Citation Impact
Citing Papers
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Reversal of Neurological Defects in a Mouse Model of Rett Syndrome
2007 StandoutScience
Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
2003 StandoutScience
Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein
2000 StandoutNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
2009 Standout
Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent
1998
Recombinant Adenovirus Expressing Von Hippel-Lindau-Mediated Cell Cycle Arrest Is Associated with the Induction of Cyclin-Dependent Kinase Inhibitor p27Kip1
1998
Closing the gap: Systematic integration of multiplexed functional data resolves variants of uncertain significance in BRCA1, TP53, and PTEN
2021
Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
2010
Organization of restriction-modification systems
1991
mTOR Signaling in Growth Control and Disease
2012 Standout
Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes
1999
The von Hippel–Lindau Tumor Suppressor Gene
2001 StandoutNobel
Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters
2002
Chronic non-spherocytic haemolytic disorders associated with glucose-6-phosphate dehydrogenase variants
2000
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Sequence-specific DNA binding by theMspl DNA methyltransferase
1992 StandoutNobel
Renal-Cell Carcinoma
1996 Standout
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
1992
Molecular Genetic Analysis of the von Hippel-Lindau Disease Tumor Suppressor Gene in Familial and Sporadic Cerebellar Hemangioblastomas
1997
The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing
2003 StandoutNobel
DNA (cytosine-5)-methyltransferases in mouse cells and tissues. studies with a mechanism-based probe
1997
Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
2007 Standout
Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia
2004 StandoutNobel
von Hippel-Lindau Disease
1997 StandoutNobel
Molecular Features of Mollicutes
1993
DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein
1991
Anemia and the liver
2002
Inhibition of Rad3 DNA helicase activity by DNA adducts and abasic sites: implications for the role of a DNA helicase in damage-specific incision of DNA
1993
The DNA (cytosine-5) methyltransferases
1994 Nobel
Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
2001
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
2004 StandoutNobel
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Protein Mediates Ubiquitination of Activated Atypical Protein Kinase C
2001
Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase–deficient heterozygotes
2001
Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome
1995 StandoutNobel
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene
2018
Modifiers of risk of hereditary breast and ovarian cancer
2002
Inhibition of Insulin-like Growth Factor-I-mediated Cell Signaling by the von Hippel-Lindau Gene Product in Renal Cancer
2000
The von Hippel-Lindau Gene Product Inhibits Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Renal Cell Carcinoma by Blocking Protein Kinase C Pathways
1997
The fission yeast gene pmt1+encodes a DNA methyltransferase homologue
1995 StandoutNobel
Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells
1998
Mechanisms of angiogenesis
1997 StandoutNature
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
2005
Epigenetic Control of Mouse Oct-4 Gene Expression in Embryonic Stem Cells and Trophoblast Stem Cells
2004
Polycomb complexes repress developmental regulators in murine embryonic stem cells
2006 StandoutNature
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
1999 Standout
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
1998 StandoutNature
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Neonatal Hyperbilirubinemia
2001 Standout
Cloning and nucleotide sequence of the genes coding for theSau961 restriction and modification enzymes
1990
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
The VHL tumour-suppressor gene paradigm
1998 StandoutNobel
Angiogenesis as a therapeutic target
2005 StandoutNature
Activation of Sp1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor Transcription Requires Specific Interaction with Protein Kinase C ζ
1998
Intrahippocampal Transplantation of Transgenic Neural Precursor Cells Overexpressing Interleukin-1 Receptor Antagonist Blocks Chronic Isolation-Induced Impairment in Memory and Neurogenesis
2007
Inactivation of the von Hippel–Lindau ( VHL ) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL ‐independent pathway in clear cell renal tumourigenesis
1998
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.
1992
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Racial variability in the UDP-glucuronosyltransferase 1 ( UGT1A1 ) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
1998 Standout
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.
1996
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
von Hippel-Lindau Disease
2006 StandoutNobel
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Organization of Ureaplasma urealyticum urease gene cluster and expression in a suppressor strain of Escherichia coli
1996 StandoutNobel
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
The sequence specificity domain of cytosine-C5 methylases
1991 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Gene
2020
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.
1998 StandoutNobel
Engineering allosteric regulation in protein kinases
2018
Glucose-6-phosphate dehydrogenase deficiency
2008 Standout
Yeast RAD3 protein binds directly to both SSL2 and SSL1 proteins: implications for the structure and function of transcription/repair factor b.
1994 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
The Molecular Basis of Von Hippel-Lindau Disease
1997 StandoutNobel
Works of Paul Renbaum being referenced
FMR1 Epigenetic Silencing Commonly Occurs in Undifferentiated Fragile X-Affected Embryonic Stem Cells
2014
Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells
2003
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population
2005
Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene
1996
Interaction of M·SssI and M·HhaI with single-base mismatched oligodeoxynucleotide duplexes
1995
A dual role for interleukin-1 in hippocampal-dependent memory processes
2007
Cloning, characterization, and expression inEscherichia coliof the gene coding for the CpG DNA methylase fromSpiroplasma sp.strain MQ1(M Sssl)
1990
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers
2001
Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: A dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia
1997
Neonatal Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-deficient Heterozygotes
1999
Genomic analysis of inherited breast cancer among Palestinian women: Genetic heterogeneity and a founder mutation in TP53
2017
Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene.
1995