Standout Papers
Citation Impact
Citing Papers
Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling
2005
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Sensitization of Human Carcinoma Cells to Alkylating Agents by Small Interfering RNA Suppression of 3-Alkyladenine-DNA Glycosylase
2005 StandoutNobel
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
2011 StandoutScience
NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer
2010 StandoutNobel
Direct Removal of Alkylation Damage from DNA by AlkB and Related DNA Dioxygenases
2006 StandoutNobel
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
2002
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Targeting histone lysine demethylases — Progress, challenges, and the future
2014
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
2015 StandoutNobel
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
2011 StandoutNobel
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
Base-excision repair of oxidative DNA damage
2007 StandoutNature
Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA
2006
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents
2007
ALKBH1-Mediated tRNA Demethylation Regulates Translation
2016
Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
2009
Human Genetics Shape the Gut Microbiome
2014 Standout
AlkB dioxygenase in preventing MMS-induced mutagenesis in Escherichia coli: Effect of Pol V and AlkA proteins
2005
The interacting pathways for prevention and repair of oxidative DNA damage
2003
Inhibition of 2-oxoglutarate dependent oxygenases
2011
Epigenetic reprogramming in mammals
2005
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
2008 Nature
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging
2008
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
DNA repair pathways as targets for cancer therapy
2008
AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation
2004
Expression and sub‐cellular localization of human ABH family molecules
2007
Substrate specificities of bacterial and human AlkB proteins
2004
Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies
2004
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
2015 Standout
Dynamic RNA Modifications in Gene Expression Regulation
2017 Standout
Alkylation damage in DNA and RNA—repair mechanisms and medical significance
2004
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
2011 StandoutNobel
DNA Damage, Aging, and Cancer
2009 Standout
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
2003
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo
2005
C → T mutagenesis and γ‐radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases
2005 StandoutNobel
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA
2011
Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues
2005
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
2012 Standout
Human AlkB Homolog 1 Is a Mitochondrial Protein That Demethylates 3-Methylcytosine in DNA and RNA
2008
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
2017
Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations
2009 StandoutNobel
Human AlkB Homologue 5 Is a Nuclear 2-Oxoglutarate Dependent Oxygenase and a Direct Target of Hypoxia-Inducible Factor 1α (HIF-1α)
2011 StandoutNobel
The AlkB Domain of Mammalian ABH8 Catalyzes Hydroxylation of 5‐Methoxycarbonylmethyluridine at the Wobble Position of tRNA
2010
Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins
2004
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
The intricate structural chemistry of base excision repair machinery: Implications for DNA damage recognition, removal, and repair
2007
Mycobacterium tuberculosis Rv3406 Is a Type II Alkyl Sulfatase Capable of Sulfate Scavenging
2013 StandoutNobel
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage
2006
Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB
2006 Nature
Evidence for the slow reaction of hypoxia‐inducible factor prolyl hydroxylase 2 with oxygen
2010
Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis
2007 StandoutNobel
DNA repair by bacterial AlkB proteins
2003
Oxidative demethylation of 3‐methylthymine and 3‐methyluracil in single‐stranded DNA and RNA by mouse and human FTO
2008
Impaired placental trophoblast lineage differentiation in Alkbh1−/− mice
2007
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Crystal structure of the FTO protein reveals basis for its substrate specificity
2010 Nature
Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites
2009
Repair of alkylated DNA: Recent advances
2006 StandoutNobel
Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome
2016
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
Fe(II)/α-Ketoglutarate-Dependent Hydroxylases and Related Enzymes
2004
Repair of methyl lesions in DNA and RNA by oxidative demethylation
2006
Who's on first in the cellular response to DNA damage?
2003
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
2013 Standout
Structural studies on human 2-oxoglutarate dependent oxygenases
2010
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
2008 Standout
Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors
2010
Repairing DNA-methylation damage
2004
Cloning and Characterization of Rhodotorula glutinis Thymine Hydroxylase
2009
Trends in Obesity Among Adults in the United States, 2005 to 2014
2016 Standout
Non-Heme Fe(IV)–Oxo Intermediates
2007 Standout
High Expression of a New Marker PCA-1 in Human Prostate Carcinoma
2005
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases
2015 StandoutNobel
Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine inalkB Escherichia coli
2004
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Direct Repair of the Exocyclic DNA Adduct 1,N6-Ethenoadenine by the DNA Repair AlkB Proteins
2005
2-Oxoglutarate-Dependent Oxygenases
2018
Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
2009
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
2004 StandoutNobel
Reporter Ligand NMR Screening Method for 2-Oxoglutarate Oxygenase Inhibitors
2012
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
DNA Double-Strand Breaks
2002 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Direct Reversal of DNA Alkylation Damage
2006
Preparation and Characterization of the Native Iron(II)-Containing DNA Repair AlkB Protein Directly fromEscherichia coli
2004
Works of Pertti Koivisto being referenced
Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases
2004 StandoutNobel
Butadiene diolepoxide- and diepoxybutane-derived DNA adducts at N7-guanine: a high occurrence of diolepoxide-derived adducts in mouse lung after 1,3-butadiene exposure
1999
Minimal Methylated Substrate and Extended Substrate Range of Escherichia coli AlkB Protein, a 1-Methyladenine-DNA Dioxygenase
2003 StandoutNobel
Dynamic states of the DNA repair enzyme AlkB regulate product release
2008
Reversal of DNA alkylation damage by two human dioxygenases
2002 StandoutNobel