Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Voltage sensor conformations in the open and closed states in rosetta structural models of K + channels
2006 StandoutNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
How directed evolution reshapes the energy landscape in an enzyme to boost catalysis
2020 Science
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
2002 StandoutScience
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase
2020
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
2020
Glutamic Acid-rich Proteins of Rod Photoreceptors Are Natively Unfolded
2005
Adsorbate-induced lattice deformation in IRMOF-74 series
2017
Rhodopsin and Phototransduction
1993
Chemistry of Soft Porous Crystals: Structural Dynamics and Gas Adsorption Properties
2020 StandoutNobel
A Conserved Tripeptide in CNG and HCN Channels Regulates Ligand Gating by Controlling C-Terminal Oligomerization
2004
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Identification of the sodium-calcium exchanger as the major ricin-binding glycoprotein of bovine rod outer segments and its localization to the plasma membrane
1990
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice
2001
Improving and repurposing biocatalysts via directed evolution
2015
Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation
2001
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells
1998
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
2001
Poly(ADP-ribose) polymerase activation by reactive nitrogen species—Relevance for the pathogenesis of inflammation
2005
Evolution of dynamical networks enhances catalysis in a designer enzyme
2021
Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid
1993 StandoutNature
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Role of PARP Under Stress Conditions: Cell Death or Protection?
2003
Cardioprotective effects of poly(ADP-ribose) polymerase inhibition
2005
Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9
1997
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development
1998
The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
2002 Standout
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
1997 Standout
Coiled Coils Direct Assembly of a Cold-Activated TRP Channel
2006 StandoutNobel
Signal flow in visual transduction
1992
Oxidative stress and regional ischemia-reperfusion injury: the peroxynitrite–poly(ADP-ribose) polymerase connection
2003
Poly(ADP-ribose) polymerase activation in the reperfused myocardium
2004
The versatility and universality of calcium signalling
2000 Standout
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis
2004
Molecular interactions between poly(ADP‐ribose) polymerase (PARP I) and topoisomerase I (Topo I): identification of topology of binding
2001
8 Growth Factor-Regulated Proteases and Extracellular Matrix Remodeling during Mammalian Development
1990
Widely Applicable Pd‐Catalyzed trans‐Selective Monoalkylation of Unactivated 1,1‐Dichloro‐1‐alkenes and Pd‐Catalyzed Second Substitution for the Selective Synthesis of E or Z Trisubstituted Alkenes
2005 StandoutNobel
Structure and functions of arrestins
1994
Family of cyclic nucleotide gated ion channels
1995
Retinitis pigmentosa
2006 Standout
Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis
2001
Inhibitors and activators of ADP-ribosylation reactions
1994
The cGMP-gated Channel and Related Glutamic Acid-rich Proteins Interact with Peripherin-2 at the Rim Region of Rod Photoreceptor Disc Membranes
2001
Inhibition of Homodimerization of Poly(ADP-ribose) Polymerase by Its C-terminal Cleavage Products Produced during Apoptosis
2000
Characterization of the G Protein-coupled Receptor Kinase GRK4
1996 StandoutNobel
Calcium-binding proteins in the nervous system
1992
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-κB in inflammatory disorders
2002
Role of peroxynitrite and neuronal nitric oxide synthase in the activation of poly(ADP-ribose) synthetase in a murine model of cerebral ischemia-reperfusion
1998
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
2000 StandoutNature
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Further characterization of the cellular plasminogen binding site: evidence that plasminogen 2 and lipoprotein a compete for the same site
1989
Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents*
2002
Mode of action of poly(ADP-ribose) glycohydrolase
1994
Peroxynitrite‐induced thymocyte apoptosis: the role of caspases and poly (ADP‐ribose) synthetase (PARS) activation
1998
High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol
2006 StandoutNobel
Visual transduction in Drosophila
2001 Nature
Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase
1995 StandoutNobel
Molecular cloning, primary structure, and orientation of the vertebrate photoreceptor cell protein peripherin in the rod outer segment disk membrane
1990
Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
2011
Repair of O6-alkylguanine by alkyltransferases
2000
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion
1998
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
2001
Calcium signaling
1995 Standout
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Activation of Poly(ADP-Ribose) Polymerase-1 Is a Central Mechanism of Lipopolysaccharide-Induced Acute Lung Inflammation
2002
Role of Poly(ADP-Ribose) Polymerase-1 Activation in the Pathogenesis of Diabetic Complications: Endothelial Dysfunction, as a Common Underlying Theme
2005
Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism
1991 StandoutNobel
Structure of the outer mitochondrial membrane: ordered arrays of porelike subunits in outer-membrane fractions from neurospora crassa mitochondria
1982
New inhibitors of poly(ADP-ribose) polymerase and their potential therapeutic targets
2002
Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects
1997
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
PTEN Activity Is Modulated During Ischemia and Reperfusion
2005 StandoutNobel
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Structural and functional evidence for multiple channel complexes in the outer membrane of Neurospora crassa mitochondria.
1983 StandoutNobel
CNG AND HCN CHANNELS: Two Peas, One Pod
2005
Genetic Disruption of Poly (ADP-Ribose) Synthetase Inhibits the Expression of P-Selectin and Intercellular Adhesion Molecule-1 in Myocardial Ischemia/Reperfusion Injury
1998
The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.
1986
Detection of Poly(ADP-ribose) Polymerase Activation in Oxidatively Stressed Cells and Tissues Using Biotinylated NAD Substrate
2002
Temperature-Stable Compelled Composite Superhydrophobic Porous Coordination Polymers Achieved via an Unattainable de Novo Synthetic Method
2018 StandoutNobel
Production of chiral compounds using immobilized cells as a source of biocatalysts
2015
Mechanistic Insights into Enantioselective CH Photooxygenation of Aldehydes via Enamine Catalysis
2015
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase
1998
Binding of plasminogen to cultured human endothelial cells.
1986
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
2003 Standout
Unexpected Diffusion Anisotropy of Carbon Dioxide in the Metal–Organic Framework Zn2(dobpdc)
2018
Glycobiology: Toward Understanding the Function of Sugars
1996 Standout
Na(+)-Ca2+ exchangers from rod outer segments and cardiac sarcolemma: comparison of properties
1991
Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.
1990 StandoutNobel
The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes
2019
Artificial Molecular Machines
2015 Standout
Characterization of an Extremely Large, Ligand-Induced Conformational Change in Plasminogen
1990 StandoutScienceNobel
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
1999 Standout
Perspective: Defining and quantifying the role of dynamics in enzyme catalysis
2016 Nobel
Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future
2013
Poly(ADP-ribose) (PAR) polymer is a death signal
2006 Standout
Dual Catalysis Strategies in Photochemical Synthesis
2016 Standout
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Plasminogen receptors, urokinase receptors, and their modulation on human endothelial cells
1988
Homo- and heteromeric assembly of TRPV channel subunits
2005
Cyclic Nucleotide-Gated Ion Channels
2002
Palladium-Catalyzed Synthesis of Butatrienes
2000
Theoretical Insight into Gate-Opening Adsorption Mechanism and Sigmoidal Adsorption Isotherm into Porous Coordination Polymer
2018 StandoutNobel
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase
2000
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
The Influence of Intrinsic Framework Flexibility on Adsorption in Nanoporous Materials
2017
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Sodium/Calcium Exchange: Its Physiological Implications
1999 Standout
Structure of synaptogyrin (p29) defines novel synaptic vesicle protein.
1995 StandoutNobel
Selective heteromeric assembly of cyclic nucleotide-gated channels
2003
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Structure and mechanism of the G protein-coupled receptor kinases.
1993 StandoutNobel
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Structural basis for gating charge movement in the voltage sensor of a sodium channel
2011 StandoutNobel
Works of Paul Bauer being referenced
The evolution of multiple active site configurations in a designed enzyme
2018
Binding of the cGMP-gated Channel to the Na/Ca-K Exchanger in Rod Photoreceptors
2000
Selective augmentation of histone H1 phosphorylation sites by interaction of poly(ADP-ribose) polymerase and cdc2-kinase: Comparison with protein kinase C
2001
Evidence for two functionally different membrane fractions in bovine retinal rod outer segments.
1988
Subunit Stoichiometry of the CNG Channel of Rod Photoreceptors
2002
Apparent Role of Adenosine Diphosphoribosyl Transferase in the Development of Mytilus edulis and the Inhibition of Differentiation by Ligands of the Enzyme Protein
1991
Association of cyclic GMP‐gated channels and Na(+)‐Ca(2+)‐K+ exchangers in bovine retinal rod outer segment plasma membranes.
1992
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase
1995
Force Field Independent Metal Parameters Using a Nonbonded Dummy Model
2014
Chapter 15 Separation and Some Properties of the Inner and Outer Membranes of Yeast Mitochondria
1975
BCNU is a caspase-mediated inhibitor of drug-induced apoptosis.
1998
Obtaining Optical Purity for Product Diols in Enzyme-Catalyzed Epoxide Hydrolysis: Contributions from Changes in both Enantio- and Regioselectivity
2012
Macromolecular association of ADP-ribosyltransferase and its correlation with enzymic activity
1990
Binding of topo I to PARP I - antibody immunocomplex.
2000
Regulation of components of the inflammatory response by 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase and pleiotropic modifier of cellular signal pathways
1997
Activation of topoisomerase I by poly [ADP-ribose] polymerase.
2000
Cooperative Electrostatic Interactions Drive Functional Evolution in the Alkaline Phosphatase Superfamily
2015
Ca2+ binding capacity of cytoplasmic proteins from rod photoreceptors is mainly due to arrestin.
1990
Modification of growth related enzymatic pathways and apparent loss of tumorigenicity of a ras-transformed bovine endothelial cell line by treatment with 5-iodo-6-amino-1,2-benzopyrone (INH2BP)
1996
Identification of stereoisomers based on dielectric studies: dipole moments of chloroalkenes and chlorocumulenes
1994
Interaction of plasmin with endothelial cells
1984
Stereo- and Regioselectivity in Catalyzed Transformation of a 1,2-Disubstituted Vicinal Diol and the Corresponding Diketone by Wild Type and Laboratory Evolved Alcohol Dehydrogenases
2018