Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
A Critical Role for IL-21 in Regulating Immunoglobulin Production
2002 Science
Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor
2002 Science
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
2004 StandoutScienceNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100
2001
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
1996 StandoutNature
Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis
2009
CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organs
2006 Nature
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
T-cell receptor signal transmission: who gives an ITAM?
2003
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis
2006
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
1995 Nature
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
2011
Iron Regulatory Proteins Are Essential for Intestinal Function and Control Key Iron Absorption Molecules in the Duodenum
2008
Antiphospholipid antibody panels and recurrent pregnancy loss: prevalence of anticardiolipin antibodies compared with other antiphospholipid antibodies
1996
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
2010
Antiphospholipid Thrombosis: Clinical Course after the First Thrombotic Event in 70 Patients
1992
Defects in enteric innervation and kidney development in mice lacking GDNF
1996 StandoutNature
Iron Regulatory Proteins Secure Mitochondrial Iron Sufficiency and Function
2010
Cyclophilin A Regulates TCR Signal Strength in CD4+ T Cells via a Proline-Directed Conformational Switch in Itk
2004
Balancing Acts
2004 Standout
Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy
2009
Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions
2007
Suppression by TFR cells leads to durable and selective inhibition of B cell effector function
2016
Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene
1997
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
1995
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage
2010
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
1995
Missing Pieces in the NF-κB Puzzle
2002 Standout
Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis
2005
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Two to Tango: Regulation of Mammalian Iron Metabolism
2010 Standout
Physiological consequences of β-adrenergic receptor disruption
1998
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Epidemiology of the Antiphospholipid Antibody Syndrome
2000
T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/polymorphisms and splice variants of T cell receptor ? chain messenger RNA
2001
Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses
1998 Standout
The Antiphospholipid Syndrome
2002 Standout
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Plasma cell differentiation requires the transcription factor XBP-1
2001 Nature
Dendritic-cell trafficking to lymph nodes through lymphatic vessels
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis
1992
Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
1995
Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5)
2012
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
2000
Association of anti-β2 glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus
1992
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Signals involved in thymocyte positive and negative selection
1999
Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development
2002
A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression
2009
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
1995 Nature
NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development
2000
Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein.
1996
Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice
1997
Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity
2009
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
1997 Standout
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
2009 StandoutNature
A signal strength hypothesis of thymic selection: preliminary considerations
1995
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators
1999
Points of control in inflammation
2002 StandoutNature
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
2008
IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development
2001
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
1998 Standout
NF-κB at the crossroads of life and death
2002 Standout
The Human IgE Germline Promoter is Regulated By Interleukin‐4, Interleukin‐13, Interferon‐α and Interferon‐γ Via an Interferon‐γ‐Activated Site and Its Flanking Regions
1996
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
2001
Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: A four-year prospective study from the italian registry
1996
Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia
2008
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases
1996 StandoutNobel
Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development
2006
Protein S-nitrosylation: purview and parameters
2005 Standout
Natural killer cells, viruses and cancer
2001
Iron Regulatory Proteins: From Molecular Mechanisms to Drug Development
2010
Positive and Negative Selection of T Cells
2003
Signaling Life and Death in the Thymus: Timing Is Everything
2003 Science
The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T Cells
2003
Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3.
1999
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia
2012
Regulatory T Cells: Mechanisms of Differentiation and Function
2007 Standout
A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.
1996
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity
2009
Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export
2000
Early Onset of CD8 Transgene Expression Inhibits the Transition from DN3 to DP Thymocytes
2000
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Medical Perspective Antiphospholipid Antibodies, Thrombosis and Atherosclerosis in Systemic Lupus Erythematosus: a Unifying 'Membrane Stress Syndrome' Hypothesis
1994
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
1995 Science
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
Reduced generation but efficient TCR beta-chain selection of CD4+8+ double-positive thymocytes in mice with compromised CD3 complex signaling.
1999
Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2
2005
Reduced Generation but Efficient TCRβ-Chain Selection of CD4+8+ Double-Positive Thymocytes in Mice with Compromised CD3 Complex Signaling
1999
Retroviral integrase superfamily: the structural perspective
2009
Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3
1995 Science
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
Mammalian Tissue Oxygen Levels Modulate Iron-Regulatory Protein Activities in Vivo
2004 Science
Th2 Lymphoproliferative Disorder of Lat Y136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells
2008
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
2001 Science
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Functional Redundancy of the Nuclear Factor κB Inhibitors IκBα and IκBβ
1998
Distinct Activities of p52/NF-κB Required for Proper Secondary Lymphoid Organ Microarchitecture: Functions Enhanced by Bcl-3
1999
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior
2007
Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase
1994 Science
Cellular responses to psychomotor stimulant and neuroleptic drugs are abnormal in mice lacking the D1 dopamine receptor
1996 Nobel
Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment
2001 Nobel
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells
2003 StandoutNobel
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2
1995
Use of Antithrombotic Agents During Pregnancy
2001
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
2010 StandoutNobel
Follicular Helper T Cells
2016
A Phospholipid-β2-Glycoprotein I Complex Is an Antigen for Anticardiolipin Antibodies Occurring in Autoimmune Disease But Not with Infection
1992
The Effects of Low-intensity Warfarin on Coagulation Activation in Patients with Antiphospholipid Antibodies and Systemic Lupus Erythematosus
1999
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
2005
Regulatory roles of IL-10–producing human follicular T cells
2019 StandoutNobel
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
2003 Standout
Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network
2008
Autoreactivity, dynamic tuning and selectivity
2001
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
Iκb Kinase α Is Essential for Mature B Cell Development and Function
2001
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Follicular helper T cells mediate IgE antibody response to airborne allergens
2016
Place Cells and Place Recognition Maintained by Direct Entorhinal-Hippocampal Circuitry
2002 StandoutScienceNobel
Chronic Inflammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF-κB1) but Expressing p50
1998
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses
1998
Works of Paul E. Love being referenced
Regulation of TCR Signal Transduction in Murine Thymocytes by Multiple TCR ζ-Chain Signaling Motifs
1998
Selective Expression Rather than Specific Function of Txk and Itk Regulate Th1 and Th2 Responses
2008
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
2001
Themis, a T cell–specific protein important for late thymocyte development
2009
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
2015
Essential Role of LAT in T Cell Development
1999
Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development
1995
CD5-mediated inhibition of TCR signaling during intrathymic selection and development does not require the CD5 extracellular domain
2002
TCR ζ chain in T cell development and selection
1997
ITAM Multiplicity and Thymocyte Selection
2000
Antiphospholipid Antibodies: Anticardiolipin and the Lupus Anticoagulant in Systemic Lupus Erythematosus (SLE) and in Non-SLE Disorders
1990
A potential role for CD69 in thymocyte emigration
2002
Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
1995
Combined Natural Killer Cell and Dendritic Cell Functional Deficiency in KARAP/DAP12 Loss-of-Function Mutant Mice
2000
Failure to Produce Mitochondrial DNA Results in Embryonic Lethality in Rnaseh1 Null Mice
2003
Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
2004
Distinct Structure and Signaling Potential of the γδTCR Complex
2002
Critical Roles for the Bcl-3 Oncoprotein in T Cell–Mediated Immunity, Splenic Microarchitecture, and Germinal Center Reactions
1997
Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture
1998
Function of Cd3ε-Mediated Signals in T Cell Development
2000
Differential effects of zeta and eta transgenes on early alpha/beta T cell development.
1994
A Role for the Tec Family Tyrosine Kinase Txk in T Cell Activation and Thymocyte Selection
1999
Specific requirement for CD3ɛ in T cell development
1998
CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity
1998
Critical Relationship Between TCR Signaling Potential and TCR Affinity During Thymocyte Selection
2000
Fine Tuning of TCR Signaling by CD5
2001
A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation
2002 Science
Role of the Multiple T Cell Receptor (TCR)-ζ Chain Signaling Motifs in Selection of the T Cell Repertoire
1997
Altered striatal function in a mutant mouse lacking D1A dopamine receptors.
1994
Knock-in Mutation of the Distal Four Tyrosines of Linker for Activation of T Cells Blocks Murine T Cell Development
2001
Involvement of the SHP-1 Tyrosine Phosphatase in Regulation of T Cell Selection
1999
Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs.
1998
T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex
1993 Science
Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection
2005
Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene.
1992
T Cell Development in Mice Lacking All T Cell Receptor ζ Family Members (ζ, η, and FcεRIγ)
1998
Role of TCR ζ Chain in T Cell Development and Selection
1994 Science