Standout Papers
- Antibodies to a scrapie prion protein (1984)
- Creutzfeldt–Jakob Disease Prion Proteins in Human Brains (1985)
- Antibodies to the scrapie protein decorate prion rods. (1985)
- Scrapie prions aggregate to form amyloid-like birefringent rods (1983)
- Scrapie and Creutzfeldt-Jakob disease prion proteins share physical properties and antigenic determinants. (1985)
Citation Impact
Citing Papers
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
2009 Standout
Molecular Cloning of a Human Prion Protein cDNA
1986 StandoutNobel
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Distinct prion proteins in short and long scrapie incubation period mice
1987 StandoutNobel
Prion protein is necessary for normal synaptic function
1994 Nature
Pro→Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome
1989
Purification and properties of the cellular prion protein from Syrian hamster brain
1992 StandoutNobel
Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da
1988 StandoutNobel
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Chapter 37: PrPSc causes nerve cell death and stimulates astrocyte proliferation: a paradox
1992
Chemistry and biology of prions
1992
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
1993
Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state
1995
Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease
1991 Nature
Immunohistochemical verification of senile and kuru plaques in Creutzfeldt‐Jakob disease and the allied disease
1988
Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein
1989 StandoutNobel
Prions and Neurodegenerative Diseases
1987 StandoutNobel
Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease
1991 StandoutNobel
The new biology of spongiform encephalopathy: infectious amyloidoses with a genetic twist
1991 Nobel
Neurotoxicity of a prion protein fragment
1993 Nature
The chemistry of scrapie infection: implications of the ‘ice 9’ metaphor
1995
N-terminal sequence of prion protein is also intergrated into kuru plaques in patients with Gerstmann-Stra¨ussler syndrome
1991
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
1990 StandoutNobel
A 60-kDa Prion Protein (PrP) with Properties of Both the Normal and Scrapie-associated Forms of PrP
1995
Nuclease-resistant polyadenylated RNAs of significant size are detected by PCR in highly purified Creutzfeldt-Jakob disease preparations
1990
Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C
1990
BIOLOGY AND GENETICS OF PRION DISEASES
1994
Scrapie prions: a three-dimensional model of an infectious fragment
1996
A 'unified theory' of prion propagation
1991 Nature
Metal‐dependent α‐helix formation promoted by the glycine‐rich octapeptide region of prion protein
1996
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
Sensitive enzyme-linked immunosorbent assay for detection of PrPSc in crude tissue extracts from scrapie-affected mice
1997
Genetic Control of Prion Incubation Period in Mice
2007 Nobel
Thermal stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity
1993 Nobel
Prion Protein Peptides Induce .alpha.-Helix to .beta.-Sheet Conformational Transitions
1995
Molecular properties of complexes formed between the prion protein and synthetic peptides
1997 StandoutNobel
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Bovine spongiform encephalopathy: detection and quantitation of fibrils, fibril protein (PrP) and vacuolation in brain
1990
Prion Protein Isoforms, a Convergence of Biological and Structural Investigations
1995 StandoutNobel
Asparagine-linked glycosylation of the scrapie and cellular prion proteins
1989
scrapie Amyloid (Prion) Protein Has the Conformational Characteristics of an Aggregated Molten Globule Folding Intermediate
1994 Nobel
The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis
1991
Evidence for a secretory form of the cellular prion protein
1987 StandoutNobel
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Genetic and Infectious Prion Diseases
1993
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
1989 StandoutNobel
Sulfated glycosaminoglycans in amyloid plaques of prion diseases
1989 StandoutNobel
IMMUNOSTAINING OF SCRAPIE CEREBRAL AMYLOID PLAQUES WITH ANTISERA RAISED TO SCRAPIE–ASSOCIATED FIBRILS (SAF)
1988
Identification of cellular proteins binding to the scrapie prion protein
1990 StandoutNobel
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles
1992 StandoutNobel
Scrapie strains retain their distinctive characteristics following passages of homogenates from different brain regions and spleen.
1997
Immunologic and Molecular Biologic Studies of Prion Proteins in Bovine Spongiform Encephalopathy
1993 StandoutNobel
An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease
1990
Comparative sequence analysis and expression of bovine PrP gene in mouse L-929 cells
1992
Scrapie prion protein contains a phosphatidylinositol glycolipid
1987
Human prion diseases
1994 StandoutNobel
Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations
1988 Nobel
Variation in the characteristics of 10 mouse-passaged scrapie lines derived from five scrapie-positive sheep
1991
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv
1997 StandoutNobel
Fibrils from brains of cows with new cattle disease contain scrapie-associated protein
1988 Nature
Eight prion strains have PrPSc molecules with different conformations
1998 Nobel
Creutzfeldt‐Jakob disease patients with congophilic kuru plaques have the missense variant prion protein common to Gerstmann‐Sträussler syndrome
1990
Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions
1995
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
1991 StandoutNatureNobel
Analysis of linkage between scrapie incubation period and the prion protein gene in mice
1990
Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulation
1992 Nature
Search for a Putative Scrapie Genome in Purified Prion Fractions Reveals a Paucity of Nucleic Acids
1991
Replication of the Scrapie Agent in Hamsters Infected Intracerebrally Confirms the Pathogenesis of an Amyloid-inducing Virosis
1988
Expression of Amino-Terminally Truncated PrP in the Mouse Leading to Ataxia and Specific Cerebellar Lesions
1998
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes
1993
Purification and properties of the cellular and scrapie hamster prion proteins
1988
Molecular biology of prion diseases
1994
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Organ Distribution of Proteinase-resistant Prion Protein in Humans and Mice with Creutzfeldt-Jakob Disease
1989
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
A novel hamster prion protein mRNA contains an extra exon: increased expression in scrapie
1997
Transmissible Mink Encephalopathy Species Barrier Effect Between Ferret and Mink: PrP Gene and Protein Analysis
1994
Mice devoid of PrP are resistant to scrapie
1993 Standout
Creutzfeldt-Jakob disease and dementias
1989
Neurofibrillary tangles of the Indiana kindred of Gerstmann-Stra¨ussler-Scheinker disease share antigenic determinants with those of Alzheimer disease
1990
GENETICS OF RESPONSE TO SLOW VIRUS (PRION) INFECTION
1990
Biochemical Differences among Scrapie-associated Fibrils Support the Biological Diversity of Scrapie Agents
1985
Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.
1996 StandoutNobel
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
1987 StandoutNature
Genomic structure of the human prion protein gene.
1991
Transmissible spongiform encephalopathies: The threat of BSE to man
1990
Scrapie PrP 27-30 is a sialoglycoprotein
1985
Mutation and polymorphism of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease (CJD).
1993 StandoutNobel
Two alleles of a neural protein gene linked to scrapie in sheep.
1990 Standout
Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain
1985 Nature
The major protein of SAF is absent from spleen and thus not an essential part of the scrapie agent
1986
Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis
1992 StandoutNobel
Pathogenesis of Scrapie: Study of the Temporal Development of Clinical Symptoms, of Infectivity Titres and Scrapie-associated Fibrils in Brains of Hamsters Infected Intraperitoneally
1986
Properties of scrapie prion protein liposomes.
1988 StandoutNobel
Linkage of prion protein and scrapie incubation time genes
1986 StandoutNobel
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
1993 StandoutNobel
Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones
1988
Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.
1995
Molecular characteristics of the major scrapie prion protein
1984 StandoutNobel
Regional mapping of prion proteins in brain.
1992 StandoutNobel
Chemical chaperones interfere with the formation of scrapie prion protein.
1996 StandoutNobel
Unraveling prion diseases through molecular genetics
1989 StandoutNobel
Molecular Characteristics of Prion Rods Purified from Scrapie-Infected Hamster Brains
1986 StandoutNobel
Scrapie prions selectively modify the stress response in neuroblastoma cells.
1995
Purification and structural studies of a major scrapie prion protein
1984 StandoutNobel
Amyloid plaques in Creutzfeldt‐Jakob disease stain with prion protein antibodies
1986 StandoutNobel
The sequential development of abnormal prion protein accumulation in mice with Creutzfeldt-Jakob disease.
1992
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
1993 Standout
Characterization of nucleic acids in membrane vesicles from scrapie-infected hamster brain
1985
Prions are novel infectious pathogens causing scrapie and creutzfeldt—Jakob disease
1986 StandoutNobel
Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent
1992
Proposed three-dimensional structure for the cellular prion protein.
1994 StandoutNobel
Developmental expression of prion protein gene in brain
1987 StandoutNobel
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.
1985
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity
1996 StandoutNobel
Immunological comparison of scrapie-associated fibrils isolated from animals infected with four different scrapie strains
1986
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.
1996
Immunoaffinity purification and neutralization of scrapie prion infectivity.
1988
Scrapie and Cellular Prion Proteins Share Polypeptide Epitopes
1986
Evidence of mitochondrial involvement in scrapie infection
1989
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]
1995
Detection of Scrapie-associated Fibril (SAF) Proteins Using Anti-SAF Antibody in Non-purified Tissue Preparations
1986
Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane.
1993 Standout
Human Prion Protein cDNA: Molecular Cloning, Chromosomal Mapping, and Biological Implications
1986 Science
Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells
1994
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
Prions and prion proteins 1
1991 StandoutNobel
Normal and scrapie-associated forms of prion protein differ in their sensitivities to phospholipase and proteases in intact neuroblastoma cells
1990
Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]
1987 StandoutNobel
Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.
1986
Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues.
1986
Attempts to restore scrapie prion infectivity after exposure to protein denaturants.
1993
The Scrapie Agent: “A Virus by Any Other Name”
1991
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
1996 StandoutScienceNobel
Immunohistochemical confirmation of Creutzfeldt-Jakob disease with a long clinical course with amyloid plaque core antibodies.
1988
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
1991 StandoutNobel
Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.
1990
Prion-Protein Immunoreactivity in Human Transmissible Dementias
1986 StandoutNobel
Scrapie prion proteins are synthesized in neurons.
1986 StandoutNobel
Scrapie: concept of a virus-induced amyloidosis of the brain.
1985
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Specific proteins associated with Creutzfeldt-Jakob disease and scrapie share antigenic and carbohydrate determinants.
1985
Three Hamster Species with Different Scrapie Incubation Times and Neuropathological Features Encode Distinct Prion Proteins
1990 StandoutNobel
Genetics and Polymorphism of the Mouse Prion Gene Complex: Control of Scrapie Incubation Time
1988 StandoutNobel
Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells
1989
Propagation of prion strains through specific conformers of the prion protein
1997 StandoutNobel
Conformational transitions, dissociation, and unfolding of scrapie amyloid (prion) protein.
1993
Brain Regional Distribution of Prion Protein PrP27-30 in Mice Stereotaxically Microinjected with Different Strains of Scrapie
1993
Prions
1998 StandoutNobel
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Physical properties of the Creutzfeldt-Jakob disease agent
1989
Infection-Specific Particle from the Unconventional Slow Virus Diseases
1984 ScienceNobel
Biology and Structure of Scrapie Prions
1986 StandoutNobel
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.
1990
Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time.
1988 StandoutNobel
Separation and properties of cellular and scrapie prion proteins.
1986 StandoutNobel
Localization of a human gene homologous to the PrP gene on the p ARM of chromosome 20 and detection of PrP-related antigens in normal human brain
1986
A kinetic model for amyloid formation in the prion diseases: importance of seeding.
1993
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins
1988 StandoutNobel
Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy
1994
A cellular gene encodes scrapie PrP 27-30 protein
1985 StandoutNobel
Immunoblotting of Creutzfeldt‐Jakob disease prion proteins: Host species—specific epitopes
1987 StandoutNobel
The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).
1986
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis
1991 StandoutNobel
Antisera to scrapie-associated fibril protein and prion protein decorate scrapie-associated fibrils
1987
Prions: Novel Infectious Pathogens
1984 StandoutNobel
Transmission of Scrapie in Hamsters
1985 StandoutNobel
Conservation of infectivity in purified fibrillary extracts of scrapie-infected hamster brain after sequential enzymatic digestion or polyacrylamide gel electrophoresis.
1990 Nobel
Cloning of a Gene Whose Expression Is Increased in Scrapie and in Senile Plaques in Human Brain
1985 Science
Identification of prion amyloid filaments in scrapie-infected brain
1985
Biogenesis and transmembrane orientation of the cellular isoform of the scrapie prion protein [published errratum appears in Mol Cell Biol 1987 May;7(5):2035]
1987
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state
1991
Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent
1995
The protein component of scrapie-associated fibrils is a glycosylated low molecular weight protein.
1985
Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform
1997
Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie
1989
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.
1992 StandoutNobel
Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins.
1990 StandoutNobel
The search for scrapie agent nucleic acid
1990
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.
1990 StandoutNobel
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.
1991
Evidence suggesting that PrP is not the infectious agent in Creutzfeldt-Jakob disease.
1987
Prion diseases of humans and animals
1996 StandoutNobel
Monoclonal Antibodies to the Cellular and Scrapie Prion Proteins
1986
Inherited prion diseases.
1994 StandoutNobel
Recombinant scrapie-like prion protein of 106 amino acids is soluble
1996 StandoutNobel
Creutzfeldt‐Jakob disease: Clinical analysis of a consecutive series of 230 neuropathologically verified cases
1986 Nobel
Some Speculations about Prions, Amyloid, and Alzheimer's Disease
1984 StandoutNobel
Prion liposomes
1990 StandoutNobel
Clinical and Pathological Features and Laboratory Confirmation of Creutzfeldt–Jakob Disease in a Recipient of Pituitary-Derived Human Growth Hormone
1985 Nobel
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.
1994
Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.
1993
Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism.
1994
Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
1992 StandoutNobel
Purified prion proteins and scrapie infectivity copartition into liposomes.
1987 StandoutNobel
Diagnosis of Creutzfeldt-Jakob Disease by Western Blot Identification of Marker Protein in Human Brain Tissue
1986 Nobel
Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins
1987
Characterization of Antisera against Scrapie-associated Fibrils (SAF) from Affected Hamster and Cross-reactivity with SAF from Scrapie-affected Mice and from Patients with Creutzfeldt-Jakob Disease
1985
Conservation of the cellular gene encoding the scrapie prion protein
1986 StandoutNobel
Molecular mass, biochemical composition, and physicochemical behavior of the infectious form of the scrapie precursor protein monomer.
1990 Nobel
Works of Paul E. Bendheim being referenced
Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease
2002
A Modified Host Protein Model of Scrapie
2007
Isolation and structural studies of the intact scrapie agent protein
1987
Purification and Partial Characterization of the Normal Cellular Homologue of the Scrapie Agent Protein
1988
Purification of Scrapie Agents: How Far Have We Come?
1991
Cellular isoform of the scrapie agent protein participates in lymphocyte activation
1990
Antibodies to the scrapie protein decorate prion rods.
1985 StandoutNobel
Scrapie prions aggregate to form amyloid-like birefringent rods
1983 StandoutNobel
Anti-prions and other agents
1991 Nature
Molecular location of a species-specific epitope on the hamster scrapie agent protein
1991
Nearly ubiquitous tissue distribution of the scrapie agent precursor protein
1992
Scrapie-associated prion protein accumulates in astrocytes during scrapie infection.
1991
THE NATURE OF THE UNCONVENTIONAL SLOW INFECTION AGENTS REMAINS A PUZZLE
1989
A 54-kDa normal cellular protein may be the precursor of the scrapie agent protease-resistant protein.
1986
Creutzfeldt–Jakob Disease Prion Proteins in Human Brains
1985 StandoutNobel
Copurification of Sp33-37 and Scrapie Agent from Hamster Brain Prior to Detectable Histopathology and Clinical Disease
1991
Scrapie and Creutzfeldt-Jakob disease prion proteins share physical properties and antigenic determinants.
1985 StandoutNobel
Antibodies to a scrapie prion protein
1984 StandoutNatureNobel