Citation Impact
Citing Papers
T cell metabolism drives immunity
2015
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Oxidative stress and autophagy: the clash between damage and metabolic needs
2014 Standout
HIF-independent role of prolyl hydroxylases in the cellular response to amino acids
2012
The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy
2015 StandoutNobel
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
2010
Targeting autophagy in obesity: from pathophysiology to management
2018
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health
2014
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
Cross-talk between ER and HER2 regulates c-MYC-mediated glutamine metabolism in aromatase inhibitor resistant breast cancer cells
2015
Regulation and function of mTOR signalling in T cell fate decisions
2012
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
2011 Standout
mTOR Signaling in Growth Control and Disease
2012 Standout
MYC on the Path to Cancer
2012 Standout
Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System
2000 StandoutNobel
Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening
2015
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Nutrient transporters: the Achilles’ heel of anabolism
2013
The role of autophagy in neurodegenerative disease
2013 Standout
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
2013
Functions of autophagy in normal and diseased liver
2013
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
2001 Standout
Glutaminolysis Activates Rag-mTORC1 Signaling
2012
Glutamine and cancer: cell biology, physiology, and clinical opportunities
2013
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation
2015
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
2013
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
2010 Standout
Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells
2000
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
2013
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
2009
In vitro systems for studying intestinal drug absorption
1995
Historical landmarks of autophagy research
2013 StandoutNobel
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
2015
Autophagy: Renovation of Cells and Tissues
2011 Standout
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization
2019 StandoutNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation
2013
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
2012 Nobel
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
2015
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Autophagy in Human Health and Disease
2013 Standout
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
2016
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
2010
Methods in Mammalian Autophagy Research
2010 Standout
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
mTOR regulation of autophagy
2010 Standout
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Autophagy and Aging
2011 Standout
Autophagy as a target for anticancer therapy
2011
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
2013 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation
2012
Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion
2014
Revealing the world of RNA interference
2004 StandoutNatureNobel
Glutamine addiction: a new therapeutic target in cancer
2010
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication
2015
The PI3K Pathway in Human Disease
2017 Standout
Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target
2013
Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria
2010
PP2AT61ɛ Is an Inhibitor of MAP4K3 in Nutrient Signaling to mTOR
2010
Autophagy
2012
Autophagy in the liver: functions in health and disease
2017
Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension
2011
Under the ROS: Thiol network is the principal suspect for autophagy commitment
2010
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
2015 Nature
With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
2010
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
2014
Coactivator SRC-2–dependent metabolic reprogramming mediates prostate cancer survival and metastasis
2015
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
Targeting glutamine transport to suppress melanoma cell growth
2014
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
2015
Fundamentals of cancer metabolism
2016 Standout
Progress in the Delivery of Therapeutic Oligonucleotides: Organ/Cellular Distribution and Targeted Delivery of OligonucleotidesIn Vivo
2003
Regulation Mechanisms and Signaling Pathways of Autophagy
2009 Standout
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Differential regulation of mTORC1 by leucine and glutamine
2015 Science
Antisense Oligonucleotides: Promise and Reality
2001
The Jun Kinase 2 Isoform Is Preferentially Required for Epidermal Growth Factor-Induced Transformation of Human A549 Lung Carcinoma Cells
1999
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
2015
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
2012
Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation
2015 StandoutNobel
Metabolic reprogramming and cancer progression
2020 StandoutScience
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch
2016
2012
The Role of Cell Surface Receptors in the Activation of Human B Cells by Phosphorothioate Oligonucleotides
2000
How do ESCRT proteins control autophagy?
2009
The potential for isoenzyme‐selective modulation of protein kinase C
1997
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
2013
Autophagy and Metabolism
2010 StandoutScience
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
2009
Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs
2015
The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1
2015
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
2006 StandoutScience
C2 Domains of Protein Kinase C Isoforms α, β, and γ: Activation Parameters and Calcium Stoichiometries of the Membrane-Bound State
2002
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
2009
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
2015
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
2011
IL-32 Promotes Angiogenesis
2013
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
mTOR signaling at a glance
2009 Standout
Works of Paul Nicklin being referenced
Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension
2010
Pulmonary Bioavailability of a Phosphorothioate Oligonucleotide (CGP 64128A): Comparison with Other Delivery Routes
1998
Interactions of Phosphodiester and Phosphorothioate Oligonucleotides with Intestinal Epithelial Caco-2 Cells
1996
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
2009
Proline uptake by monolayers of human intestinal absorptive (Caco-2) cells in vitro
1992
Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.
1996
Second-generation antisense oligonucleotides: structure—activity relationships and the design of improved signal-transduction inhibitors
1996