affects Growth and Reproduction in Transgenic Mice
2002