Citation Impact
Citing Papers
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
Contributions by MutL Homologues Mlh3 and Pms2 to DNA Mismatch Repair and Tumor Suppression in the Mouse
2005
Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in Europe
2012 Science
Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair
2007 StandoutNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
2005 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates
2006
An integrated map of genetic variation from 1,092 human genomes
2012 StandoutNature
HIF and fumarate hydratase in renal cancer
2007
Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe
2018 StandoutNobel
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
2002 Nature
TGF-β and cancer
1999
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
2010 StandoutNobel
A role for mitochondrial enzymes in inherited neoplasia and beyond
2003
De novo germline mutation in the serine–threonine kinase STK11/LKB1 gene associated with Peutz–Jeghers syndrome
2004
Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response
2010
Role of Transforming Growth Factor β in Human Disease
2000 Standout
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
1995
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC
1997
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients
1996
Mitochondrial genome variation and the origin of modern humans
2000 StandoutNatureNobel
The genomic landscape of Neanderthal ancestry in present-day humans
2014 StandoutNatureNobel
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
Mutations in the Fumarate Hydratase Gene Cause Hereditary Leiomyomatosis and Renal Cell Cancer in Families in North America
2003
Genetic pathways in colorectal and other cancers
1999
From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family
2003
Familial Cutaneous Leiomyomatosis Is a Two-Hit Condition Associated with Renal Cell Cancer of Characteristic Histopathology
2001
Genetic predisposition, environment and cancer incidence: A nationwide twin study in Finland, 1976-1995
1999
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
PTEN: One Gene, Many Syndromes
2003
A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 ( SMAD4)
2004 Standout
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
2000
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
2007 Standout
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
Putting tumours in context
2001 Standout
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
2001
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Mitochondrial tumour suppressors: a genetic and biochemical update
2005
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
1996
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer
2005
The Molecular Basis of Turcot's Syndrome
1995
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Searching for the hereditary causes of renal-cell carcinoma
2004
Substrate Binding Tunes Conformational Flexibility and Kinetic Stability of an Amino Acid Antiporter
2009
Non–coding RNA genes and the modern RNA world
2001
Constipation, polyps, or cancer? let PTEN predict your future
2003
Hereditary Colorectal Cancer
2003 Standout
LKB1; linking cell structure and tumor suppression
2008
An early modern human from Romania with a recent Neanderthal ancestor
2015 StandoutNatureNobel
Signaling of transforming growth factor‐β family members through Smad proteins
2000
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
1999
Genetics of Peutz-Jeghers Syndrome, Carney Complex and Other Familial Lentiginoses
2000
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Epithelial-Mesenchymal Transition
2009
The LKB1 tumor suppressor negatively regulates mTOR signaling
2004
The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
1999
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome
2001
Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency
2003
mtDNA Analysis Reveals a Major Late Paleolithic Population Expansion from Southwestern to Northeastern Europe
1998
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase
2003
Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
2000 Standout
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Perspectives of identity by descent (IBD) mapping in founder populations
1995
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
TGF-β signaling by Smad proteins
2000
The Human Condition—A Molecular Approach
2014 StandoutNobel
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling
2004
microRNAs
2001 StandoutNobel
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
2010
TGF-β signaling by Smad proteins
2000
Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer
2003
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway
2000
Lynch Syndrome Genes
2005
Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
2000
Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population.
1996 StandoutNobel
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal
2014 StandoutNobel
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.
2002
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Pten is essential for embryonic development and tumour suppression
1998 Standout
Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
2009
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
2003 Standout
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells
1999
Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
1999
Colorectal carcinoma survival among hereditary nonpolyposis colorectal carcinoma family members
1998
Review
1995
Nuclear and mitochondrial DNA sequences from two Denisovan individuals
2015 StandoutNobel
Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch Repair
2005
Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction
1999
Ribosomopathies: human disorders of ribosome dysfunction
2010
Chemokine ReceptorCXCR4Expression in Colorectal Cancer Patients Increases the Risk for Recurrence and for Poor Survival
2005
Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators
1999 Science
Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation
2013 StandoutNobel
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Genetics of Cowden syndrome: through the looking glass of oncology.
1998
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
TbetaR-I(6A) is a candidate tumor susceptibility allele.
1999
STEM CELL NICHE: Structure and Function
2005
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
TGF-β and cancer
2005
Dysregulation of the TSC-mTOR pathway in human disease
2004 Standout
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Genetic Testing for Cancer Predisposition
2001
Works of Pertti Sistonen being referenced
Diagnosis of Twin Zygosity by Mailed Questionnaire
1978
Little evidence for involvement of MLH3 in colorectal cancer predisposition
2003
Worldwide mutation spectrum in cartilage-hair hypoplasia: ancient founder origin of the major70A→G mutation of the untranslated RMRP
2002
Linkage Disequilibrium Mapping of the Cornea Plana Congenita Gene CNA2
1995
Common Deletion of SMAD4 in Juvenile Polyposis Is a Mutational Hotspot
2002
Y chromosomal polymorphisms reveal founding lineages in the Finns and the Saami
1999
SMAD genes in juvenile polyposis
1999
Lysinuric Protein Intolerance (LPI) Gene Maps to the Long Arm of Chromosome 14
1997
Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer
1994
High-Resolution Genetic Mapping of the Cartilage-Hair Hypoplasia (CHH) Gene in Amish and Finnish Families
1994
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
1997
Cohen syndrome gene assigned to the long arm of chromosome 8 by linkage analysis
1994
Cartilage-hair hypoplasia gene assigned to chromosome 9 by linkage analysis
1993
Swedish Population Substructure Revealed by Genome-Wide Single Nucleotide Polymorphism Data
2011
Regional differences among the Finns: A Y-chromosomal perspective
2006
Genome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe
2008
Cornea plana congenita gene assigned to the long arm of chromosome 12 by linkage analysis
1995
Inherited susceptibility to uterine leiomyomas and renal cell cancer
2001
mtDNA Haplotype Analysis in Finnish Families with Leber Hereditary Optic Neuroretinopathy
1997
Low-level microsatellite instability in most colorectal carcinomas.
2002
mtDNA haplotype analysis in Finnish families with leber hereditary optic neuroretinopathy.
1998
Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis
1998 Science