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Citing Papers
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Structural aspects of serpin inhibition
1994 Nobel
Murine Heparin Cofactor II: Purification, cDNA Sequence, Expression, and Gene Structure
1994
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
1993 StandoutNobel
Crystal Structure of lac Repressor Core Tetramer and Its Implications for DNA Looping
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1994
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1995
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1993
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3
2007
A Polymeric Protein Anchors the Chromosomal Origin/ParB Complex at a Bacterial Cell Pole
2008 StandoutNobel
Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed and reactive site cleaved serpins: comparison of .alpha.1-proteinase inhibitor, .alpha.1-antichymotrypsin, antithrombin III, .alpha.2-antiplasmin, angiotensinogen, and ovalbumin
1991
Structural basis for serpin inhibitor activity
1995
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
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MreB Actin-Mediated Segregation of a Specific Region of a Bacterial Chromosome
2005
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
2001 StandoutNature
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
2006 Nature
Loop-inserted and thermostabilized structure of P1-p1′ cleaved ovalbumin mutant R339T 1 1Edited by R. Huber
2002
Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase
1996
Kinetics versus Thermodynamics in Protein Folding
1994 StandoutNobel
Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus
1998 StandoutNobel
The crystal structure of plasminogen activator inhibitor 2 at 2.0 Å resolution: implications for serpin function
1999
A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1
1995
Preparation and Characterization of Latent α1-Antitrypsin
1995
.alpha.1-Proteinase Inhibitor Variant T345R. Influence of P14 Residue on Substrate and Inhibitory Pathways
1994
The structural puzzle of how serpin serine proteinase inhibitors work
1996
The structure of active serpin 1K from Manduca sexta
1999
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
2006
Stopped Flow Fluorescence Energy Transfer Measurement of the Rate Constants Describing the Reversible Formation and the Irreversible Rearrangement of the Elastase-α1-Proteinase Inhibitor Complex
1998
Structural changes in glycogen phosphorylase induced by phosphorylation
1988 Nature
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
Evidence for the extent of insertion of the active site loop of intact .alpha.1 proteinase inhibitor in .beta.-sheet A
1992 Nobel
Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
2007
cis-Acting DNA from Fission Yeast Centromeres Mediates Histone H3 Methylation and Recruitment of Silencing Factors and Cohesin to an Ectopic Site
2002
Dynamic Regulation of Histone Lysine Methylation by Demethylases
2007
Engineering Plasminogen Activator Inhibitor 1 Mutants with Increased Functional Stability
1994
JmjC-domain-containing proteins and histone demethylation
2006
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Serpin α1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy
1996
High-resolution structure prediction and the crystallographic phase problem
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The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion
1994 StandoutNobel
A 2.1 Å resolution structure of an uncleaved α1-antitrypsin shows variability of the reactive center and other loops11Edited by R. Huber
2001
Serpin tertiary structure transformation
1991
Histone demethylation by a family of JmjC domain-containing proteins
2005 StandoutNature
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved α1-antitrypsin at 2.7 å
1996
Effects of mutations in the hinge region of serpins
1993
Identification of centerin: a novel human germinal center B cell-restricted serpin
2000
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
2000
JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
2006
Structural basis of latency in plasminogen activator inhibitor-1
1992 Nature
The diverse functions of histone lysine methylation
2005 Standout
Crystal structure of cleaved human α1-antichymotrypsin at 2.7 å resolution and its comparison with other serpins
1991 Nobel
Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement
2018 StandoutNobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Antithrombin Cambridge II, 384 Ala to Ser Further evidence of the role of the reactive centre loop in the inhibitory function of the serpins
1991
A spring-loaded mechanism for the conformational change of influenza hemagglutinin
1993
Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity
2016
Characterization of a Human α1-Antitrypsin Variant That Is as Stable as Ovalbumin
1998
Crystal structure of uncleaved ovalbumin at 1·95 Å resolution
1991
Generation, Control, and Processing of Cellular Calcium Signals
2001
What do dysfunctional serpins tell us about molecular mobility and disease?
1995
C1 inhibitor hinge region mutations produce dysfunction by different mechanisms
1992
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide
1998
The allosteric transition of glycogen phosphorylase
1989 Nature
Inhibitory conformation of the reactive loop of α1-antitrypsin
1996
Conversion of .alpha.1-Antichymotrypsin into a Human Neutrophil Elastase Inhibitor: Demonstration of Variants with Different Association Rate Constants, Stoichiometries of Inhibition, and Complex Stabilities
1994
Rapid leukocyte migration by integrin-independent flowing and squeezing
2008 Nature
Re-SET-ting heterochromatin by histone methyltransferases
2001
Localization of the binding site for the human high-affinity Fc receptor on IgG
1988 StandoutNatureNobel
The binding site for C1q on IgG
1988 StandoutNatureNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Natural protein proteinase inhibitors and their interaction with proteinases
1992 Nobel
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
2006 Nature
Prokaryotic origin of the actin cytoskeleton
2001 Nature
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
Wild-type α1-antitrypsin is in the canonical inhibitory conformation
1998
Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop
1994
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor.
1992
The sequences of small proteins are not extensively optimized for rapid folding by natural selection
1998 StandoutNobel
Protein domain movements: detection of rigid domains and visualization of hinges in comparisons of atomic coordinates
1997
Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families
1991
A hinge region mutation in C1-inhibitor (Ala436–>Thr) results in nonsubstrate-like behavior and in polymerization of the molecule.
1993
Serpin Structure, Mechanism, and Function
2002 Standout
Immunoglobulin G: Functional sites
1985
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography
1997 Science
A major estrogen-regulated protein secreted from the liver of Xenopus laevis is a member of the serpin superfamily. Nucleotide sequence of cDNA and hormonal induction of mRNA.
1992
The catabolism of intact, reactive centre-cleaved and proteinase-complexed C1 inhibitor in the guinea pig
1996
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
1994
The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.
1991
Sequence and domain organization of scruin, an actin-cross-linking protein in the acrosomal process of Limulus sperm.
1995
Proposed three-dimensional structure for the cellular prion protein.
1994 StandoutNobel
Chromatin and oxygen sensing in the context of JmjC histone demethylases
2014
Molecular evolution of plasminogen activator inhibitor-1 functional stability.
1995
Neuroserpin, an axonally secreted serine protease inhibitor.
1996
Structure of a serpin–protease complex shows inhibition by deformation
2000 Nature
Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum
2009
Biological implications of a 3 å structure of dimeric antithrombin
1994
Antichymotrypsin interaction with chymotrypsin. Partitioning of the complex.
1993
Single amino acid substitutions of alpha 1-antitrypsin that confer enhancement in thermal stability
1994
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
1994
ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins.
1986
Multiscale natural moves refine macromolecules using single-particle electron microscopy projection images
2012 StandoutNobel
A unique interhelical insertion in plasminogen activator inhibitor-2 contains three glutamines, Gln83, Gln84, Gln86, essential for transglutaminase-mediated cross-linking.
1994
A meta-analysis of randomized controlled trials
2019 Standout
Architecture and function of metallopeptidase catalytic domains
2013
Kinetic characterization of the substrate reaction between a complex of antithrombin with a synthetic reactive-bond loop tetradecapeptide and four target proteinases of the inhibitor.
1992
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy
2014 StandoutNobel
Adenine nucleotide binding sites on beef heart F1 ATPase: photoaffinity labeling of beta-subunit Tyr-368 at a noncatalytic site and beta Tyr-345 at a catalytic site.
1987 StandoutNobel
Ligand binding: proteinase-protein inhibitor interactions
1991 Nobel
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
1989 StandoutScience
Atomic structures and function of periplasmic receptors for active transport and chemotaxis
1991
Translating the Histone Code
2001 StandoutScience
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)
1994
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
The C1q receptor site on immunoglobulin G
1980 Nature
Molecular recognition
1991
Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties.
1993
Mechanism by which the lectin actinohivin blocks HIV infection of target cells
2009 StandoutNobel
Kinetically Controlled Folding of the Serpin Plasminogen Activator Inhibitor 1
1996
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
2007
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
RADIOLYTIC PROTEIN FOOTPRINTING WITH MASS SPECTROMETRY TO PROBE THE STRUCTURE OF MACROMOLECULAR COMPLEXES
2006
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Works of Paul McLaughlin being referenced
Effect of selenium supplementation on biochemical markers and outcome in critically ill patients
2006
The Crystal Structure of Plasma Gelsolin: Implications for Actin Severing, Capping, and Nucleation
1997
Structure of gelsolin segment 1-actin complex and the mechanism of filament severing
1993 Nature
Dimerisation of a chromo shadow domain and distinctions from the chromodomain as revealed by structural analysis
2000
The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA
2014
Uridine(5′)diphospho(1)‐α‐d ‐glucose
1988
Crystal structure of ovalbumin as a model for the reactive centre of serpins
1990 Nature
Latrunculin alters the actin-monomer subunit interface to prevent polymerization
2000
Methylation: lost in hydroxylation?
2005
Glycogen phosphorylase b — the molecular anatomy of a large regulatory enzyme
1985
Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate
1984
Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
1987
Invadolysin
2004
Rat Clq : Similarity to human Clq in functional and compositional properties
1978
Protein-Oligosaccharide Interactions: Lysozyme, Phosphorylase, Amylases
1988