Citation Impact
Citing Papers
Indoles from commensal bacteria extend healthspan
2017
Vascular Klotho Deficiency Potentiates the Development of Human Artery Calcification and Mediates Resistance to Fibroblast Growth Factor 23
2012 Standout
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
2007 Standout
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update
2011 Standout
Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group
2016
Efficacy of glutamine-enriched enteral feeding formulae in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.
2016
Cancer Metabolism and Elevated O-GlcNAc in Oncogenic Signaling
2014
The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized trials
2016
Omega-3 supplementation in patients with sepsis: a systematic review and meta-analysis of randomized trials
2017
Glutamine, fish oil and antioxidants in critical illness: MetaPlus trial post hoc safety analysis
2016
The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans
2016
Comparisons between intragastric and small intestinal delivery of enteral nutrition in the critically ill: a systematic review and meta-analysis
2013
Increased IgA and IgM responses against gut commensals in chronic depression: Further evidence for increased bacterial translocation or leaky gut
2012
Early high protein intake is associated with low mortality and energy overfeeding with high mortality in non-septic mechanically ventilated critically ill patients
2014
A J-shaped relationship between caloric intake and survival in critically ill patients
2015
From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.
2014 Standout
Safety and efficacy of an olive oil-based triple-chamber bag for parenteral nutrition: a prospective, randomized, multi-center clinical trial in China
2015
Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials
2016
Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool
2011
Engineering precision nanoparticles for drug delivery
2020 Standout
Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection
2002
Validation of a point-of-care instrument for bedside glutamine screening in the intensive care unit
2015
CECAL LIGATION AND PUNCTURE
2005
Glutamine supplementation in serious illness: A systematic review of the evidence*
2002
A Randomized Clinical Trial of Ciprofloxacin and Metronidazole to Treat Acute Pouchitis
2001
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
The role of visceral proteins in the nutritional assessment of intensive care unit patients
2003
Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle
2004
Microbial tryptophan catabolites in health and disease
2018 Standout
Circadian Clock Genes as Modulators of Sensitivity to Genotoxic Stress
2005
Ulcerative Colitis
2011 Standout
ESPEN guideline: Clinical nutrition in surgery
2017 Standout
ESPEN guideline on clinical nutrition in the intensive care unit
2018 Standout
A guide to immunometabolism for immunologists
2016 Standout
When Early Enteral Feeding Is Not Possible in Critically Ill Patients
2011
Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients
2004
Efficacy of arginine-enriched enteral formulas in the reduction of surgical complications in head and neck cancer: A systematic review and meta-analysis
2014
Antioxidant Vitamins and Trace Elements in Critical Illness
2016
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
2011
Clinical review: Sepsis and septic shock - the potential of gene arrays
2012
EFFECTIVENESS AND COST-EFFECTIVENESS OF SUPPLEMENTAL GLUTAMINE DIPEPTIDE IN TOTAL PARENTERAL NUTRITION THERAPY FOR CRITICALLY ILL PATIENTS: A DISCRETE EVENT SIMULATION MODEL BASED ON ITALIAN DATA
2012
Malnutrition as an enteric infectious disease with long-term effects on child development
2008
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Therapeutic benefits of glutamine: An umbrella review of meta-analyses
2017
Genetics and genomics in pediatric septic shock
2012
Meta-analysis is not enough: The critical role of pathophysiology in determining optimal care in clinical nutrition
2015
Influence of Parenteral Nutrition Delivery System on the Development of Bloodstream Infections in Critically Ill Patients
2012
Mice depleted of CD8+ T and NK cells are resistant to injury caused by cecal ligation and puncture
2004
Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72
2004
Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis
2003
Previous heat shock facilitates the glutamine-induced expression of heat-shock protein 72 in septic liver
2007
A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation
2012
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
2013 Standout
Monitoring nutrition in the ICU
2018
Severe Sepsis and Septic Shock
2013 Standout
Timing of PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation: The PROTINVENT retrospective study
2018
Perioperative Intravenous Glutamine Supplemetation in Major Abdominal Surgery for Cancer
2009
Preemptive enteral nutrition enriched with eicosapentaenoic acid, gamma-linolenic acid and antioxidants in severe multiple trauma: a prospective, randomized, double-blind study
2015
Specialized nutritional support interventions in critically ill patients on renal replacement therapy
2012
Relevance of non-nutritional calories in mechanically ventilated critically ill patients
2016
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Immunodesign of experimental sepsis by cecal ligation and puncture
2008 Standout
A prospective randomized trial of enteral glutamine in critical illness
2003
Indirect calorimetry in nutritional therapy. A position paper by the ICALIC study group
2016
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient
2016 Standout
Mechanisms of sepsis-induced organ dysfunction
2007
Early combined parenteral and enteral nutrition for pancreaticoduodenectomy - Retrospective cohort analysis
2016
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Antioxidant supplementation in sepsis and systemic inflammatory response syndrome
2007
Management of perioperative nutrition support
2006
Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study
2009
High-dose intravenous selenium does not improve clinical outcomes in the critically ill: a systematic review and meta-analysis
2016
Ulcerative colitis
2012 Standout
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient
2016 Standout
The effect of l-alanyl-l-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients*
2011
Synbiotics, Prebiotics, Glutamine, or Peptide in Early Enteral Nutrition: A Randomized Study in Trauma Patients
2007
REVIEW: Ischemia—Reperfusion Injury of the Intestine and Protective Strategies Against Injury
2004
Will We Ever Agree on Protein Requirements in the Intensive Care Unit?
2017
Protein for the critically ill patient—what and when?
2013
The Physiologic Response and Associated Clinical Benefits From Provision of Early Enteral Nutrition
2009
Decreased mortality and infectious morbidity in adult burn patients given enteral glutamine supplements: A prospective, controlled, randomized clinical trial*
2003
Cost-effectiveness analysis of immune-modulating nutritional support for gastrointestinal cancer patients
2013
Human Protein and Amino Acid Requirements
2016
Pragmatic approach to nutrition in the ICU: Expert opinion regarding which calorie protein target
2013
Sepsis and septic shock
2018 Standout
Low serum selenium is associated with the severity of organ failure in critically ill children
2017
Long-term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel
2008
Causes and Consequences of Interrupted Enteral Nutrition
2014
Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial
2017
The Impact of Glutamine Dipeptide–Supplemented Parenteral Nutrition on Outcomes of Surgical Patients
2010
Nutrition in the ICU
2018
A meta-analysis of trials using the intention to treat principle for glutamine supplementation in critically ill patients with burn
2013
European evidence-based Consensus on the management of ulcerative colitis: Special situations
2008
Evaluation of Bioelectrical Impedance Analysis in Critically Ill Patients: Results of a Multicenter Prospective Study
2016
Early enteral supplementation with key pharmaconutrients improves Sequential Organ Failure Assessment score in critically ill patients with sepsis: Outcome of a randomized, controlled, double-blind trial*
2008
Role of the gut microbiota in nutrition and health
2018 Standout
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
2009 Standout
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Sarcopenia
2019 Standout
Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients
2011
The Canadian Critical Care Nutrition Guidelines in 2013
2013
Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature
2004
Preoperative Standard Oral Nutrition Supplements vs Immunonutrition: Results of a Systematic Review and Meta-Analysis
2014
Ulcerative colitis
2016 Standout
Glutamine dipeptide-supplemented parenteral nutrition improves the clinical outcomes of critically ill patients: A systematic evaluation of randomised controlled trials
2016
Temporal nutritional and inflammatory changes in children with severe head injury fed a regular or an immune-enhancing diet: A randomized, controlled trial
2005
Evaluation of the Effects of a Preoperative 2‐Hour Fast With Maltodextrine and Glutamine on Insulin Resistance, Acute‐Phase Response, Nitrogen Balance, and Serum Glutathione After Laparoscopic Cholecystectomy
2012
Whole body protein turnover in critically ill patients with multiple organ failure
2014
Application of ultrasound for muscle assessment in sarcopenia: towards standardized measurements
2018
Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group
2017
A randomized synbiotic trial to prevent sepsis among infants in rural India
2017 Nature
Update on postinjury nutrition
2008
Recent advances in genetic predisposition to clinical acute lung injury
2009
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient:
2009 Standout
Gastric cancer
2020 Standout
Lower versus higher dose of enteral caloric intake in adult critically ill patients: a systematic review and meta-analysis
2016
Lipid metabolism in critical illness
2016
The Effect of Preoperative Oral Immunonutrition on Complications and Length of Hospital Stay After Elective Surgery for Pancreatic Cancer–A Randomized Controlled Trial
2016
Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production
2008 Standout
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
2012 Standout
Can the Intestinal Dysmotility of Critical Illness be Differentiated from Postoperative Ileus?
2011
Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis
2015
Early versus Late Parenteral Nutrition in Critically Ill Adults
2011 Standout
Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations
2012
Nutrition in Patients with Gastric Cancer: An Update
2015
Early enteral administration of immunonutrition in critically ill children: results of a blinded randomized controlled clinical trial
2005
The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
2010
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
Energy expenditure in mechanically ventilated patients: The weight of body weight!
2015
Gastrointestinal symptoms in intensive care patients
2009
Recomendaciones para el soporte nutricional y metabólico especializado del paciente crítico. Actualización. Consenso SEMICYUC-SENPE: Paciente séptico
2011
Gastrointestinal dysmotility in the critically ill
2016
Oral Glutamine Reduces Radiation Morbidity in Breast Conservation Surgery
2013
Tolerability and efficacy of a low-volume enteral supplement containing key nutrients in the critically ill
2011
L-alanyl-L-glutamine dipeptide–supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: The French controlled, randomized, double-blind, multicenter study*
2006
Fundamental determinants of protein requirements in the ICU
2014
Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy
2009
Standard and immunomodulating enteral nutrition in patients after extended gastrointestinal surgery – A prospective, randomized, controlled clinical trial
2008
The acute respiratory distress syndrome
2012 Standout
Are prospective cohort studies an appropriate tool to answer clinical nutrition questions?
2013
Intravenous alanyl-L-glutamine balances glucose–insulin homeostasis and facilitates recovery in patients undergoing colonic resection
2013
Perioperative GLY-GLN Infusion Diminishes the Surgery-Induced Period of Immunosuppression
2003
Immunonutrition in critically ill patients: a systematic review and analysis of the literature
2008
Practicalities of nutrition support in the intensive care unit: The usefulness of gastric residual volume and prokinetic agents with enteral nutrition
2011
Glycosylation in cancer: mechanisms and clinical implications
2015 Standout
Nutrition Support in Clinical Practice: Review of Published Data and Recommendations for Future Research Directions
1997
Effect of a Fish Oil and Arginine-Fortified Diet in Thermally Injured Patients
2006
Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome
2007
The pros, cons, and many unknowns of probiotics
2019 Standout
ESPEN endorsed recommendations: Nutritional therapy in major burns
2013
Vitamin D and outcomes in adult critically ill patients. A systematic review and meta-analysis of randomized trials
2016
The Association Between Nutritional Adequacy and Long-Term Outcomes in Critically Ill Patients Requiring Prolonged Mechanical Ventilation
2015
Extracellular histones are major mediators of death in sepsis
2009 Standout
The role of inflammation in depression: from evolutionary imperative to modern treatment target
2015 Standout
Use of antioxidant supplements during breast cancer treatment: a comprehensive review
2008
Adequate Nutrition May Get You Home
2015
The gut microbiota shapes intestinal immune responses during health and disease
2009 Standout
Glutamine Increases Autophagy Under Basal and Stressed Conditions in Intestinal Epithelial Cells
2008
Effect of Amino Acid Infusion on Human Postoperative Colon Protein Synthesis in Situ
2005
The disconnect between animal models of sepsis and human sepsis
2006
The influence of protein provision in the early phase of intensive care on clinical outcomes for critically ill patients on mechanical ventilation.
2017
Vitamin C revisited
2014
Longitudinal changes in anthropometrics and impact on self-reported physical function after traumatic brain injury
2017
High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU
2014
Oral Glutamine Is Effective for Preventing Oxaliplatin-Induced Neuropathy in Colorectal Cancer Patients
2007
European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis
2008
Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline
2014 Standout
Effect of Glutamine Dipeptide Supplementation on Primary Outcomes for Elective Major Surgery: Systematic Review and Meta-Analysis
2015
Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon
2012 StandoutNobel
Glutamine supplementation to critically ill patients?
2014
Oral Delivery of Biologics for Precision Medicine
2019
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
2014 Standout
Effect of Critical Illness on Triglyceride Absorption
2014
TROPHIC AND CYTOPROTECTIVE NUTRITION FOR INTESTINAL ADAPTATION , MUCOSAL REPAIR, AND BARRIER FUNCTION
2003
Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility
2006
Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
2011 Standout
Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations
2012 Standout
Circadian Clock, Cancer, and Chemotherapy
2014 StandoutNobel
A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES)
2016
Calorie delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis
2016
Guidelines for Perioperative Care in Elective Rectal/Pelvic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations
2012 Standout
Nutrition support in clinical practice: review of published data and recommendations for future research directions. Summary of a conference sponsored by the National Institutes of Health, American Society for Parenteral and Enteral Nutrition, and American Society for Clinical Nutrition
1997
Promoting Perioperative Metabolic and Nutritional Care
2015
HEAT-SHOCK PROTEINS, MOLECULAR CHAPERONES, AND THE STRESS RESPONSE: Evolutionary and Ecological Physiology
1999 Standout
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Glutamine dipeptide-supplemented parenteral nutrition in patients with colorectal cancer
2004
Works of Paul E. Wischmeyer being referenced
Parenteral glutamine supplementation in critical illness: a systematic review
2014
Distance of Cecum Ligated Influences Mortality, Tumor Necrosis Factor-Alpha and Interleukin-6 Expression following Cecal Ligation and Puncture in the Rat
2003
Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis
2016
Tailoring nutrition therapy to illness and recovery
2017
Does artificial nutrition improve outcome of critical illness? An alternative viewpoint!
2013
A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial
2017
Clinical review: optimizing enteral nutrition for critically ill patients - a simple data-driven formula
2011
Metabolic and nutritional support of critically ill patients: consensus and controversies
2015
Glutamine in Critical Illness: The Time Has Come, The Time Is Now
2010
Optimizing energy and protein balance in the ICU
2013
Erythromycin vs Metoclopramide for Facilitating Gastric Emptying and Tolerance to Intragastric Nutrition in Critically Ill Patients
2008
Glutamine: Mode of action in critical illness
2007
Nutrition Therapy Cost Analysis in the US
2011
Glutamine attenuates tumor necrosis factor-α release and enhances heat shock protein 72 in human peripheral blood mononuclear cells
2002
Perioperative Use of Arginine-supplemented Diets: A Systematic Review of the Evidence
2011
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
2013
Pharmacologically Dosed Oral Glutamine Reduces Myocardial Injury in Patients Undergoing Cardiac Surgery
2012
Pharmaconutrition Review
2013
Lactobacillus rhamnosus GG Improves Outcome in Experimental Pseudomonas aeruginosa Pneumonia
2013
Glutamine attenuates lung injury and improves survival after sepsis: Role of enhanced heat shock protein expression*
2005
Bedside ultrasound measurement of skeletal muscle
2014
Optimizing the Dose of Glutamine Dipeptides and Antioxidants in Critically Ill Patients: A Phase I Dose‐Finding Study
2007
The evolution of nutrition in critical care: how much, how soon?
2013
Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression
2007
Glutamine‐Mediated Attenuation of Cellular Metabolic Dysfunction and Cell Death After Injury Is Dependent on Heat Shock Factor‐1 Expression
2006
Glutamine and Antioxidants in the Critically Ill Patient
2014
Relationship of Vitamin D Deficiency to Clinical Outcomes in Critically Ill Patients
2012
Glutamine and heat shock protein expression
2002
Summary Points and Consensus Recommendations From the North American Surgical Nutrition Summit
2013
Nutrition Therapy in Critically Ill Infants and Children
2008
GLUTAMINE PREVENTS ACTIVATION OF NF-κB AND STRESS KINASE PATHWAYS, ATTENUATES INFLAMMATORY CYTOKINE RELEASE, AND PREVENTS ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) FOLLOWING SEPSIS
2005
Glutamine: role in gut protection in critical illness
2006
GLUTAMINE REDUCES CYTOKINE RELEASE, ORGAN DAMAGE, AND MORTALITY IN A RAT MODEL OF ENDOTOXEMIA
2001
The Future of Critical Care Nutrition Therapy
2010
Bedside Ultrasound Is a Practical and Reliable Measurement Tool for Assessing Quadriceps Muscle Layer Thickness
2013
Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control
2001
Gastric Motility Function in Critically Ill Patients Tolerant vs Intolerant to Gastric Nutrition
2008
Parenteral glutamine increases serum heat shock protein 70 in critically ill patients
2005
Clinical Evidence for Pharmaconutrition in Major Elective Surgery
2013
Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis
2015
Glutamine: role in critical illness and ongoing clinical trials
2008
The glutamine story: where are we now?
2006
Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness
2009
Nutrition Therapy for the Critically Ill Surgical Patient
2010
Chronic Pouchitis After Ileal Pouch-Anal Anastomosis: Responses to Butyrate and Glutamine Suppositories in a Pilot Study
1993
An Evidence‐Based Approach to Perioperative Nutrition Support in the Elective Surgery Patient
2013
Extracellular Superoxide Dismutase Haplotypes Are Associated with Acute Lung Injury and Mortality
2008
Performance-enhancing sports supplements: Role in critical care
2009
Enteral fish oil in critical illness
2014
Clinical Applications of l ‐Glutamine: Past, Present, and Future
2003
Glutamine's protection against cellular injury is dependent on heat shock factor-1
2006
Glutamine Induces Heat Shock Protein Expression Via O‐Glycosylation and Phosphorylation of HSF‐1 and Sp1
2008
Role of L-glutamine in critical illness: new insights
2003
Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity
2009
Glutamine protects intestinal epithelial cells: role of inducible HSP70
1997
Parenteral nutrition and calorie delivery in the ICU
2012
Glutamine
2012
Prevention of chemotherapy and radiation toxicity with glutamine
2003
A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients
2014
Role of the microbiome, probiotics, and ‘dysbiosis therapy’ in critical illness
2016
Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology
2015
Glutamine induces heat shock protein and protects against endotoxin shock in the rat
2001