Citation Impact
Citing Papers
Formation and properties of C1‐inhibitor polymers
1995
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Recombinant human pigment epithelium‐derived factor (PEDF): Characterization of PEDF overexpressed and secreted by eukaryotic cells
1996
Human Ovalbumin Serpin Evolution: Phylogenic Analysis, Gene Organization, and Identification of New PI8-Related Genes Suggest That Two Interchromosomal and Several Intrachromosomal Duplications Generated the Gene Clusters at 18q21–q23 and 6p25
1999
Linkage between the Hormone Binding Site and the Reactive Center Loop of Thyroxine Binding Globulin
2000
Structural Mechanisms for Domain Movements in Proteins
1994
Serine 380 (P14) → Glutamate Mutation Activates Antithrombin as an Inhibitor of Factor Xa
2000
Structural aspects of serpin inhibition
1994 Nobel
Murine Heparin Cofactor II: Purification, cDNA Sequence, Expression, and Gene Structure
1994
Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin
1997
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
1993 StandoutNobel
Pigment Epithelium-derived Factor Behaves Like a Noninhibitory Serpin
1995
MENT, a Heterochromatin Protein That Mediates Higher Order Chromatin Folding, Is a New Serpin Family Member
1999
Interaction of subtilisins with serpins
1996
Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates
1995
Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands
2000 Nature
A Role for Corticosteroid-Binding Globulin in Delivery of Cortisol to Activated Neutrophils*
1990
Lysine Residue 114 in Human Antithrombin III Is Required for Heparin Pentasaccharide-mediated Activation
1997
The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions
1994
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins
1992
Crystal structure of an uncleaved α1‐antitrypsin reveals the conformation of its inhibitory reactive loop
1995
Plasminogen‐activator inhibitor type 2 (PAI‐2) is a spontaneously polymerising SERPIN
1993
Neurotransmitter action: Opening of ligand-gated ion channels
1993
Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed and reactive site cleaved serpins: comparison of .alpha.1-proteinase inhibitor, .alpha.1-antichymotrypsin, antithrombin III, .alpha.2-antiplasmin, angiotensinogen, and ovalbumin
1991
Structural basis for serpin inhibitor activity
1995
A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms
2008 StandoutNobel
Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family
1995
Mechanism of Heparin Activation of Antithrombin
1998
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Loop-inserted and thermostabilized structure of P1-p1′ cleaved ovalbumin mutant R339T 1 1Edited by R. Huber
2002
Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase
1996
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria
2009
Kinetics versus Thermodynamics in Protein Folding
1994 StandoutNobel
Interaction between the P14 Residue and Strand 2 of β-Sheet B Is Critical for Reactive Center Loop Insertion in Plasminogen Activator Inhibitor-2
2001
The crystal structure of plasminogen activator inhibitor 2 at 2.0 Å resolution: implications for serpin function
1999
A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1
1995
The Molecular Interactions of Heat Shock Protein 47 (Hsp47) and Their Implications for Collagen Biosynthesis
2001
Molecular Cloning of Bomapin (Protease Inhibitor 10), a Novel Human Serpin That Is Expressed Specifically in the Bone Marrow
1995
Requirement of Lysine Residues Outside of the Proposed Pentasaccharide Binding Region for High Affinity Heparin Binding and Activation of Human Antithrombin III
1996
Additivity in Effects of Vitronectin and Monoclonal Antibodies against α-Helix F of Plasminogen Activator Inhibitor-1 on Its Reactions with Target Proteinases
2004
Preparation and Characterization of Latent α1-Antitrypsin
1995
.alpha.1-Proteinase Inhibitor Variant T345R. Influence of P14 Residue on Substrate and Inhibitory Pathways
1994
The structural puzzle of how serpin serine proteinase inhibitors work
1996
Refined X-ray crystallographic structure of the poliovirus 3C gene product 1 1Edited By D. Rees
1997
The structure of active serpin 1K from Manduca sexta
1999
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
Stopped Flow Fluorescence Energy Transfer Measurement of the Rate Constants Describing the Reversible Formation and the Irreversible Rearrangement of the Elastase-α1-Proteinase Inhibitor Complex
1998
S‐ovalbumin, an ovalbumin conformer with properties analogous to those of loop‐inserted serpins
1995
Implications for function and therapy of a 2.9 å structure of binary-complexed antithrombin
1998
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
2000
Kinetic Characterization of the Proteinase Binding Defect in a Reactive Site Variant of the Serpin, Antithrombin
1995
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Evidence for the extent of insertion of the active site loop of intact .alpha.1 proteinase inhibitor in .beta.-sheet A
1992 Nobel
Topology of the Stable Serpin-Protease Complexes Revealed by an Autoantibody That Fails to React with the Monomeric Conformers of Antithrombin
1999
Characterization of Cucurbita maxima Phloem Serpin-1 (CmPS-1)
2000
Cleaved antitrypsin polymers at atomic resolution
2000
Engineering Plasminogen Activator Inhibitor 1 Mutants with Increased Functional Stability
1994
Crystal structure of the apoptotic suppressor CrmA in its cleaved form
2000
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
Alpha plus beta folds revisited: some favoured motifs
1993
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
Identification of a Nuclear Targeting Domain in the Insertion between Helices C and D in Protease Inhibitor-10
1999
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
The Z type variation of human α1-antitrypsin causes a protein folding defect
1995
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
The Conformational Activation of Antithrombin
2000
Heparin Enhances the Specificity of Antithrombin for Thrombin and Factor Xa Independent of the Reactive Center Loop Sequence
2001
Serpin α1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy
1996
Protein folding in the landscape perspective: Chevron plots and non-arrhenius kinetics
1998
The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion
1994 StandoutNobel
A 2.1 Å resolution structure of an uncleaved α1-antitrypsin shows variability of the reactive center and other loops11Edited by R. Huber
2001
Evidence That Translocation of the Proteinase Precedes Its Acylation in the Serpin Inhibition Pathway
2000
Helix D Elongation and Allosteric Activation of Antithrombin
2002
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved α1-antitrypsin at 2.7 å
1996
Effects of mutations in the hinge region of serpins
1993
Importance of the Hinge Region between α-Helix F and the Main Part of Serpins, Based upon Identification of the Epitope of Plasminogen Activator Inhibitor Type 1 Neutralizing Antibodies
2000
Identification of centerin: a novel human germinal center B cell-restricted serpin
2000
Sialic acid-specific lectins: occurrence, specificity and function
2006
Searching protein structure databases has come of age
1994
Not your average density
1997
Arginine substitutions in the hinge region of antichymotrypsin affect serpin β-sheet rearrangement
1996
Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage
2000
Crystal Structure of the Complex of Plasminogen Activator Inhibitor 2 with a Peptide Mimicking the Reactive Center Loop
2001
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin
1990
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
2000
Role of Arginine 129 in Heparin Binding and Activation of Antithrombin
2000
Peptide‐Based Inhibitors of Amyloid Assembly
2006
Structural basis of latency in plasminogen activator inhibitor-1
1992 Nature
Influence of the P5 Residue on α1-Proteinase Inhibitor Mechanism
1998
Crystal structure of cleaved human α1-antichymotrypsin at 2.7 å resolution and its comparison with other serpins
1991 Nobel
Vectorial delivery of macromolecules into cells using peptide-based vehicles
2001
A serpin‐induced extensive proteolytic susceptibility of urokinase‐type plasminogen activator implicates distortion of the proteinase substrate‐binding pocket and oxyanion hole in the serpin inhibitory mechanism
2001
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
AB5 toxins: structures and inhibitor design
2000
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease
2001
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Antithrombin Cambridge II, 384 Ala to Ser Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins
1991
The 2.6 Å structure of antithrombin indicates a conformational change at the heparin binding site 1 1Edited by R. Huber
1997
Heterologous Expression of Three Plant Serpins with Distinct Inhibitory Specificities
1996
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1·95Å resolution
1992
Conformational Change and Intermediates in the Unfolding of α1-Antichymotrypsin
2000
The Solution Structure of the S1 RNA Binding Domain: A Member of an Ancient Nucleic Acid–Binding Fold
1997
A spring-loaded mechanism for the conformational change of influenza hemagglutinin
1993
Genetics and respiratory disease bullet 2: Alpha1-antitrypsin deficiency, cirrhosis and emphysema
1998
The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides
1995
Purified native subunits of bacterial luciferase are active in the bioluminescence reaction but fail to assemble into the .alpha..beta. structure
1993
Characterization of a Human α1-Antitrypsin Variant That Is as Stable as Ovalbumin
1998
The mechanism of Z α1-antitrypsin accumulation in the liver
1992 Nature
C1 inhibitor hinge region mutations produce dysfunction by different mechanisms
1992
Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition
2022
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo
1998 StandoutNobel
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
1998
Inhibitory conformation of the reactive loop of α1-antitrypsin
1996
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Conversion of .alpha.1-Antichymotrypsin into a Human Neutrophil Elastase Inhibitor: Demonstration of Variants with Different Association Rate Constants, Stoichiometries of Inhibition, and Complex Stabilities
1994
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Crystal structure of the 30 s ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 s RNA
2002 StandoutNobel
Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity 1 1Edited by D. Rees
2001
Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor‐1 and the arginine‐specific proteinases trypsin, LMW u‐PA, HMW u‐PA, and t‐PA: Use of site‐specific fluorescent probes of local environment
2002
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Formation of the Covalent Chymotrypsin·Antichymotrypsin Complex Involves No Large-scale Movement of the Enzyme
2001
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
2004
Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein
1998
Role of Arginine 132 and Lysine 133 in Heparin Binding to and Activation of Antithrombin
1996
Natural protein proteinase inhibitors and their interaction with proteinases
1992 Nobel
Specificity of Serine Proteinase/Serpin Complex Binding to Very‐Low‐Density Lipoprotein Receptor and α2‐Macroglobulin Receptor/Low‐Density‐Lipoprotein‐Receptor‐Related Protein
1997
Study of the Structural Dynamics of the E. coli 70S Ribosome Using Real-Space Refinement
2003 StandoutNobel
Principles determining the structure of β-sheet barrels in proteins II. The observed structures
1994
A 2.6 å structure of a serpin polymer and implications for conformational disease 1 1Edited by R. Huber
1999
Alzheimer's Peptide Aβ1–42 Binds to Two β-Sheets of α1-Antichymotrypsin and Transforms It from Inhibitor to Substrate
1998
Wild-type α1-antitrypsin is in the canonical inhibitory conformation
1998
Bypassing the kinetic trap of serpin protein folding by loop extension
2000
Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop
1994
Apparent Formation of Sodium Dodecyl Sulfate-stable Complexes between Serpins and 3,4-Dichloroisocoumarin-inactivated Proteinases Is Due to Regeneration of Active Proteinase from the Inactivated Enzyme
1997
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Significance of secondary structure predictions on the reactive center loop region of seprins: a model for the folding of serpins into a metastable state
1996
Lung Polymers in Z α 1 -Antitrypsin Deficiency-related Emphysema
1998
Major proteinase movement upon stable serpin–proteinase complex formation
1997
The anticoagulant activation of antithrombin by heparin
1997
Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor.
1992
The sequences of small proteins are not extensively optimized for rapid folding by natural selection
1998 StandoutNobel
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin involved in virulence
2001
Characterization of recombinant C1 inhibitor P1 variants.
1992
A hinge region mutation in C1-inhibitor (Ala436–>Thr) results in nonsubstrate-like behavior and in polymerization of the molecule.
1993
Serpin Structure, Mechanism, and Function
2002 Standout
Visualization of protein S1 within the 30S ribosomal subunit and its interaction with messenger RNA
2001 StandoutNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
A major estrogen-regulated protein secreted from the liver of Xenopus laevis is a member of the serpin superfamily. Nucleotide sequence of cDNA and hormonal induction of mRNA.
1992
OB(oligonucleotide/oligosaccharide binding)-fold: common structural and functional solution for non-homologous sequences.
1993
The catabolism of intact, reactive centre-cleaved and proteinase-complexed C1 inhibitor in the guinea pig
1996
Chemical Glycobiology
2001 StandoutScienceNobel
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
1994
The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.
1991
Overexpression of angiotensin AT 1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block
1997 StandoutNobel
Localization of vitronectin binding domain in plasminogen activator inhibitor-1.
1994
Proposed three-dimensional structure for the cellular prion protein.
1994 StandoutNobel
Crystal Structure of an Initiation Factor Bound to the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
Maspin acts at the cell membrane to inhibit invasion and motility of mammary and prostatic cancer cells.
1996
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
2000 StandoutNobel
Salmon antithrombin has only three carbohydrate side chains, and shows functional similarities to human β‐antithrombin
2000
The cardiac renin-angiotensin system. An appraisal of present experimental and clinical evidence.
1991
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
Protease specificity and heparin binding and activation of recombinant protease nexin I.
1991
Molecular evolution of plasminogen activator inhibitor-1 functional stability.
1995
Leukocyte chemoattractant peptides from the serpin heparin cofactor II.
1991
Neuroserpin, an axonally secreted serine protease inhibitor.
1996
Structure of a serpin–protease complex shows inhibition by deformation
2000 Nature
Common themes in microbial pathogenicity revisited
1997 Standout
Antichymotrypsin interaction with chymotrypsin. Partitioning of the complex.
1993
Single amino acid substitutions of alpha 1-antitrypsin that confer enhancement in thermal stability
1994
Inactive conformation of the serpin α1-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational disease
2000
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
1994
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
1998 StandoutScienceNobel
A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.
1994
Inactivation of papain by antithrombin due to autolytic digestion: a model of serpin inactivation of cysteine proteinases
1998
Molecular biology of angiotensinogen.
1991
Kinetic characterization of the substrate reaction between a complex of antithrombin with a synthetic reactive-bond loop tetradecapeptide and four target proteinases of the inhibitor.
1992
Chemically tunable mucin chimeras assembled on living cells
2015 StandoutNobel
Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants
1990
Ligand binding: proteinase-protein inhibitor interactions
1991 Nobel
Isolation and characterization of a novel human pancreas-specific gene,pancpin, that is down-regulated in pancreatic cancer cells
1998
Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor
1998
The necrotic Gene in Drosophila Corresponds to One of a Cluster of Three Serpin Transcripts Mapping at 43A1.2
2000
The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins
2001
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)
1994
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.
1994
TAPping into mRNA Export
2001 StandoutScienceNobel
Imaging the glycome
2008 StandoutNobel
Molecular cloning of a serine proteinase inhibitor from Brugia malayi
1995
Molecular recognition
1991
Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties.
1993
Crystal Structure of Hemolin: A Horseshoe Shape with Implications for Homophilic Adhesion
1998 Science
Kinetically Controlled Folding of the Serpin Plasminogen Activator Inhibitor 1
1996
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
A unified statistical framework for sequence comparison and structure comparison
1998 StandoutNobel
The SEC receptor recognizes a pentapeptide neodomain of alpha 1-antitrypsin-protease complexes
1991
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
The Reaction of Serpins with Proteinases Involves Important Enthalpy Changes
2001
Serpins in theCaenorhabditis elegans genome
1999
Clustering of low-energy conformations near the native structures of small proteins
1998 StandoutNobel
Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
2014 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
2002 StandoutNobel
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism
2002
Works of Penelope E. Stein being referenced
Dysfunctional Variants and the Structural Biology of the Serpins
1997
Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli
1992 Nature
How Small Peptides Block and Reverse Serpin Polymerisation
2004
Mobile reactive centre of serpins and the control of thrombosis
1991 Nature
Serpin tertiary structure transformation
1991
The crystal structure of pertussis toxin
1994
Crystal structure of ovalbumin as a model for the reactive centre of serpins
1990 Nature
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion
1999
Crystal structure of uncleaved ovalbumin at 1·95 Å resolution
1991
What do dysfunctional serpins tell us about molecular mobility and disease?
1995
Structure of a pertussis toxin–sugar complex as a model for receptor binding
1994
Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity
1993
Hormone binding globulins undergo serpin conformational change in inflammation
1988 Nature
Correction: Mobile reactive centre of serpins and the control of thrombosis
1993 Nature
Biological implications of a 3 å structure of dimeric antithrombin
1994
Effect of angiotensin on myocardial function
1970
Ovalbumin and angiotensinogen lack serpin S–R conformational change
1989
Review
1996