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Citing Papers
6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding.
1987
DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task
2000 StandoutNobel
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
1997 StandoutNature
Correlates of physical activity: why are some people physically active and others not?
2012 Standout
Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice
1999 StandoutNobel
Getting Formal with Dopamine and Reward
2002 Standout
Association of dopamine d, and d2 receptors with specific cellular elements in the basal ganglia of the cat: The uneven topography of dopamine receptors in the striatum is determined by intrinsic striatal cells, not nigrostriatal axons
1988
The selective dopamine antagonist properties of BRL 34778: a novel substituted benzamide
1988 StandoutNobel
Forebrain substrates of reward and motivation
2005
Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids
2015
Dopamine Receptor Subtype Agonists and Feeding Behavior
1995
Asymmetric Catalysis by Chiral Hydrogen‐Bond Donors
2006 Standout
Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes
1993
Memory enhancement by post-training peripheral administration of low doses of dopamine agonists: Possible autoreceptor effect
1993
Behavioural evidence for “D-1-like” dopamine receptor subtypes in rat brain using the new isochroman agonist A 68930 and isoquinoline antagonist BW 737C
1993
Addictive Drugs and Brain Stimulation Reward
1996
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
GPCR functional selectivity has therapeutic impact
2007
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
1990 StandoutNature
Dopamine receptors mediate alterations in striato-nigral dynorphin and substance p pathways
1987
Partial and full dopamine D1 receptor agonists in mice and rats: relation between behavioural effects and stimulation of adenylate cyclase activity in vitro
1992
Postsynaptic dopamine (DA) receptor stimulator properties of the putative DA autoreceptor-selective agonist B-HT 920 uncovered by co-treatment with the D-1 agonist SK&F 38393
1987 StandoutNobel
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
2005 StandoutNature
Dopamine D1 Agonist SKF 38393 Increases the State of Phosphorylation of ARPP‐21 in Substantia Nigra
1993 StandoutNobel
Drugs acting on brain dopamine receptors: A conceptual re-evaluation five years after the first selective D-1 antagonist
1989
Receptor Subtypes in Opioid and Stimulant Reward
1992
From Ionic Currents to Molecular Mechanisms
2000 Standout
Neurobiology of Depression
2002 Standout
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
Antipsychotic Properties of the Partial Dopamine Agonist (−)-3-(3-Hydroxyphenyl)-N-n-Propylpiperidine (Preclamol) in Schizophrenia
1998 StandoutNobel
Azetidine derivatives as novel γ-aminobutyric acid uptake inhibitors: Synthesis, biological evaluation, and structure–activity relationship
2010
Dissociating the effects of altered dopaminergic function on performance and learning
1989
Effects of Pharmacological Agents upon a Transgenic Model of Parkinson’s Disease in Drosophila melanogaster
2002
Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions
1994
Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat.
1989
Tyrosine 140 of the γ-Aminobutyric Acid Transporter GAT-1 Plays a Critical Role in Neurotransmitter Recognition
1997
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons
1995 StandoutNobel
Evidence for a Distinct D1Like Dopamine Receptor that Couples to Activation of Phosphoinositide Metabolism in Brain
1994
Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications
1987
Localization of drug reward mechanisms by intracranial injections
1992
Role of D1 and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats
1989
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice
2003 StandoutNobel
The Pyrrolo[2,1-a]isoquinoline Alkaloids
2011
Dopamine in Motivational Control: Rewarding, Aversive, and Alerting
2010 Standout
Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception
1996
Drug Dependence, a Chronic Medical Illness
2000 Standout
DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats
1997
Dopamine receptors: Molecular biology, biochemistry and behavioural aspects
1994
Parkinson's Disease
2003 Standout
Neural Mechanisms of the Reinforcing Action of Cocaine
1984
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases
1996 StandoutNobel
In vivo receptor binding, neurochemical and functional studies with the dopamine D-1 receptor antagonist SCH 23390
1988 StandoutNobel
Two dopamine receptors: Biochemistry, physiology and pharmacology
1984
Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization
1980
Pharmacological Specificity of Conditioned Avoidance Response Inhibition in Rats: Inhibition by Neuroleptics and Correlation to Dopamine Receptor Blockade
1982
Iron Catalysis in Organic Synthesis
2015 Standout
Topography of substantia nigra innervation by D1 receptor-containing striatal neurons
1987
Catalytic Asymmetric Additions of Enol Silanes to In Situ Generated Cyclic, AliphaticN‐Acyliminium Ions
2021 StandoutNobel
A Neural Substrate of Prediction and Reward
1997 StandoutScience
Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor
1981 Nature
The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity
1984
Functional evidence for selective dopamine D-1 receptor blockade by SCH 23390
1984
Neurogenetic Adaptive Mechanisms in Alcoholism
1987 StandoutScience
Stereoselective Synthesis of An Isoquinolinopyrrolidinone by Acyliminium Ion Cyclization of Chiral Hydroxylactams
1995
Electrophysiological evidence for the existence of both D-1 and D-2 dopamine receptors in the rat nucleus accumbens
1986
Characterization of dopamine autoreceptor and [3H]spiperone binding sites in vitro with classical and novel dopamine receptor agonists
1983
Effect of dopamine D-1 and D-2 receptor selective drugs on dopamine release and metabolism in rat striatum in vivo
1986
Opposing Roles of Dopamine D1 and D2 Receptors in Nigral γ‐[3H]Aminobutyric Acid Release?
1987
Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food
1978 Science
Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum
1981 Nature
Selective D1 and D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions
1987
Evidence for a stepwise mechanism in formal hetero-Diels-Alder reactions of N-arylimines
1996
D 1 Dopamine Receptor Activation Required for Postsynaptic Expression of D 2 Agonist Effects
1987 Science
Self-stimulation response decrement patterns differentiate clonidine, baclofen and dopamine antagonists from drugs causing performance deficit
1982
Intracellular studies on the dopamine-induced firing inhibition of neostriatal neurons in vitro: Evidence for D1 receptor involvement
1987
Asymmetric synthesis of both enantiomers of novel tetracyclic heterocycle, furo[3′,2′:2,3]pyrrolo[2,1-a]isoquinoline derivative via a diastereoselective N-acyliminium ion cyclization
1997
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
1980 StandoutNatureNobel
Thermoregulatory cold-defense deficits in rats with preoptic/anterior hypothalamic lesions
1976
SCH 23390 antagonizes apomorphine- and ergot-induced hypothermia
1986
Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain
1986
Neuroleptic-induced attenuation of brain stimulation reward in rats.
1978
Phosphine Organocatalysis
2018 Standout
Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion
2001 Standout
Dopaminergic mechanisms and motor function: Characterization of D-1 and D-2 dopamine receptor interactions
1986
Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics
1984
Intramolecular amidoalkylation cyclizations in synthesis of novel pyrrolo(or isoindolo)thieno[2]benzazepines
1997
Synthesis of (tetrahydrofuran-2-yl)acetates based on a ‘cyclization/hydrogenation/enzymatic kinetic resolution’ strategy
2006
The pharmacological and anatomical substrates of the amphetamine response in the rat
1975
Brown Adipose Tissue: Function and Physiological Significance
2004 Standout
Action of drugs of abuse on brain reward systems: An update with specific attention to opiates
1982
Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis
1985 StandoutNobel
Prevention of the Nigrostriatal Toxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine by Inhibitors of 3,4‐Dihydroxyphenylethylamine Transport
1986
Differential effects of amphetamine isomers on SN self-stimulation: Evidence for DA neuron subtypes
1983
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
The Synthesis of Isoquinoline Alkaloid and Its Related Compounds Using Alanine Derivatives as Chiral Auxiliaries
2003
Homogeneous Catalysis in Supercritical Fluids
1999 StandoutNobel
The D-1 Dopamine Receptor and the Search for its Functional Role: From Neurochemistry to Behaviour
1987
Phosphine-catalyzed dearomatizing [3+2] annulations of isoquinolinium methylides with allenes
2014
A Comparison of the Vascular Dopamine Receptor with Other Dopamine Receptors
1978
Asymmetric Synthesis of Isoquinoline Alkaloids
2004 Standout
Kinetic and pharmacological profiles of the in vitro binding of the potent dopamine agonist [3H]N,N-dipropyl-5,6-dihydroxy-2-aminotetralin to rat striatal membranes
1985
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
1988 Standout
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
2003 StandoutNobel
Cellular and Molecular Mechanisms of Drug Dependence
1988 StandoutScience
Self-injection of amphetamine directly into the brain
1983
Preferential inhibition of ligand binding to calf striatal dopamine D1 receptors by SCH 23390
1983
Intracranial self-stimulation in relation to the ascending dopaminergic systems of the midbrain: A moveable electrode mapping study
1980
Differential behavioural effects of dopamine agonists in developing rats: A study of 3-PPP enantiomers
1983
Multiple receptors for dopamine
1979 StandoutNature
Differential involvement of dopamine D-1 and D-2 receptors in the circling behaviour induced by apomorphine, SK & F 38393, pergolide and LY 171555 in 6-hydroxydopamine-lesioned rats
1985
Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance
2017 Standout
Dopamine-receptor agonists: Mechanisms underlying autoreceptor selectivity
1985 StandoutNobel
Cyclizations of N-Acyliminium Ions
2004 Standout
A psychomotor stimulant theory of addiction.
1987 Standout
Cannabinoid receptor localization in brain.
1990 Standout
Action of drugs of abuse on brain reward systems
1980
Neurophysiological evidence that D-1 dopamine receptor blockade attenuates postsynaptic but not autoreceptor-mediated effects of dopamine agonists
1986
DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
2004 StandoutNobel
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions
2017 StandoutNobel
Catecholamine theories of reward: A critical review
1978
The role of dopamine in locomotor activity and learning
1983
Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors
1986
The anhedonia hypothesis: Mark III
1985
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
1990 StandoutScience
Characterization of Dopamine Receptors Associated with Aldosterone Secretion in Rat Adrenal Glomerulosa*
1986
Effects of putative dopamine autoreceptor agonists in pharmacological models related to dopaminergic and neuroleptic activity
1982
Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats
1984
Brain reward circuitry: Four circuit elements “wired” in apparent series
1984
Neuroleptics and operant behavior: The anhedonia hypothesis
1982
Dopamine Receptors: From Structure to Function
1998 Standout
Does pimozide block the reinforcing effect of brain stimulation?
1982
Synthesis of a new tetracyclic system related to aptazapine (CGS 7525A) by one-pot double annelation
1988
Locomotor Activity in D2 Dopamine Receptor-Deficient Mice Is Determined by Gene Dosage, Genetic Background, and Developmental Adaptations
1998
Brain substrates for reinforcement and drug self-administration
1981
Differential effects of pimozide on response-rate and choice accuracy in a self-stimulation paradigm in mice
1985
Works of Paulette E. Setler being referenced
Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
1982
Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin
1984
Rotation produced by administration of dopamine and related substances directly into the supersensitive caudate nucleus
1978
Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships
1987
Biochemical changes accompanying unilateral 6-hydroxydopamine lesions in the rat substantia nigra
1978
Simultaneous rate-independent and rate-dependent assessment of intracranial self-stimulation: Evidence for the direct involvement of dopamine in brain reinforcement mechanisms
1979
Effects of GABAergic drugs on brain stimulation reward as assessed by a ‘threshold’ method
1981
Eating caused by 6‐hydroxydopamine‐induced release of noradrenaline in the diencephalon of the rat
1972
Blockade of intracranial self-stimulation by antipsychotic drugs: Failure to correlate with central alpha-noradrenergic blockade
1977
The central effects of a novel dopamine agonist
1978
Differential attenuation of some effects of haloperidol in rats given scopolamine
1976
Orally Active and Potent Inhibitors of γ-Aminobutyric Acid Uptake
1985
Differential effects of dopamine agonists in mature and immature rats
1981
Peripheral cardiovascular dopamine receptors
1977
A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen
1985